The mechanisms and functions of spontaneous neurotransmitter release

Molecular anatomy of a trafficking organelle

Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373 · see citing works

Quantal components of the end‐plate potential

del Castillo, J., & Katz, B. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005129 · Cited by 2,201 · see citing works

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

Heuser, J. E., & Reese, T. S. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.57.2.315 · Cited by 2,147 · see citing works

Membrane Fusion: Grappling with SNARE and SM Proteins

Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027 · see citing works

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works

Spontaneous subthreshold activity at motor nerve endings

Fatt, P., & Katz, B. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004735 · Cited by 1,847 · see citing works

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C. (1994) · Cell · doi:10.1016/0092-8674(94)90556-8 · Cited by 1,483 · see citing works

Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.

Heuser, J. E., Reese, T. S., Dennis, M. J., Jan, Y. N., Jan, L. Y., & Evans, L. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.81.2.275 · Cited by 1,415 · see citing works

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.022 · Cited by 1,197 · see citing works

Dendritic Protein Synthesis, Synaptic Plasticity, and Memory

Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 894 · see citing works

SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice

Schoch, S., Deák, F., Königstorfer, A., Mozhayeva, M. G., Sara, Y., Südhof, T. C., & Kavalali, E. T. (2001) · Science · doi:10.1126/science.1064335 · Cited by 664 · see citing works

Miniature Neurotransmission Stabilizes Synaptic Function via Tonic Suppression of Local Dendritic Protein Synthesis

Sutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633 · see citing works

Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics

Jahr, C., & Stevens, C. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-09-03178.1990 · Cited by 569 · see citing works

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

Washbourne, P., Thompson, P. M., Carta, M., da Costa, E. T., Mathews, J. R., López‐Bendito, G., Molnár, Z., Bêcher, M. W., Valenzuela, C. F., Partridge, L. D., et al. (2001) · Nature Neuroscience · doi:10.1038/nn783 · Cited by 535 · see citing works

Miniature synaptic events maintain dendritic spines via AMPA receptor activation

McKinney, R. A., Capogna, M., Dürr, R., Gähwiler, B. H., & Thompson, A. S. M. (1999) · Nature Neuroscience · doi:10.1038/4548 · Cited by 523 · see citing works

Neurotrophin Regulation of Cortical Dendritic Growth Requires Activity

McAllister, A. K., Katz, L. C., & Lo, D. C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80239-1 · Cited by 503 · see citing works

Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release

Kaeser, P. S., & Regehr, W. G. (2014) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170338 · Cited by 447 · see citing works

Nanoscale Scaffolding Domains within the Postsynaptic Density Concentrate Synaptic AMPA Receptors

MacGillavry, H. D., Song, Y., Raghavachari, S., & Blanpied, T. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.009 · Cited by 442 · see citing works

An Isolated Pool of Vesicles Recycles at Rest and Drives Spontaneous Neurotransmission

Sara, Y., Virmani, T., Deák, F., Liu, X., & Kavalali, E. T. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.056 · Cited by 399 · see citing works

Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity

Aoto, J., Nam, C. I., Poon, M. M., Ting, P., & Chen, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.012 · Cited by 397 · see citing works

Mechanisms Underlying the Rapid Induction and Sustained Expression of Synaptic Homeostasis

Frank, C. A., Kennedy, M. J., Goold, C. P., Marek, K. W., & Davis, G. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.029 · Cited by 384 · see citing works

Supersensitivity of skeletal muscle produced by botulinum toxin

Thesleff, S. (1960) · The Journal of Physiology · doi:10.1113/jphysiol.1960.sp006463 · Cited by 322 · see citing works

Doc2b Is a High-Affinity Ca ²⁺ Sensor for Spontaneous Neurotransmitter Release

Groffen, A. J., Martens, S., Arazola, R. D., Cornelisse, L. N., Lozovaya, N., de Jong, A. P. H., Goriounova, N. A., Habets, R. L. P., Takai, Y., Borst, J. G., et al. (2010) · Science · doi:10.1126/science.1183765 · Cited by 313 · see citing works

Modulation of Presynaptic Store Calcium Induces Release of Glutamate and Postsynaptic Firing

Sharma, G., & Vijayaraghavan, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00322-2 · Cited by 297 · see citing works

A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth

Huntwork, S., & Littleton, J. T. (2007) · Nature Neuroscience · doi:10.1038/nn1980 · Cited by 292 · see citing works

Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion

Lou, X., Scheuß, V., & Schneggenburger, R. (2005) · Nature · doi:10.1038/nature03568 · Cited by 289 · see citing works

Acute suppression of spontaneous neurotransmission drives synaptic potentiation

Nosyreva, E., Szabla, K., Autry, A. E., Ryazanov, A. G., Monteggia, L. M., & Kavalali, E. T. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4998-12.2013 · Cited by 283 · see citing works

Development of Excitatory Circuitry in the Hippocampus

Hsia, A. Y., Malenka, R. C., & Nicoll, R. A. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.2013 · Cited by 279 · see citing works

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

Xu, J., Pang, Z. P., Shin, O.-H., & Südhof, T. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2320 · Cited by 274 · see citing works

Postsynaptic Decoding of Neural Activity: eEF2 as a Biochemical Sensor Coupling Miniature Synaptic Transmission to Local Protein Synthesis

Sutton, M. A., Taylor, A. M., Ito, H. T., Pham, A., & Schuman, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.030 · Cited by 274 · see citing works

Synaptobrevin is essential for fast synaptic-vesicle endocytosis

Deák, F., Schoch, S., Liu, X., Südhof, T. C., & Kavalali, E. T. (2004) · Nature Cell Biology · doi:10.1038/ncb1185 · Cited by 259 · see citing works

Synaptic Mechanisms Underlying Rapid Antidepressant Action of Ketamine

Kavalali, E. T., & Monteggia, L. M. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12040531 · Cited by 258 · see citing works

Reversal of synaptic vesicle docking at central synapses

Murthy, V. N., & Stevens, C. F. (1999) · Nature Neuroscience · doi:10.1038/9149 · Cited by 254 · see citing works

Activity-Dependent Suppression of Miniature Neurotransmission through the Regulation of DNA Methylation

Nelson, E. D., Kavalali, E. T., & Monteggia, L. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3796-07.2008 · Cited by 254 · see citing works

Autonomous Function of Synaptotagmin 1 in Triggering Synchronous Release Independent of Asynchronous Release

Maximov, A., & Südhof, T. C. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.006 · Cited by 238 · see citing works

Overlapping Role of Dynamin Isoforms in Synaptic Vesicle Endocytosis

Raimondi, A., Ferguson, S. M., Lou, X., Armbruster, M., Paradise, S., Giovedı̀, S., Messa, M., Kono, N., Takasaki, J., Cappello, V., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.031 · Cited by 237 · see citing works

Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses

Gideons, E. S., Kavalali, E. T., & Monteggia, L. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323920111 · Cited by 232 · see citing works

Distinct Requirements for Evoked and Spontaneous Release of Neurotransmitter Are Revealed by Mutations in theDrosophilaGeneneuronal-synaptobrevin

Deitcher, D. L., Ueda, A., Stewart, B. A., Burgess, R. W., Kidokoro, Y., & Schwarz, T. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02028.1998 · Cited by 231 · see citing works

A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse

Fredj, N. B., & Burrone, J. (2009) · Nature Neuroscience · doi:10.1038/nn.2317 · Cited by 231 · see citing works

MeCP2-Dependent Transcriptional Repression Regulates Excitatory Neurotransmission

Nelson, E. D., Kavalali, E. T., & Monteggia, L. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.062 · Cited by 218 · see citing works

Doc2 Is a Ca2+ Sensor Required for Asynchronous Neurotransmitter Release

Yao, J., Gaffaney, J. D., Kwon, S. E., & Chapman, E. R. (2011) · Cell · doi:10.1016/j.cell.2011.09.046 · Cited by 218 · see citing works

Development of Vesicle Pools during Maturation of Hippocampal Synapses

Mozhayeva, M. G., Sara, Y., Liu, X., & Kavalali, E. T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00654.2002 · Cited by 216 · see citing works

Quantal events shape cerebellar interneuron firing

Carter, A. G., & Regehr, W. G. (2002) · Nature Neuroscience · doi:10.1038/nn970 · Cited by 214 · see citing works

Spontaneous and Evoked Release Are Independently Regulated at Individual Active Zones

Melom, J. E., Akbergenova, Y., Gavornik, J. P., & Littleton, J. T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3334-13.2013 · Cited by 210 · see citing works

Spontaneous and evoked glutamate release activate two populations of NMDA receptors with limited overlap

Atasoy, D., Ertunç, M., Moulder, K., Blackwell, J., Chung, C.-Y., Su, J.-Z., & Kavalali, E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2432-08.2008 · Cited by 201 · see citing works

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

Chicka, M. C., Hui, E., Liu, H., & Chapman, E. R. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1463 · Cited by 198 · see citing works

Some Observations on Biological Noise

Fatt, P., & Katz, B. (1950) · Nature · doi:10.1038/166597a0 · Cited by 186 · see citing works

Primary Afferent Activation of Thermosensitive TRPV1 Triggers Asynchronous Glutamate Release at Central Neurons

Peters, J. H., McDougall, S. J., Fawley, J. A., Smith, S. M., & Andresen, M. C. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.017 · Cited by 181 · see citing works

Differential regulation of spontaneous and evoked neurotransmitter release at central synapses

Ramirez, D. M. O., & Kavalali, E. T. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.01.007 · Cited by 177 · see citing works

Local Presynaptic Activity Gates Homeostatic Changes in Presynaptic Function Driven by Dendritic BDNF Synthesis

Jakawich, S. K., Nasser, H. B., Strong, M. J., McCartney, A. J., Perez, A. S., Rakesh, N., Carruthers, C. J. L., & Sutton, M. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.034 · Cited by 171 · see citing works

v-SNARE composition distinguishes synaptic vesicle pools

Hua, Z., Leal-Ortiz, S., Foss, S. M., Waites, C. L., Garner, C. C., Voglmaier, S. M., & Edwards, R. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.010 · Cited by 168 · see citing works

Vti1a Identifies a Vesicle Pool that Preferentially Recycles at Rest and Maintains Spontaneous Neurotransmission

Ramirez, D. M. O., Khvotchev, M. V., Trauterman, B., & Kavalali, E. T. (2012) · Neuron · doi:10.1016/j.neuron.2011.10.034 · Cited by 166 · see citing works

VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission

Raingo, J., Khvotchev, M. V., Liu, P., Darios, F. D., Li, Y. C., Ramirez, D. M. O., Adachi, M., Lemieux, P., Tóth, K., Davletov, B. A., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3067 · Cited by 164 · see citing works

Evoked and Spontaneous Transmission Favored by Distinct Sets of Synapses

Peled, E. S., Newman, Z. L., & Isacoff, E. Y. (2014) · Current Biology · doi:10.1016/j.cub.2014.01.022 · Cited by 158 · see citing works

Doc2 supports spontaneous synaptic transmission by a Ca2+-independent mechanism

Pang, Z., Bacaj, T., Yang, X., Zhou, P., Xu, W., & Südhof, T. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.011 · Cited by 157 · see citing works

Alterations in Transmission, Vesicle Dynamics, and Transmitter Release Machinery at NCAM-Deficient Neuromuscular Junctions

Polo‐Parada, L., Böse, C., & Landmesser, L. T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00521-9 · Cited by 155 · see citing works

Acute Dynamin Inhibition Dissects Synaptic Vesicle Recycling Pathways That Drive Spontaneous and Evoked Neurotransmission

Chung, C., Baryłko, B., Leitz, J., Liu, X., & Kavalali, E. T. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3427-09.2010 · Cited by 154 · see citing works

Cholesterol‐dependent balance between evoked and spontaneous synaptic vesicle recycling

Wasser, C. R., Ertunç, M., Liu, X., & Kavalali, E. T. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.123133 · Cited by 150 · see citing works

Structural Determinants of Synaptobrevin 2 Function in Synaptic Vesicle Fusion

Deák, F., Shin, O., Kavalali, E. T., & Südhof, T. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5272-05.2006 · Cited by 150 · see citing works

A new probe for super-resolution imaging of membranes elucidates trafficking pathways

Revelo, N. H., Kamin, D., Truckenbrodt, S., Wong, A. B., Reuter‐Jessen, K., Reisinger, E., Moser, T., & Rizzoli, S. O. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201402066 · Cited by 150 · see citing works

Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channels

Ermolyuk, Y. S., Alder, F. G., Surges, R., Pavlov, I. Y., Timofeeva, Y., Kullmann, D. M., & Volynski, K. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3563 · Cited by 148 · see citing works

Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool

Groemer, T. W., & Klingauf, J. (2007) · Nature Neuroscience · doi:10.1038/nn1831 · Cited by 147 · see citing works

Syntaxin‐1 N‐peptide and Habc‐domain perform distinct essential functions in synaptic vesicle fusion

Zhou, P., Pang, Z. P., Yang, X., Zhang, Y., Rosenmund, C., Bacaj, T., & Südhof, T. C. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.307 · Cited by 140 · see citing works

Rab3D Is Not Required for Exocrine Exocytosis but for Maintenance of Normally Sized Secretory Granules

Riedel, D., Antonin, W., Fernández‐Chacón, R., de Toledo, G. Á., Jo, T., Geppert, M., Valentijn, J. A., Valentijn, K. M., Jamieson, J. D., Südhof, T. C., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6487-6497.2002 · Cited by 134 · see citing works

Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission

Bal, M., Leitz, J., Reese, A. L., Ramirez, D. M. O., Durakoglugil, M., Herz, J., Monteggia, L. M., & Kavalali, E. T. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.024 · Cited by 131 · see citing works

Differential Effects of SNAP-25 Deletion on Ca2+-Dependent and Ca2+-Independent Neurotransmission

Bronk, P., Deák, F., Wilson, M. C., Liu, X., Südhof, T. C., & Kavalali, E. T. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00226.2007 · Cited by 126 · see citing works

Visualizing presynaptic function

Kavalali, E. T., & Jorgensen, E. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3578 · Cited by 126 · see citing works

Autapses and Networks of Hippocampal Neurons Exhibit Distinct Synaptic Transmission Phenotypes in the Absence of Synaptotagmin I

Liu, H., Dean, C., Arthur, C. P., Dong, M., & Chapman, E. R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1341-09.2009 · Cited by 122 · see citing works

The SNARE Vti1a-β Is Localized to Small Synaptic Vesicles and Participates in a Novel SNARE Complex

Antonin, W., Riedel, D., & von Mollard, G. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05724.2000 · Cited by 113 · see citing works

The same synaptic vesicles drive active and spontaneous release

Wilhelm, B. G., Groemer, T. W., & Rizzoli, S. O. (2010) · Nature Neuroscience · doi:10.1038/nn.2690 · Cited by 111 · see citing works

Synaptotagmin Increases the Dynamic Range of Synapses by Driving Ca2+-Evoked Release and by Clamping a Near-Linear Remaining Ca2+ Sensor

Kochubey, O., & Schneggenburger, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.013 · Cited by 109 · see citing works

Spontaneous Glutamate Release Is Independent of Calcium Influx and Tonically Activated by the Calcium-Sensing Receptor

Vyleta, N. P., & Smith, S. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6398-10.2011 · Cited by 107 · see citing works

Spontaneous Neurotransmission: An Independent Pathway for Neuronal Signaling?

Kavalali, E. T., Chung, C., Khvotchev, M., Leitz, J., Nosyreva, E., Raingo, J., & Ramirez, D. M. O. (2011) · Physiology · doi:10.1152/physiol.00040.2010 · Cited by 104 · see citing works

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses

Scheuber, A., Rudge, R. E., Danglot, L., Raposo, G., Binz, T., Poncer, J. C., & Galli, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603511103 · Cited by 103 · see citing works

Cholesterol and synaptic transmitter release at crayfish neuromuscular junctions

Zamir, O., & Charlton, M. P. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098319 · Cited by 100 · see citing works

Decrease in Calcium Concentration Triggers Neuronal Retinoic Acid Synthesis during Homeostatic Synaptic Plasticity

Wang, H.-L., Zhang, Z., Hintze, M., & Chen, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3964-11.2011 · Cited by 99 · see citing works

Miniature Neurotransmission Regulates Drosophila Synaptic Structural Maturation

Choi, B. J., Imlach, W. L., Jiao, W., Wolfram, V., Wu, Y., Grbic, M., Cela, C., Baines, R., Nitabach, M. N., & McCabe, B. D. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.012 · Cited by 97 · see citing works

A common origin of synaptic vesicles undergoing evoked and spontaneous fusion

Hua, Y., Sinha, R., Martineau, M., Kahms, M., & Klingauf, J. (2010) · Nature Neuroscience · doi:10.1038/nn.2695 · Cited by 95 · see citing works

Deconstructing complexin function in activating and clamping Ca 2+ -triggered exocytosis by comparing knockout and knockdown phenotypes

Yang, X., Cao, P., & Südhof, T. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321367110 · Cited by 92 · see citing works

Contribution of Active Zone Subpopulation of Vesicles to Evoked and Spontaneous Release

Koenig, J. H., & Ikeda, K. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.4.1495 · Cited by 92 · see citing works

Use-Dependent AMPA Receptor Block Reveals Segregation of Spontaneous and Evoked Glutamatergic Neurotransmission

Sara, Y., Bal, M., Adachi, M., Monteggia, L. M., & Kavalali, E. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5234-10.2011 · Cited by 82 · see citing works

Synaptic Ribbons Influence the Size and Frequency of Miniature-like Evoked Postsynaptic Currents

Mehta, B., Snellman, J., Chen, S., Li, W., & Zenisek, D. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.024 · Cited by 82 · see citing works

Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics

Zhou, K., Stawicki, T. M., Goncharov, A., & Jin, Y. (2013) · eLife · doi:10.7554/elife.01180 · Cited by 79 · see citing works

Multiple Spatial and Kinetic Subpopulations of CaMKII in Spines and Dendrites as Resolved by Single-Molecule Tracking PALM

Lu, H. E., MacGillavry, H. D., Frost, N. A., & Blanpied, T. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4364-13.2014 · Cited by 78 · see citing works

Vesicle association and exocytosis at ribbon and extraribbon sites in retinal bipolar cell presynaptic terminals

Zenisek, D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709067105 · Cited by 77 · see citing works

NMDA Receptor Activation by Spontaneous Glutamatergic Neurotransmission

Espinosa, F., & Kavalali, E. T. (2009) · Journal of Neurophysiology · doi:10.1152/jn.90754.2008 · Cited by 77 · see citing works

Differential dependence of phasic transmitter release on synaptotagmin 1 at GABAergic and glutamatergic hippocampal synapses

Kerr, A. M., Reisinger, E., & Jonas, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800621105 · Cited by 75 · see citing works

Intraterminal Ca2+and Spontaneous Transmitter Release at the Frog Neuromuscular Junction

Angleson, J. K., & Betz, W. J. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.1.287 · Cited by 71 · see citing works

Miniature IPSCs in Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca2+Channels via Microdomain Coupling

Goswami, S. P., Bucurenciu, I., & Jónás, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6104-11.2012 · Cited by 70 · see citing works

Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity

Lindskog, M., Li, L., Groth, R. D., Poburko, D., Thiagarajan, T. C., Han, X., & Tsien, R. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016399107 · Cited by 70 · see citing works

Independent Vesicle Pools Underlie Different Modes of Release during Neuronal Development

Andreae, L., Fredj, N. B., & Burrone, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5181-11.2012 · Cited by 69 · see citing works

Neural transmitter release: From quantal secretion to exocytosis and beyond—The Fenn Lecture

Katz, B. (2003) · Journal of Neurocytology · doi:10.1023/b:neur.0000020603.84188.03 · Cited by 69 · see citing works

Differential Motion Dynamics of Synaptic Vesicles Undergoing Spontaneous and Activity-Evoked Endocytosis

Peng, A., Rotman, Z., Deng, P., & Klyachko, V. A. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.023 · Cited by 65 · see citing works

Cannabinoid 1 and Transient Receptor Potential Vanilloid 1 Receptors Discretely Modulate Evoked Glutamate Separately from Spontaneous Glutamate Transmission

Fawley, J. A., Hofmann, M. E., & Andresen, M. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0315-14.2014 · Cited by 65 · see citing works

Store-Operated Calcium Entry Promotes the Degradation of the Transcription Factor Sp4 in Resting Neurons

Lalonde, J., Saia, G., & Gill, G. (2014) · Science Signaling · doi:10.1126/scisignal.2005242 · Cited by 62 · see citing works

Fast Synaptic Vesicle Reuse Slows the Rate of Synaptic Depression in the CA1 Region of Hippocampus

Ertunç, M., Sara, Y., Chung, C., Atasoy, D., Virmani, T., & Kavalali, E. T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4051-06.2007 · Cited by 62 · see citing works

Opposing functions of two sub‐domains of the SNARE‐complex in neurotransmission

Weber, J. P., Reim, K., & Sørensen, J. B. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.130 · Cited by 59 · see citing works

Tetanus neurotoxin-insensitive vesicle-associated membrane protein localizes to a presynaptic membrane compartment in selected terminal subsets of the rat brain

Muzerelle, A., Alberts, P., Martı́nez-Arca, S., Jeannequin, O., Lafaye, P. J., Mazié, J. C., Galli, T., & Gaspar, P. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00567-0 · Cited by 57 · see citing works

Presynaptic Miniature Gabaergic Currents in Developing Interneurons

Trigo, F. F., Bouhours, B., Rostaing, P., Papageorgiou, G., Corrie, J. E. T., Triller, A., Ogden, D., & Marty, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.030 · Cited by 54 · see citing works

Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA

Williams, C. L., Chen, W., Lee, C.-H., Yaeger, D. B., Vyleta, N. P., & Smith, S. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3162 · Cited by 53 · see citing works

Ca2+–Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1

Wang, D., Epstein, D. J., Khalaf, O., Srinivasan, S., Williamson, W. R., Fayyazuddin, A., Quiocho, F. A., & Hiesinger, P. R. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201312109 · Cited by 52 · see citing works

A Sequential Vesicle Pool Model with a Single Release Sensor and a Ca2+-Dependent Priming Catalyst Effectively Explains Ca2+-Dependent Properties of Neurosecretion

Walter, A. M., Pinheiro, P. S., Verhage, M., & Sørensen, J. B. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003362 · Cited by 46 · see citing works

Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures

Pan, Z., Segal, M. M., & Lipton, S. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15423 · Cited by 43 · see citing works

The SNARE protein vti1a functions in dense‐core vesicle biogenesis

Walter, A. M., Kurps, J., de Wit, H., Schöning, S., Toft‐Bertelsen, T. L., Lauks, J., Ziomkiewicz, I., Weiss, A. N., Schulz, A., von Mollard, G. F., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201387549 · Cited by 43 · see citing works

Innervation by a GABAergic Neuron Depresses Spontaneous Release in Glutamatergic Neurons and Unveils the Clamping Phenotype of Synaptotagmin-1

Wierda, K. D. B., & Sørensen, J. B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3934-13.2014 · Cited by 40 · see citing works

Spontaneous transmitter release recruits postsynaptic mechanisms of long-term and intermediate-term facilitation in Aplysia

Jin, I., Udo, H., Rayman, J. B., Puthanveettil, S. V., Kandel, E. R., & Hawkins, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206846109 · Cited by 40 · see citing works

Selective Inhibition of Spontaneous But Not Ca2+-Dependent Release Machinery by Presynaptic Group II mGluRs in Rat Cerebellar Slices

Glitsch, M. D. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01282.2005 · Cited by 36 · see citing works

The role of non-canonical SNAREs in synaptic vesicle recycling

Ramirez, D. M. O., & Kavalali, E. T. (2012) · Cellular Logistics · doi:10.4161/cl.20114 · Cited by 30 · see citing works

Spontaneous transmitter release is critical for the induction of long-term and intermediate-term facilitation in Aplysia

Jin, I., Puthanveettil, S. V., Udo, H., Karl, K. A., Kandel, E. R., & Hawkins, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206914109 · Cited by 30 · see citing works

A Novel Role for γ-Secretase: Selective Regulation of Spontaneous Neurotransmitter Release from Hippocampal Neurons

Pratt, K. G., Zhu, P., Watari, H., Cook, D. G., & Sullivan, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4625-10.2011 · Cited by 27 · see citing works

Mefloquine selectively increases asynchronous acetylcholine release from motor nerve terminals

McArdle, J. J., Sellin, L. C., Coakley, K. M., Potian, J. G., & Högnason, K. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.09.011 · Cited by 22 · see citing works

Neurotransmission: Spontaneous and Evoked Release Filing for Divorce

Walter, A. M., Haucke, V., & Sigrist, S. J. (2014) · Current Biology · doi:10.1016/j.cub.2014.01.037 · Cited by 22 · see citing works

Possible contributions of a novel form of synaptic plasticity inAplysiato reward, memory, and their dysfunctions in mammalian brainPreprint

Hawkins, R. D. (2013) · Learning & Memory · doi:10.1101/lm.031237.113 · Cited by 17 · see citing works

Quantal neurotransmitter release from early endosomes?

Bauerfeind, R., Huttner, W. Β., Almers, W., & Augustine, G. J. (1994) · Trends in Cell Biology · doi:10.1016/0962-8924(94)90191-0 · Cited by 17 · see citing works

SPONTANEOUS TRANSMITTER RELEASE AT THE NEUROMUSCULAR JUNCTION

Thesleff, S. (1988) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1988.tb00625.x · Cited by 5 · see citing works

Depolarization-Induced Suppression of Spontaneous Release in the Avian Midbrain

Penzo, M. A., & Peña, J. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6388-10.2011 · Cited by 5 · see citing works

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

Piwecka, M., Glažar, P., Hernandez-Miranda, L. R., Memczak, S., Wolf, S. A., Rybak-Wolf, A., Filipchyk, A., Klironomos, F., Cerda Jara, C. A., Fenske, P., et al. (2017) · Science · doi:10.1126/science.aam8526 · Cited by 1,210 · see citing works

Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats

Zhang, Y., Xu, J., Ruan, Y. C., Yu, M. K., O'Laughlin, M., Wise, H., Chen, D., Tian, L., Shi, D., Wang, J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4162 · Cited by 1,051 · see citing works

Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology

Pirazzini, M., Rossetto, O., Eleopra, R., & Montecucco, C. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.012658 · Cited by 776 · see citing works

The Role of NMDA Receptors in Alzheimer’s Disease

Liu, J., Chang, L., Song, Y., Li, H., & Wu, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00043 · Cited by 535 · see citing works

Transcellular Nanoalignment of Synaptic Function

Biederer, T., Kaeser, P. S., & Blanpied, T. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.006 · Cited by 352 · see citing works

The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms

Chanaday, N. L., Cousin, M. A., Milosevic, I., Watanabe, S., & Morgan, J. R. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1158-19.2019 · Cited by 255 · see citing works

Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit

Bezaire, M. J., Raikov, I., Burk, K., Vyas, D., & Soltesz, I. (2016) · eLife · doi:10.7554/elife.18566 · Cited by 198 · see citing works

Transmission, Development, and Plasticity of Synapses

Harris, K. P., & Littleton, J. T. (2015) · Genetics · doi:10.1534/genetics.115.176529 · Cited by 196 · see citing works

Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

Aggarwal, A., Liu, R., Chen, Y., Ralowicz, A. J., Bergerson, S. J., Tomáška, F., Mohar, B., Hanson, T., Hasseman, J. P., Reep, D., et al. (2023) · Nature Methods · doi:10.1038/s41592-023-01863-6 · Cited by 192 · see citing works

Targeting Homeostatic Synaptic Plasticity for Treatment of Mood Disorders

Kavalali, E. T., & Monteggia, L. M. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.015 · Cited by 179 · see citing works

Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting

Biglari, N., Gaziano, I., Schumacher, J., Radermacher, J., Paeger, L., Klemm, P., Chen, W., Corneliussen, S., Wunderlich, C. M., Sue, M. W., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00854-0 · Cited by 164 · see citing works

How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release

Maxeiner, S., Luo, F., Tan, A., Schmitz, F., & Südhof, T. C. (2016) · The EMBO Journal · doi:10.15252/embj.201592701 · Cited by 153 · see citing works

Functional organization of postsynaptic glutamate receptors

Scheefhals, N., & MacGillavry, H. D. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.05.002 · Cited by 151 · see citing works

Dynamic Interactions of Plant CNGC Subunits and Calmodulins Drive Oscillatory Ca2+ Channel Activities

Pan, Y., Chai, X., Gao, Q., Zhou, L., Zhang, S., Li, L., & Luan, S. (2019) · Developmental Cell · doi:10.1016/j.devcel.2018.12.025 · Cited by 148 · see citing works

Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

Smith, H., Bourne, J. N., Cao, G., Chirillo, M. A., Ostroff, L. E., Watson, D. J., & Harris, K. M. (2016) · eLife · doi:10.7554/elife.15275 · Cited by 146 · see citing works

Unconventional NMDA Receptor Signaling

Doré, K., Stein, I. S., Brock, J. A., Castillo, P. E., Zito, K., & Sjöström, P. J. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1825-17.2017 · Cited by 145 · see citing works

Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain

Deng, M., Chen, S., & Pan, H. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03047-y · Cited by 145 · see citing works

Input-Specific Plasticity and Homeostasis at the Drosophila Larval Neuromuscular Junction

Newman, Z. L., Hoagland, A., Aghi, K., Worden, K., Levy, S. L., Son, J. H., Lee, L. P., & Isacoff, E. Y. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.028 · Cited by 132 · see citing works

Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity

Banerjee, A., Larsen, R. S., Philpot, B. D., & Paulsen, O. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.11.001 · Cited by 131 · see citing works

Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation

Matikainen‐Ankney, B. A., Kezunovic, N., Mesias, R., Tian, Y., Williams, F. M. K., Huntley, G. W., & Benson, D. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3314-15.2016 · Cited by 131 · see citing works

Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains

de Arce, K. P., Schrod, N., Metzbower, S. R., Allgeyer, E. S., Kong, G. K.-W., Tang, A., Krupp, A. J., Stein, V., Liu, X., Bewersdorf, J., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.11.011 · Cited by 124 · see citing works

Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo

Xie, K., Wang, N., Lin, X., Wang, Z., Zhao, X. J., Fang, P., Yue, H., Kim, J., Luo, J., Cui, S., et al. (2020) · eLife · doi:10.7554/elife.50345 · Cited by 121 · see citing works

Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation

Castro, B. D., Bernstein, A. M., Coppola, G., Sofroniew, M. V., & Khakh, B. S. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109508 · Cited by 115 · see citing works

The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling

Zhang, Z., Marro, S. G., Zhang, Y., Arendt, K. L., Patzke, C., Zhou, B., Fair, T., Yang, N., Südhof, T. C., Wernig, M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aar4338 · Cited by 110 · see citing works

Neurotransmitters Regulation and Food Intake: The Role of Dietary Sources in Neurotransmission

Gasmi, A., Nasreen, A., Menzel, A., Benahmed, A. G., Pivina, L. M., Noor, S., Peana, M., Chirumbolo, S., & Bjørklund, G. (2022) · Molecules · doi:10.3390/molecules28010210 · Cited by 110 · see citing works

The pre-synaptic fusion machinery

Brünger, A. T., Choi, U. B., Lai, Y., Leitz, J., White, K. I., & Zhou, Q. (2019) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2019.03.007 · Cited by 104 · see citing works

Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine

Tornese, P., Sala, N., Bonini, D., Bonifacino, T., La Via, L., Milanese, M., Treccani, G., Seguini, M., Ieraci, A., Mingardi, J., et al. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100160 · Cited by 101 · see citing works

Approaches and Limitations in the Investigation of Synaptic Transmission and Plasticity

Glasgow, S. D., McPhedrain, R., Madranges, J. F., Kennedy, T. E., & Ruthazer, E. S. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00020 · Cited by 100 · see citing works

Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

Abrahamsson, T., Chou, C. Y. C., Li, S. S. Y., Mancino, A. S., Costa, R. P., Brock, J. A., Nuro, E., Buchanan, K. A., Elgar, D., Blackman, A. V., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.030 · Cited by 99 · see citing works

Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress

Chanaday, N. L., Nosyreva, E. D., Shin, O., Zhang, H., Aklan, İ., Atasoy, D., Борисович, Б. И., & Kavalali, E. T. (2021) · Neuron · doi:10.1016/j.neuron.2021.02.023 · Cited by 95 · see citing works

Adult-born neurons modify excitatory synaptic transmission to existing neurons

Adlaf, E. W., Vaden, R. J., Niver, A. J., Manuel, A. F., Onyilo, V. C., Araujo, M. T., Dieni, C. V., Vo, H. T., King, G. D., Wadiche, J. I., et al. (2017) · eLife · doi:10.7554/elife.19886 · Cited by 93 · see citing works

Molecular mechanisms governing Ca2+ regulation of evoked and spontaneous release

Schneggenburger, R., & Rosenmund, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4044 · Cited by 92 · see citing works

Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity

Cho, R. W., Buhl, L. K., Volfson, D., Tran, A., Li, F., Akbergenova, Y., & Littleton, J. T. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.011 · Cited by 92 · see citing works

Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength

Ramsey, A. M., Tang, A., LeGates, T. A., Gou, X., Carbone, B. E., Thompson, S. M., Biederer, T., & Blanpied, T. A. (2021) · Science Advances · doi:10.1126/sciadv.abf3126 · Cited by 90 · see citing works

Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses

Li, S., Raychaudhuri, S., Lee, S. A., Brockmann, M. M., Wang, J., Kusick, G. F., Prater, C. M., Syed, S., Falahati, H., Ramos, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21004-x · Cited by 89 · see citing works

Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function

Kawai, M., Imaizumi, K., Ishikawa, M., Shibata, S., Shinozaki, M., Shibata, T., Hashimoto, S., Kitagawa, T., Ago, K., Kajikawa, K., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110019 · Cited by 86 · see citing works

Molecular Underpinnings of Synaptic Vesicle Pool Heterogeneity

Crawford, D. C., & Kavalali, E. T. (2015) · Traffic · doi:10.1111/tra.12262 · Cited by 84 · see citing works

NMDA receptors and synaptic plasticity in the anterior cingulate cortex

Chen, Q., Li, X., & Zhuo, M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108749 · Cited by 84 · see citing works

Towards resolving the presynaptic NMDA receptor debate

Bouvier, G., Larsen, R. S., Moreno, A. R., Paulsen, O., & Sjöström, P. J. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.12.020 · Cited by 82 · see citing works

Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-administration and Stress-Induced Reinstatement in Rats

Schmeichel, B. E., Herman, M. A., Roberto, M., & Koob, G. F. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.010 · Cited by 81 · see citing works

Interaction of neurotransmitters and neurochemicals with lymphocytes

Kerage, D., Sloan, E. K., Mattarollo, S. R., & McCombe, P. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.04.006 · Cited by 80 · see citing works

Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network

Polepalli, J. S., Wu, H., Goswami, D., Halpern, C. H., Südhof, T. C., & Malenka, R. C. (2017) · Nature Neuroscience · doi:10.1038/nn.4471 · Cited by 79 · see citing works

Presynaptic origins of distinct modes of neurotransmitter release

Chanaday, N. L., & Kavalali, E. T. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.03.005 · Cited by 78 · see citing works

A review of dorsal root ganglia and primary sensory neuron plasticity mediating inflammatory and chronic neuropathic pain

Jang, K., & Garraway, S. M. (2024) · Neurobiology of Pain · doi:10.1016/j.ynpai.2024.100151 · Cited by 78 · see citing works

Spontaneous neurotransmission signals through store-driven Ca2+ transients to maintain synaptic homeostasis

Reese, A. L., & Kavalali, E. T. (2015) · eLife · doi:10.7554/elife.09262 · Cited by 78 · see citing works

Homeostatic Plasticity and External Input Shape Neural Network Dynamics

Zierenberg, J., Wilting, J., & Priesemann, V. (2018) · Physical Review X · doi:10.1103/physrevx.8.031018 · Cited by 78 · see citing works

Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies

Alten, B., Zhou, Q., Shin, O., Esquivies, L. R., Lin, P.-Y., White, K. I., Sun, R., Chung, W. K., Monteggia, L. M., Brünger, A. T., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.10.012 · Cited by 76 · see citing works

Brain activity is not only for thinking

Laumann, T. O., & Snyder, A. Z. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.04.002 · Cited by 76 · see citing works

Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets

Li, Y. C., & Kavalali, E. T. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013342 · Cited by 73 · see citing works

The role of spontaneous neurotransmission in synapse and circuit development

Andreae, L. C., & Burrone, J. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24154 · Cited by 73 · see citing works

Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone

Körber, C., & Kuner, T. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00005 · Cited by 72 · see citing works

Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease

Chakroborty, S., Hill, E. S., Christian, D. T., Helfrich, R., Riley, S., Schneider, C., Kapecki, N., Mustaly-Kalimi, S., Seiler, F. A., Peterson, D. A., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0307-7 · Cited by 71 · see citing works

CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse

Dong, W., Radulović, T., Goral, R. O., Thomas, C. I., Montesinos, M. S., Guerrero‐Given, D., Hagiwara, A., Putzke, T., Hida, Y., Abe, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.024 · Cited by 70 · see citing works

Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice

Lim, C., Kim, H., Yu, N., Kang, S. J., Kim, T., Ko, H., Lee, J., Yang, J.-E., Ryu, H.-H., Park, T., et al. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.016 · Cited by 69 · see citing works

Complexins: small but capable

Mohrmann, R., Dhara, M., & Bruns, D. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1998-8 · Cited by 67 · see citing works

Calcium-Sensing Receptor: A Key Target for Extracellular Calcium Signaling in Neurons

Jones, B., & Smith, S. M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00116 · Cited by 67 · see citing works

miR-34a deficiency in APP/PS1 mice promotes cognitive function by increasing synaptic plasticity via AMPA and NMDA receptors

Xu, Y., Chen, P., Wang, X., Yao, J., & Zhuang, S. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.01.045 · Cited by 65 · see citing works

Direct Electrochemical Detection of Glutamate, Acetylcholine, Choline, and Adenosine Using Non-Enzymatic Electrodes

Shadlaghani, A., Farzaneh, M., Kinser, D., & Reid, R. C. (2019) · Sensors · doi:10.3390/s19030447 · Cited by 63 · see citing works

P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus

Xu, J. P., Bernstein, A. M., Wong, A., Lu, X., Khoja, S., Yang, X. W., Davies, D. L., Micevych, P. E., Sofroniew, M. V., & Khakh, B. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1496-16.2016 · Cited by 63 · see citing works

Ligand diffusion in proteins via enhanced sampling in molecular dynamics

Rydzewski, J., & Nowak, W. (2017) · Physics of Life Reviews · doi:10.1016/j.plrev.2017.03.003 · Cited by 63 · see citing works

Glutamate signalling: A multifaceted modulator of oligodendrocyte lineage cells in health and disease

Spitzer, S. O., Volbracht, K., Lundgaard, I., & Káradóttir, R. T. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.06.014 · Cited by 62 · see citing works

Miniaturized Implantable Fluorescence Probes Integrated with Metal–Organic Frameworks for Deep Brain Dopamine Sensing

Ling, W., Shang, X., Yu, C., Li, C., Xu, K., Feng, L., Wei, Y., Tang, T., & Huang, X. L. (2024) · ACS Nano · doi:10.1021/acsnano.4c00632 · Cited by 61 · see citing works

Cellular responses and functions of α7 nicotinic acetylcholine receptor activation in the brain: A narrative review

Xu, Z.-Q., Zhang, W.-J., Su, D.-F., Zhang, G.-Q., & Miao, C.-Y. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-273 · Cited by 60 · see citing works

Bridging Rapid and Sustained Antidepressant Effects of Ketamine

Kim, J.-W., Suzuki, K., Kavalali, E. T., & Monteggia, L. M. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.02.003 · Cited by 59 · see citing works

Selective alterations of NMDAR function and plasticity in D1 and D2 medium spiny neurons in the nucleus accumbens shell following chronic intermittent ethanol exposure

Renteria, R., Maier, E. Y., Buske, T. R., & Morrisett, R. A. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.004 · Cited by 59 · see citing works

Single synapse evaluation of the postsynaptic NMDA receptors targeted by evoked and spontaneous neurotransmission

Reese, A. L., & Kavalali, E. T. (2016) · eLife · doi:10.7554/elife.21170 · Cited by 59 · see citing works

Permanent dynamic transporter-mediated turnover of glutamate across the plasma membrane of presynaptic nerve terminals: arguments in favor and against

Borisova, Т. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0023 · Cited by 58 · see citing works

Rapid homeostatic plasticity and neuropsychiatric therapeutics

Kavalali, E. T., & Monteggia, L. M. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01411-4 · Cited by 57 · see citing works

Goldfish morphology as a model for evolutionary developmental biology

Ota, K. G., & Abe, G. (2016) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.224 · Cited by 57 · see citing works

Putative duality of presynaptic events

Borisova, Т., & Borysov, A. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0044 · Cited by 57 · see citing works

N-terminal domain of complexin independently activates calcium-triggered fusion

Lai, Y., Choi, U. B., Zhang, Y., Zhao, M., Pfuetzner, R. A., Wang, A. L., Diao, J., & Brünger, A. T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604348113 · Cited by 57 · see citing works

The Relevance of AgRP Neuron-Derived GABA Inputs to POMC Neurons Differs for Spontaneous and Evoked Release

Rau, A. R., & Hentges, S. T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0647-17.2017 · Cited by 56 · see citing works

Mechanisms of 5‐HT 1A receptor‐mediated transmission in dorsal raphe serotonin neurons

Courtney, N. A., & Ford, C. (2015) · The Journal of Physiology · doi:10.1113/jp271716 · Cited by 55 · see citing works

Active presynaptic ribosomes in the mammalian brain, and altered transmitter release after protein synthesis inhibition

Scarnati, M. S., Kataria, R., Biswas, M., & Paradiso, K. G. (2018) · eLife · doi:10.7554/elife.36697 · Cited by 55 · see citing works

Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex

Koga, K., Shimoyama, S., Yamada, A., Furukawa, T., Nikaido, Y., Furue, H., Nakamura, K., & Ueno, S. (2018) · Molecular Pain · doi:10.1177/1744806918783478 · Cited by 53 · see citing works

The role of eEF2 kinase in the rapid antidepressant actions of ketamine

(2020) · Advances in Pharmacology · doi:10.1016/bs.apha.2020.04.005 · Cited by 52 · see citing works

Dysfunction of the SNARE complex in neurological and psychiatric disorders

Chen, F., Chen, H., Chen, Y., Wei, W., Sun, Y., Zhang, L., Cui, L., & Wang, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105469 · Cited by 52 · see citing works

Structure of POPC Lipid Bilayers in OPLS3e Force Field

Kurki, M., Poso, A., Bartos, P., & Miettinen, M. S. (2022) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.2c00395 · Cited by 52 · see citing works

Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy

Crawford, D. C., Ramirez, D. M. O., Trauterman, B., Monteggia, L. M., & Kavalali, E. T. (2017) · Nature Communications · doi:10.1038/ncomms14436 · Cited by 51 · see citing works

Experience-Dependent and Differential Regulation of Local and Long-Range Excitatory Neocortical Circuits by Postsynaptic Mef2c

Rajkovich, K. E., Loerwald, K. W., Hale, C. F., Hess, C. T., Gibson, J. R., & Huber, K. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.022 · Cited by 48 · see citing works

Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex

Tian, Z., Yamanaka, M., Bernabucci, M., Zhao, M., & Zhuo, M. (2017) · Molecular Brain · doi:10.1186/s13041-017-0303-1 · Cited by 47 · see citing works

Direct Anandamide Activation of TRPV1 Produces Divergent Calcium and Current Responses

Fenwick, A. J., Fowler, D. K., Wu, S.-W., Ragozzino, F. J., Lindberg, J. E. M., Kinch, D. C., & Peters, J. H. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00200 · Cited by 47 · see citing works

Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells

Grabner, C. P., & Moser, T. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811814115 · Cited by 47 · see citing works

Searching for principles of brain computation

Maass, W. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.06.003 · Cited by 47 · see citing works

Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit

Zbili, M., Rama, S., Benitez, M.-J., Fronzaroli‐Molinières, L., Bialowas, A., Boumedine-Guignon, N., Garrido, J. J., & Debanne, D. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110601118 · Cited by 46 · see citing works

Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death

Weidinger, A., Milivojev, N., Hosmann, A., Duvigneau, J. C., Szabo, C., Törö, G., Rauter, L., Vaglio-Garro, A., Mkrtchyan, G. V., Trofimova, L., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102669 · Cited by 45 · see citing works

Implantable bioelectronic devices for photoelectrochemical and electrochemical modulation of cells and tissues

Shi, J., Li, P., Kim, S., & Tian, B. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00285-7 · Cited by 45 · see citing works

The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area

Castro, M. A. D., Trettel, F., Milior, G., Maggi, L., Ragozzino, D., & Limatola, C. (2016) · Scientific Reports · doi:10.1038/srep34633 · Cited by 45 · see citing works

Electrochemical Detection of Dopamine and Serotonin in the Presence of Interferences in a Rotating Droplet System

Kundys, M., Bączyńska, E., & Jönsson‐Niedziółka, M. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b02967 · Cited by 45 · see citing works

Nano-Organization at the Synapse: Segregation of Distinct Forms of Neurotransmission

Guzikowski, N. J., & Kavalali, E. T. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.796498 · Cited by 45 · see citing works

A Forward Genetic Screen in Zebrafish Identifies the G-Protein-Coupled Receptor CaSR as a Modulator of Sensorimotor Decision Making

Jain, R. A., Wolman, M. A., Marsden, K. C., Nelson, J. C., Shoenhard, H., Echeverry, F. A., Szi, C., Bell, H., Skinner, J., Cobbs, E. N., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.03.025 · Cited by 44 · see citing works

Synaptic plasticity mechanisms common to learning and alcohol use disorderPreprint

Lovinger, D. M., & Abrahao, K. P. (2018) · Learning & Memory · doi:10.1101/lm.046722.117 · Cited by 44 · see citing works

Ca 2+ Dependence of Synaptic Vesicle Endocytosis

Leitz, J., & Kavalali, E. T. (2015) · The Neuroscientist · doi:10.1177/1073858415588265 · Cited by 43 · see citing works

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons

Beccano-Kelly, D. A., Cherubini, M., Mousba, Y., Cramb, K. M. L., Giussani, S., Caiazza, M. C., Rai, P., Vingill, S., Bengoa‐Vergniory, N., Ng, B., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107044 · Cited by 42 · see citing works

Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling

Roberts, B. M., Lopes, E. F., & Cragg, S. J. (2021) · Cells · doi:10.3390/cells10030709 · Cited by 42 · see citing works

Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain

Vardar, G., Salazar-Lázaro, A., Zobel, S., Trimbuch, T., & Rosenmund, C. (2022) · eLife · doi:10.7554/elife.78182 · Cited by 41 · see citing works

Memristor coupled fractional-order Hopfield neural network composed by heterogeneous neurons and its FPGA implementation

Luo, D., Wang, C., Liang, J., & Deng, Q. (2025) · Nonlinear Dynamics · doi:10.1007/s11071-025-11603-4 · Cited by 40 · see citing works

Spontaneous and evoked neurotransmission are partially segregated at inhibitory synapses

Horvath, P. M., Piazza, M. K., Monteggia, L. M., & Kavalali, E. T. (2020) · eLife · doi:10.7554/elife.52852 · Cited by 40 · see citing works

Muscle Nicotinic Acetylcholine Receptors May Mediate Trans-Synaptic Signaling at the Mouse Neuromuscular Junction

Wang, X., McIntosh, J. M., & Rich, M. M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1789-17.2018 · Cited by 38 · see citing works

Differential regulation of spontaneous and evoked neurotransmitter release at central synapses

Ramirez, D. M. O., & Kavalali, E. T. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.01.007 · Cited by 177 · see citing works

Partitioning the Synaptic Landscape: Distinct Microdomains for Spontaneous and Spike-Triggered Neurotransmission

Sutton, M. A., & Schuman, E. M. (2009) · Science Signaling · doi:10.1126/scisignal.265pe19 · Cited by 34 · see citing works

Spontaneous and Evoked Release Are Independently Regulated at Individual Active Zones

Melom, J. E., Akbergenova, Y., Gavornik, J. P., & Littleton, J. T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3334-13.2013 · Cited by 210 · see citing works

Common strength and localization of spontaneous and evoked synaptic vesicle release sites

Loy, K., Welzel, O., Kornhuber, J., & Groemer, T. W. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-23 · Cited by 5 · see citing works

Neurotransmission: Spontaneous and Evoked Release Filing for Divorce

Walter, A. M., Haucke, V., & Sigrist, S. J. (2014) · Current Biology · doi:10.1016/j.cub.2014.01.037 · Cited by 22 · see citing works