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Cited by 1,190

The DOI matches its Crossref record.

Identification of a signal for rapid export of proteins from the nucleus

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Wen, Wei, Meinkotht, Judy L, Tsien, Roger Y, Taylor, Susan S·1995·Cell
DOI 10.1016/0092-8674(95)90435-2
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Abstract

Active nuclear import of protein is controlled by nuclear localization signals (NLSs), but nuclear export is not understood well. Nuclear trafficking of the catalytic (C) subunit of cAMP-dependent protein kinase (cAPK) is critical for regulation of gene expression. The heat-stable inhibitor (PKl) of cAPK contains a nuclear export signal (NES) that triggers rapid, active net extrusion of the C-PKl complex from the nucleus. This NES (residues 35-49), fused or conjugated to heterologous proteins, was sufficient for rapid nuclear export. Hydrophobic residues were critical. The NES is a slightly weaker signal than the SV40 NLS. A sequence containing only residues 37-46, LALKLAGLDI, is also sufficient for nuclear export. This is an example of a protein-based NES having no obvious association with RNA. A similar sequence, LQLPPLERLTL, from Rev, an RNA-binding protein of HIV-1, also is an NES.

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Metadata

Authors
Wen, W., Meinkotht, J. L., Tsien, R. Y., & Taylor, S. S.
Venue
Cell
Publisher
Elsevier BV
Published
1995-08
Volume
82
Issue
3
Pages
463-473
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(95)90435-2
OpenAlex
W1963705823
Cited by
1,190
References
0
FWCI
25.82
Type
journal article
Language
en
Open access
hybrid

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