Micronutrients in Health and Disease
Open accessAbstract
Micronutrients play a central part in metabolism and in the maintenance of tissue function. An adequate intake therefore is necessary, but provision of excess supplements to people who do not need them may be harmful. Single micronutrient deficiency states are comparatively easily recognised and treated. Subclinical deficiency, often of multiple micronutrients, is more difficult to recognise, and laboratory assessment is often complicated by the acute phase response. Clinical benefit is most likely in those people who are severely depleted and at risk of complications, and is unlikely if this is not the case. There is little evidence for supplements leading to a reduction in the incidence of infections in the elderly population, in coronary artery disease, or in malignant disease. The best evidence for benefit is in critical illness, and in children in developing countries consuming a deficient diet. More clinical trials are required with good clinical outcomes to optimise intake in prevention and treatment of disease.
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Micronutrients (vitamins and minerals) are essential for human health and exert numerous functions including antioxidant defence.
“Despite their tiny amount, micronutrients, i.e., vitamins and minerals, are essential for human health, exerting numerous functions, including antioxidant defence ranging from genome-related processes, such as DNA replication and repair, to metabolic processes and antioxidant defence [407,408].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [407]
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- Authors
- Shenkin, A.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Shenkin, A
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-01
- Volume
- 82
- Issue
- 971
- Pages
- 559-567
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- PMC
- PMC2585731
- OpenAlex
- W2112473561
- Cited by
- 357
- References
- 99
- Citations by year
- 2026: 11 · 2025: 36 · 2024: 38 · 2023: 37 · 2022: 36 · 2021: 34 · 2020: 36 · 2019: 21 · 2018: 16 · 2017: 16 · 2016: 13 · 2015: 9 · 2014: 14 · 2013: 6 · 2012: 4
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Postgraduate Medical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- micronutrients, micronutrient deficiency, subclinical deficiency, micronutrient supplementation, acute phase response, critical illness, infection control, older adults, coronary artery disease, cancer, developing countries, nutritional assessment
- MeSH terms
- Deficiency Diseases, Diet, Health Status, Humans, Metabolic Diseases, Nutrition Disorders, Nutritional Status, Reference Values, Risk Factors, Socioeconomic Factors, Vitamins, Micronutrients, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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