Schizophrenia and the frontal lobe
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Schizophrenia emerges in late adolescence and is associated with reduced cognitive flexibility, often with frontal lobe hypometabolism.
“Schizophrenia is another condition emerging during late adolescence that is associated with reduced cognitive flexibility, often accompanied by frontal lobe hypometabolism94.”
From Cognitive and behavioural flexibility: Neural mechanisms and clinical considerations (2021) · cites this paper as [94]
Cites
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Cognitive and behavioural flexibility: Neural mechanisms and clinical considerations
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- Authors
- WEINBERGER, D.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- WEINBERGER, D
- ORCID
- WEINBERGER, D
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1988
- Volume
- 11
- Issue
- 8
- Pages
- 367-370
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2034269648
- Cited by
- 262
- References
- 23
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 9 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, prefrontal cortex, frontal lobe dysfunction, regional cerebral blood flow, brain metabolism, cognitive activation, blunted affect, lack of insight, problem-solving deficits
- MeSH terms
- Frontal Lobe, Humans, Schizophrenia
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