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Cited by 267Schizophrenia research and treatmentNeural and Behavioral Psychology StudiesHistorical and Modern Theater Studies

Neuropsychological evidence for frontostriatal dysfunction in schizophrenia

Elliott, R., McKenna, P. J., Robbins, T. W., Sahakian, B. J.·1995·Psychological Medicine
DOI 10.1017/s0033291700033523
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Abstract

SYNOPSIS: Schizophrenics and controls were compared on a computerized test of attentional set-shifting which provides a componential analysis of the Wisconsin Card Sort Test and has previously been shown to be sensitive to frontal lobe dysfunction and Parkinson's disease. The main test was of extra-dimensional shifting where subjects are required to shift reponse to an alternative perceptual dimension. In one condition, termed ‘perseveration’, subjects are required to shift to a novel dimension and ignore the previously relevant one. In the other condition, termed ‘learned irrelevance’, subjects are required to shift to the previously irrelevant dimension and ignore a novel one. Chronic medicated schizophrenics (N = 32) show a highly significant impairment on the perseveration but not the learned irrelevance condition, as compared to normal age and IQ matched controls (N = 24). This was true even of a subgroup of patients with preserved IQ. The impairments in attentional set-shifting failed to correlate with patients' scores on the Mini-Mental State Examination (mean; S.D. 26·8; 1·8) or with scores on a test of recognition memory. These results provide evidence for a specific deficit in a set-shifting test of executive function and support a hypothesis of frontostriatal dysfunction in schizophrenia.

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  • Behavioral studies report that sensitivity to reward is intact in schizophrenia, but deficits are evident in rapid reward learning on trial-to-trial feedback, such as reversal learning, and in reward-related decision-making.

    “Behavioral studies of reward learning have reported that sensitivity to reward is intact in schizophrenia, but deficits are evident in rapid reward learning on the basis of trial-to-trial feedback, such as reversal learning, and in reward-related decision-making [406,409-413].”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [409]

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Authors
Elliott, R., McKenna, P. J., Robbins, T. W., & Sahakian, B. J.
Affiliations
University of Cambridge (GB)
Corresponding author
Sahakian, B. J.
ORCID
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
1995-05
Volume
25
Issue
3
Pages
619-630
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291700033523
OpenAlex
W2093066661
Cited by
267
References
52
Citations by year
2024: 3 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 13 · 2015: 16 · 2014: 8 · 2013: 12 · 2012: 3
FWCI
8.50
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 5183 d)
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
schizophrenia, frontostriatal dysfunction, set-shifting, perseveration, executive function, Wisconsin Card Sorting Test, learned irrelevance, frontal lobe dysfunction, antipsychotic drugs, cognitive impairment
MeSH terms
Adult, Aged, Attention, Corpus Striatum, Dominance, Cerebral, Female, Frontal Lobe, Humans, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Psychometrics, Mental Recall, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents

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