Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder
Open accessAbstract
IMPORTANCE: Psychotic disorders (including schizophrenia, schizoaffective disorder, and psychotic bipolar disorder) are devastating illnesses characterized by breakdown in the integration of information processing. Recent advances in neuroimaging allow for the estimation of brain networks on the basis of intrinsic functional connectivity, but the specific network abnormalities in psychotic disorders are poorly understood. OBJECTIVE: To compare intrinsic functional connectivity across the cerebral cortex in patients with schizophrenia spectrum disorders or psychotic bipolar disorder and healthy controls. DESIGN, SETTING, AND PARTICIPANTS: We studied 100 patients from an academic psychiatric hospital (28 patients with schizophrenia, 32 patients with schizoaffective disorder, and 40 patients with bipolar disorder with psychosis) and 100 healthy controls matched for age, sex, race, handedness, and scan quality from December 2009 to October 2011. MAIN OUTCOMES AND MEASURES: Functional connectivity profiles across 122 regions that covered the entire cerebral cortex. RESULTS: Relative to the healthy controls, individuals with a psychotic illness had disruption across several brain networks, with preferential reductions in functional connectivity within the frontoparietal control network (P < .05, corrected for family-wise error rate). This functionally defined network includes portions of the dorsolateral prefrontal cortex, posteromedial prefrontal cortex, lateral parietal cortex, and posterior temporal cortex. This effect was seen across diagnoses and persisted after matching patients and controls on the basis of scan quality. CONCLUSIONS AND RELEVANCE: Our study results support the view that cortical information processing is disrupted in psychosis and provides new evidence that disruptions within the frontoparietal control network may be a shared feature across both schizophrenia and affective psychosis.
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Complex, distributed disruptions in resting-state networks are consistently implicated in Schizophrenia, ADHD, and Autism.
“Complex, distributed disruptions in resting-state networks are consistently implicated in Schizophrenia (Baker et al., 2014; Khadka et al., 2013; Satterthwaite et al., 2015), ADHD (Castellanos and Aoki, 2016; Fair et al., 2012b), and Autism (Kessler et al., 2016; Moseley et al., 2015; Supekar et al., 2013)”
From Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature (2017) · cites this paper as Baker et al., 2014
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- Authors
- Baker, J. T., Holmes, A. J., Masters, G. A., Yeo, B. T. T., Krienen, F., Buckner, R. L., & Öngür, D.
- Affiliations
- Harvard University (US)
- Psychotic Disorders Division, McLean Hospital, Belmont, Massachusetts3Department of Psychiatry, Harvard Medical School, Cambridge, Massachusetts
- Corresponding author
- Baker, Justin T.
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2014-02-01
- Volume
- 71
- Issue
- 2
- Pages
- 109
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC4435541
- OpenAlex
- W2170422206
- Cited by
- 435
- References
- 48
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 25 · 2023: 16 · 2022: 34 · 2021: 43 · 2020: 34 · 2019: 41 · 2018: 54 · 2017: 66 · 2016: 32 · 2015: 31 · 2014: 17 · 2013: 1
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- National University of Singapore (submittedVersion)
- Funders
- National Institutes of Health (5k23mh104515-05)
- National Institute of Mental Health (R01MH094594, K23-MH104515, K23MH079982, K01MH099232)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- schizophrenia, psychotic bipolar disorder, schizoaffective disorder, intrinsic functional connectivity, frontoparietal network, cerebral cortex, dorsolateral prefrontal cortex, lateral parietal cortex, posterior temporal cortex, psychosis
- MeSH terms
- Adult, Association, Bipolar Disorder, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Nerve Net, Parietal Lobe, Psychotic Disorders, Schizophrenia, Prefrontal Cortex, Connectome
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