Sleep Deprivation in the Rat: VII. Immune Function
Abstract
Immune function studies were performed on splenic lymphocytes obtained from rats subjected to total or paradoxical sleep deprivation. Spleen cell counts, in vitro lymphocyte proliferation responses to mitogens, and in vitro and in vivo plaque-forming cell responses to antigens were obtained. Sleep-deprived rats were roughly equivalent to both their yoked controls and home-cage controls in all assays. The results do not support the hypothesis that sleep deprivation results in immune suppression as measured by the above-mentioned parameters.
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Vaccinations with hepatitis A virus and influenza A H1N1 virus in healthy participants appeared not to cause gross sleep changes in the night following vaccination, but there was no comparison of sleep data to a placebo-vaccinated control group.
“Vaccinations with hepatitis A virus (320, 325) and influenza A H1N1 (swine flu) virus (34) in healthy participants appeared to not cause any gross sleep changes in the night following the vaccination, but there was no comparison of sleep data to a placebo-vaccinated control group in these studies.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [34]
A single night without sleep on the night following vaccination against hepatitis A, hepatitis B, and H1N1 reduces the antigen-specific antibody response to a similar extent.
“Further studies showed that also a single night without sleep on the night following vaccination against hepatitis A, hepatitis B, and H1N1 (swine flu) reduces the antigen-specific antibody response (which reflects immunological memory) to a similar extent (34, 320, 325).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [34]
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Dement, W. C., & Chang, J. L. (2004) · Lung biology in health and disease · doi:10.1201/b14428-3
- Authors
- Benca, R. M., Kushida, C. A., Everson, C. A., Kalski, R., Bergmann, B. M., & Rechtschaffen, A.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Rechtschaffen, Allan
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-01
- Volume
- 12
- Issue
- 1
- Pages
- 47-52
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2422841511
- Cited by
- 54
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH18428, MH-4151)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, immune function, splenocytes, lymphocyte proliferation, mitogen response, plaque-forming cells, antigen-specific immunity, REM sleep deprivation, total sleep deprivation, immunosuppression
- MeSH terms
- Animals, Antibody Formation, B-Lymphocytes, Cerebral Cortex, Electroencephalography, Immune Tolerance, Lymphocyte Activation, Male, Rats, Inbred Strains, Sleep Deprivation, Sleep Stages, Sleep, REM, T-Lymphocytes, Rats
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