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A preliminary trial of ascorbic acid as supplemental therapy for autism
Abstract
1. This study presents the results of a 30-week double-blind, placebo-controlled trial exploring the effectiveness of ascorbic acid (8g/70kg/day) as a supplemental pharmacological treatment for autistic children in residential treatment. 2. Residential school children (N = 18) were randomly assigned to either ascorbate-ascorbate-placebo treatment order group or ascorbate-placebo-ascorbate treatment order group. Each treatment phase lasted 10 weeks and behaviors were rated weekly using the Ritvo-Freeman scale. 3. Significant group by phase interactions were found for total scores and also sensory motor scores indicating a reduction in symptom severity associated with the ascorbic acid treatment. 4. These results were consistent with a hypothesized dopaminergic mechanism of action of ascorbic acid.
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Other antioxidants including omega-3 fatty acids have been studied in ASD with mixed results.
“Other antioxidants have been studied in ASD including omega-3 fatty acids [71, 72] with mixed results”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [72]
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Metadata
- Authors
- Dolske, M. C., Spollen, J., McKay, S., Lancashire, E., & Tolbert, L.
- Affiliations
- University of Alabama at Birmingham (US)
- ORCID
- Spollen, John
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 17
- Issue
- 5
- Pages
- 765-774
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2083633216
- Cited by
- 168
- References
- 19
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 12 · 2014: 15 · 2013: 5 · 2012: 11
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Keywords
- vitamin C, vitamin C supplementation, autism spectrum disorder, children with autism, residential treatment, sensory-motor behavior, dopaminergic mechanisms
- MeSH terms
- Adolescent, Adult, Ascorbic Acid, Autistic Disorder, Child, Double-Blind Method, Female, Humans, Male, Psychiatric Status Rating Scales
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