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Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity
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“Effects that are consistent with a role in arousal of pyramidal cell networks include depolarization of cortical neurons through the reduction of a variety of membrane K+ currents (McCormick, 1992), modulation of the h-current (Wang et al., 2007), which controls neuronal and dendritic excitability (Magee, 2000), and control of synaptic transmission, through the modulation of presynaptic terminals”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as McCormick, 1992
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“The release of either of these neurotransmitters can potentially modulate the state of cortical activity through cell type, and even subcellular, specific effects.”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as McCormick, 1992
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“Through the modulation of ionic currents, the release of norephinephrine or acetylcholine can not only control the membrane potential and excitability of cortical neurons, but also strongly suppress the generation of slow oscillations.”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as McCormick, 1992
In the citing paper
“Layer 5 pyramidal cells, in particular, respond to the activation of α1 adrenergic and muscarinic cholinergic receptors with depolarization towards firing threshold, and an increase in excitability through the reduction of K+ currents that function to dampen the generation of repetitive trains of action potentials (McCormick, 1992).”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as McCormick, 1992
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Metadata
- Authors
- McCormick, D. A.
- Affiliations
- Yale University (US)
- Corresponding author
- McCormick, David A.
- ORCID
- McCormick, David A.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 1992-10
- Volume
- 39
- Issue
- 4
- Pages
- 337-388
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2028311911
- Cited by
- 1,117
- References
- 439
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 17 · 2023: 38 · 2022: 19 · 2021: 38 · 2020: 25 · 2019: 26 · 2018: 16 · 2017: 20 · 2016: 27 · 2015: 25 · 2014: 26 · 2013: 33 · 2012: 22
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Progress in Neurobiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Alfred P. Sloan Foundation
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- neurotransmitters, thalamus, cerebral cortex, neuromodulation, thalamocortical activity, thalamocortical circuits
- MeSH terms
- Animals, Cerebral Cortex, Humans, Thalamus, Neurotransmitter Agents
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