The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
Intracrinology
Abstract
A large proportion of androgens in men (40%), and the majority of estrogens in women (75% before menopause and close to 100% after menopause), are synthesized in peripheral target tissues from precursor steroids of adrenal origin. The genes encoding the enzymes responsible for the formation and metabolism of androgens and estrogens are expressed in a large series of peripheral tissues, thus providing the basis for a promising new area in hormone action, namely intracrinology. These steroidogenic and steroid metabolizing enzymes should become a major target of novel therapies for steroid-sensitive diseases, particularly breast and prostate cancer.
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In the citing paper
“This process of peripheral cell specific activation and inactivation is known as pre- and post-receptor steroid metabolism or steroid ” intracrinology” [45,[59], [60], [61]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [59]
In the citing paper
“This metabolism prevents the over-activation of the AR as well as the release of significant amounts of the activated androgens back into circulation (Labrie, 1991).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Labrie, 1991
In the citing paper
“where the locally produced sex steroids are exerting their action in the same cells in which their synthesis takes place without significant diffusion into the circulation”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“most of the androgens in women, especially after menopause, are synthesized in peripheral intracrine tissues from the inactive precursors dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) of adrenal origin.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“The sex steroids made in peripheral tissues are then inactivated locally into more water-soluble compounds that diffuse into the general circulation where they can be measured.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“supplementation with physiological amounts of exogenous DHEA permits the biosynthesis of androgens (essentially testosterone and DHT) and estrogens only in the target tissues that contain the specific steroidogenic enzymes (25,33).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“Our best estimate of the intracrine formation of estrogens in peripheral tissues in women is in the order of 75% before menopause and close to 100% after menopause (25).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“Because the postmenopausal ovary does not secrete estrogens, intratumoral E 2 is necessarily made from adrenal precursor steroids (25).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“Man is unique, with some other primates, in having adrenals that secrete large amounts of the precursor steroids DHEA and DHEA-S, which are converted into 4-dione and then into potent androgens and/or estrogens in peripheral tissues (Refs.25, 77, and 78; Fig. 3).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“the human adrenals secrete large amounts of the precursor steroids DHEA and DHEA-S, both of which are converted into androgens in target intracrine tissues (25,35,78,92,249,254,255).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“the inhibition of tumor growth seen after DHEA treatment in ovariectomized animals results from its intracrine in situ conversion into androgens in the mammary gland (25,35,78,92,255).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“by itself, DHEA does not possess any significant androgenic or estrogenic activity, its activity being dependent upon its transformation into androgens and/or estrogens in peripheral target intracrine tissues (25).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
In the citing paper
“women, at menopause, are not only deprived from estrogens because of a rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of a progressive decrease of serum DHEA levels starting quite a few years before menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [25]
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Self-citationAka, J. A., Mazumdar, M., & Lin, S. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.042 · Cited by 42
GnRH agonists and the rapidly increasing use of combined androgen blockade in prostate cancer
Labrie, F. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0165 · Cited by 42
Self-citationKeller, G., Grimm, V., Vogelsang, H., Bischoff, P., Mueller, J., Siewert, J. R., & Höfler, H. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19961127)68:5 · Cited by 76
Androgens, estrogens, and hydroxysteroid dehydrogenases
Mizrachi, D., & Auchus, R. J. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.08.029 · Cited by 41
Al‐Dujaili, E. A. S., Kenyon, C. J., Nicol, M. R., & Mason, J. I. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.12.011 · Cited by 41
Steroid Sulfation in Neurodegenerative Diseases
Vítků, J., Hill, M., Kolátorová, L., Havrdová, E., & Kancheva, R. L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.839887 · Cited by 42
CYP1B1 gene in endometrial cancer
Sasaki, M., Kaneuchi, M., Fujimoto, S., Tanaka, Y., & Dahiya, R. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(03)00079-0 · Cited by 40
Labrie, F., Cusan, L., Gomez, J., Martel, C., Bérubé, R., Bélanger, P., Chaussade, V., Deloche, C., & Leclaire, J. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.02.003 · Cited by 39
Self-citationDHEA: A Biologist's Perspective
Hornsby, P. J. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb02941.x · Cited by 41
Effect of dehydroepiandrosterone on vaginal and uterine histomorphology in the rat.
Sourla, A., Flamand, M., Bélanger, A., & Labrie, F. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00052-1 · Cited by 40
Self-citationSuppression of estrogen actions in human lung cancer
Miki, Y., Abe, K., Suzuki, S., Suzuki, T., & Sasano, H. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.02.018 · Cited by 40
The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers
Rižner, T. L., Thalhammer, T., & Özvegy‐Laczka, C. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00346 · Cited by 41
Conversion of pregnenolone to DHEA by human 17α‐hydroxylase/17,20‐lyase (P450c17)
Soucy, P., & Luu‐The, V. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01349.x · Cited by 40
Meier, M., Möller, G., & Adamski, J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.03702.x · Cited by 40
Rižner, T. L., Žakelj‐Mavrič, M., Plemenitaš, A., & Zorko, M. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(96)00098-2 · Cited by 40
Crucial role of cytokines in sex steroid formation in normal and tumoral tissues
Simard, J., & Gingras, S. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00387-7 · Cited by 40
Sex Steroids, Carcinogenesis, and Cancer Progression
CASTAGNETTA, L. A. M., Granata, O. M., Cocciadiferro, L., Saetta, A., Polito, L. M., Bronte, G., Rizzo, S., Campisi, I., Agostara, B., & Carruba, G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.028 · Cited by 39
Pangenomic changes induced by DHEA in the skin of postmenopausal women
Calvo, E. L., Luu-The, V., Morissette, J., Martel, C., Labrie, C., Bernard, B., Bernerd, F., Deloche, C., Chaussade, V., Leclaire, J., et al. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.10.008 · Cited by 42
Self-citationDehydroepiandrosterone, androgens and the mammary gland
Labrie, F. (2006) · Gynecological Endocrinology · doi:10.1080/09513590600624440 · Cited by 39
Self-citationVicker, N., Lawrence, H. R., Allan, G. M., Bubert, C., Smith, A., Tutill, H. J., Purohit, A., Day, J. M., Mahon, M. F., Reed, M. J., et al. (2006) · ChemMedChem · doi:10.1002/cmdc.200500087 · Cited by 39
Chen, C., Puy, L. A., Simard, J., Li, X., Singh, S. M., & Labrie, F. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12324390 · Cited by 39
Self-citationAshworth, J., Smyth, J., Pendleton, N., Horan, M., Payton, A., Worthington, J., Ollier, W., & Ashcroft, G. (2008) · Clinical Genetics · doi:10.1111/j.1399-0004.2007.00927.x · Cited by 38
Metadata
- Authors
- Labrie, F.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Labrie, Fernand
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 1991-07
- Volume
- 78
- Issue
- 3
- Pages
- C113-C118
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W4246234200
- Cited by
- 685
- References
- 29
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 6 · 2023: 15 · 2022: 17 · 2021: 17 · 2020: 8 · 2019: 18 · 2018: 20 · 2017: 19 · 2016: 21 · 2015: 27 · 2014: 30 · 2013: 22 · 2012: 17
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Keywords
- intracrinology, androgen production, estrogen synthesis, steroidogenic enzymes, steroid metabolism, tissue-specific gene expression, breast cancer, prostate cancer
- MeSH terms
- Adrenal Glands, Androgens, Breast Neoplasms, Dehydroepiandrosterone, Estrogens, Female, Humans, Male, Menopause, Prostatic Neoplasms, Gene Expression, Dehydroepiandrosterone Sulfate
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