A multicenter trial of bupropion for cocaine dependence in methadone-maintained patients
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We conducted a multi-site, placebo-controlled, randomized double-blind clinical trial comparing bupropion HCL (300 mg/day) to placebo for the treatment of cocaine dependence in methadone-maintained subjects. A total of 149 subjects at three sites participated in a 12-week study. Outcome measures included cocaine use, level of depression, and psychosocial functioning. Results showed no significant differences between placebo and bupropion. Exploratory analyses suggested a medication effect for the subset of subjects depressed at study entry. The need to target subgroups of cocaine abusers in future pharmacotherapy trials and the possible role of treatment readiness are discussed.
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Limited information was identified on the appropriate medical workup for a patient who becomes intoxicated from a ruptured package of body-concealed stimulants.
“limited information was identified on the appropriate medical workup for a patient who becomes intoxicated from a ruptured package of bodyconcealed stimulants.[251][252][253][254][255]”
From The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder (2024) · cites this paper as [252]
The Procedure section describes baseline assessments for a bupropion trial in methadone-maintained patients, not a medical workup for intoxication after a concealed stimulant package ruptures. Searches for package rupture, body concealment, and emergency evaluation found no passage addressing that scenario; page numbers were unavailable in our copy. (LLM, conf=0.75)
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- Authors
- Margolin, A., Kosten, T. R., Avants, S. K., Wilkins, J., Ling, W., Beckson, M., Arndt, I. O., Cornish, J., Ascher, J. A., Li, S.-H., & Bridge, P.
- Affiliations
- Yale University (US)
- VA West Los Angeles Medical Center (US)
- Philadelphia VA Medical Center (US)
- National Institute on Drug Abuse (US)
- Corresponding author
- Margolin, Arthur
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 40
- Issue
- 2
- Pages
- 125-131
- ISSN
- 0376-8716 (ISSN-L)
- OpenAlex
- W2025702178
- Cited by
- 168
- References
- 3
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 7
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Drug and Alcohol Dependence (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (P50DA004060, DA06190, R18DA006190, DA04060)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- bupropion, cocaine dependence, methadone maintenance treatment, pharmacotherapy, depression, psychosocial functioning, treatment readiness, subgroup analysis
- MeSH terms
- Adult, Cocaine, Double-Blind Method, Female, Humans, Male, Methadone, Placebos, Severity of Illness Index, Bupropion, Treatment Outcome, Substance-Related Disorders
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