Cited by 377T-cell and B-cell ImmunologyTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence

Effros, Rita B., Boucher, Nathalie, Porter, Verna, Zhu, Xiaoming, Spaulding, Carolyn, Walford, Roy L., Kronenberg, Mitchell, Cohen, Daniel, Schächter, François·1994·Experimental Gerontology

DOI 10.1016/0531-5565(94)90073-6

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Abstract

The dramatic decline in immune function with age, especially in T cell proliferative activity, has been documented extensively in experimental animal models and in clinical studies of the elderly. A similar proliferative decline is also seen in long-term T lymphocyte cultures used to study in vitro cellular senescence. We have compared the peripheral blood T lymphocytes of centenarians and younger controls for the cell surface expression of CD28, a costimulatory molecule that is required for optimal activation and proliferation following engagement of the T cell receptor. Our analysis shows a significant decrease (p < 0.001) in the percentage of T cells expressing CD28 in the elderly cohort, with values ranging from 44% to 90%, as compared to the mean control value of 91%. The decline in the percentage of CD28+ T cells correlates with a reduction in the CD4/CD8 ratio (r2 = 0.695, p < 0.0001). Concommitantly, experiments using an in vitro T cell culture system showed a progressive loss of CD28 expression with culture "age." The concordance of proliferative decline and loss of CD28 in the centenarians and in the in vitro cultures suggest that a Hayflick phenomenon may operate in vivo leading to immunosenescence.

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Authors: Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F.
Affiliations: University of California, Los Angeles (US)
Fondation Jean Dausset-CEPH (FR)
Corresponding author: Effros, Rita B.
ORCID: Effros, Rita B.
Boucher, Nathalie
Zhu, Xiaoming
Kronenberg, Mitchell
Cohen, Daniel
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 1994-11
Volume: 29
Issue: 6
Pages: 601-609
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/0531-5565(94)90073-6
OpenAlex: W2037915406
Cited by: 377
References: 21
Citations by year: 2026: 5 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 13 · 2020: 8 · 2019: 17 · 2018: 14 · 2017: 14 · 2016: 11 · 2015: 9 · 2014: 10 · 2013: 16 · 2012: 14
FWCI: 3.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
Funders: Amgen
National Institutes of Health (5r01ag005309-06)
National Institute on Aging (AG00427, AG05309, AG-00424)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: immunosenescence, CD28, centenarians, T cell proliferation, cellular senescence, CD4/CD8 ratio, costimulatory molecules
MeSH terms: Adult, Aged, Aged, 80 and over, Cells, Cultured, Humans, Middle Aged, T-Lymphocytes, Linear Models, Case-Control Studies, T-Lymphocyte Subsets, Cellular Senescence, CD28 Antigens, Lymphocyte Count

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Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence

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