Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery
Open accessAbstract
We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. In immature neurons, gamma-aminobutyric acid (GABA) is the primary excitatory neurotransmitter. We found that, shortly before delivery, there is a transient reduction in the intracellular chloride concentration and an excitatory-to-inhibitory switch of GABA actions. These events were triggered by oxytocin, an essential maternal hormone for labor. In vivo administration of an oxytocin receptor antagonist before delivery prevented the switch of GABA actions in fetal neurons and aggravated the severity of anoxic episodes. Thus, maternal oxytocin inhibits fetal neurons and increases their resistance to insults during delivery.
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Oxytocin supports the critical transition from excitatory to inhibitory GABA functioning, catalyzing neurons to undergo electrophysical changes, critical for the infant's survival because the oxytocin-dependent GABA transition protects the fetal brain from hypoxic conditions that otherwise might take place during parturition.
“Oxytocin supports the critical transition from excitatory to inhibitory functioning, catalyzing neurons to undergo electrophysical changes, critical for the infant’s survival because the oxytocin-dependent GABA transition protects the fetal brain from hypoxic conditions that otherwise might take place during parturition.”
From The evolved nest, oxytocin functioning, and prosocial development (2023) · cites this paper as Tyzio et al., 2006
Shortly before delivery a reduction in the intracellular chloride concentration of neurons induced by oxytocin leads to a transitory excitatory-to-inhibitory switch of GABA actions.
“Shortly before delivery a reduction in the intracellular chloride concentration of neurons induced by oxytocin leads to a transitory excitatory-to-inhibitory switch of GABA actions 29 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [29]
The transitory excitatory-to-inhibitory switch of GABA actions shortly before delivery is thought to increase the resistance of neurons to hypoxia and ischemic damage during delivery.
“This is thought to increase the resistance of neurons to hypoxia and ischemic damage during delivery.”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [29]
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- Authors
- Tyzio, R., Cossart, R., Khalilov, I., Minlebaev, M., Hübner, C. A., Represa, A., Ben-Ari, Y., & Khazipov, R.
- Affiliations
- Inserm (FR)
- Institut de Neurobiologie de la Méditerranée, INSERM U29, Université de la Méditerranée, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France.
- Venue
- Science
- Published
- 2006-12-15
- Volume
- 314
- Issue
- 5806
- Pages
- 1788-1792
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052465889
- Cited by
- 485
- References
- 32
- Citations by year
- 2026: 4 · 2025: 18 · 2024: 16 · 2023: 11 · 2022: 28 · 2021: 29 · 2020: 36 · 2019: 29 · 2018: 42 · 2017: 31 · 2016: 31 · 2015: 24 · 2014: 30 · 2013: 26 · 2012: 23
- FWCI
- 20.12
- Type
- journal article
- Language
- en
- Open access
- green
- inserm.hal.science
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- fetal brain, GABA signaling, intracellular chloride, oxytocin receptor, labor, anoxia, fetal neurons, neuroprotection
- MeSH terms
- Action Potentials, Animals, Animals, Newborn, Benzamides, Chlorides, Female, Fetal Hypoxia, Fetus, gamma-Aminobutyric Acid, Hippocampus, Indoles, Maternal-Fetal Exchange, Neural Inhibition, Neurons, Oxytocin, Pregnancy, Receptors, GABA-A, Vasotocin, Signal Transduction, Rats, Wistar, Receptors, Oxytocin, Patch-Clamp Techniques, Sodium-Potassium-Chloride Symporters, Parturition, Sodium Potassium Chloride Symporter Inhibitors, Rats, GABA-A Receptor Agonists, GABA-A Receptor Antagonists, Solute Carrier Family 12, Member 2, In Vitro Techniques
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