Cited by 153Microtubule and mitosis dynamicsHereditary Neurological DisordersGenetic and Kidney Cyst Diseases

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Cloning and localization of a conventional kinesin motor expressed exclusively in neurons

Niclas, Joshua, Navone, Francesca, Hom-Booker, Nora, Vale, Ronald D.·1994·Neuron

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Abstract

Kinesin is a microtubule-based motor protein involved in organelle transport in neuronal and nonneuronal cells. Although a single kinesin motor has been thought to serve all cell types, we document here that neurons express a second conventional kinesin heavy chain (nKHC) that is 65% identical in amino acid sequence to the ubiquitously expressed kinesin heavy chain (uKHC). By preparing antibodies which distinguish between the two KHCs, we demonstrate that nKHC is a nucleotide-dependent microtubule-binding protein which partially cofractionates with membrane organelles. Immunolocalization experiments show that nKHC is distributed throughout the CNS but is highly enriched in subsets of neurons. In hippocampal neurons in culture, uKHC is distributed uniformly throughout the neuron, whereas nKHC is selectively concentrated in the cell body. These results demonstrate that mammalian neuronal tissue contains two conventional kinesin motors which may serve distinct functions in microtubule-based transport.

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LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,218
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512
Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction
Mullis, K., Faloona, F., Scharf, S., Saiki, R., Horn, G., & Erlich, H. (1986) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1986.051.01.032 · Cited by 3,558
Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project
Adams, M. D., Kelley, J. M., Gocayne, J. D., Dubnick, M., Polymeropoulos, M. H., Xiao, H., Merril, C. R., Wu, A. C. K., Olde, B., Moreno, R. F., et al. (1991) · Science · doi:10.1126/science.2047873 · Cited by 2,276
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180

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Authors: Niclas, J., Navone, F., Hom-Booker, N., & Vale, R. D.
Affiliations: University of California, San Francisco (US)
ORCID: Navone, Francesca
Vale, Ronald D.
Venue: Neuron
Publisher: Elsevier BV
Published: 1994-05
Volume: 12
Issue: 5
Pages: 1059-1072
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/0896-6273(94)90314-x
OpenAlex: W2081395783
Cited by: 153
References: 58
Citations by year: 2025: 4 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 4
FWCI: 4.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM38499)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: kinesin heavy chain, microtubule transport, hippocampal neurons, organelle transport, microtubule-binding protein, immunolocalization
MeSH terms: Aging, Amino Acid Sequence, Animals, Animals, Newborn, Brain, Cells, Cultured, Cloning, Molecular, Drosophila, Fluorescent Antibody Technique, HeLa Cells, Hippocampus, Humans, Molecular Sequence Data, Neurons, Poly A, Recombinant Fusion Proteins, RNA, RNA, Messenger, Sciatic Nerve, Blotting, Northern, Organelles, Gene Expression, Kinesins, Sequence Homology, Amino Acid, Macromolecular Substances, Rats

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Cloning and localization of a conventional kinesin motor expressed exclusively in neurons

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