CoChat
Sign Up
Cited by 16Coffee research and impactsNutritional Studies and DietAlcohol Consumption and Health Effects

Coffee consumption and risk of acute myocardial infarction in Italian males

D'Avanzo, Barbara, La Vecchia, Carlo, Tognoni, Gianni, Franceschi, Silvia, Grazia Franzosi, Maria, Nobili, Alessandro, Santoro, Luigi, Scarsi, Giovanni·1993·Annals of Epidemiology
DOI 10.1016/1047-2797(93)90081-e
Open this paper in CoChat — free account

Abstract

The relationship between coffee consumption and acute myocardial infarction (AMI) was analyzed using data from a case-control study conducted in 1988 to 1989 within the framework of the GISSI-2 trial on streptokinase versus alteplase and heparin versus no heparin in the treatment of AMI. A total of 801 male patients with AMI and 792 control subjects who were hospitalized in several Italian regions for diseases unrelated to known or potential risk factors for cardiovascular diseases were included. Compared with coffee nondrinkers, the multivariate relative risks (RRs), after allowance for age, education, body mass index, smoking habits, alcohol consumption, family history of AMI, cholesterol level, history of diabetes, and hypertension, were 0.8 (95% confidence interval (CI), 0.5 to 1.2) for consumption of one cup/d, 1.3 (95% CI, 0.9 to 2.0) for two cups/d, 1.8 (95% CI, 1.1 to 2.7) for three cups, 2.5 (95% CI, 1.5 to 4.1) for four cups, and 2.6 (95% CI, 1.6 to 4.2) for five cups or more. The trend in risk with dose was statistically significant (P < 0.001). Duration of coffee consumption was not associated with the risk of AMI. The RRs for daily coffee consumption were elevated across strata of various covariates, including age, smoking habits, cholesterol level, diabetes, and hypertension, with a particularly elevated (although not significantly heterogeneous) estimate in patients younger than 50 years (RR, 5.7; 95% CI, 3.0 to 10.9 for four or more cups/d). The RR in patients who drank four or more cups of coffee per day and were current smokers was 8.1 (95% CI, 5.1 to 13.0), suggesting an unfavorable effect on the combination of cigarette smoking and high coffee intake on the risk of AMI.

Integrity signals

Registry

Crossref · 10.1016/1047-2797(93)90081-e

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

2 of the 38 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
D'Avanzo, B., La Vecchia, C., Tognoni, G., Franceschi, S., Grazia Franzosi, M., Nobili, A., Santoro, L., & Scarsi, G.
Affiliations
  • Mario Negri Institute for Pharmacological Research (IT)
  • Ente Ospedaliero Ospedali Galliera (IT)
ORCID
Venue
Annals of Epidemiology
Publisher
Elsevier BV
Published
1993-11
Volume
3
Issue
6
Pages
595-600
ISSN
1047-2797 (ISSN-L)
DOI
10.1016/1047-2797(93)90081-e
OpenAlex
W2034763134
Cited by
16
References
38
Citations by year
2018: 1 · 2017: 1 · 2016: 2 · 2014: 1
FWCI
0.33
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Annals of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
coffee consumption, acute myocardial infarction, cardiovascular risk factors, dose-response relationship, smoking, young men, risk stratification
MeSH terms
Adult, Aged, Coffee, Humans, Italy, Male, Middle Aged, Myocardial Infarction, Risk Factors, Case-Control Studies, Randomized Controlled Trials as Topic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review