Overview of orexin/hypocretin system
Open accessAbstract
A series of recent studies has established the orexin/hypocretin system as a critical regulator of sleep/wake states. Its deficiency results in the sleep disorder narcolepsy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy and insomnia. Moreover, accumulating evidence indicates that the orexin/hypocretin system regulates sleep and wakefulness through interactions with neuronal systems that regulate emotion, reward, and energy homeostasis. Here, we briefly summarize the progress of orexin/hypocretin studies and future perspectives.
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The orexin system has been shown to be overactive when sleep deprivation is behaviorally enforced.
“The orexin system has been shown to be overactive when sleep deprivation is behaviorally enforced (36).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [36]
Orexins are synthesized by neurons in the lateral hypothalamus and stimulate arousal and feeding.
“Orexins are synthesized by neurons in the lateral hypothalamus and stimulate arousal and feeding (36).”
From Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men (2014) · cites this paper as [36]
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Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works
Self-citationThe hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · see citing works
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466 · see citing works
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095 · see citing works
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613 · see citing works
The International Classification of Sleep Disorders: Diagnostic and Coding Manual
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-5-413_1 · Cited by 2,416 · see citing works
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118 · see citing works
Reduced Number of Hypocretin Neurons in Human Narcolepsy
Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089 · see citing works
Hypocretin (orexin) deficiency in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776 · see citing works
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659 · see citing works
The sleep switch: hypothalamic control of sleep and wakefulness
Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656 · see citing works
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401 · see citing works
Self-citationNeural substrates of awakening probed with optogenetic control of hypocretin neurons
Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K., & de Lecea, L. (2007) · Nature · doi:10.1038/nature06310 · Cited by 1,341 · see citing works
A role for lateral hypothalamic orexin neurons in reward seeking
Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005) · Nature · doi:10.1038/nature04071 · Cited by 1,311 · see citing works
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Sakurai, T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2092 · Cited by 1,276 · see citing works
Self-citationOrexin A activates locus coeruleus cell firing and increases arousal in the rat
Hagan, J. J., Leslie, R. A., Patel, S., Evans, M. L., Wattam, T. A., Holmes, S., Benham, C. D., Taylor, S. G., Routledge, C., Hemmati, P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10911 · Cited by 1,234 · see citing works
Mignot, E., Lammers, G. J., Ripley, B., Okun, M., Nevsimalova, S., Overeem, S., Vankova, J., Black, J., Harsh, J., Bassetti, C., et al. (2002) · Archives of Neurology · doi:10.1001/archneur.59.10.1553 · Cited by 1,126 · see citing works
Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M., & Nakazato, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.748 · Cited by 1,050 · see citing works
Self-citationHypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K.-I., Sugiyama, F., Goto, K., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00331-3 · Cited by 936 · see citing works
Self-citationDischarge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle
Lee, M., Hassani, O. K., & Jones, B. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1887-05.2005 · Cited by 870 · see citing works
Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons
Mileykovskiy, B. Y., Kiyashchenko, L. I., & Siegel, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.035 · Cited by 841 · see citing works
Promotion of sleep by targeting the orexin system in rats, dogs and humans
Roch, C., Dingemanse, J., Koberstein, R., Hoever, P., Aissaoui, H., Flores, S., Mueller, C., Nayler, O., van Gerven, J., de Haas, S. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1544 · Cited by 578 · see citing works
Afferents to the orexin neurons of the rat brain
Yoshida-Court, K., McCormack, S. L., España, R. A., Crocker, A. J., & Scammell, T. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20859 · Cited by 573 · see citing works
Arousal effect of orexin A depends on activation of the histaminergic system
Huang, Z., Qu, W., Li, W., Mochizuki, T., Eguchi, N., Watanabe, T., Urade, Y., & Hayaishi, O. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181330998 · Cited by 555 · see citing works
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., & de Lecea, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507480102 · Cited by 520 · see citing works
Narita, M., Nagumo, Y., Hashimoto, S., Narita, M., Khotib, J., Miyatake, M., Sakurai, T., Yanagisawa, M., Nakamachi, T., Shioda, S., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2761-05.2006 · Cited by 516 · see citing works
Self-citationOrexin/Hypocretin Excites the Histaminergic Neurons of the Tuberomammillary Nucleus
Eriksson, K. S., Sergeeva, O. A., Brown, R. E., & Haas, H. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09273.2001 · Cited by 509 · see citing works
Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons
Bourgin, P., Huitrón‐Reséndiz, S., Spier, A. D., Fabre, V., Morte, B., Criado, J. R., Sutcliffe, J. G., Henriksen, S. J., & de Lecea, L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07760.2000 · Cited by 508 · see citing works
Narcolepsy is strongly associated with the T-cell receptor alpha locus
Hallmayer, J. F., Faraco, J. H., Lin, L., Hesselson, S., Winkelmann, J., Kawashima, M., Mayer, G., Plazzi, G., Nevšímalová, S., Bourgin, P., et al. (2009) · Nature Genetics · doi:10.1038/ng.372 · Cited by 478 · see citing works
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.010 · Cited by 468 · see citing works
Self-citationWinsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A. J., Sakurai, T., Kilduff, T. S., Horvath, T. L., & de Lecea, L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3459-04.2004 · Cited by 462 · see citing works
Self-citationA key role for orexin in panic anxiety
Johnson, P. L., Truitt, W. A., Fitz, S. D., Minick, P. E., Dietrich, A. D., Sanghani, S. P., Träskman‐Bendz, L., Goddard, A. W., Brundin, L., & Shekhar, A. (2009) · Nature Medicine · doi:10.1038/nm.2075 · Cited by 416 · see citing works
Liu, R.-J., van den Pol, A. N., & Aghajanian, G. K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09453.2002 · Cited by 392 · see citing works
Cox, C. D., Breslin, M. J., Whitman, D. B., Schreier, J. D., McGaughey, G. B., Bogusky, M. J., Roecker, A. J., Mercer, S. P., Bednar, R. A., Lemaire, W., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100541c · Cited by 381 · see citing works
Mieda, M., Willie, J. T., Hara, J., Sinton, C. M., Sakurai, T., & Yanagisawa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400590101 · Cited by 341 · see citing works
Self-citationBurdakov, D., Gerasimenko, O. V., & Verkhratsky, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4925-04.2005 · Cited by 337 · see citing works
Attenuated defense response and low basal blood pressure in orexin knockout mice
Kayaba, Y., Nakamura, A., Kasuya, Y., Ohuchi, T., Yanagisawa, M., Komuro, I., Fukuda, Y., & Kuwaki, T. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00671.2002 · Cited by 337 · see citing works
Increased body-mass index in patients with narcolepsy
Schuld, A., Hebebrand, J., Geller, F., & Pollmächer, T. (2000) · The Lancet · doi:10.1016/s0140-6736(05)74704-8 · Cited by 331 · see citing works
Independent Feeding and Metabolic Actions of Orexins in Mice
Lubkin, M., & Stricker‐Krongrad, A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9750 · Cited by 325 · see citing works
Orexins/hypocretins excite basal forebrain cholinergic neurones
Eggermann, E., Serafin, M., Bayer, L., Machard, D., Saint-Mleux, B., Jones, B. E., & Mühlethaler, M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00512-7 · Cited by 316 · see citing works
Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action
España, R. A., Baldo, B. A., Kelley, A. E., & Berridge, C. W. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00319-0 · Cited by 311 · see citing works
Elevated Tribbles homolog 2–specific antibody levels in narcolepsy patients
Cvetkovic-Lopes, V., Bayer, L., Dorsaz, S., Maret, S., Pradervand, S., Dauvilliers, Y. A., Lecendreux, M., Lammers, G. J., Donjacour, C. E. H. M., Pasquier, R. D., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41366 · Cited by 306 · see citing works
Orexins Activate Histaminergic Neurons via the Orexin 2 Receptor
Yamanaka, A., Tsujino, N., Funahashi, H., Honda, K., Guan, J., Wang, Q.-P., Tominaga, M., Goto, K., Shioda, S., & Sakurai, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6318 · Cited by 297 · see citing works
Self-citationControl of hypothalamic orexin neurons by acid and CO 2
Williams, R. H., Jensen, L. T., Verkhratsky, A., Fugger, L. H., & Burdakov, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702676104 · Cited by 284 · see citing works
Burlet, S., Tyler, C. J., & Leonard, C. S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02862.2002 · Cited by 284 · see citing works
Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat
Brown, R. E., Sergeeva, O. A., Eriksson, K. S., & Haas, H. L. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00178-7 · Cited by 269 · see citing works
Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non-REM and REM Sleep
Mieda, M., Hasegawa, E., Kisanuki, Y. Y., Sinton, C. M., Yanagisawa, M., & Sakurai, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6506-10.2011 · Cited by 268 · see citing works
Self-citationEnhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity
Funato, H., Tsai, A. L., Willie, J. T., Kisanuki, Y. Y., Williams, S. C., Sakurai, T., & Yanagisawa, M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.010 · Cited by 262 · see citing works
Self-citationAcute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice
Tsunematsu, T., Kilduff, T. S., Boyden, E. S., Takahashi, S., Tominaga, M., & Yamanaka, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0784-11.2011 · Cited by 256 · see citing works
Pharmacogenetic Modulation of Orexin Neurons Alters Sleep/Wakefulness States in Mice
Sasaki, K., Suzuki, M., Mieda, M., Tsujino, N., Roth, B. L., & Sakurai, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020360 · Cited by 248 · see citing works
Self-citationTakahashi, K., Lin, J., & Sakai, K. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.058 · Cited by 235 · see citing works
Dugovic, C., Shelton, J. E., Aluisio, L. E., Fraser, I. C., Jiang, X., Sutton, S. W., Bonaventure, P., Yun, S., Li, X., Lord, B., et al. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.152009 · Cited by 229 · see citing works
Orexins (hypocretins) directly excite tuberomammillary neurons
Bayer, L., Eggermann, E., Serafin, M., Saint-Mleux, B., Machard, D., Jones, B. E., & Mühlethaler, M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01777.x · Cited by 198 · see citing works
A Role for Hypocretin (Orexin) in Male Sexual Behavior
Muschamp, J. W., Dominguez, J. M., Sato, S. M., Shen, R., & Hull, E. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4121-06.2007 · Cited by 192 · see citing works
Xi, M.-C., Morales, F. R., & Chase, M. H. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02317-4 · Cited by 188 · see citing works
Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids
Karnani, M., Apergis‐Schoute, J., Adamantidis, A., Jensen, L. T., de Lecea, L., Fugger, L. H., & Burdakov, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.027 · Cited by 166 · see citing works
van den Pol, A. N., Ghosh, P. K., Liu, R., Li, Y., Aghajanian, G. K., & Gao, X. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.017426 · Cited by 158 · see citing works
Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
Miyagawa, T., Kawashima, M., Nishida, N., Ohashi, J., Kimura, R., Fujimoto, A., Shimada, M., Morishita, S., Shigeta, T., Lin, L., et al. (2008) · Nature Genetics · doi:10.1038/ng.231 · Cited by 152 · see citing works
Haynes, A. C., Chapman, H., Taylor, C., Moore, G. B. T., Cawthorne, M. A., Tadayyon, M., Clapham, J. C., & Arch, J. R. S. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00358-5 · Cited by 142 · see citing works
The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions
Zeitzer, J. M., Nishino, S., & Mignot, E. J.-M. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.05.006 · Cited by 135 · see citing works
Effects of lateral preoptic area application of orexin-A on sleep–wakefulness
Methippara, M. M., Alam, M. N., Szymusiak, R. S., & McGinty, D. (2000) · Neuroreport · doi:10.1097/00001756-200011090-00004 · Cited by 126 · see citing works
Spontaneous Food Choice in Narcolepsy
Lammers, G. J., Pijl, H., Iestra, J. A., Langius, J. A. E., Buunk, G., & Meinders, A. E. (1996) · SLEEP · doi:10.1093/sleep/19.1.75 · Cited by 122 · see citing works
Bassetti, C. L., & Aldrich, M. S. (1996) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70273-5 · Cited by 115 · see citing works
Xie, X., Wisor, J. P., Hara, J., Crowder, T. L., LeWinter, R. D., Khroyan, T. V., Yamanaka, A., Diano, S., Horváth, T. L., Sakurai, T., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35115 · Cited by 106 · see citing works
Self-citationOn the Treatment of Rapid Eye Movement Narcolepsy
Guilleminault, C., Carskadon, M., & Dement, W. C. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490310092014 · Cited by 103 · see citing works
Zhang, W., Sakurai, T., Fukuda, Y., & Kuwaki, T. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00704.2005 · Cited by 103 · see citing works
Self-citationA Role for Orexin in Central Vestibular Motor Control
Zhang, J., Li, B., Yu, L., He, Y.-C., Li, H.-Z., Zhu, J., & Wang, J.-J. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.026 · Cited by 102 · see citing works
Tsunematsu, T., Fu, L.-Y., Yamanaka, A., Ichiki, K., Tanoue, A., Sakurai, T., & van den Pol, A. N. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3490-07.2008 · Cited by 70 · see citing works
Self-citationHutcheson, D. M., Quarta, D., Halbout, B., Rigal, A., Valerio, E., & Heidbreder, C. A. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328343d761 · Cited by 69 · see citing works
Genetic Studies in the Sleep Disorder NarcolepsyPreprint
Kadotani, H., Faraco, J. H., & Mignot, E. J.-M. (1998) · Genome Research · doi:10.1101/gr.8.5.427 · Cited by 64 · see citing works
Horvath (1999) · doi:10.1002/(sici)1096-9861(19991213)415:2
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Multiple roles for orexin/hypocretin in addiction
Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59489-1.00007-0 · Cited by 215 · see citing works
Guyon, A., Balbo, M., Morselli, L. L., Tasali, E., Leproult, R., L'Hermite-Balériaux, M., Van Cauter, E., & Spiegel, K. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4254 · Cited by 127 · see citing works
- Authors
- Mieda, M., & Sakurai, T.
- Affiliations
- Kanazawa University (JP)
- Corresponding author
- Sakurai, Takeshi
- Venue
- Progress in brain research
- Publisher
- Elsevier
- Published
- 2012
- Volume
- 198
- Pages
- 5-14
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W150108873
- Cited by
- 64
- References
- 72
- Citations by year
- 2026: 5 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 11 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 11 · 2014: 8 · 2013: 5 · 2012: 1
- FWCI
- 15.35
- Type
- book chapter
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Society for the Promotion of Science (23659134, 24390052)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- sleep regulation, wakefulness, narcolepsy, insomnia, sleep disorders, energy homeostasis, reward, emotions, sleep-wake states
- MeSH terms
- Orexins, Animals, Homeostasis, Humans, Neuropeptides, Sleep, Wakefulness, Intracellular Signaling Peptides and Proteins
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