Cited by 42Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorAutism Spectrum Disorder Research

Neuropsychological measures probably facilitate heritability research of ADHD

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ROMMELSE, N, ALTINK, M, MARTIN, N, BUSCHGENS, C, BUITELAAR, J, SERGEANT, J, OOSTERLAAN, J·2008·Archives of Clinical Neuropsychology

Abstract

Previous studies, in which cognitive and motor neuropsychological tasks were administered to 816 children from Attention-Deficit/Hyperactivity Disorder (ADHD)- and control-families, showed that various of these measures appeared useful for genetic research in ADHD by forming candidate endophenotypes: underlying, heritable, vulnerability traits that mark an enhanced liability for developing ADHD. The current study extends these findings by showing that six of these ten measures correlate more strongly between siblings than an ADHD composite, suggesting these measures may have a larger heritability than ADHD itself. Significant sibling cross-correlations also suggested that six of ten neuropsychological measures related to similar familial (and heritable) factors as ADHD, suggesting these measures to be useful for ADHD genetic research. An aggregated neuropsychological composite appeared to be the most powerful, since it correlated more strongly between siblings than most individual task measures. These findings suggest heritability research in ADHD will probably be facilitated by including neuropsychological measures.

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Crossref · 10.1016/j.acn.2008.06.002

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  • Genetic effects on reward processing in control participants have been described.

    “Moreover, genetic effects on reward processing in control participants have been described 25.”

    From Increased neural responses to reward in adolescents and young adults with attention-deficit/hyperactivity disorder and their unaffected siblings (2015) · cites this paper as [25]

    The Results (§3.1–3.2; page unavailable) report familial influences on cognitive and motor neuropsychological measures, and the Participants section (§2.1; page unavailable) includes control families. No passage found when searching for reward processing, reward, or reinforcement describes genetic effects on reward processing in control participants. (LLM, conf=0.75)

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Research works printed but not linked: 3

  1. Almasy, L., & Blangero, J. (2001). Endophenotypes as quantitative risk factors for psychiatric disease: Rationale and study design. American Journal of Medical Genetics, 105, 42-44.
  2. Chen, P. Y., & Popovich, P. M. (2002). Correlation: Parametric and nonparametric measures. Thousand Oaks, CA: Sage Publications.
  3. De Sonneville, L. M. J. (1999). Amsterdam Neuropsychological Task: A computer-aided assessment program. In B. P. L. M. Den Brinker, P. J. Beek, A. N. Brand, S. J. Maarse, & L. J. M. Mulder (Eds.), Cognitive ergonomics, clinical assessment and computer-assisted learning: Computers in psychology (pp. 204-217). Lisse, The Netherlands: Swets & Zeitlinger.

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Authors
ROMMELSE, N., ALTINK, M., MARTIN, N., BUSCHGENS, C., BUITELAAR, J., SERGEANT, J., & OOSTERLAAN, J.
Affiliations
  • Radboud University Nijmegen (NL)
  • Curtin University (AU)
  • Vrije Universiteit Amsterdam (NL)
Corresponding author
ROMMELSE, N
Venue
Archives of Clinical Neuropsychology
Published
2008-09
Volume
23
Issue
5
Pages
579-591
ISSN
0887-6177 (ISSN-L)
OpenAlex
W2108940014
Cited by
42
References
94
Citations by year
2026: 5 · 2025: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 3
FWCI
3.05
Type
journal article
Language
en
Open access
Locations
  • Archives of Clinical Neuropsychology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • VU Research Portal (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
  • National Institutes of Health
  • U.S. Public Health Service
  • National Institute of Mental Health (R01MH062873, R01 MH62873-01A1)
  • National Center for Research Resources (RR-03655, P41RR003655)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
attention deficit hyperactivity disorder, heritability, endophenotypes, neuropsychological measures, genetic susceptibility, children
MeSH terms
Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Family Health, Female, Humans, Male, Mental Processes, Neuropsychological Tests, Research, Young Adult

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