Neuropsychological measures probably facilitate heritability research of ADHD
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Previous studies, in which cognitive and motor neuropsychological tasks were administered to 816 children from Attention-Deficit/Hyperactivity Disorder (ADHD)- and control-families, showed that various of these measures appeared useful for genetic research in ADHD by forming candidate endophenotypes: underlying, heritable, vulnerability traits that mark an enhanced liability for developing ADHD. The current study extends these findings by showing that six of these ten measures correlate more strongly between siblings than an ADHD composite, suggesting these measures may have a larger heritability than ADHD itself. Significant sibling cross-correlations also suggested that six of ten neuropsychological measures related to similar familial (and heritable) factors as ADHD, suggesting these measures to be useful for ADHD genetic research. An aggregated neuropsychological composite appeared to be the most powerful, since it correlated more strongly between siblings than most individual task measures. These findings suggest heritability research in ADHD will probably be facilitated by including neuropsychological measures.
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Genetic effects on reward processing in control participants have been described.
“Moreover, genetic effects on reward processing in control participants have been described 25.”
From Increased neural responses to reward in adolescents and young adults with attention-deficit/hyperactivity disorder and their unaffected siblings (2015) · cites this paper as [25]
The Results (§3.1–3.2; page unavailable) report familial influences on cognitive and motor neuropsychological measures, and the Participants section (§2.1; page unavailable) includes control families. No passage found when searching for reward processing, reward, or reinforcement describes genetic effects on reward processing in control participants. (LLM, conf=0.75)
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Self-citation
- Authors
- ROMMELSE, N., ALTINK, M., MARTIN, N., BUSCHGENS, C., BUITELAAR, J., SERGEANT, J., & OOSTERLAAN, J.
- Affiliations
- Radboud University Nijmegen (NL)
- Curtin University (AU)
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- ROMMELSE, N
- Venue
- Archives of Clinical Neuropsychology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09
- Volume
- 23
- Issue
- 5
- Pages
- 579-591
- ISSN
- 0887-6177 (ISSN-L)
- PMC
- PMC3895968
- OpenAlex
- W2108940014
- Cited by
- 42
- References
- 94
- Citations by year
- 2026: 5 · 2025: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Clinical Neuropsychology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service
- National Institute of Mental Health (R01MH062873, R01 MH62873-01A1)
- National Center for Research Resources (RR-03655, P41RR003655)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, heritability, endophenotypes, neuropsychological measures, genetic susceptibility, children
- MeSH terms
- Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Family Health, Female, Humans, Male, Mental Processes, Neuropsychological Tests, Research, Young Adult
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