Nanomaterial based drug delivery systems for the treatment of neurodegenerative diseases
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The recent advances in applications of nanotechnology including the use of inorganic, polymeric, magnetic and carbon nanomaterials in drug delivery for treatment of neurodegenerative diseases are reported.
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Nanoparticles have substantial surface area-to-volume ratios, making them ideal for drug modification or attachment of detection probes.
“They also have substantial surface area-to-volume ratios, which makes them ideal for drug modification or attachment of detection probes [32–34].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [34]
The Carbon Nanomaterials section (page unavailable) says graphene nanoparticles can be functionalized to conjugate drugs and contrast agents to their surfaces. The paper also describes nanoparticle surface modification for imaging and therapy, but the passages do not attribute this capacity to a substantial surface-area-to-volume ratio or specifically discuss attaching detection probes. (LLM, conf=0.84)
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- Authors
- Masoudi Asil, S., Ahlawat, J., Guillama Barroso, G., & Narayan, M.
- Affiliations
- The Department of Environmental Science & Engineering
- The University of Texas at El Paso (US)
- The Department of Chemistry
- Corresponding author
- Narayan, Mahesh
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 8
- Issue
- 15
- Pages
- 4109-4128
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- PMC
- PMC7439575
- OpenAlex
- W3036295808
- Cited by
- 181
- References
- 153
- Citations by year
- 2026: 19 · 2025: 27 · 2024: 53 · 2023: 37 · 2022: 26 · 2021: 19
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1SC3 GM111200 01A1)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- nanomaterials, drug delivery systems, neurodegenerative diseases, blood-brain barrier, blood-CSF barrier, P-glycoprotein, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Huntington's disease, prion disease, nanoparticles, magnetic nanoparticles, polymeric nanoparticles, carbon nanoparticles, cell-penetrating peptides, receptor-mediated transcytosis, blood-brain barrier disruption, local drug delivery
- MeSH terms
- Aged, Blood-Brain Barrier, Humans, Drug Delivery Systems, Neurodegenerative Diseases, Nanotechnology, Nanoparticles
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