Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer’s disease pathology
Open accessAbstract
Oxidative stress has been implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer's disease (AD). Several proteins have been identified as targets of oxidative damage in AD dementia (usually stages V/VI of Braak) and in subjects with mild cognitive impairment associated with middle stages of AD pathology (stage IV of Braak). In this study, we investigate whether brain proteins are locally modified by oxidative stress at the first stages of AD-related pathology when morphological lesions are restricted to the entorhinal and transentorhinal cortices of neurofibrillary pathology (stages I/II of Braak). Using a proteomic approach, we show that the alpha subunit of the mitochondrial adenosine triphosphate (ATP)-synthase is distinctly lipoxidized in the entorhinal cortex at Braak stages I/II compared with age-matched controls. In addition, ATP-synthase activity is significantly lower in Braak stages I/II than age-matched control, while electron transport chain, expressed by the mitochondrial complex I activity, remains not affected. This is the first study showing oxidative damage in the first stage, and clinically silent period, of AD-related pathology characterized by entorhinal and transentorhinal tauopathy.
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The activities of LDH, aconitase, and ATP synthase are significantly decreased as a result of oxidation.
“The activities of LDH, aconitase, and ATP synthase are significantly decreased as a result of oxidation [54,55,56,61]”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [61]
The Results (page unavailable) report a significant decrease in ATP-synthase activity in entorhinal cortex from AD Braak stage I/II cases, and the Discussion associates that loss with lipoxidative damage. The paper does not report decreased LDH or aconitase activity, so it supports only the ATP-synthase part of the claim. (LLM, conf=0.90)
Experimental — accuracy not yet measuredEntorhinal cortex neurons are particularly prone to damage by oxidative stress and mitochondrial dysfunction.
“In this view, entorhinal cortex (EC) neurons are particularly prone to damage by OS and mitochondria dysfunction [94,95].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [95]
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- Authors
- Terni, B., Boada, J., Portero‐Otin, M., Pamplona, R., & Ferrer, I.
- Affiliations
- Bellvitge University Hospital (ES)
- Universitat de Lleida (ES)
- Venue
- Brain Pathology
- Publisher
- Wiley
- Published
- 2009-12-07
- Volume
- 20
- Issue
- 1
- Pages
- 222-233
- ISSN
- 1015-6305 (ISSN-L)
- 1750-3639
- PMC
- PMC8094794
- OpenAlex
- W2130376265
- Cited by
- 159
- References
- 56
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 13 · 2023: 13 · 2022: 12 · 2021: 21 · 2020: 12 · 2019: 4 · 2018: 9 · 2017: 7 · 2016: 12 · 2015: 2 · 2014: 6 · 2013: 7 · 2012: 12
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repositori ObertUDL (University of Lleida) (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion)
- Funders
- “la Caixa” Foundation
- European Commission
- Generalitat de Catalunya
- Universitat de Barcelona
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, oxidative stress, mitochondrial ATP synthase, entorhinal cortex, transentorhinal cortex, lipid oxidation, Braak stages, neurofibrillary pathology, tauopathy, mitochondrial complex I, electron transport chain, early Alzheimer's disease, mild cognitive impairment
- MeSH terms
- Adenosine Triphosphatases, Aged, Alzheimer Disease, Borohydrides, Carrier Proteins, Female, Humans, Hydrolysis, Male, Membrane Proteins, Middle Aged, Mitochondria, Mass Spectrometry, Trypsin, Blotting, Western, Electrophoresis, Gel, Two-Dimensional, Lipid Peroxidation, Neurofibrillary Tangles, Oxidative Stress, Disease Progression, Microscopy, Confocal, Entorhinal Cortex, Fluorescent Antibody Technique, Direct, Mitochondrial Proton-Translocating ATPases
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