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Caffeinated coffee consumption, cardiovascular disease, and heart valve disease in the elderly (from the Framingham Study)

Greenberg, James A., Chow, Grant, Ziegelstein, Roy C.·2008·The American Journal of Cardiology
DOI 10.1016/j.amjcard.2008.07.046
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Abstract

The relation between caffeinated coffee consumption and heart disease morbidity and mortality is of great interest given the extensive use of this beverage. A recent prospective epidemiologic study found a strong protective association in elderly subjects without moderate to severe hypertension in the NHANES. To test this association in the Framingham Heart Study population, in which cardiovascular risk factors and health behaviors were carefully documented, Cox regression analyses were conducted for 1,354 subjects aged 65.4 to 96.6 years at study entry. There were 210 deaths from cardiovascular disease and 118 from coronary heart disease (CHD) during 10.1 years of follow-up. A significant negative association between caffeinated coffee consumption and CHD mortality was observed for subjects with systolic blood pressure (BP) <160 mm Hg and diastolic BP <100 mm Hg. The decrease in risk of CHD mortality for any caffeinated coffee versus none was 43% (95% confidence interval 9 to 64). This decreased risk appeared to be caused primarily by an inverse prospective relation between caffeinated coffee consumption and the development or progression of heart valve disease. The decrease in risk of heart valve disease for subjects with systolic BP <160 mm Hg and diastolic BP <100 mm Hg for any caffeinated coffee versus none was 43% (95% confidence interval 4 to 66). In conclusion, caffeinated coffee consumption was associated with lower risk of CHD mortality and heart valve disease development or progression in older Framingham subjects without moderate or severe hypertension.

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Crossref · 10.1016/j.amjcard.2008.07.046

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  • In Greenberg et al. (2008), risk of CHD, stroke and total CVD did not increase significantly across categories of total caffeine intake or caffeinated beverages consumed; risk of CVD and CHD mortality significantly decreased across categories in subjects ≥65 years, normotensive individuals and subjects with untreated stage 1 hypertension, whereas decaffeinated beverages did not affect risk.

    “The risk of CHD, stroke and total CVD did not increase significantly across categories of total caffeine intake (> 30, 30-100, 100-350 and ≥ 350 mg per day) or of caffeinated beverages consumed (< 0.5, 0.5 to < 2, 2 to < 4 and ≥ 4 servings per day).The risk of CVD and CHD mortality significantly decreased across categories of caffeine and caffeinated beverages consumption in subjects ≥ 65 years of”

    From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Greenberg et al., 2008

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Authors
Greenberg, J. A., Chow, G., & Ziegelstein, R. C.
Affiliations
  • City University of New York (US)
  • Johns Hopkins University (US)
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
2008-12
Volume
102
Issue
11
Pages
1502-1508
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/j.amjcard.2008.07.046
OpenAlex
W2037052643
Cited by
61
References
33
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 4 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 3
FWCI
3.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
cardiovascular mortality, coronary heart disease mortality, valvular heart disease, older adults, hypertension, systolic blood pressure, Framingham Heart Study
MeSH terms
Age Factors, Aged, Aged, 80 and over, Blood Pressure, Caffeine, Cardiovascular Diseases, Coffee, Female, Heart Valve Diseases, Humans, Hypertension, Life Style, Male, Prospective Studies, United States, Health Behavior, Logistic Models, Proportional Hazards Models

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