The gut microbiome in food allergy

Zhao, William; Ho, Hsi-en; Bunyavanich, Supinda

doi:10.1016/j.anai.2018.12.012

Cited by 160Food Allergy and Anaphylaxis ResearchGut microbiota and healthProbiotics and Fermented Foods

The gut microbiome in food allergy

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Zhao, William, Ho, Hsi-en, Bunyavanich, Supinda·2019·Annals of Allergy, Asthma & Immunology

DOI 10.1016/j.anai.2018.12.012PMC PMC6389411

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Abstract

Objective To review observational human, murine, and interventional trial studies that have examined the gut microbiome in food allergy, and to provide perspective on future investigations in this field.Data sources A review of the published literature was performed with PubMed, and clinical studies catalogued at ClinicalTrials.gov were also reviewed.Study selections The most recent relevant studies, seminal works, and topical clinical trials were selected.Results Gut dysbiosis likely precedes the development of food allergy, and the timing of such dysbiosis is critical. Gut microbiota associated with individual food allergies may be distinct. Murine models support the importance of gut microbiota in shaping immune maturation and tolerance. Gut microbiota may affect food allergy susceptibility by modulating type 2 immunity, influencing immune development and tolerance, regulating basophil populations, and promoting intestinal barrier function. Ongoing and future interventional trials of probiotics, prebiotics, synbiotics, and fecal microbiota transfer will help translate our understanding of the gut microbiome in food allergy to clinical practice. Future work in this area will include deepening of current research foci, as well as expansion of efforts to include the virome, mycobiome, and interactions between the microbiome, host, and environment. Robust and consistent study designs, multidimensional profiling, and systems biology approaches will enable this future work.Conclusion By advancing research on the microbiome in food allergy, we can further our understanding of food allergy and derive new approaches for its prevention and therapy.

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Available evidence from human intervention studies is limited to early childhood, where synbiotics have shown positive effects in asthma associated with an increase in bifidobacteria.
“The available evidence from human intervention studies is limited to early childhood, where, for example, synbiotics have shown positive effects in asthma associated with an increase in bifidobacteria (Wopereis et al., 2014; Zhao et al., 2019).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Zhao et al., 2019

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[18]Bunyavanich S, Shen N, Grishin A, Wood R, Burks W, Dawson P, Early-life gut microbiome composition and milk allergy resolution. J Allergy Clin Immunol 2016. PMC5056801 27292825

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Authors: Zhao, W., Ho, H.-E., & Bunyavanich, S.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Bunyavanich, Supinda
ORCID: Ho, Hsi-en
Bunyavanich, Supinda
Venue: Annals of Allergy, Asthma & Immunology
Publisher: Elsevier BV
Published: 2019-03
Volume: 122
Issue: 3
Pages: 276-282
ISSN: 1081-1206 (ISSN-L)
DOI: 10.1016/j.anai.2018.12.012
PMC: PMC6389411
OpenAlex: W2906449201
Cited by: 160
References: 65
Citations by year: 2026: 11 · 2025: 22 · 2024: 26 · 2023: 22 · 2022: 20 · 2021: 28 · 2020: 20 · 2019: 11
FWCI: 2.17
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Annals of Allergy Asthma & Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01AI118833, U19AI136053)
Topics: Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, food allergy, gut dysbiosis, immune tolerance, Th2 immune response, intestinal barrier function, probiotics, prebiotics, synbiotics, fecal microbiota transplantation, microbiota-targeted interventions, food allergy prevention, mouse model
MeSH terms: Gastrointestinal Microbiome, Animals, Food Hypersensitivity, Humans

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