The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs
Open accessAbstract
The gastrointestinal (GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions (e.g., digestion, absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease susceptibility. Specific stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed.
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“In piglets, early weaning stress impairs intestinal barrier function (271) and increases inflammation (272) and oxidative stress (273).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [271]
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Citations
Cites
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BackgroundThe microbiota in adaptive immune homeostasis and disease
Honda, K., & Littman, D. R. (2016) · Nature · doi:10.1038/nature18848 · Cited by 1,846 · cited 1×
“…receivedmuch attention as an important defense barrier through several proposed mechanisms, reviewing the body of microbiome studies is beyond the scope of this review, but we direct readers to other excellent reviews on the topic (Backhed et al., 2005; Honda and Littman, 2016; Kelly et al., 2015).”
BackgroundIgE and mast cells in allergic disease
Galli, S. J., & Tsai, M. (2012) · Nature Medicine · doi:10.1038/nm.2755 · Cited by 1,799 · cited 2×
“Mast cells are required for host defense and wound healing; however, excessive activation of mast cells is a central pathophysiologic mechanisms in inflammatory disease such as allergy and asthma and functional stress-related GI disorders including irritable bowel syndrome in humans (Boeckxstaens, 2015; Galli and Tsai…”
BackgroundIntestinal barrier function: molecular regulation and disease pathogenesis
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“, IL-17A, IL-33, IL-23 and transforming growth factor-b), which have important immunomodulatory properties (Schiering et al., 2014).”
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Cited by
Sorted by citations
Wang, X., Tsai, T.-C., Deng, F., Wei, X., Chai, J., Knapp, J., APPLE, J. K., Maxwell, C. V. V., Lee, J. A., Li, Y., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0721-7 · Cited by 528
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451
Gastrointestinal tract (gut) health in the young pig
Pluske, J. R., Turpin, D. L., & Kim, J.-C. (2018) · Animal nutrition · doi:10.1016/j.aninu.2017.12.004 · Cited by 418
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BackgroundInfluentialWeaning stress and intestinal health of piglets: A review
Tang, X., Xiong, K., Fang, R., & Li, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1042778 · Cited by 444
Nutritional Intervention for the Intestinal Development and Health of Weaned Pigs
Xiong, X., Tan, B., Song, M., Ji, P., Kim, K., Yin, Y., & Liu, Y. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00046 · Cited by 217
Metadata
- Authors
- Moeser, A. J., Pohl, C. S., & Rajput, M.
- Affiliations
- Michigan State University (US)
- Corresponding author
- Moeser, Adam J.
- Venue
- Animal nutrition
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 3
- Issue
- 4
- Pages
- 313-321
- ISSN
- 2405-6383 (ISSN-L)
- 2405-6545
- PMC
- PMC5941262
- OpenAlex
- W2732972012
- Cited by
- 452
- References
- 95
- Citations by year
- 2026: 54 · 2025: 53 · 2024: 61 · 2023: 63 · 2022: 85 · 2021: 60 · 2020: 38 · 2019: 34 · 2018: 4
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Animal nutrition (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (HD072968)
- USDA National Institute of Food and Agriculture (2017-67015-26673)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- weaning stress, gastrointestinal barrier, pigs, gut health, intestinal epithelium, enteric nervous system, intestinal immunity, disease susceptibility, early life stress, barrier dysfunction
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