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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
Open accessAbstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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Metadata
- Authors
- Coutard, B., Valle, C., de Lamballerie, X., Canard, B., Seidah, N. G., & Decroly, E.
- Venue
- Antiviral Research
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 176
- Pages
- 104742
- ISSN
- 0166-3542 (ISSN-L)
- OpenAlex
- W3005409321
- Cited by
- 1,679
- References
- 6
- FWCI
- 46.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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