Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Abstract
The aging process is associated with a low-grade chronic inflammation and the accumulation of senescent cells into tissues. Diverse stresses can trigger cellular senescence, a cell fate characterized by cell-cycle arrest and flat morphology. Oncogenic signaling can also induce cellular senescence which has been termed oncogene-induced senescence (OIS). Senescent cells display a pro-inflammatory phenotype which has been called the senescence-associated secretory phenotype (SASP). The secretomes associated with SASP contain colony-stimulating factors and chemokines which stimulate the generation of myeloid-derived suppressor cells (MDSC) by enhancing myelopoiesis in bone marrow and spleen. Enhanced myelopoiesis and increased level of MDSCs have been observed in bone marrow, spleen, and blood in both tumor-bearing and aged mice. Immunosuppressive MDSCs are recruited via chemotaxis into inflamed tissues where they proliferate and consequently suppress acute inflammatory reactions by inhibiting the functions of distinct components of innate and adaptive immunity. For instance, MDSCs stimulate the activity of immunosuppressive regulatory T-cells (Tregs). They also increase the expression of amino acid catabolizing enzymes and the secretion of anti-inflammatory cytokines, e.g. IL-10 and TGF-β, and reactive oxygen species (ROS). On the other hand, the accumulation of MDSCs into tissues exerts harmful effects in chronic pathological disorders, e.g. tumors and many age-related diseases, since the immunosuppression induced by MDSCs impairs the clearance of senescent and cancer cells and also disturbs the maintenance of energy metabolism and tissue proteostasis. The co-operation between senescent cells and immunosuppressive MDSCs regulates not only tumorigenesis and chronic inflammatory disorders but it also might promote inflammaging during the aging process.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many factors in the tumor microenvironment, including cAMP, glucose competition, and oncogenic stress, can induce senescence of T cells, macrophages, natural killer cells, and dendritic cells.
“The role of immunosenescence in tumors is sophisticated: the many factors involved include cAMP, glucose competition, and oncogenic stress in the tumor microenvironment, which can induce the senescence of T cells, macrophages, natural killer cells, and dendritic cells.”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [58]
Tumor cells activate the PKA-CREB and P38 pathways by producing cAMP, thereby causing DNA damage and senescence of T cells.
“In addition, tumor cells activate the PKA-CREB and P38 pathways by producing cAMP, thereby causing DNA damage and senescence of T cells [51, 53, 58–63].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [58]
Increased levels of myeloid-derived suppressor cells are observed in the bone marrow, blood, and spleen of tumor-bearing aged mice; this accumulation plays a detrimental role because MDSC-induced immunosuppression impairs senescence and tumor cell clearance and interferes with energy metabolism and maintenance of tissue protein homeostasis.
“Furthermore, increased levels of myeloid-derived suppressor cells (MDSCs) are observed in the bone marrow, blood, and spleen of tumor-bearing aged mice; this accumulation plays a detrimental role because MDSC-induced immunosuppression impairs senescence and tumor cell clearance and interferes with energy metabolism and maintenance of tissue protein homeostasis [58].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [58]
SASP-expressing senescent cells secrete chemokines and cytokines, which recruit MDSCs to local regions and result in immune escape and tumor cell metastasis.
“SASP-expressing senescent cells secrete several kinds of chemokines and cytokines, which recruit MDSCs to local regions and result in immune escape and tumor cell metastasis [58].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [58]
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
mTOR Signaling in Growth, Metabolism, and Disease
Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works
Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753 · see citing works
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works
mTOR Signaling in Growth, Metabolism, and Disease.
Saxton, R., & Sabatini, D. (2017) · Cell · doi:10.1016/j.cell.2017.03.035 · Cited by 3,889 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,634 · see citing works
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 1× · see citing works
“Cellular senescence is a hallmark of both aging and tumorigenesis (Collado et al. 2007; Campisi 2013).”
BackgroundCellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · see citing works
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Bronte, V., Brandau, S., Chen, S.-H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12150 · Cited by 2,751 · see citing works
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works
Hallmarks of Cellular Senescence
Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605 · see citing works
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · cited 1× · see citing works
“Cellular senescence is a hallmark of both aging and tumorigenesis (Collado et al. 2007; Campisi 2013).”
BackgroundA complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · see citing works
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,199 · see citing works
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · cited 8× · see citing works
“…on the secretomes of senescent cells with SASP have revealed that the secretion profiles are significantly dependent on the context of senescence, e.g. stress stimuli and cell types involved (Kuilman et al. 2008; Rodier et al. 2009; Freund et al. 2010; Maciel-Baron et al. 2016; Wiley et al. 2016).”
BackgroundInfluentialThe Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
Kumar, V., Patel, S., Tcyganov, E., & Gabrilovich, D. I. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.004 · Cited by 2,008 · see citing works
Chemokine signaling via the CXCR2 receptor reinforces senescence
Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works
Myeloid-derived suppressor cells coming of age
Veglia, F., Perego, M., & Gabrilovich, D. I. (2018) · Nature Immunology · doi:10.1038/s41590-017-0022-x · Cited by 1,774 · see citing works
Senescence in Health and Disease
He, S., & Sharpless, N. E. (2017) · Cell · doi:10.1016/j.cell.2017.05.015 · Cited by 1,766 · see citing works
Cellular senescence in cancer and aging.
Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell · doi:10.1016/j.cell.2007.07.003 · Cited by 1,708 · see citing works
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621 · see citing works
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works
Baar, M. P., Brandt, R. M. C., Putavet, D. A., Klein, J. D. D., Derks, K. W. J., Bourgeois, B. R. M., Stryeck, S., Rijksen, Y., van Willigenburg, H., Feijtel, D. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.031 · Cited by 1,454 · see citing works
Huang, B., Pan, P.-Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M., & Chen, S.-H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1299 · Cited by 1,435 · see citing works
Programmed cell senescence during mammalian embryonic development
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428 · see citing works
Inflammatory networks during cellular senescence: causes and consequences.
Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.03.003 · Cited by 1,354 · see citing works
Senescent cells: an emerging target for diseases of ageing
Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.116 · Cited by 1,284 · see citing works
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.011 · Cited by 1,275 · see citing works
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
Nagaraj, S., Gupta, K., Писарев, В. М., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. P., & Gabrilovich, D. I. (2007) · Nature Medicine · doi:10.1038/nm1609 · Cited by 1,176 · see citing works
Cellular senescence drives age-dependent hepatic steatosis
Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15691 · Cited by 1,044 · see citing works
The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.
Allavena, P., Sica, A., Solinas, G., Porta, C., & Mantovani, A. (2008) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.07.004 · Cited by 1,044 · see citing works
Cellular senescence: a translational perspective
Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013 · see citing works
Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116110108 · Cited by 991 · see citing works
Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor
Marigo, I., Bosio, E., Solito, S., Mesa, C., Fernández, A., Dolcetti, L., Ugel, S., Sonda, N., Bicciato, S., Falisi, E., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.010 · Cited by 854 · see citing works
Sinha, P., Clements, V. K., Bunt, S. K., Albelda, S. M., & Ostrand-Rosenberg, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.977 · Cited by 847 · see citing works
Lindau, D., Gielen, P. R., Kroesen, M., Wesseling, P., & Adema, G. J. (2012) · Immunology · doi:10.1111/imm.12036 · Cited by 817 · see citing works
Tu, S., Bhagat, G., Cui, G., Takaishi, S., Kurt‐Jones, E. A., Rickman, B. H., Betz, K. S., Penz-Österreicher, M., Björkdahl, O., Fox, J. G., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.10.011 · Cited by 815 · see citing works
Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells
Corzo, C. A., Cotter, M. J., Cheng, P., Cheng, F., Kusmartsev, S. A., Sotomayor, E. M., Padhya, T. A., McCaffrey, T. V., McCaffrey, J. C., & Gabrilovich, D. I. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900092 · Cited by 765 · see citing works
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763 · see citing works
Self-citationProinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells
Sinha, P., Okoro, C., Foell, D., Freeze, H. H., Ostrand‐Rosenberg, S., & Srikrishna, G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4666 · Cited by 722 · see citing works
Beerman, I., Bhattacharya, D., Zandi, S., Sigvardsson, M., Weissman, I. L., Bryder, D., & Rossi, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000834107 · Cited by 711 · see citing works
DNA damage response and cellular senescence in tissues of aging mice
Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696 · see citing works
Bunt, S. K., Yang, L.-L., Sinha, P., Clements, V., Leips, J., & Ostrand-Rosenberg, S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2354 · Cited by 680 · see citing works
Orjalo, A. V., Bhaumik, D., Gengler, B. K., Scott, G. K., & Campisi, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905299106 · Cited by 654 · see citing works
Hoechst, B., Voigtlaender, T., Ormandy, L. A., Gamrekelashvili, J., Zhao, F., Wedemeyer, H. H., Lehner, F., Manns, M. P., Greten, T. F., & Korangy, F. (2009) · Hepatology · doi:10.1002/hep.23054 · Cited by 646 · see citing works
Chang, A. L., Miska, J., Wainwright, D. A., Dey, M., Rivetta, C. V., Yu, D., Kanojia, D., Pituch, K. C., Qiao, J., Pytel, P., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0144 · Cited by 640 · see citing works
Senescent cells as a source of inflammatory factors for tumor progression
Davalos, A. R., Coppe, J.-P., Campisi, J., & Desprez, P.-Y. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9220-9 · Cited by 636 · see citing works
Matthews, C., Gorenne, I., Scott, S., Figg, N., Kirkpatrick, P., Ritchie, A., Goddard, M., & Bennett, M. (2006) · Circulation Research · doi:10.1161/01.res.0000233315.38086.bc · Cited by 615 · see citing works
Yu, J., Du, W., Fang, Y., Wang, Y., Li, H., Cao, S., Yu, W., Shen, C., Liu, J., & Ren, X. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201449 · Cited by 608 · see citing works
Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
Chen, Y.-Q., & Guillemin, G. (2009) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s2097 · Cited by 589 · see citing works
L-arginine metabolism in myeloid cells controls T-lymphocyte functions
Bronte, V., Serafini, P., Mazzoni, A., Segal, D. M., & Zanovello, P. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00132-7 · Cited by 588 · see citing works
Astrocyte Senescence as a Component of Alzheimer’s Disease
Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045069 · Cited by 586 · see citing works
Accumulation of senescent cells in Mitotic tissue of aging primates
Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works
Dolcetti, L., Peranzoni, E., Ugel, S., Marigo, I., Fernández, A., Mesa, C., Geilich, M., Winkels, G., Traggiai, E., Casati, A., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200939903 · Cited by 568 · see citing works
Yang, H., Antoine, D. J., Andersson, U., & Tracey, K. J. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1212662 · Cited by 542 · see citing works
Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression
Bunt, S. K., Sinha, P., Clements, V. K., Leips, J., & Ostrand‐Rosenberg, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.1.284 · Cited by 539 · see citing works
Ostrand-Rosenberg, S., & Fenselau, C. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701019 · Cited by 509 · see citing works
Coppé, J.-P., Rodier, F., Patil, C. K., Freund, A., Desprez, P.-Y., & Campisi, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.257071 · Cited by 506 · see citing works
Obermajer, N., Muthuswamy, R., Lesnock, J. L., Edwards, R. P., & Kaliński, P. (2011) · Blood · doi:10.1182/blood-2011-07-365825 · Cited by 499 · see citing works
Katoh, H., Wang, D., Daikoku, T., Sun, H., Dey, S. K., & DuBois, R. N. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.10.009 · Cited by 477 · see citing works
Obermajer, N., Muthuswamy, R., Odunsi, K. O., Edwards, R. P., & Kaliński, P. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2449 · Cited by 465 · see citing works
p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
Davalos, A. R., Kawahara, M., Malhotra, G. K., Schaum, N., Huang, J., Ved, U., Beausejour, C. M., Coppe, J.-P., Rodier, F., & Campisi, J. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201206006 · Cited by 439 · see citing works
TGFβ signaling plays a critical role in promoting alternative macrophage activation
Gong, D., Shi, W., Yi, S.-J., Chen, H., Groffen, J., & Heisterkamp, N. (2012) · BMC Immunology · doi:10.1186/1471-2172-13-31 · Cited by 424 · see citing works
Cellular senescence: a link between cancer and age-related degenerative disease?
Campisi, J., Andersen, J. K., Kapahi, P., & Melov, S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.09.001 · Cited by 421 · see citing works
Alfaro, C., Teijeira, A., Oñate, C., Pérez, G., Sanmamed, M. F., Andueza, M. P., Alignani, D., Labiano, S., Azpilikueta, A., Rodriguez-Paulete, A., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2463 · Cited by 417 · see citing works
Senescence-associated inflammatory responses: aging and cancer perspectives
Lasry, A., & Ben-Neriah, Y. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.009 · Cited by 408 · see citing works
Myeloid derived suppressor cells in human diseases
Greten, T. F., Manns, M. P., & Korangy, F. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.01.003 · Cited by 398 · see citing works
Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence
Chicas, A., Wang, X., Zhang, C., McCurrach, M., Zhao, Z., Mert, O., Dickins, R. A., Narita, M., Zhang, M., & Lowe, S. W. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.023 · Cited by 388 · see citing works
Kumar, V., Cheng, P., Condamine, T., Mony, S., Languino, L. R., McCaffrey, J. C., Hockstein, N., Guarino, M., Masters, G., Penman, E., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.014 · Cited by 371 · see citing works
Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment
Kovtonyuk, L. V., Fritsch, K., Feng, X., Manz, M. G., & Takizawa, H. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00502 · Cited by 371 · see citing works
How ageing processes influence cancer
de Magalhães, J. P. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3497 · Cited by 367 · see citing works
Cellular senescence in osteoarthritis pathology
McCulloch, K., Litherland, G. J., & Rai, T. S. (2017) · Aging Cell · doi:10.1111/acel.12562 · Cited by 367 · see citing works
CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers
Huang, B., Lei, Z., Zhao, J., Gong, W., Liu, J., Chen, Z., Liu, Y., Li, D., Yuan, Y., Zhang, G.-M., et al. (2007) · Cancer Letters · doi:10.1016/j.canlet.2006.12.012 · Cited by 349 · see citing works
Umemura, N., Saio, M., Suwa, T., Kitoh, Y., Bai, J., Nonaka, K., Ouyang, G., Okada, M., Balázs, M., Ádány, R., et al. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0907611 · Cited by 347 · see citing works
NKG2D ligands mediate immunosurveillance of senescent cells
Sagiv, A., Burton, D. G. A., Moshayev, Z., Vadai, E., Wensveen, F., Ben-Dor, S., Golani, O., Polic, B., & Krizhanovsky, V. (2016) · Aging · doi:10.18632/aging.100897 · Cited by 345 · see citing works
The network and the remodeling theories of aging: historical background and new perspectives
Franceschi, C., Valensin, S., Bonafè, M., Paolisso, G., Yashin, A. I., Monti, D., & De Benedictis, G. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00172-8 · Cited by 335 · see citing works
Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M., & Soininen, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07738.x · Cited by 333 · see citing works
Self-citationMyeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis
Waight, J. D., Netherby, C. S., Hensen, M. L., Miller, A., Hu, Q., Liu, S., Bogner, P. N., Farren, M. R., Lee, K. P., Liu, K., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68189 · Cited by 324 · see citing works
Suppression of antigen presentation by IL-10
Mittal, S. K., & Roche, P. A. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.12.009 · Cited by 318 · see citing works
Stress, cell senescence and organismal ageing
de Magalhães, J. P., & Passos, J. F. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.07.001 · Cited by 316 · see citing works
Sade-Feldman, M., Kanterman, J., Ish‐Shalom, E., Elnekave, M., Horwitz, E. P., & Baniyash, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.007 · Cited by 306 · see citing works
Keeping the eIF2 alpha kinase Gcn2 in check
Castilho, B. A., Shanmugam, R., da Silva, R. C., Ramesh, R., Himme, B. M., & Sattlegger, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.04.006 · Cited by 303 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
Regulatory T Cells and the Immune Aging Process: A Mini-Review
Jagger, A., Shimojima, Y., Goronzy, J. J., & Weyand, C. M. (2014) · Gerontology · doi:10.1159/000355303 · Cited by 301 · see citing works
Zhang, H., Ye, Y. L., Li, M.-X., Ye, S.-B., Huang, W.-R., Cai, T.-T., He, J., Peng, J.-Y., Duan, T., Cui, J., et al. (2016) · Oncogene · doi:10.1038/onc.2016.367 · Cited by 279 · see citing works
Impact of cellular senescence signature on ageing research
Sikora, E., Arendt, T., Bennett, M., & Narita, M. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.002 · Cited by 264 · see citing works
Rosenkranz, D., Weyer, S. W., Tolosa, E., Gaenslen, A., Berg, D., Leyhe, T., Gasser, T., & Stoltze, L. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.05.011 · Cited by 255 · see citing works
Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease
Erusalimsky, J. D., & Kurz, D. J. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.010 · Cited by 252 · see citing works
Aging and cancer: The role of macrophages and neutrophils
Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.008 · Cited by 251 · see citing works
A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism
Pribluda, A., Elyada, E., Wiener, Z., Hamza, H., Goldstein, R. E., Biton, M., Burstain, I., Morgenstern, Y., Brachya, G., Billauer, H., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.005 · Cited by 239 · see citing works
Verschoor, C. P., Johnstone, J., Millar, J., Dorrington, M. G., Habibagahi, M., Lelic, A., Loeb, M., Bramson, J. L., & Bowdish, D. M. E. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0912461 · Cited by 235 · see citing works
The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells
Lu, C., Redd, P. S., Lee, J. R., Savage, N. M., & Liu, K. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1247135 · Cited by 234 · see citing works
On the origin of myeloid-derived suppressor cells
Millrud, C. R., Bergenfelz, C., & Leandersson, K. (2016) · Oncotarget · doi:10.18632/oncotarget.12278 · Cited by 232 · see citing works
Macrophage Migration Inhibitory Factor Induces Macrophage Recruitment via CC Chemokine Ligand 2
Gregory, J. L., Morand, E. F., McKeown, S. J., Ralph, J. A., Hall, P., Yang, Y. H., McColl, S. R., & Hickey, M. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.8072 · Cited by 229 · see citing works
Ageing and the immune system: focus on macrophages
Linehan, E., & Fitzgerald, D. (2015) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi-d-14-00035 · Cited by 227 · see citing works
Cellular senescence: Immunosurveillance and future immunotherapy
Burton, D. G. A., & Stolzing, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.02.001 · Cited by 221 · see citing works
Phenotype, development, and biological function of myeloid-derived suppressor cells
Zhao, Y., Wu, T., Shao, S., Shi, B., & Zhao, Y. X. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1004983 · Cited by 220 · see citing works
TGF-β1 regulation of dendritic cells
Strobl, H., & Knapp, W. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)00256-7 · Cited by 216 · see citing works
Simpson, K. D., Templeton, D. J., & Cross, J. V. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201161 · Cited by 214 · see citing works
Morales, J. K., Kmieciak, M., Knutson, K. L., Bear, H. D., & Manjili, M. H. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0622-8 · Cited by 214 · see citing works
Tumour suppression by p53: the importance of apoptosis and cellular senescence
Zuckerman, V., Wolyniec, K., Sionov, R. V., Haupt, S., & Haupt, Y. (2009) · The Journal of Pathology · doi:10.1002/path.2584 · Cited by 210 · see citing works
Immunosurveillance of senescent cells: the bright side of the senescence program
Sagiv, A., & Krizhanovsky, V. (2013) · Biogerontology · doi:10.1007/s10522-013-9473-0 · Cited by 208 · see citing works
Wang, Y., Wehling‐Henricks, M., Samengo, G., & Tidball, J. G. (2015) · Aging Cell · doi:10.1111/acel.12350 · Cited by 205 · see citing works
Melk, A., Kittikowit, W., Sandhu, I., Halloran, K. M., Grimm, P., Schmidt, B. M. W., & Halloran, P. F. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00032.x · Cited by 205 · see citing works
Human regulatory T cells induce T-lymphocyte senescence
Ye, J., Huang, X., Hsueh, E. C., Zhang, Q., Ma, C., Zhang, Y., Varvares, M. A., Hoft, D. F., & Peng, G. (2012) · Blood · doi:10.1182/blood-2012-03-416040 · Cited by 198 · see citing works
Agius, E., Lacy, K. E., Vukmanovic‐Stejic, M., Jagger, A. L., Papageorgiou, A., Hall, S., Reed, J. R., Curnow, J., Fuentes‐Duculan, J., Buckley, C. D., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090896 · Cited by 189 · see citing works
Aging is associated with increased regulatory T ‐cell function
Garg, S. K., Delaney, C. E., Toubai, T., Ghosh, A. K., Reddy, P. R., Banerjee, R. V., & Yung, R. L. (2013) · Aging Cell · doi:10.1111/acel.12191 · Cited by 184 · see citing works
Context-dependent effects of cellular senescence in cancer development.
Lecot, P., Alimirah, F., Desprez, P.-Y., Campisi, J., & Wiley, C. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.115 · Cited by 183 · see citing works
Cellular senescence impact on immune cell fate and function
Vicente, R., Mausset-Bonnefont, A.-L., Jorgensen, C., Louis-Plence, P., & Brondello, J.-M. (2016) · Aging Cell · doi:10.1111/acel.12455 · Cited by 151 · see citing works
Höchst, B., Schildberg, F. A., Sauerborn, P., Gäbel, Y. A., Gevensleben, H., Goltz, D., Heukamp, L. C., Türler, A., Ballmaier, M., Gieseke, F., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.033 · Cited by 142 · see citing works
Lee, C., Kwak, Y., Yang, T., Han, J. H., Park, S., Ye, M. B., Lee, W., Sim, K.-Y., Kang, J., Kim, Y., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.062 · Cited by 142 · see citing works
Myeloid-Derived Suppressor Cells in Bacterial Infections
Ost, M., Singh, A., Peschel, A., Mehling, R., Rieber, N. P., & Hartl, D. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00037 · Cited by 132 · see citing works
A Role for Immature Myeloid Cells in Immune Senescence
Enioutina, E. Y., Bareyan, D., & Daynes, R. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002987 · Cited by 130 · see citing works
Maciel-Barón, L. A., Morales-Rosales, S. L., Aquino-Cruz, A. A., Triana-Martínez, F., Galván-Arzate, S., Luna-López, A., González-Puertos, V. Y., López-Díazguerrero, N. E., Torres, C., & Königsberg, M. (2016) · AGE · doi:10.1007/s11357-016-9886-1 · Cited by 128 · see citing works
The Fountain of Youth by Targeting Senescent Cells?
de Keizer, P. L. J. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.11.006 · Cited by 127 · see citing works
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01795-9 · Cited by 122 · see citing works
Self-citationMyeloid‐derived suppressor cells: the dark knight or the joker in viral infections?
Yergin, C. G., Narayanan, S., & Hahn, Y. S. (2013) · Immunological Reviews · doi:10.1111/imr.12084 · Cited by 120 · see citing works
Xiao, P., Wan, X., Cui, B., Liu, Y., Qiu, C., Rong, J., Zheng, M., Song, Y., Chen, L., He, J., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1063772 · Cited by 114 · see citing works
Ray, A., Chakraborty, K., & Ray, P. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00052 · Cited by 108 · see citing works
Flores, R. R., Clauson, C. L., Cho, J., Lee, B.-C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J., & Robbins, P. D. (2017) · Aging Cell · doi:10.1111/acel.12571 · Cited by 107 · see citing works
Bueno, V., Sant’Anna, O. A., & Lord, J. M. (2014) · AGE · doi:10.1007/s11357-014-9729-x · Cited by 97 · see citing works
Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration
Irvine, K. M., Skoien, R., Bokil, N. J., Melino, M., Thomas, G. P., Loo, D., Gabrielli, B., Hill, M. M., Sweet, M. J., Clouston, A. D., et al. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17851 · Cited by 97 · see citing works
Saiwai, H., Kumamaru, H., Ohkawa, Y., Kubota, K., Kobayakawa, K., Yamada, H., Yokomizo, T., Iwamoto, Y., & Okada, S. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12135 · Cited by 92 · see citing works
The immunobiology of myeloid-derived suppressor cells in cancer
Motallebnezhad, M., Jadidi‐Niaragh, F., Qamsari, E. S., Bagheri, S., Gharibi, T., & Yousefi, M. (2015) · Tumor Biology · doi:10.1007/s13277-015-4477-9 · Cited by 92 · see citing works
Suppression of T cells by myeloid-derived suppressor cells in cancer
Chen, J., Ye, Y., Liu, P., Yu, W., Wei, F., Li, H., & Yu, J. (2016) · Human Immunology · doi:10.1016/j.humimm.2016.12.001 · Cited by 87 · see citing works
Myeloid-derived suppressor cells and tumor escape from immune surveillance
Umansky, V., Blattner, C., Fleming, V., Hu, X., Gebhardt, C., Altevogt, P., & Utikal, J. S. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0597-6 · Cited by 80 · see citing works
NK Cell Response to Vaccinia Virus Is Regulated by Myeloid-Derived Suppressor Cells
Fortin, C. F., Huang, X., & Yang, Y. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200584 · Cited by 76 · see citing works
Polarization and reprogramming of myeloid-derived suppressor cells
Yang, W., Ma, G., Chen, S. H., & Pan, P. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt009 · Cited by 74 · see citing works
Nacionales, D. C., Szpila, B. E., Ungaro, R. F., López, M. C., Zhang, J., Gentile, L. F., Cuenca, A. L., Vanzant, E. L., Mathias, B. J., Jyot, J., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500984 · Cited by 73 · see citing works
Novel Role for Tumor-Induced Expansion of Myeloid-Derived Cells in Cancer Cachexia
Cuenca, A. G., Cuenca, A. L., Winfield, R. D., Joiner, D. N., Gentile, L. F., Delano, M. J., Kelly‐Scumpia, K. M., Scumpia, P. O., Matheny, M. K., Scarpace, P. J., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302895 · Cited by 72 · see citing works
SETD1B Activates iNOS Expression in Myeloid-Derived Suppressor Cells
Redd, P. S., Ibrahim, M. L., Klement, J. D., Sharman, S. K., Paschall, A. V., Yang, D., Nayak-Kapoor, A., & Liu, K. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2238 · Cited by 69 · see citing works
Okwan-Duodu, D. K., Umpierrez, G. E., Brawley, O. W., & Diaz, R. (2013) · Europe PMC (PubMed Central) · Cited by 68 · see citing works
Wang, J., Shirota, Y., Bayık, D., Shirota, H., Tross, D., Gulley, J. L., Wood, L. V., Berzofsky, J. A., & Klinman, D. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402004 · Cited by 68 · see citing works
Lim, H. X., Hong, H.-J., Cho, D., & Kim, T. S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401282 · Cited by 67 · see citing works
Senescence and cancer: An evolving inflammatory paradox
Ruhland, M. K., Coussens, L. M., & Stewart, S. A. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.10.001 · Cited by 60 · see citing works
Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult
Loftus, T. J., Mohr, A. M., & Moldawer, L. L. (2017) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000395 · Cited by 58 · see citing works
Cheng, L., Wang, J., Li, X., Xing, Q. R., Du, P., Su, L., & Wang, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017631 · Cited by 55 · see citing works
Interferon regulatory factor‐8 modulates the development of tumour‐induced CD11b+Gr‐1+ myeloid cells
Stewart, T. J., Greeneltch, K. M., Reid, J., Liewehr, D. J., Steinberg, S. M., Liu, K., & Abrams, S. I. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00685.x · Cited by 52 · see citing works
Sensing and translation of pathogen signals into demand-adapted myelopoiesis
Boettcher, S., & Manz, M. G. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000201 · Cited by 51 · see citing works
C/EBPβ enhances NF–κB-associated signalling by reducing the level of IκB-α
Cappello, C., Zwergal, A., Kanclerski, S., Haas, S. C., Kandemir, J. D., Huber, R., Page, S., & Brand, K. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.08.009 · Cited by 46 · see citing works
Bayık, D., Tross, D., & Klinman, D. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00608 · Cited by 42 · see citing works
HMGB1 promotes myeloid-derived suppressor cells and renal cell carcinoma immune escape
Li, J., Sun, J., Rong, R., Long, L., Shang, W., Song, D., Feng, G., & Luo, F. (2017) · Oncotarget · doi:10.18632/oncotarget.18796 · Cited by 41 · see citing works
Zhao, W., Xu, Y., Xu, J., Wu, D., Zhao, B., Yin, Z., & Wang, X. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.04.010 · Cited by 38 · see citing works
Amino Acid Metabolism Related to Immune Tolerance by MDSCs
Yang, B., Wang, X., & Ren, X. (2012) · International Reviews of Immunology · doi:10.3109/08830185.2012.679989 · Cited by 35 · see citing works
Aging of the hematopoietic stem cells niche
Nakamura‐Ishizu, A., & Suda, T. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1641-8 · Cited by 35 · see citing works
Yao, L., Abe, M., Kawasaki, K., Akbar, S. M. F., Matsuura, B., Onji, M., & Hiasa, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149948 · Cited by 33 · see citing works
Periasamy, S., & Harton, J. A. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy049 · Cited by 15 · see citing works
Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers
David, G. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.21116 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Immunosenescence: molecular mechanisms and diseases
Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 1,023 · see citing works
The senescence-associated secretory phenotype and its physiological and pathological implications
Wang, B., Han, J., Elisseeff, J. H., & Demaria, M. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00727-x · Cited by 948 · see citing works
Immunosenescence: a key player in cancer development
Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works
Do, H. T. T., Lee, C. H., & Cho, J. (2020) · Cancers · doi:10.3390/cancers12020287 · Cited by 236 · see citing works
Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy
Bule, P., Aguiar, S. I., Aires‐da‐Silva, F., & Dias, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189804 · Cited by 187 · see citing works
Activation of immunosuppressive network in the aging process
Salminen, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100998 · Cited by 153 · see citing works
Self-citationImmunosenescence and inflammaging: Mechanisms and role in diseases
Ajoolabady, A., Praticò, D., Tang, D., Zhou, S., Franceschi, C., & Ren, J. T. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102540 · Cited by 159 · see citing works
The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
Sun, Y., Wang, X., Liu, T., Zhu, X., & Pan, X. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00815-5 · Cited by 151 · see citing works
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01795-9 · Cited by 122 · see citing works
Self-citationThe efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
Chaib, S., López-Domínguez, J. A., Lalinde-Gutiérrez, M., Prats, N., Marin, I., Boix, O., García-Garijo, A., Meyer, K., Muñoz, M. I., Aguilera, M., et al. (2024) · Nature Cancer · doi:10.1038/s43018-023-00712-x · Cited by 114 · see citing works
Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases
Salminen, A. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01988-7 · Cited by 110 · see citing works
Self-citationThe role of myeloid-derived suppressor cells (MDSC) in the inflammaging process
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.09.001 · Cited by 100 · see citing works
Self-citationER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01904-z · Cited by 98 · see citing works
Self-citationZhang, F., Guo, J., Yu, S., Zheng, Y., Duan, M., Zhao, L., Wang, Y., Yang, Z., & Jiang, X. (2024) · 癌症：英文版 · doi:10.1002/cac2.12591 · Cited by 93 · see citing works
Senescence-Associated Pro-inflammatory Cytokines and Tumor Cell Plasticity
Vernot, J. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00063 · Cited by 83 · see citing works
Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies
Wei, Y., Giunta, S., & Xia, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158165 · Cited by 69 · see citing works
Xia, S., Wu, J., Zhou, W., Zhang, M., Zhao, K., Liu, J., Tian, D., & Liao, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03853-y · Cited by 52 · see citing works
Sun, S., Ni, S.-H., Li, Y., Liu, X., Deng, J., Chen, Z., Li, H., Feng, W., Huang, Y., Li, D.-N., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03874-7 · Cited by 51 · see citing works
Spleen in innate and adaptive immunity regulation
Aliyu, M., Zohora, F. T., & Saboor-Yaraghi, A. A. (2020) · AIMS Allergy and Immunology · doi:10.3934/allergy.2021001 · Cited by 50 · see citing works
Du, M., Sun, L., Guo, J. J., & Lv, H. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107198 · Cited by 49 · see citing works
Cellular senescence and hematological malignancies: From pathogenesis to therapeutics
Hu, D., Yuan, S., Zhong, J., Liu, Z., Wang, Y., Liu, L., Li, J., Wen, F., Liu, J., & Zhang, J. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107817 · Cited by 45 · see citing works
Sharma, R. (2021) · Biogerontology · doi:10.1007/s10522-021-09936-9 · Cited by 45 · see citing works
Cellular senescence in cancer: molecular mechanisms and therapeutic targets
Jin, P., Duan, X., Li, L., Zhou, P., Zou, C., & Xie, K. (2024) · MedComm · doi:10.1002/mco2.542 · Cited by 46 · see citing works
Epithelial-mesenchymal transition: When tumor cells meet myeloid-derived suppressor cells
Cai, J., Cui, Y., Yang, J., & Wang, S. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188564 · Cited by 43 · see citing works
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109771 · Cited by 36 · see citing works
Self-citationImmunosenescence and cancer: Opportunities and challenges
Fu, Z., Xu, H., Yue, L., Zheng, W., Pan, L., Gao, F., & Liu, X. (2023) · Medicine · doi:10.1097/md.0000000000036045 · Cited by 35 · see citing works
Photodynamic Therapy and Adaptive Immunity Induced by Reactive Oxygen Species: Recent Reports
Aebisher, D., Woźnicki, P., & Bartusik‐Aebisher, D. (2024) · Cancers · doi:10.3390/cancers16050967 · Cited by 34 · see citing works
Oxidative stress in multiple organs after sepsis in elderly rats
Margotti, W., Goldim, M. P. D. S., Machado, R. S., Bagio, É., Perin, C. H. D., Bernades, G. C., Lanzzarin, E., Stork, S. D. S., Cidreira, T., Denicol, T. L., et al. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111705 · Cited by 32 · see citing works
Salminen, A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102694 · Cited by 33 · see citing works
Self-citationZeng, D., Wang, M., Wu, J., Lin, S., Ye, Z., Zhou, R., Wang, G., Wu, J., Sun, H., Bin, J., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.620688 · Cited by 30 · see citing works
Wang, H., Yu, Y., Li, R., Zhang, H., Chen, Z., Sun, C., & Zhuang, J. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.022 · Cited by 32 · see citing works
Brem, S. S. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100859 · Cited by 27 · see citing works
T-cell Senescence in the Tumor Microenvironment
Huang, L., Zhang, C., Jiang, A., Lin, A., Zhu, L., Mou, W., Zeng, D., Liu, Z., Tang, B., Zhang, J., et al. (2025) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0894 · Cited by 27 · see citing works
Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes
Sabbatinelli, J., Matacchione, G., Giuliani, A., Ramini, D., Rippo, M. R., Procopio, A. D., Bonafè, M., & Olivieri, F. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111667 · Cited by 27 · see citing works
Ali, S., Borin, T. F., Piranlioglu, R., Ara, R., Lebedyeva, I., Angara, K., Achyut, B. R., Arbab, A. S., & Rashid, M. H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246646 · Cited by 24 · see citing works
Immunosenescence: A new direction in anti-aging research
Li, H., Lin, S., Wang, Y., Shi, Y., Fang, X., Wang, J., Cui, H., Bian, Y., & Qi, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112900 · Cited by 21 · see citing works
Connections between Metabolism and Epigenetic Modification in MDSCs
Dai, H., Xu, H., Wang, S., & Ma, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197356 · Cited by 21 · see citing works
Cellular Senescence in Non-Small Cell Lung Cancer
Zhu, H., Sun, J., Zhang, C., Li, P., Tan, C., Yang, M., & Zhao, G. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2812357 · Cited by 19 · see citing works
Jinna, N., Rida, P. C. G., Su, T., Gong, Z., Yao, S., LaBarge, M. A., Natarajan, R. D., Jovanović‐Talisman, T., Ambrosone, C. B., & Seewaldt, V. L. (2022) · Cells · doi:10.3390/cells11233818 · Cited by 18 · see citing works
Immunosenescence and Inflammaging in COVID-19
Asghari, F., Asghary, A., Zolbanin, N. M., Faraji, F., & Jafari, R. (2023) · Viral Immunology · doi:10.1089/vim.2023.0045 · Cited by 16 · see citing works
Cellular senescence in the tumor with a bone niche microenvironment: friend or foe?
Alavimanesh, S., Jazi, N. N., Choubani, M., Saeidi, F., Afkhami, H., Yarahmadi, A., Ronaghi, H., Khani, P., & Modarressi, M. H. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01564-8 · Cited by 17 · see citing works
Wan, Y., Mu, X., Zhao, J., Li, L., Xu, W., & Zhang, M. (2024) · Biomedical Reports · doi:10.3892/br.2024.1754 · Cited by 15 · see citing works
Magri, S., Masetto, E., Solito, S., Francescato, S., Belluzzi, E., Pozzuoli, A., Berizzi, A., Ruggieri, P., & Mandruzzato, S. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00199-5 · Cited by 15 · see citing works
New Perspectives on Myeloid-Derived Suppressor Cells and Their Emerging Role in Haematology
Bizymi, N., Matthaiou, A. Μ., Matheakakis, A., Voulgari, I., Aresti, N., Zavitsanou, K., Karasachinidis, A., Mavroudi, I., Pontikoglou, C. G., & Papadaki, H. Α. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185326 · Cited by 12 · see citing works
Tackling cellular senescence by targeting miRNAs
Wang, Z., Gao, J., & Xu, C. (2022) · Biogerontology · doi:10.1007/s10522-022-09972-z · Cited by 12 · see citing works
Myeloid-Derived Suppressor Cells (MDSCs) at the Crossroad of Senescence and Cancer
Talarico, G., Orecchioni, S., Falvo, P., & Bertolini, F. (2025) · Cancers · doi:10.3390/cancers17132251 · Cited by 12 · see citing works
Alexa‐Stratulat, T., Tanasa, M. P., Cianga, V. A., & Antoniu, S. A. (2022) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2022.2139242 · Cited by 11 · see citing works
Zhuang, Q., Huang, L., Zeng, Y., Wu, X., Qiao, G., Liu, M., Wang, L., Zhou, Y., & Xiong, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.876168 · Cited by 10 · see citing works
He, Z., Fahlberg, M. D., Takahashi, N., Slisarenko, N., Rout, N., Didier, E. S., & Kuroda, M. J. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.1hi1120-779r · Cited by 9 · see citing works
Almasabi, S., Boyd, R. L., Ahmed, A. U., & Williams, B. R. G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.836005 · Cited by 9 · see citing works
Chen, Y. J., Liao, Y., Tram, V. T. N., Lin, C. H., Liao, K., & Liu, C.-L. (2020) · Life · doi:10.3390/life10100246 · Cited by 9 · see citing works
Cheng, J., Zheng, J., Ma, C., Li, Y., & Hao, H. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.05.010 · Cited by 8 · see citing works
Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer
Meguro, S., Makabe, S., Yaginuma, K., Onagi, A., Tanji, R., Matsuoka, K., Hoshi, S., Koguchi, T., Kayama, E., Hata, J., et al. (2025) · Current Oncology · doi:10.3390/curroncol32080467 · Cited by 8 · see citing works
Li, Y., Li, H., He, Q., & Yang, X.-C. (2022) · Molecules · doi:10.3390/molecules28010195 · Cited by 7 · see citing works
Nie, B., Duan, Y., Xie, X., Qiu, L., Shi, S., Fan, Z., Zheng, X., & Jiang, L. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1204530 · Cited by 8 · see citing works
The Interplay of Aging and Cancer: Mechanisms, Implications, and Therapeutic Strategies
Wang, L., Luo, Y., Chen, X., Wang, Y., & Zhang, Y. (2025) · MedComm – Oncology · doi:10.1002/mog2.70041 · Cited by 8 · see citing works
Cao, D., Naiyila, X., Li, J., Huang, Y. C., Chen, Z., Chen, B., Li, J., Guo, J., Dong, Q., Ai, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.705280 · Cited by 7 · see citing works
Chaib, S., Lopez-Dominguez, J. A., Lalinde-Gutiérrez, M., Prats, N., Marín, I., Meyer, K. R., Muñoz, M. I., Aguilera, M., Mateo, L., Attolini, C. S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.04.501681 · Cited by 7 · see citing works
SATB1, senescence and senescence‐related diseases
Qi, W., Bai, J., Wang, R., Zeng, X., & Zhang, L. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31327 · Cited by 5 · see citing works
Aging modulation of the immune system and immunotherapy efficacy in cancer
Wang, Y., Liang, M., Mao, Y., Zhu, W., Shen, X., & Guan, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1781885 · Cited by 4 · see citing works
A Conversation with ChatGPT on Contentious Issues in Senescence and Cancer Research
Elshazly, A. M., Shahin, U., Shboul, S. A., Gewirtz, D. A., & Saleh, T. (2024) · Molecular Pharmacology · doi:10.1124/molpharm.124.000871 · Cited by 4 · see citing works
Walker, R. R., & Chiappinelli, K. B. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1862 · Cited by 4 · see citing works
A method for separation and purification of mouse splenocytes by density gradient centrifugation
Lu, Y., Fu, C., Xia, C., & Ma, S. (2020) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2020.1821712 · Cited by 4 · see citing works
Shee, S., Martinez-Martinez, Y. B., Koleske, B. N., Yabaji, S. M., Kobzik, L., Kramnik, I., & Bishai, W. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.28.645957 · Cited by 4 · see citing works
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Guo, J., Lei, L., Jin, Y., Su, L., Cui, S., & Shi, L. (2026) · Advanced Science · doi:10.1002/advs.202521776 · Cited by 3 · see citing works
Gu, X., Zhang, L., Sun, M., Zhou, Y., Ji, J., Xu, Y., You, J., & Deng, Z.-K. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18310 · Cited by 3 · see citing works
Huang, Z., Qian, C., Zhang, Z., Nian, W., Xu, Q., Cao, Y., & Fu, C. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116209 · Cited by 3 · see citing works
Shen, P., Cui, W., Lin, J., Wang, Z., Li, Z., & Liu, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1716230 · Cited by 2 · see citing works
The Role of Epstein–Barr virus-encoded Latent Membrane Proteins in Host Immune Escape
Jiang, Y., Ding, Y., Liu, S., & Luo, B. (2021) · Future Virology · doi:10.2217/fvl-2020-0320 · Cited by 2 · see citing works
Integrating cuproptosis and immunosenescence: A novel therapeutic strategy in cancer treatment
Firouzjaei, A. A., & Aghaee‐Bakhtiari, S. H. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.101983 · Cited by 3 · see citing works
Li, C., Li, C., Zhai, W., Yu, R., Xu, X., Yan, F., Zhang, H., Zhang, J., Zhao, M., Wang, L., et al. (2025) · Immunology · doi:10.1111/imm.70053 · Cited by 1 · see citing works
Tuosto, L., Gelibter, A. J., Strigari, L., Asquino, A., Siringo, M., Pace, A., Valentino, F., Capozzi, D., Bianchini, S., Bellati, F., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07719-9 · Cited by 1 · see citing works
Cellular senescence and aging at the crossroad between immunity and cancer
Kepp, O., Galluzzi, L., & Petroni, G. (2024) · Methods in cell biology · doi:10.1016/s0091-679x(24)00009-8 · Cited by 1 · see citing works
Wakita, H., Lü, Y., Li, X., Kobayashi, T., Hachiya, T., Ide, H., & Horie, S. (2024) · Cancers · doi:10.3390/cancers16071386 · Cited by 2 · see citing works
Савченко, А. А., Борисов, А. Г., Kudryavtsev, I. V., & Moshev, A. V. (2020) · Medical Immunology (Russia) · doi:10.15789/1563-0625-dop-1890 · Cited by 1 · see citing works
Cancer prognosis and immune system
Mahalanobis, S., Apoorva, Sharma, N., Luthra, R., Menon, T., & Das, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-96128-8.00004-3
Xu, X., li, Z., Wang, Z., Zhu, F., Wang, J., Wang, H., Xiong, T., Tang, Y.-Y., & Zhai, Z. (2023) · Research Square · doi:10.21203/rs.3.rs-2860595/v1
Chemokine and Cytokine Networks in Tumor Microenvironment
Mir, M. A., Sumaya, S., & Shah, M. Z. U. H. (2023) · Springer eBooks · doi:10.1007/978-981-99-4657-0_12
Fülöp, T., Cohen, A. A., Larbi, A., & Witkowski, J. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-55022-5_10
Can interventions targeting MDSCs improve the outcome of vaccination in vulnerable populations?
Perfilyeva, Y. V., Aquino, A. D., Borodin, M. A., Kali, A., Abdolla, N., Ostapchuk, Y. O., Tleulieva, R., Perfilyeva, A. V., Jainakbayev, N. T., Sharipov, K. O., et al. (2024) · International Reviews of Immunology · doi:10.1080/08830185.2024.2443423
Zhang, H.-X., & Li, H.-Y. (2026) · Medicine · doi:10.1097/md.0000000000048105
Sharma, V., Sharma, K., Semwal, A., Arora, A., Bansal, S., & Aggarwal, A. (2026) · Springer eBooks · doi:10.1007/978-981-95-9777-2_2
Kiaee, F., & Shahi, H. (2026) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.18502/ijrm.v24i7.21578
Croix, A. E. L., Gouveia, M. E. T., Bertone, P. M., Nemanic, N. M., Bahney, C. S., & Hixon, K. R. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.09.020
- Authors
- Salminen, A., Kauppinen, A., & Kaarniranta, K.
- Affiliations
- University of Eastern Finland (FI)
- Corresponding author
- Salminen, Antero
- Venue
- Biogerontology
- Published
- 2018-06-29
- Volume
- 19
- Issue
- 5
- Pages
- 325-339
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W2810097944
- Cited by
- 84
- References
- 151
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 18 · 2023: 8 · 2022: 13 · 2021: 11 · 2020: 12 · 2019: 2 · 2018: 1
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Terveyden Tutkimuksen Toimikunta (AK297267, AK307341, KK296840)
- Kuopion Yliopistollinen Sairaala (KK5503743)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- myeloid-derived suppressor cells, cellular senescence, tissue senescence, inflammaging, senescence-associated secretory phenotype, oncogene-induced senescence, myelopoiesis, immunosuppression, regulatory T cells, IL-10, TGF-beta, reactive oxygen species, chronic inflammation, age-related diseases, tumor immunosuppression, energy metabolism, proteostasis
- MeSH terms
- Myeloid-Derived Suppressor Cells, Aging, Humans, Inflammation, Signal Transduction, Cellular Senescence, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
