Gut microbiota–generated metabolites in animal health and disease
Abstract
Gut microbiota is found in virtually any metazoan, from invertebrates to vertebrates. It has long been believed that gut microbiota, more specifically, the activity of the microbiome and its metabolic products, directly influence a variety of aspects in metazoan physiology. However, the exact molecular relationship among microbe-derived gut metabolites, host signaling pathways, and host physiology remains to be elucidated. Here we review recent discoveries regarding the molecular links between gut metabolites and host physiology in different invertebrate and vertebrate animal models. We describe the different roles of gut microbiome activity and their metabolites in regulating distinct host physiology and the molecular mechanisms by which gut metabolites cause physiological homeostasis via regulating specific host signaling pathways. Future studies in this direction using different animal models will provide the key concepts to understanding the evolutionarily conserved chemical dialogues between gut microbiota and metazoan cells and also human diseases associated with gut microbiota and metabolites.
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Short-chain fatty acids are a primary energy source for intestinal epithelial cells.
“One example is the production of short-chain fatty acids (SCFAs), which are a primary energy source for intestinal epithelial cells91”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [91]
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- Authors
- Lee, W.-J., & Hase, K.
- Affiliations
- Seoul National University (KR)
- Keio University (JP)
- Corresponding author
- Lee, Won-Jae
- Hase, Koji
- Venue
- Nature Chemical Biology
- Published
- 2014-05-16
- Volume
- 10
- Issue
- 6
- Pages
- 416-424
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W1999376421
- Semantic Scholar
- 4287aae491380fe4970202d514f6a48785eb28ae
- Cited by
- 756
- References
- 12
- Citations by year
- 2026: 34 · 2025: 53 · 2024: 90 · 2023: 68 · 2022: 93 · 2021: 75 · 2020: 86 · 2019: 63 · 2018: 60 · 2017: 47 · 2016: 47 · 2015: 34 · 2014: 6
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, microbial metabolites, host-microbe interactions, dysbiosis, energy harvesting, pathogen resistance, allergic diseases, neurological disorders, host signaling pathways, invertebrate models, vertebrate models, host physiology
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Immune System, Intestines, Invertebrates, Longevity, Obesity, Vertebrates, Host-Pathogen Interactions, Microbiota
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