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The Omega-3 Index and relative risk for coronary heart disease mortality: Estimation from 10 cohort studies

Harris, William S., Del Gobbo, Liana, Tintle, Nathan L.·2017·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2017.05.007

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Abstract

Background and aims A recent 19-cohort meta-analysis examined the relationships between biomarkers of omega-3 fatty acids and risk for coronary heart disease (CHD). That study did not, however, report hazard ratios (HRs) specifically as a function of erythrocyte eicosapentaenoic (EPA) plus docosahexaenoic (DHA) levels, a metric called the Omega-3 Index in which EPA + DHA content is expressed as a percent of total fatty acids. The Omega-3 Index has been used in several recent studies and is a validated biomarker of omega-3 fatty acid tissue levels, but additional data are needed to confirm (or refute) the originally-proposed clinical cut-points of Methods The present study was therefore undertaken using published data from this meta-analysis to estimate HRs per 1-SD increase in the Omega-3 Index and median quintile values for this metric across 10 of the cohorts for which the needed data were available. Results The overall mean (SD) for the Omega-3 Index in these 10 cohort studies was 6.1% (2.1%), and the HR for a 1-SD increase was 0.85 (95% confidence interval, 0.80-0.91). Median quintile 1 and 5 levels were 4.2% vs. 8.3%, respectively. Based on these values, we estimate that risk for fatal CHD would have been reduced by about 30% moving from an Omega-3 Index of 4%-8%. Conclusions These findings support the use of 8% as reasonable therapeutic targets for the Omega-3 Index.

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Authors: Harris, W. S., Del Gobbo, L., & Tintle, N. L.
Affiliations: University of South Dakota (US)
Dordt University (US)
Corresponding author: Harris, William S.
ORCID: Harris, William S.
Tintle, Nathan L.
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2017-07
Volume: 262
Pages: 51-54
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2017.05.007
OpenAlex: W2611630545
Cited by: 183
References: 52
Citations by year: 2026: 16 · 2025: 11 · 2024: 19 · 2023: 16 · 2022: 21 · 2021: 21 · 2020: 21 · 2019: 31 · 2018: 23 · 2017: 3
FWCI: 2.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords: omega-3 index, coronary heart disease mortality, eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids, hazard ratio, therapeutic target, biomarkers
MeSH terms: Diet, Healthy, Coronary Disease, Docosahexaenoic Acids, Erythrocytes, Humans, Prognosis, Risk Factors, Time Factors, Eicosapentaenoic Acid, Cohort Studies, Biomarkers, Risk Assessment, Protective Factors

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The Omega-3 Index and relative risk for coronary heart disease mortality: Estimation from 10 cohort studies

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