Is there an association between autoimmunity and endometriosis?
Abstract
Endometriosis is a benign gynecologic disorder that affects 5-10% of women of reproductive age worldwide. It is characterized by the presence of ectopic endometrial cells and stroma in various locations outside the endometrium. In some of these women there are also a chronic local inflammatory process and presence of autoantibodies. It is not known whether this process is part of the etiology or is a secondary response to the ectopic cells. Furthermore, endometriosis shares similarities with several autoimmune diseases, which include elevated levels of cytokines, decreased apoptosis, and cell-mediated abnormalities. Our aim in this paper was to review the association between autoimmunity and endometriosis. For this purpose we conducted a thorough literature review in the MEDLINE/PubMed database using the keyword endometriosis crossed with: autoimmune disease, autoimmune diseases, autoimmunity, autoantibodies, immunity, immune-modulation, endometrial antibodies, etc.
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Endometriosis fulfills most of the classification criteria for autoimmune disease, including polyclonal B-cell activation, immunological abnormalities in T-and B-cell functions, increased apoptosis, tissue damage, and multiorgan involvement.
“Endometriosis fulfills most of the classification criteria for autoimmune disease, including polyclonal B-cell activation, immunological abnormalities in T-and B-cell functions, increased apoptosis, tissue damage, and multiorgan involvement.59”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [59]
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TSH receptor antibodies (TRAb) – A potential new biomarker for endometriosis
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The Comorbidity of Endometriosis and Systemic Lupus Erythematosus: A Systematic Review
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Western Herbal Medicine, Epigenetics, and Endometriosis
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Upregulation of Interleukin 35 in Patients With Endometriosis Stimulates Cell Proliferation
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Increased risk of alopecia areata among patients with endometriosis
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- Authors
- Eisenberg, V. H., Zolti, M., & Soriano, D.
- Affiliations
- Sheba Medical Center (IL)
- Corresponding author
- Eisenberg, Vered H.
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 11
- Issue
- 11
- Pages
- 806-814
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W1966098682
- Cited by
- 164
- References
- 152
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 17 · 2023: 13 · 2022: 24 · 2021: 17 · 2020: 11 · 2019: 15 · 2018: 10 · 2017: 9 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 11 · 2012: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autoimmunity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, autoimmunity, autoantibodies, autoimmune disease, immunomodulation, cytokines, apoptosis, chronic inflammation, ectopic endometrium
- MeSH terms
- Autoantibodies, Autoimmune Diseases, Endometriosis, Female, Humans, Infertility, Inflammation, Autoimmunity
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