Cited by 165Endometriosis Research and TreatmentReproductive System and PregnancyEctopic Pregnancy Diagnosis and Management

Is there an association between autoimmunity and endometriosis?

Eisenberg, Vered H., Zolti, Mati, Soriano, David·2012·Autoimmunity Reviews

Abstract

Endometriosis is a benign gynecologic disorder that affects 5-10% of women of reproductive age worldwide. It is characterized by the presence of ectopic endometrial cells and stroma in various locations outside the endometrium. In some of these women there are also a chronic local inflammatory process and presence of autoantibodies. It is not known whether this process is part of the etiology or is a secondary response to the ectopic cells. Furthermore, endometriosis shares similarities with several autoimmune diseases, which include elevated levels of cytokines, decreased apoptosis, and cell-mediated abnormalities. Our aim in this paper was to review the association between autoimmunity and endometriosis. For this purpose we conducted a thorough literature review in the MEDLINE/PubMed database using the keyword endometriosis crossed with: autoimmune disease, autoimmune diseases, autoimmunity, autoantibodies, immunity, immune-modulation, endometrial antibodies, etc.

Integrity signals

Registry

Crossref · 10.1016/j.autrev.2012.01.005

Cites

145 of 145 references verified0 citation errors · 0 not checkable

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Authors
Eisenberg, V. H., Zolti, M., & Soriano, D.
Affiliations
Sheba Medical Center (IL)
Corresponding author
Eisenberg, Vered H.
Venue
Autoimmunity Reviews
Publisher
Elsevier BV
Published
2012-09
Volume
11
Issue
11
Pages
806-814
ISSN
1568-9972 (ISSN-L)
OpenAlex
W1966098682
Cited by
164
References
152
Citations by year
2026: 6 · 2025: 9 · 2024: 17 · 2023: 13 · 2022: 24 · 2021: 17 · 2020: 11 · 2019: 15 · 2018: 10 · 2017: 9 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 11 · 2012: 1
FWCI
1.26
Type
journal article
Language
en
Open access
closed
Locations
  • Autoimmunity Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, autoimmunity, autoantibodies, autoimmune disease, immunomodulation, cytokines, apoptosis, chronic inflammation, ectopic endometrium
MeSH terms
Autoantibodies, Autoimmune Diseases, Endometriosis, Female, Humans, Infertility, Inflammation, Autoimmunity

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