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Developmental changes in dopamine neurotransmission in adolescence: Behavioral implications and issues in assessment
Open accessAbstract
Adolescence is characterized by increased risk-taking, novelty-seeking, and locomotor activity, all of which suggest a heightened appetitive drive. The neurotransmitter dopamine is typically associated with behavioral activation and heightened forms of appetitive behavior in mammalian species, and this pattern of activation has been described in terms of a neurobehavioral system that underlies incentive-motivated behavior. Adolescence may be a time of elevated activity within this system. This review provides a summary of changes within cortical and subcortical dopaminergic systems that may account for changes in cognition and affect that characterize adolescent behavior. Because there is a dearth of information regarding neurochemical changes in human adolescents, models for assessing links between neurochemical activity and behavior in human adolescents will be described using molecular genetic techniques. Furthermore, we will suggest how these techniques can be combined with other methods such as pharmacology to measure the impact of dopamine activity on behavior and how this relation changes through the lifespan.
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“An adolescent-limited increase in IM is a positive development that may confer evolutionary advantages and that serves ultimately--through the promotion of learning--to encourage a sense of agency as youth make the transition to adult independence (Spear, 2000; Wahlstrom et al., 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Childhood and adolescence are sensitive periods in which these systems develop and change [26–29], making them particularly vulnerable to insult.”
From Psychological impacts of “screen time” and “green time” for children and adolescents: A systematic scoping review (2020) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The brain mechanisms of interest here show a distinctive pattern of development: subcortical regions involved in incentive motivation develop faster than the prefrontal regions that exert inhibition in the interests of long-term consequences (Gladwin et al., 2011;Wahlstrom et al., 2010).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Wahlstrom et al., 2010
Experimental — accuracy not yet measuredIn the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
In the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
In the citing paper
“Importantly, biologically determined trait-based individual differences very likely interact with these age-based trends to determine developmental outcomes (Wahlstrom et al. 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al. 2010
In the citing paper
“Dopamine receptor expression also peaks around the age of puberty, though only for specific receptor subtypes in specific neuronal populations (reviewed in (Wahlstrom et al., 2010)).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Wahlstrom et al., 2010
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“…undergoes reorganization during adolescence (see Wahlstrom et al., 2010a,b; Padmanabhan and Luna, 2014) and these changes are implicated in behavioral changes and increased vulnerability to the development of psychiatric disorders (Spear, 2000, 2013; Nelson et al., 2005; Wahlstrom et al., 2010a,b).”
BackgroundChen, G., Ghazal, M., Rahman, S., & Lutfy, K. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2021.07.006
Cannard, C. (2019) · De Boeck Supérieur eBooks · doi:10.3917/dbu.canna.2019.01.0385
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Levesque, R. J. R. (2018) · Springer eBooks · doi:10.1007/978-3-319-33228-4_571
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Ye, J., Sun, H., Gao, S., Dadashkarimi, J., Rosenblatt, M., Rodriguez, R. X., Mehta, S., Jiang, R., Noble, S., Westwater, M. L., et al. (2022) · medRxiv · doi:10.1101/2022.10.07.22280835
“, 2011) and a more active dopaminergic system (Wahlstrom et al., 2010).”
BackgroundPérez-Valenzuela, E., & Laviolette, S. R. (2022) · Neuromethods · doi:10.1007/978-1-0716-2799-0_9
Mahmoud, A. J., Abdulqadir, H. H., Khalid, R. C., Dirbas, V. H., Hasan, D. F., Mahfodh, S. S., Naisan, K. Y., Arif, I. M., Yousif, I. R., Mohammed, S. N., et al. (2023) · medRxiv · doi:10.1101/2023.02.07.23285491
“39% of them watch it for the first time between the age of 15-20 years, may be this age is higher because of the neurobiological changes in the adolescence age which are increasing in dopamine levels activate penile erection, promote sexual drive with orgasmic quality and increasing of sexual hormone cause increasing…”
BackgroundCezar, L. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2022.tde-20012023-112002
Adolescent Depressive Disorder and Gene Polymorphism
Seelent, E. M. (2023) · Science Insights · doi:10.15354/si.23.re327
“The basic dopamine level of adolescents has the characteristics of changing with development (43), and the influence of Val158Met polymorphism also changes with the development of adolescents (44).”
BackgroundThe Place of Adolescence in Social Psychiatry
Rothe, E. M. (2023) · doi:10.1093/med/9780197521359.003.0009
Rothe, E. M., Ono, Y., & Pumariega, A. J. (2023) · doi:10.1093/med/9780197521359.003.0036
UNDERSTANDING ADOLESCENT BRAIN MATURATION
GRETA-LUISA, D., & DANIELA, E. A. (2023) · The Journal of School and University Medicine · doi:10.51546/jsum.2023.10202
Ginder, D. E., Tinsley, C. E., Kaiser, M. E., & Lim, M. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.03.574112
Sebaregulácia v kontexte rizikového správania v dospievaní
Banárová, K., Čerešník, M., Kňažek, G., Považanová, B., & Dolejš, M. (2023) · doi:10.5507/ff.23.24463438
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A Cross-Sectional Study on Pornography Use and Sex Differences Among High School Students
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“Additionally, regions involved in motivation, such as the nucleus accumbens (NAc), likely influence behavior, especially in relation to hunger, growth spurts, and pubertal changes, which may affect exploratory behaviors [58].”
Neurobehavioral correlates of dopamine agonist-induced eye-blinking in the marmoset monkey
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Metadata
- Authors
- Wahlstrom, D., Collins, P., White, T., & Luciana, M.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Luciana, Monica
- Venue
- Brain and Cognition
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 72
- Issue
- 1
- Pages
- 146-159
- ISSN
- 0278-2626 (ISSN-L)
- PMC
- PMC2815132
- OpenAlex
- W2168203121
- Cited by
- 311
- References
- 195
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 15 · 2023: 28 · 2022: 24 · 2021: 21 · 2020: 15 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 25 · 2015: 18 · 2014: 15 · 2013: 29 · 2012: 11
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain and Cognition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32MH017069)
- National Institute on Drug Abuse (DA017843, R01DA017843)
- National Center for Research Resources (M01RR000400, M01-RR00400)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine signaling, adolescence, appetitive behavior, risk-taking, novelty seeking, dopaminergic system, molecular genetics, pharmacological evaluation, lifespan development, cognitive and emotional development
- MeSH terms
- Adolescent, Animals, Behavior, Brain, Dopamine, Humans, Neural Pathways, Synaptic Transmission, Adolescent Development
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