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Developmental changes in dopamine neurotransmission in adolescence: Behavioral implications and issues in assessment
Open accessAbstract
Adolescence is characterized by increased risk-taking, novelty-seeking, and locomotor activity, all of which suggest a heightened appetitive drive. The neurotransmitter dopamine is typically associated with behavioral activation and heightened forms of appetitive behavior in mammalian species, and this pattern of activation has been described in terms of a neurobehavioral system that underlies incentive-motivated behavior. Adolescence may be a time of elevated activity within this system. This review provides a summary of changes within cortical and subcortical dopaminergic systems that may account for changes in cognition and affect that characterize adolescent behavior. Because there is a dearth of information regarding neurochemical changes in human adolescents, models for assessing links between neurochemical activity and behavior in human adolescents will be described using molecular genetic techniques. Furthermore, we will suggest how these techniques can be combined with other methods such as pharmacology to measure the impact of dopamine activity on behavior and how this relation changes through the lifespan.
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“An adolescent-limited increase in IM is a positive development that may confer evolutionary advantages and that serves ultimately--through the promotion of learning--to encourage a sense of agency as youth make the transition to adult independence (Spear, 2000; Wahlstrom et al., 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Childhood and adolescence are sensitive periods in which these systems develop and change [26–29], making them particularly vulnerable to insult.”
From Psychological impacts of “screen time” and “green time” for children and adolescents: A systematic scoping review (2020) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The brain mechanisms of interest here show a distinctive pattern of development: subcortical regions involved in incentive motivation develop faster than the prefrontal regions that exert inhibition in the interests of long-term consequences (Gladwin et al., 2011;Wahlstrom et al., 2010).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Wahlstrom et al., 2010
Experimental — accuracy not yet measuredIn the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
In the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
In the citing paper
“Importantly, biologically determined trait-based individual differences very likely interact with these age-based trends to determine developmental outcomes (Wahlstrom et al. 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al. 2010
In the citing paper
“Dopamine receptor expression also peaks around the age of puberty, though only for specific receptor subtypes in specific neuronal populations (reviewed in (Wahlstrom et al., 2010)).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Wahlstrom et al., 2010
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Miller, M. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00208 · Cited by 11
“Finally, changes in striatal and cortical dopamine receptor populations and dopamine transporters (DAT) over an organism’s development correspond with age-associated shifts in risk preference (Wahlstrom et al., 2010).”
BackgroundWalshe, E. A., Winston, F. K., & Romer, D. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18115640 · Cited by 12
Pardo, M., Martin, M., Gainetdinov, R. R., Mash, D. C., & Izenwasser, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315414 · Cited by 10
“Additionally, during adolescence, there are developmental changes in the DAergic system, such as in catechol-O-methyltransferase (COMT), tyrosine hydroxylase (TH), and DA, D2 and D1 receptors (please see [36]), which have been conceptualized as underlying adolescent-specific changes in motivational behavior [37].”
BackgroundPornography Addiction Detection based on Neurophysiological Computational Approach
Kamaruddin, N., Wahab, A., & Handiyani, D. (2018) · Indonesian Journal of Electrical Engineering and Computer Science · doi:10.11591/ijeecs.v10.i1.pp138-145 · Cited by 10
“Neurobehavioral, morphological, neurochemical, and pharmacological evidence suggests that the brain remains under construction during adolescence [8,9].”
BackgroundZhou, M., Gresack, J. E., Cheng, J., Uryu, K., Brichta, L., Greengard, P., & Flajolet, M. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0233-z · Cited by 10
Evaluation of Juvenile Animal Studies for Pediatric CNS-Targeted Compounds: A Regulatory Perspective
van der Laan, J. W., Malderen, K. V., de Jager, N. C. B., Duarte, D. M., Egger, G. F., Lavergne, F., Roque, C. G., Vieira, I. B., Wiesner, L., & Carleer, J. (2019) · International Journal of Toxicology · doi:10.1177/1091581819883569 · Cited by 10
“D1 and D2 receptors follow similar developmental patterns, showing a peak between PND 28 and PND 42 in the caudate and putamen, and decreasing thereafter.(18,19) However, the picture is more complicated as dopamine also occurs in the ventral striatum.”
BackgroundNicotine modulation of adolescent dopamine receptor signaling and hypothalamic peptide response
Mojica, C., Dao, J. M., Yuan, M., Loughlin, S. E., & Leslie, F. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.012 · Cited by 12
“N IH -PA Author M anuscript N IH -PA Author M anuscript dopamine, which plays a critical role in sensation seeking, reward and decision-making (Steinberg, 2008; Ernst et al., 2009; Wahlstrom et al., 2010).”
BackgroundZhao, W., Huang, L., Yang, L., Zhang, Q.-M., Chen, X., Fu, W., Du, B., Deng, X., Ji, F., Xiang, Y., et al. (2020) · Brain and Behavior · doi:10.1002/brb3.1523 · Cited by 12
Postweaning isolation affects responses to incentive contrast in adulthood
Cuenya, L., Mustaca, A., & Kamenetzky, G. (2015) · Developmental Psychobiology · doi:10.1002/dev.21273 · Cited by 9
Systematic Review: White Matter Microstructural Organization in Adolescents With Depression
Radoeva, P. D., Milev, V., Hunt, J., Legere, C. H., Deoni, S., Sheinkopf, S. J., Mazefsky, C. A., Philip, N. S., & Dickstein, D. P. (2023) · JAACAP Open · doi:10.1016/j.jaacop.2023.08.006 · Cited by 9
“Brain changes during adolescence in typical development include synaptic pruning, increased myelination, and neurotransmitter changes, 5,6 as well as increases in white matter volumes and inverted U-shaped gray matter volume trajectories across different brain regions.”
BH4 as a Therapeutic Target for ADHD: Relevance to Neurotransmitters and Stress-Driven Symptoms
Wilson, S. K., & Thomas, J. (2023) · Journal of Attention Disorders · doi:10.1177/10870547231204012 · Cited by 9
“There have also been linkages discovered between ADHD and dopamine levels in certain brain regions: people with ADHD have lower dopaminergic activity (Gehricke et al., 2017; Qiu et al., 2011; Wahlstrom et al., 2010).”
BackgroundKameda, S. R., Fukushiro, D. F., Trombin, T. F., Sanday, L., Wuo‐Silva, R., Saito, L. P., Tufik, S., D’Almeida, V., & Frussa‐Filho, R. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.046 · Cited by 9
“, 1994), adolescence (Tarazi and Baldessarini, 2000; Andersen et al., 2002; Doremus-Fitzwater et al., 2010; Wahlstrom et al., 2010) and amphetamine-induced behavioral sensitization are associated with similar mesolimbic dopaminergic plastic changes.”
BackgroundEvolutionary Perspectives on Religion and Violence
Alcorta, C. S., & Sosis, R. H. (2022) · Cambridge University Press eBooks · doi:10.1017/9781009238328 · Cited by 8
Psychophysiological features of adolescents
Nv, D. (2015) · Human Physiology · doi:10.1134/s0362119715020061 · Cited by 10
Moloney, R. A., Palliser, H. K., Dyson, R. M., Pavy, C. L., Berry, M., Hirst, J. J., & Shaw, J. C. (2024) · Developmental Neurobiology · doi:10.1002/dneu.22937 · Cited by 8
“Adolescence has been found in both rats and nonhuman primates to coincide with increases in dopaminergic receptor expression; however, there are limited studies on the direct changes to each receptor subtype in either species (Wahlstrom et al., 2010).”
BackgroundPereira, D. E., Bidô, R. D. C. D. A., Alves, M. D. C., de Melo, M. F. F. T., Costa, A. C. D. S., Dutra, L. M. G., de Morais, M. B., da Câmara, C. A. G., Viera, V., Alves, A. F., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149383 · Cited by 8
Moe, A. A. K., Scott, J. G., Burne, T. H. J., & Eyles, D. W. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116654776 · Cited by 8
“Detailed reviews on maturation of adolescent neuronal systems can be found elsewhere (Brenhouse and Andersen, 2011; Giedd, 2008; Lewis, 1997; McCutcheon and Marinelli, 2009; Spear, 2000; Sturman and Moghaddam, 2011; Wahlstrom et al., 2010).”
BackgroundNeuroscience, moral development, criminal capacity, and the Child Justice Act: justice or injustice?
Kramers-Olen, A. L. (2015) · South African Journal of Psychology · doi:10.1177/0081246315603633 · Cited by 11
Early Experience and Incentive Relativity in Adulthood
Cuenya, L., Kamenetzky, G., & Mustaca, A. E. (2014) · International Journal of Comparative Psychology · doi:10.46867/ijcp.2014.27.03.03 · Cited by 9
Bi-phasic patterns of age-related differences in dopamine D1 receptors across the adult lifespanPreprint
Johansson, J. J., Nordin, K., Pedersen, R., Karalija, N., Papenberg, G., Andersson, M., Korkki, S. M., Riklund, K., Guitart‐Masip, M., Rieckmann, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.24.493225 · Cited by 8
“2 Introduction The dopamine (DA) system undergoes profound changes across the lifespan, along with concomitant alterations in cognition ((Bäckman et al., 2010; Islam et al., 2021; Li et al., 2010; Reynolds and Flores, 2021a; Wahlstrom et al., 2010), for reviews).”
BackgroundCartágenes, S. D. C., da Silveira, C. C. S. D. M., Pinheiro, B. G., Fernandes, L. M. P., Farias, S. V., Kobayashi, N. H. C., de Souza, P. H. F. S., do Prado, A. F., Ferreira, M. K. M., Lima, R. R., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15111373 · Cited by 7
“, anxiety and depression) and cognitive functions, which undergo extensive connectivity and refinement modifications during adolescence [92,93].”
BackgroundFussell, N. J., Rowe, A. C., & Möhr, C. (2011) · Laterality Asymmetries of Body Brain and Cognition · doi:10.1080/1357650x.2010.506690 · Cited by 7
Lee, J. C. (2017) · Brain and Language · doi:10.1016/j.bandl.2017.07.006 · Cited by 7
Monahan, K. C., Guyer, A. E., Silk, J. S., Doremus‐Fitzwater, T. L., & Steinberg, L. D. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy219 · Cited by 7
Is Adolescence a Sensitive Period for the Development of Incentive-Reward Motivation?
Luciana, M., & Collins, P. F. (2021) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2021_275 · Cited by 7
Self-citationFlannery, J. S., Parr, A. C., Lindquist, K. A., & Telzer, E. H. (2025) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2025.101594 · Cited by 7
Ojha, A., Foran, W., Calabro, F. J., Sydnor, V. J., Petrie, D. J., Parr, A. C., Famalette, A., Phang, N., Sista, A., Sorrells, S. F., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116265 · Cited by 7
“…PFC is consistent with evidence of a peak in reward processing, 120 sensation seeking, and risk-taking, 12,13 —possibly via heightened CEN-related dopaminergic function 121 —in adolescence, 122 extending our understanding of the adolescent phenotype by revealing a potential role for CEN circuitry.”
Nicotine and fluoxetine alter adolescent dopamine-mediated behaviors via 5-HT1A receptor activation
Yuan, M., & Leslie, F. M. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1380123 · Cited by 6
Mugno, A. T., & Constant, D. (2021) · StatPearls · Cited by 6
Jurasaite-O’Keefe, E. (2022) · RMLE Online · doi:10.1080/19404476.2022.2024067 · Cited by 14
“…in morphology and function (Blakemore, 2012; Doremus-Fitzwater et al., 2010; Gogtay & Thompson, 2010; Paus, 2005; Schmithorst & Yuan, 2010; Wahlstrom et al., 2010) and in brain activity (Feinberg & Campbell, 2012; Ochsner et al., 2012; Romeo, 2010; Segalowitz et al., 2010; Wahlstrom et al., 2010).”
BackgroundAge moderates the effect of acute dopamine depletion on passive avoidance learning
Kelm, M. K., & Boettiger, C. A. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.01.014 · Cited by 5
“Given the decline in DA signaling following late adolescence (Wahlstrom et al., 2010), one would expect to find age-dependent improvement in learning from punishment, which is what we observed here: the ability to learn from negative feedback in the control session correlated with age: the older participants were, the…”
BackgroundInfluentialReduced brain activation during inhibitory control in children with COMT Val/Val genotype
Cope, L. M., Hardee, J. E., Soules, M. E., Burmeister, M., Zucker, R. A., & Heitzeg, M. M. (2016) · Brain and Behavior · doi:10.1002/brb3.577 · Cited by 6
Metadata
- Authors
- Wahlstrom, D., Collins, P., White, T., & Luciana, M.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Luciana, Monica
- Venue
- Brain and Cognition
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 72
- Issue
- 1
- Pages
- 146-159
- ISSN
- 0278-2626 (ISSN-L)
- PMC
- PMC2815132
- OpenAlex
- W2168203121
- Cited by
- 311
- References
- 195
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 15 · 2023: 28 · 2022: 24 · 2021: 21 · 2020: 15 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 25 · 2015: 18 · 2014: 15 · 2013: 29 · 2012: 11
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain and Cognition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32MH017069)
- National Institute on Drug Abuse (DA017843, R01DA017843)
- National Center for Research Resources (M01RR000400, M01-RR00400)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine signaling, adolescence, appetitive behavior, risk-taking, novelty seeking, dopaminergic system, molecular genetics, pharmacological evaluation, lifespan development, cognitive and emotional development
- MeSH terms
- Adolescent, Animals, Behavior, Brain, Dopamine, Humans, Neural Pathways, Synaptic Transmission, Adolescent Development
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