Cited by 690Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and PathologyAutophagy in Disease and Therapy

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Mitochondrial dysfunction in Parkinson's disease

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Winklhofer, Konstanze F., Haass, Christian·2010·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2009.08.013

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Abstract

Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to their prominent role in energy metabolism, mitochondria are intimately involved in various key cellular processes, such as the regulation of calcium homeostasis, stress response and cell death pathways. Thus, it is not surprising that an impairment of mitochondrial function results in cellular damage and is linked to aging and neurodegeneration. Many lines of evidence suggest that mitochondrial dysfunction plays a central role in the pathogenesis of Parkinson's disease (PD), starting in the early 1980s with the observation that an inhibitor of complex I of the electron transport chain can induce parkinsonism. Remarkably, recent research indicated that several PD-associated genes interface with pathways regulating mitochondrial function, morphology, and dynamics. In fact, sporadic and familial PD seem to converge at the level of mitochondrial integrity.

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
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Impaired dopamine release and synaptic plasticity in the striatum of PINK1 -deficient mice
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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
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Localization of LRRK2 to membranous and vesicular structures in mammalian brain
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Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin
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Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse
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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity
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Oxidative stress and inflammation in Parkinson's disease: is there a causal link?
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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
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Parkin Mediates Nonclassical, Proteasomal-Independent Ubiquitination of Synphilin-1: Implications for Lewy Body Formation
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LRRK2 in Parkinson's disease: protein domains and functional insights
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Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial nadh:Ubiquinone oxidoreductase (complex i)
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DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
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Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
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The Mitochondrial Inner Membrane Protein Mitofilin Controls Cristae Morphology
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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
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Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy
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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
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Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation
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Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
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Sensitivity to Oxidative Stress in DJ-1-Deficient Dopamine Neurons: An ES- Derived Cell Model of Primary Parkinsonism
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Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells
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Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson’s Disease
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Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson’s disease
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Moving Mitochondria: Establishing Distribution of an Essential Organelle
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The kinase domain of mitochondrial PINK1 faces the cytoplasm
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A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
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Authors: Winklhofer, K. F., & Haass, C.
Affiliations: German Center for Neurodegenerative Diseases (DE)
Corresponding author: Winklhofer, Konstanze F.
ORCID: Winklhofer, Konstanze F.
Haass, Christian
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2010-01
Volume: 1802
Issue: 1
Pages: 29-44
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2009.08.013
OpenAlex: W2130497877
Cited by: 688
References: 326
Citations by year: 2026: 10 · 2025: 16 · 2024: 13 · 2023: 27 · 2022: 30 · 2021: 37 · 2020: 55 · 2019: 38 · 2018: 72 · 2017: 51 · 2016: 61 · 2015: 39 · 2014: 29 · 2013: 37 · 2012: 49
FWCI: 5.83
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1784 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB 596)
German Ministry for Education and Research
the Helmholtz Alliance “Mental Health in an Ageing Society,”
the Center for Integrated Protein Science Munich
the Hans and Ilse Breuer Foundation
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: mitochondrial dysfunction, Parkinson's disease, mitochondrial dynamics, mitochondrial morphology, mitochondrial complex I inhibition, parkinsonism, electron transport chain, calcium homeostasis, stress response, cell death pathways, neurodegeneration, aging, familial Parkinson's disease, sporadic Parkinson's disease
MeSH terms: Animals, DNA, Mitochondrial, Humans, Mitochondria, Models, Biological, Parkinson Disease, Oxidative Stress, Mitochondrial Proteins

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