Peroxisomal ABC transporters: Structure, function and role in disease

Morita, Masashi; Imanaka, Tsuneo

doi:10.1016/j.bbadis.2012.02.009

Cited by 183Metabolism and Genetic DisordersDrug Transport and Resistance MechanismsPeroxisome Proliferator-Activated Receptors

Peroxisomal ABC transporters: Structure, function and role in disease

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Morita, Masashi, Imanaka, Tsuneo·2012·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2012.02.009

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Abstract

ATP-binding cassette (ABC) transporters belong to one of the largest families of membrane proteins, and are present in almost all living organisms from eubacteria to mammals. They exist on plasma membranes and intracellular compartments such as the mitochondria, peroxisomes, endoplasmic reticulum, Golgi apparatus and lysosomes, and mediate the active transport of a wide variety of substrates in a variety of different cellular processes. These include the transport of amino acids, polysaccharides, peptides, lipids and xenobiotics, including drugs and toxins. Three ABC transporters belonging to subfamily D have been identified in mammalian peroxisomes. The ABC transporters are half-size and assemble mostly as a homodimer after posttranslational transport to peroxisomal membranes. ABCD1/ALDP and ABCD2/ALDRP are suggested to be involved in the transport of very long chain acyl-CoA with differences in substrate specificity, and ABCD3/PMP70 is involved in the transport of long and branched chain acyl-CoA. ABCD1 is known to be responsible for X-linked adrenoleukodystrophy (X-ALD), an inborn error of peroxisomal β-oxidation of very long chain fatty acids. Here, we summarize recent advances and important points in our advancing understanding of how these ABC transporters target and assemble to peroxisomal membranes and perform their functions in physiological and pathological processes, including the neurodegenerative disease, X-ALD.

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Dysfunction of ABCD1 results in impaired degradation of VLCFAs in peroxisomes and consequently their accumulation in various lipid species in tissues and body fluids.
“The dysfunction of ABCD1 results in impaired degradation of VLCFAs in peroxisomes and consequently leads to their accumulation in various lipid species in tissues and body fluids.7”
From The genetic landscape of X-linked adrenoleukodystrophy: inheritance, mutations, modifier genes, and diagnosis (2015) · cites this paper as [7]
Section 5.1 states that ABCD1 dysfunction reduces peroxisomal VLCFA β-oxidation and increases VLCFA levels in the plasma and tissues of patients with X-ALD. The copy does not establish the further claim that VLCFAs accumulate in various lipid species in those tissues and body fluids; section 5.2 mentions VLCFA-containing complex lipids and phospholipids only in a proposed mechanism. (LLM, conf=0.84)
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ABC Transporters: From Microorganisms to Man
Higgins, C. F. (1992) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.08.110192.000435 · Cited by 3,985 · see citing works
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P. M., Trinh, Y. T., Zhang, Q., Urbatsch, I. L., et al. (2009) · Science · doi:10.1126/science.1168750 · Cited by 1,929 · see citing works
Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy
Cartier, N., Hacein-Bey-Abina, S., Bartholomae, C. C., Veres, G., Schmidt, M., Kutschera, I., Vidaud, M., Abel, U., Dal-Cortivo, L., Caccavelli, L., et al. (2009) · Science · doi:10.1126/science.1171242 · Cited by 1,508 · see citing works
Presenting your structures: theCCP4mgmolecular-graphics software
McNicholas, S. J., Potterton, E. A., Wilson, K. S., & Noble, M. E. M. (2011) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444911007281 · Cited by 1,312 · see citing works
Structure of a bacterial multidrug ABC transporter
Dawson, R. J. P., & Locher, K. P. (2006) · Nature · doi:10.1038/nature05155 · Cited by 1,280 · see citing works
Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
Mosser, J., Douar, A.-M., Sarde, C.-O., Kioschis, P., Feil, R., Moser, H., Poustka, A.-M., Mandel, J.-L., & Aubourg, P. (1993) · Nature · doi:10.1038/361726a0 · Cited by 1,202 · see citing works
Biochemistry of mammalian peroxisomes revisited
Wanders, R. J. A., & Waterham, H. R. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133329 · Cited by 995 · see citing works
Human ATP-binding cassette (ABC) transporter family
Vasiliou, V., Vasiliou, K., & Nebert, D. W. (2008) · Human Genomics · doi:10.1186/1479-7364-3-3-281 · Cited by 779 · see citing works
Flexibility in the ABC transporter MsbA: Alternating access with a twist
Ward, A. B., Reyes, C. L., Yu, J., Roth, C., & Chang, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709388104 · Cited by 774 · see citing works
The Arabidopsis thaliana ABC Protein Superfamily, a Complete Inventory
Sánchez‐Fernández, R., Davies, T. G. E., COLEMAN, J. O. D., & Rea, P. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103104200 · Cited by 559 · see citing works
Cholesterol metabolism in neurons and astrocytes
Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500 · see citing works
The ABC of ABCs: a phylogenetic and functional classification of ABC systems in living organisms
Dassa, E., & Bouige, P. (2001) · Research in Microbiology · doi:10.1016/s0923-2508(01)01194-9 · Cited by 481 · see citing works
Adrenoleukodystrophy: phenotype, genetics, pathogenesis and therapy
Moser, H. (1997) · Brain · doi:10.1093/brain/120.8.1485 · Cited by 478 · see citing works
The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily.
Kamijo, K., Taketani, S., Yokota, S., Osumi, T., & Hashimoto, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39595-x · Cited by 391 · see citing works
The Arabidopsis pxa1 Mutant Is Defective in an ATP-Binding Cassette Transporter-Like Protein Required for Peroxisomal Fatty Acid beta -Oxidation
Zolman, B. K., Silva, I. D., & Bartel, B. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.127.3.1266 · Cited by 364 · see citing works
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
Kassmann, C. M., Lappe-Siefke, C., Baes, M., Brügger, B., Mildner, A., Werner, H. B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., et al. (2007) · Nature Genetics · doi:10.1038/ng2070 · Cited by 357 · see citing works
The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER
Kim, P. K., Mullen, R. T., Schümann, U., & Lippincott‐Schwartz, J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200601036 · Cited by 344 · see citing works
Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism
Veldhoven, P. P. V. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r005959 · Cited by 328 · see citing works
Adrenoleukodystrophy: Incidence, new mutation rate, and results of extended family screening
Bezman, L., Moser, A. B., Raymond, G. V., Rinaldo, P., Watkins, P. A., Smith, K. D., Kass, N. E., & Moser, H. W. (2001) · Annals of Neurology · doi:10.1002/ana.101 · Cited by 324 · see citing works
Getting In or Out: Early Segregation Between Importers and Exporters in the Evolution of ATP-Binding Cassette (ABC) Transporters
Saurin, W., Hofnung, M. J., & Dassa, E. (1999) · Journal of Molecular Evolution · doi:10.1007/pl00006442 · Cited by 323 · see citing works
The ABC transporter proteins Pat1 and Pat2 are required for import of long‐chain fatty acids into peroxisomes of Saccharomyces cerevisiae.
Hettema, E. H., van Roermund, C. W., Distel, B., van den Berg, M., Vilela, C., Rodrigues‐Pousada, C., Wanders, R. J., & Tabak, H. F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00755.x · Cited by 323 · see citing works
Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis
Sacksteder, K. A., Jones, J. M., South, S. T., Li, X., Liu, Y., & Gould, S. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.5.931 · Cited by 317 · see citing works
Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP
Footitt, S., Slocombe, S. P., Larner, V. S., Kurup, S., Wu, Y., Larson, T. R., Graham, I. A., Baker, A., & Holdsworth, M. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf300 · Cited by 316 · see citing works
Jasmonic Acid Levels Are Reduced in COMATOSE ATP-Binding Cassette Transporter Mutants. Implications for Transport of Jasmonate Precursors into Peroxisomes
Theodoulou, F. L., Job, K., Slocombe, S. P., Footitt, S., Holdsworth, M. J., Baker, A., Larson, T. R., & Graham, I. A. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.059352 · Cited by 290 · see citing works
Adrenoleukodystrophy: Incidence, new mutation rate, and results of extended family screening
Bezman, L., Moser, A. B., Raymond, G. V., Watkins, P. A., Smith, K. D., KASS, N. E., & Moser, H. W. (2001) · Annals of Neurology · doi:10.1002/ana.101.abs · Cited by 237 · see citing works
The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl–CoA esters
van Roermund, C. W. T., Visser, W. F., IJlst, L., van Cruchten, A., Boek, M., Kulik, W., Waterham, H. R., & Wanders, R. J. A. (2008) · The FASEB Journal · doi:10.1096/fj.08-110866 · Cited by 233 · see citing works
Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome
Gärtner, J., Moser, H. W., & Valle, D. L. (1992) · Nature Genetics · doi:10.1038/ng0492-16 · Cited by 228 · see citing works
A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern.
Lombard-Platet, G., Savary, S., Sarde, C. O., Mandel, J. L., & Chimini, G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1265 · Cited by 222 · see citing works
Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy
Fourcade, S., Lopez-Erauskin, J., Galino, J., Duval, C., Naudi, A., Jove, M., Kemp, S., Villarroya, F., Ferrer, I., Pamplona, R., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn085 · Cited by 214 · see citing works
Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X-adrenoleukodystrophy
Pujol, A., Ferrer, I., Camps, C., Metzger, E., Hindelang, C., Callizot, N., Ruiz, M., Pàmpols, T., Giròs, M., & Mandel, J. L. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh323 · Cited by 201 · cited 1× · see citing works
“It is generally accepted that ABCD2 has a certain functional redundancy with ABCD1 [54].”
Background
Interactions of a very long chain fatty acid with model membranes and serum albumin. Implications for the pathogenesis of adrenoleukodystrophy.
Ho, J. K., Moser, H., Kishimoto, Y., & Hamilton, J. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118182 · Cited by 199 · see citing works
Glial Lipoproteins Stimulate Axon Growth of Central Nervous System Neurons in Compartmented Cultures
Hayashi, H., Campenot, R. B., Vance, D. E., & Vance, J. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313828200 · Cited by 191 · see citing works
Ped3p is a Peroxisomal ATP-Binding Cassette Transporter that might Supply Substrates for Fatty Acid β-Oxidation
Hayashi, M., Nito, K., Takei-Hoshi, R., Yagi, M., Kondo, M., Suenaga, A., Yamaya, T., & Nishimura, M. (2002) · Plant and Cell Physiology · doi:10.1093/pcp/pcf023 · Cited by 189 · see citing works
Peroxisome assembly: matrix and membrane protein biogenesis
Ma, C., Agrawal, G., & Subramani, S. E. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010022 · Cited by 185 · see citing works
Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture
Hein, S., Schonfeld, P., Kahlert, S., & Reiser, G. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn066 · Cited by 180 · see citing works
Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?
Eichler, F. S., Ren, J., Cossoy, M., Rietsch, A. M., Nagpal, S., Moser, A. B., Frosch, M. P., & Ransohoff, R. M. (2008) · Annals of Neurology · doi:10.1002/ana.21391 · Cited by 178 · see citing works
Peroxisomal Membrane Proteins Contain Common Pex19p-binding Sites that Are an Integral Part of Their Targeting Signals
Rottensteiner, H., Kramer, A., Lorenzen, S., Stein, K., Landgraf, C., Volkmer, R., & Erdmann, R. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-03-0188 · Cited by 173 · see citing works
The ABC Transporter PXA1 and Peroxisomal β-Oxidation Are Vital for Metabolism in Mature Leaves of Arabidopsis during Extended Darkness
Kunz, H., Scharnewski, M., Feussner, K., Feußner, I., Flügge, U., Fulda, M. S., & Gierth, M. (2009) · The Plant Cell · doi:10.1105/tpc.108.064857 · Cited by 170 · see citing works
The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy
Ofman, R., Dijkstra, I. M. E., van Roermund, C. W. T., Burger, N., Turkenburg, M., van Cruchten, A., van Engen, C. E., Wanders, R. J. A., & Kemp, S. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000061 · Cited by 170 · see citing works
Metabolite transport across the peroxisomal membrane
Visser, W. F., van Roermund, C. W. T., IJlst, L., Waterham, H. R., & Wanders, R. J. A. (2006) · Biochemical Journal · doi:10.1042/bj20061352 · Cited by 169 · see citing works
Peroxisomal Membrane Proteins Insert into the Endoplasmic Reticulum
van der Zand, A., Braakman, I., & Tabak, H. F. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-02-0082 · Cited by 161 · see citing works
The peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p- and Pex16p-dependent pathway
Matsuzaki, T., & Fujiki, Y. (2008) · Journal of Cell Biology · doi:10.1083/jcb.200806062 · Cited by 152 · see citing works
Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions.
Fujiki, Y., Matsuzono, Y., Matsuzaki, T., & Fransen, M. (2006) · Biochimica et Biophysica Acta · doi:10.1016/j.bbamcr.2006.09.030 · Cited by 150 · see citing works
Adrenoleukodystrophy-Related Protein Can Compensate Functionally for Adrenoleukodystrophy Protein Deficiency (X-ALD): Implications for Therapy
Netik, A., Forss-Petter, S., Holzinger, A., Molzer, B., Unterrainer, G., & Berger, J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.907 · Cited by 148 · see citing works
Homo- and Heterodimerization of Peroxisomal ATP-binding Cassette Half-transporters
Liu, L. X., Janvier, K., Berteaux-Lecellier, V., Cartier, N., Benarous, R., & Aubourg, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32738 · Cited by 141 · see citing works
Antioxidants halt axonal degeneration in a mouse model of X‐adrenoleukodystrophy
López‐Erauskin, J., Fourcade, S., Galino, J., Ruíz, M., Schlüter, A., Naudí, A., Jové, M., Portero‐Otín, M., Pamplona, R., Ferrer, I., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22363 · Cited by 135 · see citing works
Protein import machineries of peroxisomes
Rucktäschel, R., Girzalsky, W., & Erdmann, R. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.07.020 · Cited by 132 · see citing works
Adreno-leukodystrophy: Oxidative Stress of Mice and Men
Powers, J. M., Pei, Z., Heinzer, A. K., Brose, R. D., Moser, A. B., Moser, H. W., Watkins, P. A., & Smith, K. D. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000190064.28559.a4 · Cited by 131 · see citing works
Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid β-oxidation
van Roermund, C. W. T., Visser, W. F., IJlst, L., Waterham, H. R., & Wanders, R. J. A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.11.010 · Cited by 128 · see citing works
Potential Environmental and Host Participants in the Early White Matter Lesion of Adreno-Leukodystrophy: Morphologic Evidence for CD8 Cytotoxic T Cells, Cytolysis of Oligodendrocytes, and CD1-Mediated Lipid Antigen Presentation
Ito, M., Blumberg, B. M., Mock, D. J., Goodman, A. D., Moser, A. B., Moser, H. W., Smith, K. D., & Powers, J. M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.10.1004 · Cited by 125 · see citing works
Identification of a Fourth Half ABC Transporter in the Human Peroxisomal Membrane
Shani, N., Jiménez‐Sánchez, G., Steel, G., Dean, M. C., & Valle, D. L. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1925 · Cited by 124 · see citing works
Peroxisomal ABC transporters
Theodoulou, F. L., Holdsworth, M. J., & Baker, A. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.095 · Cited by 119 · see citing works
Transport of Activated Fatty Acids by the Peroxisomal ATP‐binding‐cassette Transporter Pxa2 in a Semi‐Intact Yeast Cell System
Verleur, N., Hettema, E. H., Van Roermund, C. W. T., Tabak, H. F., & Wanders, R. J. A. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00657.x · Cited by 117 · see citing works
Biochemical aspects of X-linked adrenoleukodystrophy
Kemp, S., & Wanders, R. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00391.x · Cited by 116 · see citing works
Be different—The diversity of peroxisomes in the animal kingdom
Islinger, M., Cardoso, M. J., & Schrader, M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.03.013 · Cited by 115 · see citing works
Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance
Kemp, S., Theodoulou, F. L., & Wanders, R. J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01435.x · Cited by 115 · see citing works
Plasmalogens participate in very-long-chain fatty acid-induced pathology
Brites, P., Mooyer, P. A. W., el Mrabet, L., Waterham, H. R., & Wanders, R. J. A. (2008) · Brain · doi:10.1093/brain/awn295 · Cited by 112 · see citing works
Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients
Jang, J., Kang, H., Kim, H., Kim, J. Y., Huh, Y. J., Kim, D., Yoo, J., Lee, J., Lim, B., Lee, J., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22486 · Cited by 109 · see citing works
Retroviral-mediated gene transfer corrects very-long-chain fatty acid metabolism in adrenoleukodystrophy fibroblasts.
Cartier, N., Lopez, J., Moullier, P., Rocchiccioli, F., Rolland, M. O., Jorge, P., Mosser, J., Mandel, J. L., Bougnères, P. F., & Danos, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1674 · Cited by 105 · see citing works
A key role for the peroxisomal<i>ABCD2</i>transporter in fatty acid homeostasis
Fourcade, S., Ruiz, M., Camps, C., Schlüter, A., Houten, S. M., Mooyer, P. A. W., Pàmpols, T., Dacremont, G., Wanders, R. J. A., Giròs, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90736.2008 · Cited by 104 · see citing works
Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy
Fourcade, S., Ruíz, M., Guilera, C., Hahnen, E., Brichta, L., Naudí, A., Portero‐Otín, M., Dacremont, G., Cartier, N., Wanders, R. J. A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq082 · Cited by 100 · see citing works
Suppression of peroxisomal membrane protein defects by peroxisomal ATP binding cassette (ABC) proteins
Braiterman, L. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.2.239 · Cited by 98 · see citing works
Characterization of the 70-kDa Peroxisomal Membrane Protein, an ATP Binding Cassette Transporter
Imanaka, T., Aihara, K., Takano, T., Yamashita, A., Sato, R., Suzuki, Y., Yokota, S., & Osumi, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11968 · Cited by 97 · see citing works
Self-citation
cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter
Holzinger, A., Kammerer, S., Berger, J., & Roscher, A. A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7391 · Cited by 92 · see citing works
Primary Structure of Human PMP69, a Putative Peroxisomal ABC-Transporter
Holzinger, A., Kammerer, S., & Roscher, A. A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7102 · Cited by 91 · see citing works
Head trauma can initiate the onset of adreno-leukodystrophy
Raymond, G. V., Seidman, R., Monteith, T. S., Kolodny, E., Sathe, S., Mahmood, A., & Powers, J. M. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.11.005 · Cited by 90 · see citing works
Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy
Asheuer, M., Bieche, I., Laurendeau, I., Moser, A., Hainque, B., Vidaud, M., & Aubourg, P. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi140 · Cited by 86 · see citing works
Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin
Khan, M., Singh, J., & Singh, I. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05513.x · Cited by 86 · see citing works
Oxidative Damage Compromises Energy Metabolism in the Axonal Degeneration Mouse Model of X-Adrenoleukodystrophy
Galino, J., Ruíz, M., Fourcade, S., Schlüter, A., López‐Erauskin, J., Guilera, C., Jové, M., Naudí, A., García‐Arumí, E., Andreu, A. L., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3877 · Cited by 85 · see citing works
Mirror expression of adrenoleukodystrophy and adrenoleukodystrophy related genes in mouse tissues and human cell lines
Troffer-Charlier, N., Doerflinger, N., Metzger, E., Fouquet, F., Mandel, J.-L., & Aubourg, P. (1998) · European Journal of Cell Biology · doi:10.1016/s0171-9335(98)80121-0 · Cited by 85 · see citing works
Caenorhabditis elegans utilizes dauer pheromone biosynthesis to dispose of toxic peroxisomal fatty acids for cellular homoeostasis
Joo, H.-J., Yim, Y., Jeong, P.-Y., Jin, Y.-X., Lee, J.-E., Kim, H., Jeong, S.-K., Chitwood, D. J., & Paik, Y. (2009) · Biochemical Journal · doi:10.1042/bj20090513 · Cited by 82 · see citing works
Domain Architecture and Activity of Human Pex19p, a Chaperone-like Protein for Intracellular Trafficking of Peroxisomal Membrane Proteins
Shibata, H., Kashiwayama, Y., Imanaka, T., & Kato, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402204200 · Cited by 80 · see citing works
Self-citation
Nucleotide sequence of the human 70 kDa peroxisomal membrane protein: a member of ATP-binding cassette transporters
Kamijo, K., Kamijo, T., Ueno, I., Osumi, T., & Hashimoto, T. (1992) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(92)90510-7 · Cited by 79 · see citing works
Function of the PEX19-binding Site of Human Adrenoleukodystrophy Protein as Targeting Motif in Man and Yeast
Halbach, A., Lorenzen, S., Landgraf, C., Volkmer-Engert, R., Erdmann, R., & Rottensteiner, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501750200 · Cited by 78 · see citing works
Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes
Bottelbergs, A., Verheijden, S., Hulshagen, L., Gutmann, D. H., Goebbels, S., Nave, K., Kassmann, C., & Baes, M. (2010) · Glia · doi:10.1002/glia.21027 · Cited by 78 · see citing works
Astrocyte phenotypes and their relationship to myelination
Nash, B., Ioannidou, K., & Barnett, S. C. (2010) · Journal of Anatomy · doi:10.1111/j.1469-7580.2010.01330.x · Cited by 77 · see citing works
Evolutionary Analyses of ABC Transporters of Dictyostelium discoideum
Anjard, C., & Loomis, W. F. (2002) · Eukaryotic Cell · doi:10.1128/ec.1.4.643-652.2002 · Cited by 77 · see citing works
The Arabidopsis Peroxisomal ABC Transporter, Comatose, Complements the Saccharomyces cerevisiae pxa1 pxa2Δ Mutant for Metabolism of Long-chain Fatty Acids and Exhibits Fatty Acyl-CoA-stimulated ATPase Activity
Nyathi, Y., Lousa, C. D. M., van Roermund, C. W. T., Wanders, R. J. A., Johnson, B., Baldwin, S. A., Theodoulou, F. L., & Baker, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.151225 · Cited by 73 · see citing works
Distribution and cellular localization of adrenoleukodystrophy protein in human tissues: implications for X-linked adrenoleukodystrophy
Höftberger, R., Kunze, M., Weinhofer, I., Aboul-Enein, F., Voigtländer, T., Oezen, I., Amann, G., Bernheimer, H., Budka, H., & Berger, J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.07.007 · Cited by 69 · cited 1× · see citing works
“In the CNS, ABCD1 is expressed in endothelial cells, astrocytes and microglia, and also in subpopulations of oligodendrocytes located in the corpus callosum, internal capsules and anterior commissure, but not in neurons in the adult mouse or human brain [62].”
Background
Peroxisomes, myelination, and axonal integrity in the CNS
Baes, M., & Aubourg, P. (2009) · The Neuroscientist · doi:10.1177/1073858409336297 · Cited by 65 · see citing works
ATP Binding/Hydrolysis by and Phosphorylation of Peroxisomal ATP-binding Cassette Proteins PMP70 (ABCD3) and Adrenoleukodystrophy Protein (ABCD1)
Tanaka, A. R., Tanabe, K., Morita, M., Kurisu, M., Kashiwayama, Y., Matsuo, M., Kioka, N., Amachi, T., Imanaka, T., & Ueda, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205079200 · Cited by 63 · see citing works
Self-citation
Oligodendroglial impact on axonal function and survival – a hypothesis
Kassmann, C. M., & Nave, K. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328300c71f · Cited by 63 · see citing works
Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p
Sato, Y., Shibata, H., Nakatsu, T., Nakano, H., Kashiwayama, Y., Imanaka, T., & Kato, H. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.293 · Cited by 61 · see citing works
Self-citation
70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins
Kashiwayama, Y., Seki, M., Yasui, A., Murasaki, Y., Morita, M., Yamashita, Y., Sakaguchi, M., Tanaka, Y., & Imanaka, T. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.10.031 · Cited by 60 · see citing works
Self-citation
Mouse liver PMP70 and ALDP: homomeric interactions prevail in vivo
Guimarães, C. P., Domingues, P. M., Aubourg, P. R., Fouquet, F., Pujol, A., Jiménez‐Sánchez, G., Sá-Miranda, C., & Azevedo, J. E. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.04.001 · Cited by 60 · see citing works
Insights into Peroxisome Function from the Structure of PEX3 in Complex with a Soluble Fragment of PEX19*
Schmidt, F., Treiber, N., Zocher, G., Bjelić, S., Steinmetz, M., Kalbacher, H., Stehle, T., & Dodt, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.138503 · Cited by 60 · see citing works
Therapy of X-linked adrenoleukodystrophy
Moser, H. W. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.01.004 · Cited by 59 · see citing works
Cholesterol regulates ABCD2 expression: implications for the therapy of X-linked adrenoleukodystrophy
Weinhofer, I. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.22.2701 · Cited by 59 · see citing works
Trypanosoma bruceiglycosomal ABC transporters: identification and membrane targeting
Yernaux, C., Fransen, M., Brees, C., Lorenzen, S., & Michels, P. A. M. (2006) · Molecular Membrane Biology · doi:10.1080/09687860500460124 · Cited by 57 · see citing works
Live Cell FRET Microscopy
Hillebrand, M., Verrier, S. E., Ohlenbusch, A., Schäfer, A., Söling, H.-D., Wouters, F. S., & Gärtner, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702122200 · Cited by 54 · see citing works
RNA interference of peroxisome-related genes inC. elegans: a new model for human peroxisomal disorders
Petriv, O. I., Pilgrim, D. B., Rachubinski, R. A., & Titorenko, V. I. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00044.2002 · Cited by 53 · see citing works
Substrate Specificity Overlap and Interaction between Adrenoleukodystrophy Protein (ALDP/ABCD1) and Adrenoleukodystrophy-related Protein (ALDRP/ABCD2)
Genin, E. C., Geillon, F., Gondcaille, C., Athias, A., Gambert, P., Trompier, D., & Savary, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.211912 · Cited by 53 · see citing works
Topology of ATP-Binding Domain of Adrenoleukodystrophy Gene Product in Peroxisomes
Contreras, M., Sengupta, T. K., Sheikh, F. G., Aubourg, P. R., & Singh, I. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0467 · Cited by 51 · see citing works
Role of Pex19p in the targeting of PMP70 to peroxisome
Kashiwayama, Y., Asahina, K., Shibata, H., Morita, M., Muntau, A. C., Roscher, A. A., Wanders, R. J. A., Shimozawa, N., Sakaguchi, M., Kato, H., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.10.006 · Cited by 50 · see citing works
Self-citation
Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy
Khan, M., Singh, J., Gilg, A. G., Uto, T., & Singh, I. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002329 · Cited by 49 · see citing works
The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage
Lu, J., Barron‐Casella, E. A., Brose, R. D., Heinzer, A. K., Moser, A. B., Bentley, K. L. D. M., Wand, G. S., McGuinness, M. C., Pei, Z., Watkins, P. A., et al. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700512 · Cited by 48 · see citing works
Conservation of targeting but divergence in function and quality control of peroxisomal ABC transporters: An analysis using cross-kingdom expression
Zhang, X., De Marcos Lousa, C., Schutte-Lensink, N., Ofman, R., Wanders, R. J., Baldwin, S. A., Baker, A., Kemp, S., & Theodoulou, F. L. (2011) · Biochemical Journal · doi:10.1042/bj20110249 · Cited by 43 · see citing works
Liver X Receptor α Interferes with SREBP1c-mediated Abcd2 Expression
Weinhofer, I., Kunze, M., Rampler, H., Bookout, A. L., Forss‐Petter, S., & Berger, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509450200 · Cited by 42 · see citing works
Glycosomal ABC transporters of Trypanosoma brucei: Characterisation of their expression, topology and substrate specificity
Igoillo‐Esteve, M., Mazet, M., Deumer, G., Wallemacq, P. E., & Michels, P. A. M. (2010) · International Journal for Parasitology · doi:10.1016/j.ijpara.2010.11.002 · Cited by 41 · see citing works
Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters
Roerig, P., Mayerhofer, P., Holzinger, A., & Gärtner, J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02235-9 · Cited by 40 · see citing works
ABC Subfamily D Proteins and Very Long Chain Fatty Acid Metabolism as Novel Targets in Adrenoleukodystrophy
Morita, M., Shimozawa, N., Kashiwayama, Y., Suzuki, Y., & Imanaka, T. (2011) · Current Drug Targets · doi:10.2174/138945011795378577 · Cited by 36 · see citing works
Self-citation
Identification of novel SNPs of ABCD1, ABCD2, ABCD3, and ABCD4 genes in patients with X-linked adrenoleukodystrophy (ALD) based on comprehensive resequencing and association studies with ALD phenotypes
Matsukawa, T., Asheuer, M., Takahashi, Y., Goto, J., Suzuki, Y., Shimozawa, N., Takano, H., Onodera, O., Nishizawa, M., Aubourg, P., et al. (2011) · neurogenetics · doi:10.1007/s10048-010-0253-6 · Cited by 36 · see citing works
X-linked adrenoleukodystrophy phenotype is independent of ABCD2 genotype
Maier, E. M., Mayerhofer, P. U., Asheuer, M., Köhler, W., Rothe, M., Muntau, A. C., Roscher, A. A., Holzinger, A., Aubourg, P., & Berger, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.092 · Cited by 34 · cited 1× · see citing works
“In addition to the VLCFA metabolic abnormality, modifier genes and/or environmental factors have been implicated in triggering inflammatory demyelination [81,82].”
Background
X‐linked adrenoleukodystrophy mice demonstrate abnormalities in cholesterol metabolism
Weinhofer, I., Forss‐Petter, S., Kunze, M., Žigman, M., & Berger, J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.014 · Cited by 32 · see citing works
Peroxisomal ABC transporters and β-oxidation during the life cycle of the filamentous fungus Podospora anserina
Boisnard, S., Espagne, E., Zickler, D., Bourdais, A., RIQUET, A., & Berteaux‐Lecellier, V. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.10.006 · Cited by 29 · see citing works
Targeting Elements in the Amino-Terminal Part Direct the Human 70-kDa Peroxisomal Integral Membrane Protein (PMP70) to Peroxisomes
Biermanns, M., & Gärtner, J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5220 · Cited by 28 · see citing works
Probing substrate-induced conformational alterations in adrenoleukodystrophy protein by proteolysis
Guimarães, C. P., Sá-Miranda, C., & Azevedo, J. E. (2005) · Journal of Human Genetics · doi:10.1007/s10038-004-0226-4 · Cited by 27 · see citing works
Distinct modulatory roles for thyroid hormone receptors TRα and TRβ in SREBP1-activated ABCD2 expression
Weinhofer, I., Kunze, M., Rampler, H., Forss‐Petter, S., Samarut, J., Plateroti, M., & Berger, J. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.08.002 · Cited by 26 · see citing works
MFE1, a Member of the Peroxisomal Hydroxyacyl Coenzyme A Dehydrogenase Family, Affects Fatty Acid Metabolism Necessary for Morphogenesis in Dictyostelium spp
Matsuoka, S., Saito, T., Kuwayama, H., Morita, N., Ochiai, H., & Maeda, M. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.3.638-645.2003 · Cited by 26 · see citing works
Hydrophobic Regions Adjacent to Transmembrane Domains 1 and 5 Are Important for the Targeting of the 70-kDa Peroxisomal Membrane Protein
Kashiwayama, Y., Asahina, K., Morita, M., & Imanaka, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703369200 · Cited by 24 · see citing works
Self-citation
Therapeutic effects of normal cells on ABCD1 deficient cells in vitro and hematopoietic cell transplantation in the X-ALD mouse model
Yamada, T., Ohyagi, Y., Shinnoh, N., Kikuchi, H., Osoegawa, M., Ochi, H., Kira, J., & Furuya, H. (2003) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2003.11.006 · Cited by 24 · see citing works
Nucleotide-induced conformational changes of PMP70, an ATP binding cassette transporter on rat liver peroxisomal membranes
Kashiwayama, Y., Morita, M., Kamijo, K., & Imanaka, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6588 · Cited by 24 · see citing works
Self-citation
Effects of Exogenous Hexacosanoic Acid on Biochemical Myelin Composition in Weaning and Post-Weaning Rats
Biase, A. D., Avellino, C., Pieroni, F., Quaresima, T., Grisolia, A., Cappa, M., & Salvati, S. (1997) · Neurochemical Research · doi:10.1023/a:1022451108063 · Cited by 12 · see citing works
Defect in peroxisomal multifunctional enzyme MFE1 affects cAMP relay in Dictyostelium
Matsuoka, S., Kuwayama, H., Ikeno, D., Oyama, M., & Maeda, M. (2004) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2004.00732.x · Cited by 4 · see citing works

Flagged first, then by citations

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The ABC gene family in arthropods: Comparative genomics and role in insecticide transport and resistance
Dermauw, W., & Leeuwen, T. V. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.11.001 · Cited by 638 · see citing works
Structural and Mechanistic Principles of ABC Transporters
Thomas, C., & Tampé, R. (2020) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-011520-105201 · Cited by 569 · see citing works
Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology
Sassa, T., & Kihara, A. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.017 · Cited by 302 · see citing works
Insect ATP-Binding Cassette (ABC) Transporters: Roles in Xenobiotic Detoxification and Bt Insecticidal Activity
Wu, C., Chakrabarty, S., Jin, M., Liu, K., & Xiao, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112829 · Cited by 219 · see citing works
Complexity of vitamin E metabolism
Schmölz, L. (2016) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v7.i1.14 · Cited by 218 · see citing works
Peroxisome‐mitochondria interplay and disease
Schrader, M., Costello, J. L., Godinho, L. F., & Islinger, M. (2015) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-015-9819-7 · Cited by 217 · see citing works
Structure and Mechanism of Human ABC Transporters
Alam, A., & Locher, K. P. (2023) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-111622-091232 · Cited by 200 · see citing works
The human ATP‐binding cassette (ABC) transporter superfamily
Dean, M. C., Moitra, K., & Allikmets, R. L. (2022) · Human Mutation · doi:10.1002/humu.24418 · Cited by 194 · see citing works
The role of ABC transporters in ovarian cancer progression and chemoresistance
Ween, M. P., Armstrong, M., Oehler, M. K., & Ricciardelli, C. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.05.012 · Cited by 182 · see citing works
Plant Hormone Transport and Localization: Signaling Molecules on the Move
Zhang, Y., Berman, A., & Shani, E. (2023) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-070722-015329 · Cited by 173 · see citing works
A Critical View on ABC Transporters and Their Interacting Partners in Auxin Transport
Geisler, M. M., Aryal, B., Donato, M. D., & Hao, P. (2017) · Plant and Cell Physiology · doi:10.1093/pcp/pcx104 · Cited by 159 · see citing works
A burst of ABC genes in the genome of the polyphagous spider mite Tetranychus urticae
Dermauw, W., Osborne, E. J., Clark, R. M., Grbić, M., Tirry, L., & Leeuwen, T. V. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-317 · Cited by 153 · see citing works
Diverse relations between ABC transporters and lipids: An overview
Neumann, J., Rose-Sperling, D., & Hellmich, U. A. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2016.09.023 · Cited by 150 · see citing works
Impaired Very Long-chain Acyl-CoA β-Oxidation in Human X-linked Adrenoleukodystrophy Fibroblasts Is a Direct Consequence of ABCD1 Transporter Dysfunction
Wiesinger, C., Kunze, M., Regelsberger, G., Forss-Petter, S., & Berger, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445445 · Cited by 145 · see citing works
Learning the ABCs one at a time: structure and mechanism of ABC transporters
Ford, R. C., & Beis, K. (2019) · Biochemical Society Transactions · doi:10.1042/bst20180147 · Cited by 145 · see citing works
ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
Wang, J., Wu, Z., Yang, Y., Teng, Q., Li, Y., Lei, Z., Jani, K., Kaushal, N., & Chen, Z. (2021) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.12434 · Cited by 150 · see citing works
The genetic landscape of X-linked adrenoleukodystrophy: inheritance, mutations, modifier genes, and diagnosis
Berger, J., Wiesinger, C., & Eichler, F. (2015) · The Application of Clinical Genetics · doi:10.2147/tacg.s49590 · Cited by 140 · see citing works
ABC transporters as cancer drivers: Potential functions in cancer development
Domenichini, A., Adamska, A., & Falasca, M. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.09.019 · Cited by 137 · see citing works
A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3
Ferdinandusse, S., Jimenez-Sanchez, G., Koster, J., Denis, S., Van Roermund, C. W., Silva-Zolezzi, I., Moser, A. B., Visser, W. F., Gulluoglu, M., Durmaz, O., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu448 · Cited by 134 · see citing works
Dacomitinib antagonizes multidrug resistance (MDR) in cancer cells by inhibiting the efflux activity of ABCB1 and ABCG2 transporters
Fan, Y.-F., Zhang, W., Zeng, L., Lei, Z.-N., Cai, C.-Y., Gupta, P., Yang, D.-H., Cui, Q., Qin, Z.-D., Chen, Z.-S., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.021 · Cited by 116 · see citing works
A role for the human peroxisomal half-transporter ABCD3 in the oxidation of dicarboxylic acids
van Roermund, C. W. T., IJlst, L., Wagemans, T., Wanders, R. J. A., & Waterham, H. R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.12.001 · Cited by 101 · see citing works
Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism
Dahabieh, M. S., Pietro, E. D., Jangal, M., Gonçalves, C., Witcher, M., Braverman, N., & Rincon, S. V. D. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.07.004 · Cited by 96 · see citing works
Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient
Violante, S. N., IJlst, L., Brinke, H. T., Koster, J., de Almeida, I. T., Wanders, R. J. A., Ventura, F. V., & Houten, S. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.06.007 · Cited by 95 · see citing works
An update on ABC transporters of filamentous fungi – from physiological substrates to xenobiotics
Víglaš, J., & Olejníková, P. (2021) · Microbiological Research · doi:10.1016/j.micres.2020.126684 · Cited by 91 · see citing works
Multiple ATP‐binding cassette transporters are involved in insecticide resistance in the small brown planthopper, Laodelphax striatellus
Sun, H., Pu, J., Chen, F., Wang, J., & Han, Z. (2017) · Insect Molecular Biology · doi:10.1111/imb.12299 · Cited by 91 · see citing works
ABC Transporter Genes Show Upregulated Expression in Drug-Resistant Clinical Isolates of Candida auris: A Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes
Wasi, M., Khandelwal, N. K., Moorhouse, A. J., Nair, R., Vishwakarma, P., Bravo Ruiz, G., Ross, Z. K., Lorenz, A., Rudramurthy, S. M., Chakrabarti, A., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01445 · Cited by 89 · see citing works
Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition
Gao, L., Rabbitt, E. H., Condon, J. C., Renthal, N. E., Johnston, J. M., Mitsche, M. A., Chambon, P., Xu, J., O’Malley, B. W., & Mendelson, C. R. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78544 · Cited by 88 · see citing works
Deficiency of a Retinal Dystrophy Protein, Acyl-CoA Binding Domain-containing 5 (ACBD5), Impairs Peroxisomal β-Oxidation of Very-long-chain Fatty Acids
Yagita, Y., Shinohara, K., Abe, Y., Nakagawa, K., Al-Owain, M., Alkuraya, F. S., & Fujiki, Y. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.760090 · Cited by 85 · see citing works
Unraveling fatty acid transport and activation mechanisms in Yarrowia lipolytica
Dulermo, R., Gamboa‐Meléndez, H., Ledesma‐Amaro, R., Thévenieau, F., & Nicaud, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.04.004 · Cited by 82 · see citing works
ABC Transporter Subfamily D: Distinct Differences in Behavior between ABCD1-3 and ABCD4 in Subcellular Localization, Function, and Human Disease
Kawaguchi, K., & Morita, M. (2016) · BioMed Research International · doi:10.1155/2016/6786245 · Cited by 81 · see citing works
Self-citation
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation
You, L., Chen, J., Liu, W., Xiang, Q., Luo, Z., Wang, W., Xu, W. Q., Wu, K., Qi, Z., Liu, Y., et al. (2020) · Virulence · doi:10.1080/21505594.2020.1766790 · Cited by 80 · see citing works
Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes
Mohanty, A., & McBride, H. M. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00268 · Cited by 76 · see citing works
Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease
Fanelli, F., Sepe, S., D’Amelio, M., Bernardi, C., Cristiano, L., Cimini, A., Cecconi, F., Cerù, M. P., & Moreno, S. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-8 · Cited by 76 · see citing works
Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid
Sassa, T., Wakashima, T., Ohno, Y., & Kihara, A. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m044586 · Cited by 70 · see citing works
Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism
Sychev, Z. E., Hu, A. K., DiMaio, T. A., Gitter, A., Camp, N. D., Noble, W. S., Wolf‐Yadlin, A., & Lagunoff, M. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006256 · Cited by 70 · see citing works
Genome-Wide Identification, Characterization and Phylogenetic Analysis of 50 Catfish ATP-Binding Cassette (ABC) Transporter Genes
Liu, S., Li, Q., & Liu, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063895 · Cited by 66 · see citing works
Peroxisomes and Kidney Injury
Vasko, R. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6666 · Cited by 66 · see citing works
Hepatic dysfunction in peroxisomal disorders
Baes, M. I., & Veldhoven, P. P. V. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.09.035 · Cited by 62 · see citing works
Peroxisomal Metabolite and Cofactor Transport in Humans
Chornyi, S., IJlst, L., van Roermund, C. W. T., Wanders, R. J. A., & Waterham, H. R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613892 · Cited by 61 · see citing works
Very-long-chain polyunsaturated fatty acids accumulate in phosphatidylcholine of fibroblasts from patients with Zellweger syndrome and acyl-CoA oxidase1 deficiency
Abe, Y., Honsho, M., Nakanishi, H., Taguchi, R., & Fujiki, Y. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.01.001 · Cited by 59 · see citing works
Transcriptome-Based Identification of ABC Transporters in the Western Tarnished Plant Bug Lygus hesperus
Hull, J. J., Chaney, K., Geib, S. M., Fabrick, J. A., Brent, C. S., Walsh, D. B., & Lavine, L. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113046 · Cited by 55 · see citing works
Transcriptional Response of ATP-Binding Cassette (ABC) Transporters to Insecticide in the Brown Planthopper, Nilaparvata lugens (Stål)
Zhao, L., Cai, T., Qin, Y., Zhang, Y., Jin, R., Mao, K., Liao, X., Wan, H., & Li, J. (2020) · Insects · doi:10.3390/insects11050280 · Cited by 55 · see citing works
Translocation of solutes and proteins across the glycosomal membrane of trypanosomes; possibilities and limitations for targeting with trypanocidal drugs
Gualdrón‐López, M., Brennand, A. E., Avilán, L., & Michels, P. A. M. (2012) · Parasitology · doi:10.1017/s0031182012001278 · Cited by 54 · see citing works
Association of ABC gene profiles with time to progression and resistance in ovarian cancer revealed by bioinformatics analyses
Šeborová, K., Václavíková, R., Souček, P., Elsnerová, K., Bartáková, A., Černaj, P., Bouda, J., Rob, L., Hruda, M., & Dvořák, P. (2019) · Cancer Medicine · doi:10.1002/cam4.1964 · Cited by 52 · see citing works
Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1
Kawaguchi, K., Okamoto, T., Morita, M., & Imanaka, T. (2016) · Scientific Reports · doi:10.1038/srep30183 · Cited by 51 · see citing works
Self-citation
Plant peroxisomal solute transporter proteins
Charton, L., Plett, A., & Linka, N. (2019) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12790 · Cited by 52 · see citing works
Lipid and fatty acid metabolism in trypanosomatids
de Aquino, G. P., Gomes, M. A. M., Salinas, R. K., & Laranjeira‐Silva, M. F. (2021) · Microbial Cell · doi:10.15698/mic2021.11.764 · Cited by 50 · see citing works
Glycosomal Targets for Anti-Trypanosomatid Drug Discovery
Barros-Álvarez, X., Gualdrón‐López, M., Acosta, H., Cáceres, A. J., Graminha, M. A. S., Michels, P. A. M., Concepción, J. L., & Quiñones, W. A. (2014) · Current Medicinal Chemistry · doi:10.2174/09298673113209990139 · Cited by 50 · see citing works
Tissue-Specific Transcript Profiling for ABC Transporters in the Sequestering Larvae of the Phytophagous Leaf Beetle Chrysomela populi
Strauß, A., Wang, D., Stock, M., Gretscher, R. R., Groth, M., Boland, W., & Burse, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098637 · Cited by 49 · see citing works
Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage
Sánchez‐Alegría, K., & Arias, C. (2022) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.386 · Cited by 48 · see citing works
Overcoming Taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin
Lin, H., Hu, B., He, X., Mao, J., Wang, Y., Wang, J., Zhang, T., Zheng, J., Peng, Y., & Zhang, F. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113733 · Cited by 47 · see citing works
A Unique Junctional Interface at Contact Sites Between the Endoplasmic Reticulum and Lipid Droplets
Choudhary, V., & Schneiter, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.650186 · Cited by 46 · see citing works
Peroxisomal Disorders: A Review on Cerebellar Pathologies
Munter, S. D., Verheijden, S., Régal, L., & Baes, M. I. (2015) · Brain Pathology · doi:10.1111/bpa.12290 · Cited by 44 · see citing works
The role of ATP‐binding cassette transporter genes in the progression of prostate cancer
Karataş, Ö. F., Güzel, E., Düz, M. B., Ittmann, M., & Özen, M. (2015) · The Prostate · doi:10.1002/pros.23137 · Cited by 44 · see citing works
Genome-wide identification of whole ATP-binding cassette (ABC) transporters in the intertidal copepod Tigriopus japonicus
Jeong, C., Kim, B., Lee, J., & Rhee, J. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-651 · Cited by 42 · see citing works
Genome-wide methylation is modified by caloric restriction in Daphnia magna
Hearn, J., Pearson, M., Blaxter, M., Wilson, P., & Little, T. J. (2019) · BMC Genomics · doi:10.1186/s12864-019-5578-4 · Cited by 42 · see citing works
Oxidative Stress during the Progression ofβ-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease
Porcellotti, S., Fanelli, F., Fracassi, A., Sepe, S., Cecconi, F., Bernardi, C., Cimini, A., Cerù, M. P., & Moreno, S. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/967203 · Cited by 41 · see citing works
Genome-wide identification of ATP-binding cassette ( ABC ) transporters and conservation of their xenobiotic transporter function in the monogonont rotifer ( Brachionus koreanus )
Jeong, C., Kim, H.-S., Kang, H.-M., Lee, Y. H., Zhou, B., Choe, J., & Lee, J. (2016) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2016.10.003 · Cited by 40 · see citing works
Genome-wide identification, phylogenetic analysis, and expression profiles of ATP-binding cassette transporter genes in the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)
Xiao, L., Zhang, W., Jing, T., Zhang, M., Miao, Z., Wei, D., Yuan, G., & Wang, J. (2017) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2017.10.001 · Cited by 38 · see citing works
Expression profile of the entire detoxification gene inventory of the western honeybee, Apis mellifera across life stages
Maiwald, F., Haas, J., Hertlein, G., Lueke, B., Roesner, J., & Nauen, R. (2023) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2023.105410 · Cited by 37 · see citing works
Toxin- and species-dependent regulation of ATP-binding cassette (ABC) transporters in scallops after exposure to paralytic shellfish toxin-producing dinoflagellates
Wang, H., Liu, S., Xun, X., Li, M., Lou, J., Zhang, Y., Shi, J., Hu, J., Bao, Z., & Hu, X. (2020) · Aquatic Toxicology · doi:10.1016/j.aquatox.2020.105697 · Cited by 37 · see citing works
The lysosomal protein ABCD4 can transport vitamin B12 across liposomal membranes in vitro
Kitai, K., Kawaguchi, K., Tomohiro, T., Morita, M., So, T., & Imanaka, T. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100654 · Cited by 33 · see citing works
Self-citation
d-Psicose, a sugar substitute, suppresses body fat deposition by altering networks of inflammatory response and lipid metabolism in C57BL/6J-ob/ob mice
Kim, S., Kim, S. J., Kim, H. J., & Sung, M. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.11.029 · Cited by 33 · see citing works
ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis
Kumari, S., Kumar, M., Khandelwal, N., Kumari, P., Varma, M., Vishwakarma, P., Shahi, G., Sharma, S., Lynn, A. M., Prasad, R., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202993 · Cited by 31 · see citing works
Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes
Okamoto, T., Kawaguchi, K., Watanabe, S., Agustina, R., Ikejima, T., Ikeda, K., Nakano, M., Morita, M., & Imanaka, T. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.153 · Cited by 31 · see citing works
Self-citation
Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey
Ren, J., Chung‐Davidson, Y., Yeh, C., Scott, C., Brown, T., & Li, W. (2015) · BMC Genomics · doi:10.1186/s12864-015-1677-z · Cited by 31 · see citing works
Peroxisomes and PPARs: Emerging role as master regulators of cancer metabolism
Pratama, A. M., Sharma, M., Naidu, S., Bömmel, H. M., Prabhuswamimath, S. C., Madhusudhan, T., Wihadmadyatami, H., Bachhuka, A., & Karnati, S. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102044 · Cited by 31 · see citing works
Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA‐540 expression
Kumar, S., Rani, R., Karns, R. A., & Gandhi, C. R. (2018) · The FASEB Journal · doi:10.1096/fj.201802015r · Cited by 29 · see citing works
Genome-Wide Detection of Key Genes and Epigenetic Markers for Chicken Fatty Liver
Tan, X., Liu, R., Xing, S., Zhang, Y., Li, Q., Zheng, M., Zhao, G., & Wen, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051800 · Cited by 29 · see citing works
Identification and functional analysis of ABC transporter genes related to deltamethrin resistance in Culex pipiens pallens
Xu, J., Zheng, J., Zhang, R., Wang, H., Du, J., Li, J., Zhou, D., Sun, Y., & Shen, B. (2023) · Pest Management Science · doi:10.1002/ps.7539 · Cited by 28 · see citing works
Management of adrenoleukodystrophy: From pre-clinical studies to the development of new therapies
Ma, C. Y., Li, C., Zhou, X., Zhang, Z., Jiang, H., Liu, H., Chen, H. J., Tse, H., Liao, C., & Lian, Q. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112214 · Cited by 28 · see citing works
Pathogenicity Factors of Botryosphaeriaceae Associated with Grapevine Trunk Diseases: New Developments on Their Action on Grapevine Defense Responses
Belair, M., Grau, A. L., Chong, J., Tian, X., Luo, J., Guan, X., & Pensec, F. (2022) · Pathogens · doi:10.3390/pathogens11080951 · Cited by 30 · see citing works
The multi-xenobiotic resistance (MXR) efflux activity in hemocytes of Mytilus edulis is mediated by an ATP binding cassette transporter of class C (ABCC) principally inducible in eosinophilic granulocytes
Rioult, D., Pasquier, J., Boulangé-Lecomte, C., Poret, A., Abbas, I., Marin, M., Minier, C., & Foll, F. L. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.11.012 · Cited by 26 · see citing works
Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment
Le, L. T. M., Thompson, J. R., Dang, P. X., Bhandari, J., & Alam, A. (2022) · Communications Biology · doi:10.1038/s42003-021-02970-w · Cited by 27 · see citing works
Phylogenetic analysis of the ATP-binding cassette transporter family in three mosquito species
Lu, H., Xu, Y., & Cui, F. (2015) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2015.11.006 · Cited by 26 · see citing works
Metformin‐induced mitochondrial function and ABCD 2 up‐regulation in X‐linked adrenoleukodystrophy involves AMP ‐activated protein kinase
Singh, J., Olle, B., Suhail, H., Felicella, M. M., & Giri, S. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13562 · Cited by 24 · see citing works
Tethering Fat: Tethers in Lipid Droplet Contact Sites
Bohnert, M. (2020) · Contact · doi:10.1177/2515256420908142 · Cited by 22 · see citing works
Acyl-CoA thioesterase activity of peroxisomal ABC protein ABCD1 is required for the transport of very long-chain acyl-CoA into peroxisomes
Kawaguchi, K., Mukai, E., Watanabe, S., Yamashita, A., Morita, M., So, T., & Imanaka, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-81949-3 · Cited by 22 · see citing works
Self-citation
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Theodoulou, F. L., Carrier, D. J., Schaedler, T. A., Baldwin, S. A., & Baker, A. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160040 · Cited by 22 · see citing works
Intrinsically disordered regions regulate the activities of ATP binding cassette transporters
Bickers, S. C., Sayewich, J. S., & Kanelis, V. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183202 · Cited by 21 · see citing works
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Imanaka, T. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00723 · Cited by 21 · see citing works
Self-citation
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Cholico, G. N., Fling, R. R., Zacharewski, N. A., Fader, K. A., Nault, R., & Zacharewski, T. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-95214-0 · Cited by 20 · see citing works
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Chen, C. T., Shao, Z., & Fu, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.982564 · Cited by 19 · see citing works
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Stradomska, T. J., Bachański, M., Pawłowska, J., Syczewska, M., Stolarczyk, A., & Tylki‐Szymańska, A. (2013) · Lipids · doi:10.1007/s11745-013-3761-y · Cited by 20 · see citing works
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Jeong, C., Kim, D., Kang, H.-M., Lee, Y. H., Kim, H.-S., Kim, I., & Lee, J. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.12.022 · Cited by 20 · see citing works
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Vamecq, J., Papegay, B., Nuyens, V., Boogaerts, J. G., Léo, O., & Kruys, V. (2019) · Biochimie · doi:10.1016/j.biochi.2019.10.004 · Cited by 20 · see citing works
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Khare, S., Drake, K. L., Lawhon, S. D., Nunes, J. E. S., Figueiredo, J. F., Rossetti, C., Gull, T. B., Everts, R. E., Lewin, H. A., & Adams, L. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161946 · Cited by 18 · see citing works
Suppression of ABCD2 dysregulates lipid metabolism via dysregulation of miR‐141:ACSL4 in human osteoarthritis
Park, S., Oh, J., Kim, Y., Choe, S., Chun, C. H., & Jin, E. (2018) · Cell Biochemistry and Function · doi:10.1002/cbf.3356 · Cited by 18 · see citing works
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Peng, Y., Zhao, J., Sun, Y., Wan, P., Hu, Y., Luo, G., Qin, W., & Huang, S. (2021) · Journal of Asia-Pacific Entomology · doi:10.1016/j.aspen.2021.02.006 · Cited by 18 · see citing works
Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose
Carrier, D. J., van Roermund, C. W. T., Schaedler, T. A., Rong, H. L., IJlst, L., Wanders, R. J. A., Baldwin, S. A., Waterham, H. R., Theodoulou, F. L., & Baker, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-46685-9 · Cited by 18 · see citing works
Enzymatic oxidation of polyethylene by Galleria mellonella intestinal cytochrome P450s
Son, J., Lee, S., Hwang, S., Jeong, J., Jang, S., Gong, J., Choi, J. Y., Je, Y. H., & Ryu, C. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136264 · Cited by 17 · see citing works
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Alrubia, S., Al‐Majdoub, Z. M., Achour, B., Rostami‐Hodjegan, A., & Barber, J. (2022) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2022.07.012 · Cited by 17 · see citing works
ABCD1 Gene Mutations: Mechanisms and Management of Adrenomyeloneuropathy
Volmrich, A. M., Cuénant, L. M., Forghani, I., Hsieh, S. L., & Shapiro, L. T. (2022) · The Application of Clinical Genetics · doi:10.2147/tacg.s359479 · Cited by 17 · see citing works
Genome-wide analyses of ATP-Binding Cassette (ABC) transporter gene family and its expression profile related to deltamethrin tolerance in non-biting midge Propsilocerus akamusi
Liu, W., Sun, X., Sun, W., Zhou, A., Li, R., Wang, B., Li, X., & Yan, C. (2021) · Aquatic Toxicology · doi:10.1016/j.aquatox.2021.105940 · Cited by 17 · see citing works
Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization
Mukhopadhya, I., Murray, G. I., Berry, S., Thomson, J., Frank, B., Gwozdz, G., Makinde, J., Shattock, R. J., Kelly, C. G., Iannelli, F., et al. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv335 · Cited by 17 · see citing works
Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B (LC3B)
Daniele, L. L., Caughey, J., Volland, S., Sharp, R. C., Dhingra, A., Williams, D. S., Philp, N. J., & Boesze-Battaglia, K. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00185.2019 · Cited by 16 · see citing works
PPAR-γImpairment Alters Peroxisome Functionality in Primary Astrocyte Cell Cultures
Mannelli, L. D. C., Zanardelli, M., Micheli, L., & Ghelardini, C. (2014) · BioMed Research International · doi:10.1155/2014/546453 · Cited by 16 · see citing works
Zebrafish (Danio rerio) ecotoxicological ABCB4, ABCC1 and ABCG2a gene promoters depict spatiotemporal xenobiotic multidrug resistance properties against environmental pollutants
Lim, L. W. K., Chung, H. H., Ishak, S. D., & Waiho, K. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101110 · Cited by 16 · see citing works
Genome-wide identification of ABC transporters in monogeneans
Caña‐Bozada, V. H., Morales-Serna, F. N., Garcı́a-Gasca, A., Llera‐Herrera, R., & Fajer-Avila, E. J. (2019) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2019.111234 · Cited by 15 · see citing works
A Novel Double Mutation in the ABCD1 Gene in a Patient with X-linked Adrenoleukodystrophy: Analysis of the Stability and Function of the Mutant ABCD1 Protein
Morita, M., Kobayashi, J., Yamazaki, K., Kawaguchi, K., Honda, A., Sugai, K., Shimozawa, N., Koide, R., & Imanaka, T. (2012) · JIMD Reports · doi:10.1007/8904_2012_209 · Cited by 15 · see citing works
Self-citation

Peroxisomal ABC Transporters: An Update
Tawbeh, A., Gondcaille, C., Trompier, D., & Savary, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116093 · Cited by 68 · see citing works
Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance
Kemp, S., Theodoulou, F. L., & Wanders, R. J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01435.x · Cited by 115 · see citing works
The peroxisomal ABC transporter family
Wanders, R. J. A., Visser, W. F., van Roermund, C. W. T., Kemp, S., & Waterham, H. R. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0142-x · Cited by 111 · see citing works
Peroxisomal ABC Proteins and Fatty Acid Metabolism.
Kashiwayama, Y., & Imanaka, T. (2003) · MEMBRANE · doi:10.5360/membrane.28.263
Self-citation
ABC Transporter Subfamily D: Distinct Differences in Behavior between ABCD1-3 and ABCD4 in Subcellular Localization, Function, and Human Disease
Kawaguchi, K., & Morita, M. (2016) · BioMed Research International · doi:10.1155/2016/6786245 · Cited by 81 · see citing works
Self-citation

Authors: Morita, M., & Imanaka, T.
Affiliations: University of Toyama (JP)
Corresponding author: Imanaka, Tsuneo
ORCID: Morita, Masashi
Imanaka, Tsuneo
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2012-09
Volume: 1822
Issue: 9
Pages: 1387-1396
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2012.02.009
OpenAlex: W1987601583
Cited by: 183
References: 115
Citations by year: 2026: 6 · 2025: 11 · 2024: 10 · 2023: 10 · 2022: 15 · 2021: 22 · 2020: 11 · 2019: 15 · 2018: 10 · 2017: 9 · 2016: 14 · 2015: 17 · 2014: 17 · 2013: 13 · 2012: 2
FWCI: 1.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology (20590054, 22590060, 23590072)
Ministry of Health, Labour and Welfare
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: peroxisomal ABC transporters, ABCD1, ABCD2, ABCD3, X-linked adrenoleukodystrophy, peroxisomal beta-oxidation, membrane protein targeting, neurodegenerative diseases
MeSH terms: Acyl Coenzyme A, Adrenoleukodystrophy, Animals, Biological Transport, Active, Humans, Neurons, Phylogeny, Protein Conformation, ATP-Binding Cassette Transporters, Peroxisomes, Protein Transport, Lipid Metabolism

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Peroxisomal ABC transporters: Structure, function and role in disease

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