The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs
Open accessAbstract
A wide array of molecular pathways has been investigated during the past decade in order to understand the mechanisms by which the practice of physical exercise promotes neuroprotection and reduces the risk of developing communicable and non-communicable chronic diseases. While a single session of physical exercise may represent a challenge for cell homeostasis, repeated physical exercise sessions will improve immunosurveillance and immunocompetence. Additionally, immune cells from the central nervous system will acquire an anti-inflammatory phenotype, protecting central functions from age-induced cognitive decline. This review highlights the exercise-induced anti-inflammatory effect on the prevention or treatment of common chronic clinical and experimental settings. It also suggests the use of pterins in biological fluids as sensitive biomarkers to follow the anti-inflammatory effect of physical exercise.
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Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I.-M., Nieman, D. C., & Swain, D. P. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318213fefb · Cited by 9,319
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781
Daneman, R., & Prat, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020412 · Cited by 3,437
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100 · cited 2×
“In general repeated moderate intensity exercise enhances the immune function response, reinforces the antioxidative capacity, reduces oxidative stress, and increases the efficiency of energy generation, therefore reducing the incidence of inflammatory diseases [6, 7] .”
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Exercise and Hippocampal Memory Systems
Voss, M. W., Soto, C., Yoo, S., Sodoma, M., Vivar, C., & van Praag, H. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.01.006 · Cited by 235
Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors
Alizadeh Pahlavani, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.811751 · Cited by 145
Role of senescence in the chronic health consequences of COVID-19
Wissler Gerdes, E. O., Vanichkachorn, G., Verdoorn, B. P., Hanson, G. J., Joshi, A. Y., Murad, M. H., Rizza, S. A., Hurt, R. T., Tchkonia, T., & Kirkland, J. L. (2022) · Translational Research · doi:10.1016/j.trsl.2021.10.003 · Cited by 38
Norlin, A.-K., Walter, S., Icenhour, A., Keita, Å. V., Elsenbruch, S., Bednarska, O., Jones, M. P., Simon, R., & Engström, M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.035 · Cited by 39
Cao, W., Lin, J., Xiang, W., Liu, J., Wang, B., Liao, W., & Jiang, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.866336 · Cited by 29
Chung, J., Mukerji, S., & Kozlowska, K. (2023) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674221082520 · Cited by 27
Zhang, T., & Kong, J. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1567603 · Cited by 19
Molecular Regulators of Exercise-mediated Insulin Sensitivity in Non-obese Individuals
Almuraikhy, S., Doudin, A., Domling, A., Althani, A. A. J. F., & Elrayess, M. A. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18015 · Cited by 16
Long-Term Sports Practice and Atrial Fibrillation: An Updated Review of a Complex Relationship
Petrungaro, M., Fusco, L., Cavarretta, E., Scarà, A., Borrelli, A., Romano, S., Petroni, R., D’Ascenzi, F., & Sciarra, L. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10050218 · Cited by 15
Yin, Y., Lv, G., Zhang, W., Yuan, J., Yang, Y., Wang, Y., Liu, S., Wang, S., Yan, B., Bo, H., et al. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114326 · Cited by 9
Metadata
- Authors
- Scheffer, D. D. L., & Latini, A.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 1866
- Issue
- 10
- Pages
- 165823
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W3018951806
- Cited by
- 489
- References
- 47
- FWCI
- 23.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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