Central administration of murine interferon-α induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: A mini-review and original experiments

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

A Meta-Analysis of Cytokines in Major Depression

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works

Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.

Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works

Paroxetine for the prevention of depression induced by high-dose interferon alfa.

Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., & Miller, A. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441303 · Cited by 1,120 · see citing works

Evidence for an immune response in major depression: A review and hypothesis

Maes, M. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)00101-m · Cited by 1,003 · see citing works

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000 · see citing works

Regulation of innate immune responses in the brain

Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843 · see citing works

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805 · see citing works

Neurobehavioral Effects of Interferon-α in Cancer Patients Phenomenology and Paroxetine Responsiveness of Symptom Dimensions

Capuron, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00407-9 · Cited by 797 · see citing works

Inflammation and glial responses in ischemic brain lesions

Stoll, G. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00034-3 · Cited by 794 · see citing works

Inflammation-associated depression: From serotonin to kynurenine

Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.012 · Cited by 726 · see citing works

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

Maes, M., Leonard, B. E., Myint, A. M., Kubera, M., & Verkerk, R. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.017 · Cited by 700 · see citing works

Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists

Artigas, F., Romero, L. I., de Montigny, C., & Blier, P. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10037-0 · Cited by 655 · see citing works

Cytokines and psychopathology: Lessons from interferon-α

Capuron, L., & Miller, A. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.009 · Cited by 562 · see citing works

Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin

O’Connor, J. C., André, C., Wang, Y., Lawson, M. A., Szegedi, S. S., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5032-08.2009 · Cited by 498 · see citing works

Interferon-alpha–induced changes in tryptophan metabolism

Capuron, L., Neurauter, G., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Fuchs, D., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00173-2 · Cited by 493 · see citing works

Neuropsychiatric Adverse Effects of Interferon-??: Recognition and Management

Raison, C. L., Demetrashvili, M., Capuron, L., & Miller, A. H. (2005) · CNS Drugs · doi:10.2165/00023210-200519020-00002 · Cited by 483 · see citing works

Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy

Capuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000995 · Cited by 473 · see citing works

Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

Nguyen, K. T., Deak, T., Owens, S. M., Kohno, T., Fleshner, M., Watkins, L. R., & Maier, S. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02239.1998 · Cited by 460 · see citing works

Autoradiographic Demonstration of Increased Serotonin 5-HT2 and β-Adrenergic Receptor Binding Sites in the Brain of Suicide Victims

Arango, V. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810230054009 · Cited by 420 · see citing works

Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression

Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367 · see citing works

Black sheep get the blues: a psychobiological model of social rejection and depression

Slavich, G. M., O’Donovan, A., Epel, E. S., & Kemeny, M. E. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.003 · Cited by 362 · see citing works

Interleukin-1β in Immune Cells of the Abdominal Vagus Nerve: a Link between the Immune and Nervous Systems?

Goehler, L. E., Gaykema, R. P. A., Nguyen, K. T., Lee, J. E., Tilders, F. J. H., Maier, S. F., & Watkins, L. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02799.1999 · Cited by 357 · see citing works

Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: Comorbidity between depression and neurodegenerative disorders

Anisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 334 · see citing works

Serotonin receptors: from protein to physiological function and behavior

Sari, Y. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.008 · Cited by 332 · see citing works

5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala

Hrdina, P. D., Demeter, E., Vu, T. B., Sótonyi, P., & Palkovits, M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91015-k · Cited by 327 · see citing works

The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity

Hayley, S., Poulter, M. O., Merali, Z., & Anisman, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.051 · Cited by 324 · see citing works

An fMRI study of cytokine-induced depressed mood and social pain: The role of sex differences

Eisenberger, N. I., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.040 · Cited by 313 · see citing works

The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines

Spalletta, G., Bossù, P., Ciaramella, A., Bria, P., Caltagirone, C., & Robinson, R. G. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001879 · Cited by 293 · see citing works

Higher Expression of Serotonin 5-HT2A Receptors in the Postmortem Brains of Teenage Suicide Victims

Pandey, G. N., Dwivedi, Y., Rizavi, H. S., Ren, X., Pandey, S. C., Pesold, C., Roberts, R. C., Conley, R. R., & Tamminga, C. A. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.3.419 · Cited by 281 · see citing works

Dysfunctional Attitudes and 5-HT₂ Receptors During Depression and Self-Harm

Meyer, J. H., McMain, S., Kennedy, S. H., Korman, L., Brown, G. M., DaSilva, J. N., Wilson, A. A., Blak, T., Eynan-Harvey, R., Goulding, V. S., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.90 · Cited by 264 · see citing works

Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface

Miller, A. H. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.08.006 · Cited by 261 · see citing works

5-HT and the immune system

Ahern, G. P. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.02.004 · Cited by 239 · see citing works

Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice.

Bluthé, R., Michaud, B., Poli, V., & Dantzer, R. (2000) · Physiology and Behavior · doi:10.1016/s0031-9384(00)00269-9 · Cited by 239 · see citing works

Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy

Capuron, L., Ravaud, A., Miller, A. H., & Dantzer, R. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.11.004 · Cited by 237 · see citing works

Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms

Bonaccorso, S., Puzella, A., Marino, V., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., Levrero, M., Egyed, B., Bosmans, E., et al. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00315-8 · Cited by 235 · see citing works

Kynurenines: from the perspective of major psychiatric disorders

Myint, A.-M. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08551.x · Cited by 229 · see citing works

Permeability of the blood–brain and blood–spinal cord barriers to interferons

Pan, W., Banks, W. A., & Kastin, A. J. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00034-9 · Cited by 227 · see citing works

The phenomenology and treatment of interferon-induced depression

Loftis, J. M., & Hauser, P. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.04.002 · Cited by 227 · see citing works

Effects of Antidepressant Drugs on the Behavioral and Physiological Responses to Lipopolysaccharide (LPS) in Rodents

Yirmiya, R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00226-8 · Cited by 224 · see citing works

IL-6 levels decrease with SSRI treatment in patients with major depression

Başterzi, A. D., Aydemir, Ç., Kısa, C., Aksaray, S., Tüzer, V., Yazıcı, K., & Göka, E. (2005) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.717 · Cited by 219 · see citing works

Increased 5-HT 2A Receptor Binding in Euthymic, Medication-Free Patients Recovered From Depression: A Positron Emission Study With [ 11 C]MDL 100,907

Bhagwagar, Z., Hinz, R., Taylor, M. J., Fancy, S., Cowen, P. J., & Grasby, P. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1580 · Cited by 214 · see citing works

Synergistic Effects of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α: Central Monoamine, Corticosterone, and Behavioral Variations

Brebner, K., Hayley, S., Zacharko, R., Merali, Z., & Anisman, H. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00166-9 · Cited by 214 · see citing works

Randomized controlled trial of the cognitive side-effects of magnetic seizure therapy (MST) and electroconvulsive shock (ECS)

Moscrip, T. D., Terrace, H. S., Sackeïm, H. A., & Lisanby, S. H. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570500578x · Cited by 192 · see citing works

Neuron-Specific Effects of Interleukin-1β Are Mediated by a Novel Isoform of the IL-1 Receptor Accessory Protein

Huang, Y., Smith, D. E., Ibáñez-Sandoval, O., Sims, J. E., & Friedman, W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4067-11.2011 · Cited by 164 · see citing works

Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?

Capuron, L., Fornwalt, F. B., Knight, B. T., Harvey, P. D., Ninan, P. T., & Miller, A. H. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.017 · Cited by 164 · see citing works

The effect of traumatic brain injury upon the concentration and expression of interleukin-1beta and interleukin-10 in the rat.

Kamm, K., Vanderkolk, W., Lawrence, C., Jonker, M., & Davis, A. (2004) · Journal of Trauma · doi:10.1097/01.ta.0000196345.81169.a1 · Cited by 153 · see citing works

Suppression of Cell Proliferation by Interferon-Alpha through Interleukin-1 Production in Adult Rat Dentate Gyrus

Kaneko, N., Kudo, K., Mabuchi, T., Takemoto, K., Fujimaki, K., Wati, H., Iguchi, H., Tezuka, H., & Kanba, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301137 · Cited by 152 · see citing works

Repeated interferon-α administration inhibits dopaminergic neural activity in the mouse brain

Shuto, H., Kataoka, Y., Horikawa, T., Fujihara, N., & Oishi, R. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01371-6 · Cited by 151 · see citing works

Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior

Parnet, P. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00022-x · Cited by 150 · see citing works

Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A

Shelton, R. C., Sanders‐Bush, E., Manier, D. H., & Lewis, D. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.036 · Cited by 144 · see citing works

Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects

Anisman, H., Du, L., Palkovits, M., Faludi, G., Kovács, G. G., Szontagh-Kisházi, P., Merali, Z., & Poulter, M. O. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0815 · Cited by 143 · see citing works

Endogenous opioid peptides and the control of pain

Kosterlitz, H. (1979) · Psychological Medicine · doi:10.1017/s0033291700021498 · Cited by 142 · see citing works

The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro

Curran, B. P., & O'Connor, J. J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00405-5 · Cited by 138 · see citing works

Production of interferon-γ by microglia

Kawanokuchi, J., Mizuno, T., Takeuchi, H., Kato, H., Wang, J.-J., Mitsuma, N., & Suzumura, A. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070763 · Cited by 133 · see citing works

Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

Fu, X., Zunich, S. M., O’Connor, J. C., Kavelaars, A., Dantzer, R., & Kelley, K. W. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-43 · Cited by 130 · see citing works

Interferon-α-induced depressive symptoms are related to changes in the cytokine network but not to cortisol

Wichers, M., Kenis, G., Koek, G. H., Robaeys, G., Nicolson, N. A., & Maes, M. H. J. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.09.007 · Cited by 116 · see citing works

Chronic interferon-alpha administration disrupts sleep continuity and depth in patients with hepatitis C: association with fatigue, motor slowing, and increased evening cortisol

Raison, C. L., Rye, D. B., Woolwine, B. J., Vogt, G. J., Bautista, B. M., Spivey, J. R., & Miller, A. H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.019 · Cited by 116 · see citing works

Neuropsychiatric disorders related to interferon and interleukins treatment

Myint, A. M., Schwarz, M. J., Steinbusch, H. W. M., & Leonard, B. E. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9114-5 · Cited by 116 · see citing works

Interferon-α Stimulates the Hypothalamic- Pituitary-Adrenal Axis in vivo and in vitro

Gisslinger, H., Svoboda, T., Clodi, M., Gilly, B., Ludwig, H., Havelec, L., & Luger, A. (2008) · Neuroendocrinology · doi:10.1159/000126396 · Cited by 111 · see citing works

Activation of brain macrophages/microglia cells in hepatitis C infection

Wilkinson, J., Radkowski, M., Eschbacher, J. M., & Laskus, T. (2010) · Gut · doi:10.1136/gut.2009.199356 · Cited by 107 · see citing works

Effect of single intracerebroventricular injection of α-interferon on monoamine concentrations in the rat brain

Kamata, M. (2000) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)00067-x · Cited by 105 · see citing works

Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy

Albert, P. R. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00035 · Cited by 105 · see citing works

Serotonin-1A Receptor Gene HTR1A Variation Predicts Interferon-Induced Depression in Chronic Hepatitis C

Kraus, M. R., Al‐Taie, O., Schäfer, A., Pfersdorff, M., Lesch, K., & Scheurlen, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.053 · Cited by 104 · see citing works

Neuron density and serotonin receptor binding in prefrontal cortex in suicide

Underwood, M. D., Kassir, S. A., Bakalian, M. J., Galfalvy, H., Mann, J. J., & Arango, V. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000691 · Cited by 100 · see citing works

Prophylactic SSRI during interferon alpha re‐therapy in patients with chronic hepatitis C and a history of interferon‐induced depression

Kraus, M. R., Schäfer, A., Al‐Taie, O., & Scheurlen, M. (2005) · Journal of Viral Hepatitis · doi:10.1111/j.1365-2893.2005.00554.x · Cited by 96 · see citing works

Inflammation and Depression: Why Poststroke Depression may be the Norm and Not the Exception

Pascoe, M. C., Crewther, S. G., Carey, L. M., & Crewther, D. P. (2011) · International Journal of Stroke · doi:10.1111/j.1747-4949.2010.00565.x · Cited by 94 · see citing works

Effects of stressors and immune activating agents on peripheral and central cytokines in mouse strains that differ in stressor responsivity

Gibb, J., Hayley, S. P., Poulter, M. O., & Anisman, H. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.008 · Cited by 94 · see citing works

Interferon-α-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression

Cai, W., Khaoustov, V. I., Xie, Q., Pan, T., Le, W., & Yoffe, B. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.01.024 · Cited by 93 · see citing works

Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue

Hulse, R. E., Kunkler, P. E., Fedynyshyn, J., & Kraig, R. P. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.12.023 · Cited by 93 · see citing works

Role of IL-1 in Poststroke Depressive-like Behavior in Mice

Craft, T. K. S., & DeVries, A. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.011 · Cited by 87 · see citing works

Baseline Immune Activation as a Risk Factor for the Onset of Depression During Interferon-Alpha Treatment

Wichers, M., Kenis, G., Leue, C., Koek, G. H., Robaeys, G., & Maes, M. H. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.024 · Cited by 83 · see citing works

Involvement of β-chemokines in the development of inflammatory demyelination

Banisor, I., Leist, T. P., & Kálmán, B. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-7 · Cited by 83 · see citing works

Injury-Induced Type I IFN Signaling Regulates Inflammatory Responses in the Central Nervous System

Khorooshi, R., & Owens, T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901753 · Cited by 79 · see citing works

Enhanced expression of brain interferon‐α and serotonin transporter in immunologically induced fatigue in rats

Katafuchi, T., Kondo, T., Take, S., & Yoshimura, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04478.x · Cited by 77 · see citing works

The non-steroidal anti-inflammatory drug diclofenac sodium attenuates IFN-α induced alterations to monoamine turnover in prefrontal cortex and hippocampus

Garza, R. D. L., & Asnis, G. M. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02757-4 · Cited by 63 · see citing works

Antidepressant reversal of interferon-α-induced anhedonia

Sammut, S., Bethus, I., Goodall, G., & Muscat, R. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00677-7 · Cited by 61 · see citing works

Interferon-γ deficiency modifies the motor and co-morbid behavioral pathology and neurochemical changes provoked by the pesticide paraquat

Litteljohn, D., Mangano, E. N., Shukla, N., & Hayley, S. P. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.025 · Cited by 60 · see citing works

Depressive symptoms following interferon-α therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor?

Kenis, G., Prickaerts, J., van Os, J., Koek, G. H., Robaeys, G., Steinbusch, H. W. M., & Wichers, M. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000830 · Cited by 58 · see citing works

Longitudinal course of depression, fatigue, and quality of life in patients with high risk melanoma receiving adjuvant interferon

Trask, P. C., Paterson, A. G., Esper, P., Pau, J., & Redman, B. G. (2003) · Psycho-Oncology · doi:10.1002/pon.770 · Cited by 58 · see citing works

Interferon-α effects are exaggerated when administered on a psychosocial stressor backdrop: Cytokine, corticosterone and brain monoamine variations

Anisman, H., Poulter, M. O., Gandhi, R., Merali, Z., & Hayley, S. P. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.02.008 · Cited by 57 · see citing works

Neurobehavioral Effects of Interferon-α in Patients with Hepatitis-C: Symptom Dimensions and Responsiveness to Paroxetine

McNutt, M. D., Liu, S., Manatunga, A., Royster, E. B., Raison, C. L., Woolwine, B. J., Demetrashvili, M. F., Miller, A. H., & Musselman, D. L. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.330 · Cited by 56 · see citing works

Molecular signatures of peripheral blood mononuclear cells during chronic interferon-α treatment: relationship with depression and fatigue

Felger, J. C., Cole, S. W., Pace, T. W. W., Hu, F., Woolwine, B. J., Doho, G., Raison, C. L., & Miller, A. H. (2011) · Psychological Medicine · doi:10.1017/s0033291711002868 · Cited by 56 · see citing works

Human interferon-α increases immobility in the forced swimming test in rats

Makino, M., Kitano, Y., Komiyama, C., & Takasuna, K. (2000) · Psychopharmacology · doi:10.1007/s002130050031 · Cited by 55 · see citing works

Recombinant human interferon-α does not alter reward behavior, or neuroimmune and neuroendocrine activation in rats

Garza, R. D. L., Asnis, G. M., Pedrosa, E., Stearns, C., Migdal, A. L., Reinus, J. F., Paladugu, R., & Vemulapalli, S. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.008 · Cited by 54 · see citing works

Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia

Zhu, Y., Saito, K., Murakami, Y., et al. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.08.072 · Cited by 54 · see citing works

A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT1A receptors, but a higher density of 5-HT1B receptors, compared to control rats

Nishi, K., Kanemaru, K., & Dikšić, M. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.12.011 · Cited by 54 · see citing works

Prophylactic Antidepressant Treatment in Patients With Hepatitis C on Antiviral Therapy: A Double-Blind, Placebo-Controlled Trial

Morasco, B. J., Loftis, J. M., Indest, D. W., Ruimy, S., Davison, J. W., Felker, B. L., & Hauser, P. (2010) · Psychosomatics · doi:10.1176/appi.psy.51.5.401 · Cited by 53 · see citing works

Screening for depression in patients with hepatitis C using the Beck Depression Inventory-II: do somatic symptoms compromise validity?

Patterson, A. L., Morasco, B. J., Fuller, B. E., Indest, D. W., Loftis, J. M., & Hauser, P. (2011) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2011.04.005 · Cited by 51 · see citing works

Repeated Injections of Interferon-α A/D in Balb/c Mice: Behavioral Effects

Dunn, A. L., & Crnic, L. S. (1993) · Brain Behavior and Immunity · doi:10.1006/brbi.1993.1011 · Cited by 50 · see citing works

Behavioral effects of mouse interferons-α and -γ and human interferon-α in mice

Crnic, L. S., & Segall, M. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)91106-o · Cited by 49 · see citing works

IFN-Induced Depression: A Role for NSAIDs

Asnis, G. M., MD, Garza, R. D. L., PhD, Kohn, S. R., PhD, Reinus, J. F., MD, Henderson, M., MD, et al. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4172 · Cited by 49 · see citing works

Effects of repeated stress on expression of interleukin-6 (IL-6) and IL-6 receptor mRNAS in rat hypothalamus and midbrain

Miyahara, S., Komori, T., Fujiwara, R., Shizuya, K., Yamamoto, M., Ohmori, M., & Okazaki, Y. (2000) · Life Sciences · doi:10.1016/s0024-3205(99)00626-8 · Cited by 48 · see citing works

Differential expression of interferon-γ receptor on human glial cells in vivo and in vitro

Hashioka, S., Klegeris, A., Schwab, C., Yu, S. Y., & McGeer, P. L. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.04.023 · Cited by 47 · see citing works

Microglial localization of α-interferon receptor in human brain tissues

Yamada, T., & Yamanaka, I. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11452-3 · Cited by 47 · see citing works

Interferon-gamma deficiency modifies the effects of a chronic stressor in mice: Implications for psychological pathology

Litteljohn, D., Cummings, A., Brennan, A., Gill, A., Chunduri, S., Anisman, H., & Hayley, S. P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.12.001 · Cited by 46 · see citing works

Major depression and risk of depressive symptomatology associated with short-term and low-dose interferon-α treatment

Beratis, S., Katrivanou, A., Georgiou, S., Monastirli, A., Pasmatzi, E., Gourzis, P., & Tsambaos, D. (2005) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2004.03.010 · Cited by 43 · see citing works

Effect of interferon-α on tyrosine hydroxylase and catecholamine levels in the brain of rats

Kumai, T., Tateishi, T., Tanaka, M., WATANABÉ, M., Shimizu, H., & Kobayashi, S. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00660-3 · Cited by 40 · see citing works

Stress, Learned Helplessness, and Brain Interleukin-1β

Maier, S. F., Nguyen, K. T., Terrence Deak, B., Milligan, E. D., & Watkins, L. R. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_13 · Cited by 39 · see citing works

Involvement of central opioid systems in human interferon‐α induced immobility in the mouse forced swimming test

Makino, M., Kitano, Y., Komiyama, C., Hirohashi, M., & Takasuna, K. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703432 · Cited by 38 · see citing works

Immune system activation and fatigue during treadmill running: role of interferon

DAVIS, J. M., WEAVER, J. A., Kohut, M. L., Colbert, L. H., Ghaffar, A., & Mayer, E. P. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199806000-00014 · Cited by 37 · see citing works

Interactions Between Corticotropin-Releasing Hormone and Serotonin: Implications for the Aetiology and Treatment of Anxiety Disorders

Linthorst, A. C. E. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-28082-0_7 · Cited by 37 · see citing works

Human interferon-α induces immobility in the mouse forced swimming test: involvement of the opioid system

Makino, M., Kitano, Y., Komiyama, C., Hirohashi, M., Kohno, M., Moriyama, M., & Takasuna, K. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02235-0 · Cited by 31 · see citing works

Administration of pegylated interferon-α-2a or -2b does not induce sickness behavior in Lewis rats

Loftis, J. M., Wall, J. M., Pagel, R. L., & Hauser, P. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.07.006 · Cited by 29 · see citing works

Psychiatric Side Effects of Interferon Treatment

Patten, S. B. (2006) · Current Drug Safety · doi:10.2174/157488606776930562 · Cited by 27 · see citing works

The Effect of Interferon-α on the Pituitary-Adrenal Axis

Menzies, R. D., Phelps, C., Wiranowska, M., Oliver, J. H., Chen, L., Horvath, E., & HALL, N. R. S. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.619 · Cited by 26 · see citing works

Pretreatment Levels of sTNF-R1 and sIL-6R are Associated With a Higher Vulnerability for IFN-α–induced Depressive Symptoms in Patients With Malignant Melanoma

Friebe, A., Schwarz, M., Schmid-Wendtner, M.-H., Volkenandt, M., Schmidt, F., Horn, M., Janssen, G., & Schaefer, M. (2007) · Journal of Immunotherapy · doi:10.1097/01.cji.0000211346.19330.c9 · Cited by 26 · see citing works

Administration of Interferon-Alpha in Mice Provokes Peripheral and Central Modulation of Immune Cells, Accompanied by Behavioral Effects

Orsal, A. S., Blois, S. M., Bermpohl, D., Schaefer, M., & Coquery, N. (2008) · Neuropsychobiology · doi:10.1159/000201718 · Cited by 23 · see citing works

Morphine suppresses intracellular interferon-α expression in neuronal cells

Wan, Q., Wang, X., Wang, Y., Li, S., Wang, S.-H., & Ho, W. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.04.026 · Cited by 20 · see citing works

Depression in hospitalized patients with malignant melanoma treated with interferon-alpha-2b: primary to induced disorders

Navinés, R., Gómez‐Gil, E., Puig, S., Baeza, I., Pablo, J. D., & Martín‐Santos, R. (2009) · European Journal of Dermatology · doi:10.1684/ejd.2009.0787 · Cited by 9 · see citing works

Mechanisms of altered beta-adrenergic responsiveness in the hyperthyroid and hypothyroid turkey erythrocyte

Bilezikian, J. P., & Loeb, J. N. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90282-x · Cited by 8 · see citing works

The brain reward circuitry in mood disorders

Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works

The molecular and cellular mechanisms of depression: a focus on reward circuitry

Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works

Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge

Parrott, J. M., Redus, L., & O’Connor, J. C. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0590-y · Cited by 112 · see citing works

Neurobehavioral comorbidities of epilepsy: Role of inflammation

Mazarati, A. M., Lewis, M. L., & Pittman, Q. J. (2017) · Epilepsia · doi:10.1111/epi.13786 · Cited by 96 · see citing works

The Role of Brain-Derived Neurotrophic Factor in Comorbid Depression: Possible Linkage with Steroid Hormones, Cytokines, and Nutrition

Numakawa, T., Richards, M., Nakajima, S., Adachi, N., Furuta, M., Odaka, H., & Kunugi, H. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00136 · Cited by 86 · see citing works

Visceral Inflammation and Immune Activation Stress the Brain

Holzer, P., Farzi, A., Hassan, A. M., Zenz, G., Jačan, A., & Reichmann, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01613 · Cited by 84 · see citing works

Depression as sickness behavior? A test of the host defense hypothesis in a high pathogen population

Stieglitz, J., Trumble, B. C., Thompson, M. E., Blackwell, A. D., Kaplan, H., & Gurven, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.05.008 · Cited by 62 · see citing works

N-acetyl-cysteine prevents toxic oxidative effects induced by IFN-α in human neurons

Alboni, S., Gibellini, L., Montanari, C., Benatti, C., Benatti, S., Tascedda, F., Brunello, N., Cossarizza, A., & Pariante, C. M. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000266 · Cited by 35 · see citing works

Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation

Howerton, A. R., Roland, A. V., & Bale, T. L. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0118-14.2014 · Cited by 33 · see citing works

Neonatal stress modulates sickness behavior: role for proinflammatory cytokines.

Avitsur, R., Maayan, R., & Weizman, A. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.02.009 · Cited by 29 · see citing works

Sulforaphane reduces lipopolysaccharide-induced proinflammatory markers in hippocampus and liver but does not improve sickness behavior

Townsend, B. E., & Johnson, R. W. (2015) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1103463 · Cited by 21 · see citing works

The Possible Role of Cytokines in Chemotherapy-Induced Cognitive Deficits

Myers, J. S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6306-2_15 · Cited by 26 · see citing works

The significance of proinflammatory cytokines and Th1/ Th2 balance in depression and action of antidepressants

Komori, T. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000180 · Cited by 58 · see citing works

Effects of prior stress on LPS-induced cytokine and sickness responses

Johnson, J. D., O'Connor, K. A., Hansen, M. K., Watkins, L. R., & Maier, S. F. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00230.2002 · Cited by 138 · see citing works