The DOI matches its Crossref record; 74 of the 75 references it cites were found in a registry or an index.
Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects
Open accessAbstract
Background Preclinical studies have identified certain probiotics as psychobiotics - live microorganisms with a potential mental health benefit. Lactobacillus rhamnosus (JB-1) has been shown to reduce stress-related behaviour, corticosterone release and alter central expression of GABA receptors in an anxious mouse strain. However, it is unclear if this single putative psychobiotic strain has psychotropic activity in humans. Consequently, we aimed to examine if these promising preclinical findings could be translated to healthy human volunteers.Objectives To determine the impact of L. rhamnosus on stress-related behaviours, physiology, inflammatory response, cognitive performance and brain activity patterns in healthy male participants.Methods An 8week, randomized, placebo-controlled, cross-over design was employed. Twenty-nine healthy male volunteers participated. Participants completed self-report stress measures, cognitive assessments and resting electroencephalography (EEG). Plasma IL10, IL1β, IL6, IL8 and TNFα levels and whole blood Toll-like 4 (TLR-4) agonist-induced cytokine release were determined by multiplex ELISA. Salivary cortisol was determined by ELISA and subjective stress measures were assessed before, during and after a socially evaluated cold pressor test (SECPT).Results There was no overall effect of probiotic treatment on measures of mood, anxiety, stress or sleep quality and no significant effect of probiotic over placebo on subjective stress measures, or the HPA response to the SECPT. Visuospatial memory performance, attention switching, rapid visual information processing, emotion recognition and associated EEG measures did not show improvement over placebo. No significant anti-inflammatory effects were seen as assessed by basal and stimulated cytokine levels.Conclusions L. rhamnosus was not superior to placebo in modifying stress-related measures, HPA response, inflammation or cognitive performance in healthy male participants. These findings highlight the challenges associated with moving promising preclinical studies, conducted in an anxious mouse strain, to healthy human participants. Future interventional studies investigating the effect of this psychobiotic in populations with stress-related disorders are required.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Despite promising preclinical findings in animal models, the study found no significant effects of JB-1 on mood, anxiety, sleep quality, or cognitive performance compared to placebo.”
From Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis (2026) · cites this paper as Kelly et al., 2017
In the citing paper
“Additionally, there were no notable changes in inflammatory markers or the HPA stress response.”
From Psychobiotics in mental health: insights from human clinical trials via the gut-brain axis (2026) · cites this paper as Kelly et al., 2017
In the citing paper
“However, in an eight-week crossover design, 29 healthy male volunteers who supplemented with L. rhamnosus exhibited little difference in stress-related measures, HPA axis response, inflammation, or cognitive performance in comparison to placebo [296].”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [296]
In the citing paper
“has met with somewhat mixed results in healthy human subjects with strain-specific positive results (Allen et al., 2016;Papalini et al., 2018) and a failure to translate (Kelly et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Kelly et al., 2017
In the citing paper
“However, the probiotic Lactobacillus rhamnosus failed to alter mood, anxiety, and stress-related measures when subjects faced a socially evaluated cold pressor test [392]”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [392]
In the citing paper
“For instance, L. rhamnosus was not found to be superior to placebo in modifying stress, HPA response, inflammation, or cognitive performance, and the authors highlighted the challenges associated with advancing promising preclinical studies in animals to the clinic (487).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [487]
In the citing paper
“Notably, the participants were healthy adult males and not patients with stress-related disorders.”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [487]
Citations
Cites
1 retracted
Mohammadi, A. A., Jazayeri, S., Khosravi‐Darani, K., Solati, Z., Mohammadpour, N., Asemi, Z., Adab, Z., Djalali, M., Tehrani‐Doost, M., Hosseini, M., et al. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000023 · Cited by 241
Retracted(1998) · The Journal of Clinical Psychiatry · Cited by 19,139
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Self-citationBravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Self-citationPruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00108-7 · Cited by 3,638
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683
Self-citationEEG analysis based on time domain properties
Hjorth, B. (1970) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(70)90143-4 · Cited by 1,504
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
How informative is the mouse for human gut microbiota research?
Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017400 · Cited by 1,334
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324
Psychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287
Self-citationConsumption of fermented milk product with probiotic modulates brain activity
Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110
Self-citationCorrelation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999
Self-citationMicrobiota is essential for social development in the mouse
Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.65 · Cited by 866
Self-citationWhorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00734.x · Cited by 799
Akkasheh, G., Kashani-Poor, Z., Tajabadi-Ebrahimi, M., Jafari, P., Akbari, H., Taghizadeh, M., Memarzadeh, M. R., Asemi, Z., & Esmaillzadeh, A. (2016) · Nutrition · doi:10.1016/j.nut.2015.09.003 · Cited by 767
HPA axis activation by a socially evaluated cold-pressor test
Schwabe, L., Haddad, L., & Schächinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.001 · Cited by 698
Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671
Collective unconscious: How gut microbes shape human behavior
Dinan, T. G., Stilling, R. M., Stanton, C., & Cryan, J. F. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.021 · Cited by 571
Self-citationCoull, J. T., Frith, C. D., Frackowiak, R. S. J., & Grasby, P. M. (1996) · Neuropsychologia · doi:10.1016/0028-3932(96)00029-2 · Cited by 566
Kristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0300-5 · Cited by 561
Impact of consuming a milk drink containing a probiotic on mood and cognition
Benton, D., Williams, C., & Brown, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602546 · Cited by 554
Schmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. J. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3810-0 · Cited by 522
Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.191 · Cited by 513
Self-citationInterleukin‐10 generation in atopic children following oral Lactobacillus rhamnosus GG
Pessi, T., Sütas, Y., Hurme, M., & Isolauri, E. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00948.x · Cited by 430
Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12427 · Cited by 418
Self-citationTaylor, M. J., Freemantle, N., Geddes, J. R., & Bhagwagar, Z. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.11.1217 · Cited by 406
Bifidobacteria modulate cognitive processes in an anxious mouse strain
Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365
Self-citationKarimi, K., Inman, M. D., Bienenstock, J., & Forsythe, P. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200806-951oc · Cited by 361
Self-citationDidari, T. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i10.3072 · Cited by 356
Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function
Patel, R. M., Myers, L. S., Kurundkar, A. R., Maheshwari, A., Nusrat, A., & Lin, P. W. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.10.025 · Cited by 341
Khanna, S., Pardi, D. S., Kelly, C. R., Kraft, C. S., Dhere, T., Henn, M. R., Lombardo, M.-J., Vulić, M., Ohsumi, T. K., Winkler, J. A., et al. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv766 · Cited by 324
Ma, D., Forsythe, P., & Bienenstock, J. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5308-5314.2004 · Cited by 289
Self-citationJanik, R., Thomason, L. A. M., Stanisz, A. M., Forsythe, P., Bienenstock, J., & Stanisz, G. J. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.018 · Cited by 283
Self-citationHuman Microbiota-Associated Mice: A Model with Challenges
Arrieta, M., Walter, J., & Finlay, B. B. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.04.014 · Cited by 246
Kamiya, T., Wang, L., Forsythe, P., Goettsche, G., Mao, Y., Wang, Y., Tougas, G., & Bienenstock, J. (2006) · Gut · doi:10.1136/gut.2005.070987 · Cited by 242
Self-citationWang, Y., Liu, Y., Sidhu, A., Ma, Z., McClain, C. J., & Feng, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00024.2012 · Cited by 238
Stress and the Aging Hippocampus
McEwen, B. S. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0173 · Cited by 229
Collins, S. M., Kassam, Z., & Berčík, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.004 · Cited by 214
Brain-gut-microbiota axis: challenges for translation in psychiatry
Kelly, J. R., Clarke, G. A., Cryan, J. F., & Dinan, T. G. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.02.008 · Cited by 207
Self-citationSchwabe, L., & Wolf, O. T. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.12.010 · Cited by 204
Chung, Y.-C., Jin, H.-M., Cui, Y., Kim, D. S., Jung, J. M., Park, J.-I., Jung, E.-S., Choi, E.-K., & Chae, S.-W. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.007 · Cited by 173
de Rover, M., Pironti, V. A., McCabe, J. A., Acosta‐Cabronero, J., Arana, F. S., Morein‐Zamir, S., Hodges, J. R., Robbins, T. W., Fletcher, P. C., Nestor, P. J., et al. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.03.037 · Cited by 173
Altered peripheral toll-like receptor responses in the irritable bowel syndrome
McKernan, D. P., Gaszner, G., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04624.x · Cited by 162
Self-citationKozáková, H., Schwarzer, M., Tučková, L., Šrůtková, D., Czarnowska, E., Rosiak, I., Hudcovic, T., Schabussová, I., Hermanová, P. P., Zakostelska, Z. J., et al. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.09 · Cited by 159
Harrington, J. M., Perry, I. J., Lutomski, J. E., Fitzgerald, T., Shiely, F., McGee, H. M., Barry, M. M., Lente, E. V., Morgan, K., & Shelley, E. (2009) · European Journal of Public Health · doi:10.1093/eurpub/ckp102 · Cited by 145
Eichenbaum, H., & Bunsey, M. D. (1995) · Current Directions in Psychological Science · doi:10.1111/1467-8721.ep10770954 · Cited by 139
Microbiota and neuroimmune signalling—Metchnikoff to microglia
Cryan, J. F., & Dinan, T. G. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.127 · Cited by 122
Self-citationKennedy, P. J., Cryan, J. F., Quigley, E. M. M., Dinan, T. G., & Clarke, G. (2014) · Psychological Medicine · doi:10.1017/s003329171400052x · Cited by 120
Self-citationMortaz, E., Adcock, I. M., Ricciardolo, F. L. M., Varahram, M., Jamaati, H., Velayati, A. A., Folkerts, G., & Garssen, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136455 · Cited by 108
Kennedy, P. J., Clarke, G., O‘Neill, A., Groeger, J. A., Quigley, E. M. M., Shanahan, F., Cryan, J. F., & Dinan, T. G. (2014) · Psychological Medicine · doi:10.1017/s0033291713002171 · Cited by 106
Self-citationMood by microbe: towards clinical translation
Dinan, T. G., & Cryan, J. F. (2016) · Genome Medicine · doi:10.1186/s13073-016-0292-1 · Cited by 99
Self-citationWang, B., Mao, Y., Diorio, C. J., Pasyk, M., Wu, R., Bienenstock, J., & Kunze, W. (2010) · The FASEB Journal · doi:10.1096/fj.09-153841 · Cited by 98
Self-citationMa, X., Mao, Y., Wang, B., Huizinga, J. D., Bienenstock, J., & Kunze, W. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90511.2008 · Cited by 93
Self-citationO’Mahony, C. M., Sweeney, F. F., Daly, E., Dinan, T. G., & Cryan, J. F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.038 · Cited by 80
Self-citationAntidepressants in healthy subjects: What are the psychotropic/psychological effects?
Serretti, A., Calati, R., Goracci, A., Simplicio, M. C. D., Castrogiovanni, P., & Ronchi, D. D. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.11.009 · Cited by 76
Savignac, H. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.049 · Cited by 75
Self-citationProbiotics and microbiota composition
Sanders, M. E. (2016) · BMC Medicine · doi:10.1186/s12916-016-0629-z · Cited by 72
Jazayeri, S., Mohammadi, A., Khosravi‐Darani, K., Solati, Z., Mohammadpour, N., Asemi, Z., Adab, Z., Djalali, M., Tehrani‐Doost, M., Hosseini, M., et al. (2015) · International Journal of Preventive Medicine · doi:10.4103/2008-7802.164146 · Cited by 69
Minkley, N., Schröder, T. P., Wolf, O. T., & Kirchner, W. H. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.022 · Cited by 59
Julio‐Pieper, M., O’Mahony, C. M., Clarke, G. A., Bravo, J. A., Dinan, T. G., & Cryan, J. F. (2011) · Stress · doi:10.3109/10253890.2011.607524 · Cited by 50
Self-citationForsythe, P., Wang, B., Khambati, I., & Kunze, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041234 · Cited by 48
Browne, C. A., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.020 · Cited by 48
Self-citationKennedy, P. J., Allen, A. P., O’Neill, A., Quigley, E. M. M., Cryan, J. F., Dinan, T. G., & Clarke, G. A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3767-z · Cited by 40
Self-citationHales, J. B., Israel, S. L., Swann, N. C., & Brewer, J. B. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21096 · Cited by 31
Effects of etizolam and ethyl loflazepate on the P300 event-related potential in healthy subjects
Fukami, G., Hashimoto, T., Shirayama, Y., Hasegawa, T., Watanabe, H., Fujisaki, M., Hashimoto, K., & Iyo, M. (2010) · Annals of General Psychiatry · doi:10.1186/1744-859x-9-37 · Cited by 15
Flagged first, then by citations
1 of the 75 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Bercik, 2011, The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice, Gastroenterology, 141, e593
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Self-citationThe role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
The gut microbiota–brain axis in behaviour and brain disorders
Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149
Probiotics and prebiotics in intestinal health and disease: from biology to the clinic
Sanders, M. E., Merenstein, D. J., Reid, G., Gibson, G. R., & Rastall, R. A. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0173-3 · Cited by 2,059
The neuroactive potential of the human gut microbiota in quality of life and depression
Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963
Metadata
- Authors
- Kelly, J. R., Allen, A. P., Temko, A., Hutch, W., Kennedy, P. J., Farid, N., Murphy, E., Boylan, G., Bienenstock, J., Cryan, J. F., Clarke, G., & Dinan, T. G.
- Affiliations
- University College Cork (IE)
- Alimentary Health (Ireland) (IE)
- McMaster University (CA)
- Corresponding author
- Dinan, Timothy G.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 61
- Pages
- 50-59
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2554850339
- Cited by
- 355
- References
- 75
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 28 · 2023: 47 · 2022: 42 · 2021: 46 · 2020: 36 · 2019: 44 · 2018: 32 · 2017: 26
- FWCI
- 42.85
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by-nc-nd)
- Funders
- SFI (SFI/12/RC/2273)
- HRB (HRA_POR/2011/23, HRA_POR/2012/32, HRA-POR-2-14-647, MYNEWGUT FP7-KBBE-2013-7)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- psychobiotics, probiotics, stress, cognitive performance, hypothalamic-pituitary-adrenal axis, salivary cortisol, inflammation, cytokines, TLR4, visuospatial memory, emotion recognition, healthy men
- MeSH terms
- Adult, Attention, Brain, Cognition, Double-Blind Method, Electroencephalography, Humans, Hydrocortisone, Male, Neuropsychological Tests, Saliva, Stress, Psychological, Cytokines, Cross-Over Studies, Probiotics, Lacticaseibacillus rhamnosus, Young Adult, Healthy Volunteers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
