Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice
Abstract
Although accumulating evidence suggests that activated microglia are associated with deficits in neurogenesis and contribute to the physiopathology of major depressive disorder, the role of microglia in treating depression remains poorly understood. Our previous study showed that salvianolic acid (SalB) has the regulation of neuroinflammatory responses and antidepressant-like effects. Here, we hypothesized that SalB's therapeutic effects occur because it modulates microglial phenotypes that are associated with neurogenesis. To test this hypothesis, we treated CMS-exposed C57BL/6 mice with SalB (20mg/kg, intraperitoneally, once daily) for 3weeks and investigated microglial phenotypic profiles and hippocampal neurogenesis. The results showed that the SalB treatment skewed M1 microglial polarization toward M2 activation in the hippocampus and cortex and remedied CMS-induced deficits in hippocampal neurogenesis. SalB (40µM) inhibited LPS-stimulated microglial M1 activation as well as induced M2 activation in vitro, and the cultured microglia with the SalB treatment showed enhanced neural precursor cell proliferation, differentiation, and survival. SalB treatment also ameliorated the depressive-like behaviors of the CMS-treated mice in sucrose preference, forced swimming, and tail suspension tests. These findings suggest a possible antidepressive mechanism for anti-inflammatory agents that is correlated with microglial polarization and hippocampal neurogenesis and which may provide a new microglia-targeted strategy for depression therapy.
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Stress-induced depressive-like behaviors are associated with neuroimmune regulation.
“These results suggest that stress-induced depressive-like behaviors are associated with neuroimmune regulation (28).”
From IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis (2021) · cites this paper as [28]
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- Authors
- Zhang, J., Xie, X., Tang, M., Zhang, J., Zhang, B., Zhao, Q., Han, Y., Yan, W., Peng, C., & You, Z.
- Affiliations
- University of Electronic Science and Technology of China (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
- Corresponding author
- You, Zili
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 66
- Pages
- 111-124
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2737842237
- Cited by
- 150
- References
- 57
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 21 · 2023: 15 · 2022: 21 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 7 · 2017: 1
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81571174, 81603503)
- State Key Laboratory Breeding Base of Systematic Research
- Development and Utilization of Chinese Medicine Resources (2015003)
- Key Technologies R & D Program of Sichuan Province (2015SZ0058-5)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- salvianolic acid B, microglial polarization, M2 microglia, M1 microglia, hippocampal neurogenesis, chronic mild stress, depression, antidepressant effects, neuroinflammation, neural progenitor cells, major depressive disorder
- MeSH terms
- Animals, Benzofurans, Cerebral Cortex, Depression, Depressive Disorder, Hippocampus, Inflammation, Male, Mice, Inbred C57BL, Phenotype, Stress, Psychological, Microglia, Inflammation Mediators, Depsides, Neurogenesis
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