Cited by 109Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Natural Products as a Potential Modulator of Microglial Polarization in Neurodegenerative Diseases

Jin, Xin, Liu, Ming-Yan, Zhang, Dong-Fang, Zhong, Xin, Du, Ke, Qian, Ping, Gao, Hua, Wei, Min-Jie·2019·Pharmacological Research

Abstract

Neurodegenerative diseases (NDs) are characterized by the progressive loss of structure and function of neurons most common in elderly population, mainly including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). Neuroinflammation caused by microglia as the resident macrophages of the central nervous system (CNS) plays a contributory role in the onset and progression of NDs. Activated microglia, as in macrophages, to be heterogeneous, can polarize into M1 (pro-inflammatory) and M2 (anti-inflammatory) functional phenotypes. The former elaborate pro-inflammatory mediators promoting neuroinflammation and neuronal damage. In contrast, the latter generate anti-inflammatory mediators and neurotrophins that inhibit neuroinflammation and promote neuronal healing. Consistently, the regulation of microglial polarization from M1 to M2 phenotype appears as an outstanding therapeutic and preventive approach for NDs treatment. Although non-steroidal anti-inflammatory drugs (NSAIDs) currently used to alleviate M1 microglia-associated neuroinflammation responsible for the development of NDs, these drugs have different degrees of adverse effects and limited efficacy. As the advantages of novel structure, multi-target, high efficiency and low toxicity, natural products as the modulators of microglial polarization have attracted considerable concerns in the therapeutic areas of NDs. In this review, we mainly summarized the therapeutic potential of natural products and their various molecular mechanisms for NDs treatment through modulating microglial polarization. The aim of the current review is expected to be useful to develop innovative modulators of microglial polarization from natural products for the amelioration and treatment of NDs.

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Crossref · 10.1016/j.phrs.2019.104253

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  • Phytochemicals including flavonoids, polyphenols, terpenoids, and carotenoids target multiple signaling pathways responsible for microglial activation and release of pro-inflammatory mediators, or NF-κB and p38 MAPK activation.

    “Many phytochemicals including flavonoids and other polyphenols, terpenoids, and carotenoids have indeed the ability to target multiple signaling pathways responsible for microglial activation and the subsequent release of pro-inflammatory mediators, or those involved in the activation of NF-κB and p38 MAPK”

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Authors
Jin, X., Liu, M.-Y., Zhang, D.-F., Zhong, X., Du, K., Qian, P., Gao, H., & Wei, M.-J.
Affiliations
  • China Medical University (CN)
  • National Institutes for Food and Drug Control (CN)
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2019-07
Volume
145
Pages
104253
ISSN
1043-6618 (ISSN-L)
OpenAlex
W2943027232
Cited by
109
References
263
Citations by year
2026: 6 · 2025: 13 · 2024: 15 · 2023: 16 · 2022: 21 · 2021: 17 · 2020: 15 · 2019: 5
FWCI
1.53
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Shenyang Science and Technology Bureau
  • China Postdoctoral Science Foundation
  • Department of Science and Technology of Liaoning Province
  • Ministry of Science and Technology of the People's Republic of China
  • Scientific Research Fund of Liaoning Provincial Education Department
  • National Natural Science Foundation of China
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
natural products, microglial polarization, neurodegenerative diseases, neuroinflammation, M1/M2 microglia, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, anti-inflammatory agents, neuroprotection
MeSH terms
Animals, Biological Products, Humans, Phenotype, Microglia, Neuroprotective Agents, Neurodegenerative Diseases

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