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Cited by 97Stress Responses and CortisolChild Abuse and TraumaNeuroendocrine regulation and behavior

Early deprivation under specific conditions leads to reduced interest in reward in adulthood in Wistar rats

Rüedi-Bettschen, Daniela, Pedersen, Else-Marie, Feldon, Joram, Pryce, Christopher R.·2005·Behavioural Brain Research
DOI 10.1016/j.bbr.2004.06.001
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Abstract

Early life adversity can lead to increased vulnerability to psychiatric disease including depression, with symptoms of depressed mood, impaired coping with negative events, anhedonia, reduced appetite, and elevated stress hormone activity. In rats, postnatal manipulation studies have focused on behavioural and endocrine anxiety effects, and have demonstrated that mild pup stimulation in the form of early handling (EH) is chronically anxiolytic relative to no stimulation in the form of non-handling (NH). Furthermore, apparently severe manipulations in the form of 3-4 h daily litter-dam separation (maternal separation) or pup-litter-dam separation (early deprivation, ED) are either without effect or even EH-like, relative to NH. In this Wistar rat study, we investigated the effects of ED under different circadian and thermal conditions on adulthood behavioural and endocrine responsiveness to environmental challenge, relative to NH. ED was performed on days 1-14, during either the Light or Dark phase and at either 21 degrees C (cold) or 32 degrees C (warm). Dark-cold ED adults exhibited reduced motivation to obtain sucrose in a progressive ratio schedule, tended to be less mobile in a forced swim test, but did not exhibit an escape deficit in a foot-shock pre-exposure/shuttle box test, or altered basal or stress endocrine activity. Light ED was completely without effect on adult phenotype. Even relative to stringent NH comparison, dark-cold ED leads to a long-term trait of mild gustatory anhedonia in Wistar rats.

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  • Two groups found a similar pattern in rodents: decreased willingness to work on progressive reinforcement but unchanged sucrose consumption when sucrose was given freely or on a fixed ratio.

    “A similar pattern in rodents was identified by two groups, in which there was decreased willingness to work via progressive reinforcement but unchanged consumption of sucrose when it was given freely (Rüedi-Bettschen et al., 2005) or provided on a fixed ratio (Campbell et al., 2017).”

    From The effects of early life stress on reward processing (2018) · cites this paper as Rüedi-Bettschen et al., 2005

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Authors
Rüedi-Bettschen, D., Pedersen, E.-M., Feldon, J., & Pryce, C. R.
Affiliations
ETH Zurich (CH)
Corresponding author
Pryce, Christopher R.
ORCID
Pryce, Christopher R.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2005-01
Volume
156
Issue
2
Pages
297-310
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2004.06.001
OpenAlex
W2094651236
Cited by
97
References
62
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 4
FWCI
2.59
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
childhood adversity, early deprivation, maternal separation, early handling, anhedonia, reward motivation, sucrose intake, circadian phase, thermal conditions, depression vulnerability, stress hormones, forced swim test, escape behavior, Wistar rats
MeSH terms
Adrenocorticotropic Hormone, Age Factors, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Conditioning, Operant, Corticosterone, Endocrine System, Female, Handling, Psychological, Male, Maternal Deprivation, Photic Stimulation, Pregnancy, Reinforcement, Psychology, Reinforcement Schedule, Reward, Stress, Psychological, Swimming, Rats, Wistar, Rats

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