Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions
Abstract
Background Adverse life events occurring early in development may alter the correct program of brain maturation and render the organism more vulnerable to psychiatric disorders. Identification of persistent changes associated with these events is crucial for the development of novel therapeutic strategies.Methods We used postnatal repeated maternal deprivation (MD) from postnatal day (PND) 2-14 to investigate changes in brain-derived neurotrophic factor (BDNF) levels. RNase protection assay and enzyme linked immunosorbent assay were employed to determine the anatomic profile of neurotrophin expression at different ages following MD.Results We found that MD produces a short-term up-regulation of neurotrophin expression in hippocampus and prefrontal cortex, as measured on PND 17, whereas at adulthood, a selective reduction of BDNF expression was observed in prefrontal cortex. When adult animals were challenged with a chronic swim stress paradigm, both a reduced expression of BDNF in prefrontal cortex and a significant reduction in striatal protein levels were found only in control subjects, whereas levels in the MD group were not further decreased.Conclusions Our data suggest that MD produces a significant reduction of BDNF expression within prefrontal cortex and striatum, which may render these structures less plastic and more vulnerable under challenging conditions.
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BDNF regulates neuron survival, plasticity, and synaptic function, plays an integral role in differentiation during development, is affected by stress, and is associated with major depression and suicidal behavior.
“Brain-derived neurotrophic factor (BDNF) regulates neuron survival, plasticity, and synaptic function (169-174), plays an integral role in differentiation during development (175, 176), is affected by stress (177), and is associated with major depression and suicidal behavior (178).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [177]
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Cobolli Gigli, C., Scaramuzza, L., Gandaglia, A., Bellini, E., Gabaglio, M., Parolaro, D., Kilstrup-Nielsen, C., Landsberger, N., & Bedogni, F. (2016) · PLOS ONE · doi:10.1371/journal.pone.0153473 · Cited by 37 · see citing works
Aykaç, A., Öncül, Ş., & Onur, R. (2018) · Marmara Pharmaceutical Journal · doi:10.12991/mpj.2018.56 · Cited by 2 · see citing works
“In these models, BDNF levels and its mRNA expression are reported to be lower in the blood and certain brain areas [2,4-9].”
Background
- Authors
- Roceri, M., Cirulli, F., Pessina, C., Peretto, P., Racagni, G., & Riva, M. A.
- Affiliations
- University of Milan (IT)
- Istituto Superiore di Sanità (IT)
- University of Turin (IT)
- Corresponding author
- Riva, Marco A
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 55
- Issue
- 7
- Pages
- 708-714
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2034658390
- Cited by
- 317
- References
- 67
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 13 · 2016: 18 · 2015: 20 · 2014: 21 · 2013: 20 · 2012: 24
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- maternal deprivation, brain-derived neurotrophic factor, neurotrophin expression, prefrontal cortex, striatum, hippocampus, neuroplasticity, childhood adversity, age-related changes, rat brain
- MeSH terms
- Aging, Animals, Animals, Newborn, Arousal, Brain, Corpus Striatum, Disease Models, Animal, Female, Frontal Lobe, Hippocampus, Male, Maternal Deprivation, Neuronal Plasticity, Pregnancy, Reference Values, RNA, Messenger, Schizophrenia, Stress, Psychological, Gene Expression, Rats, Sprague-Dawley, Prefrontal Cortex, Brain-Derived Neurotrophic Factor, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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