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Juvenile peer play experience and the development of the orbitofrontal and medial prefrontal cortices
Abstract
The experience of peer play during the juvenile phase in rats is known to be important for the development of adult social competence. Adult social competence is also compromised by damage to the orbitofrontal cortex (OFC), an area known to be involved in social behavior. We therefore hypothesized that the functioning of the OFC in social behavior is facilitated through the experience of peer play during the juvenile period. Further, because the OFC and medial prefrontal cortex (mPFC) are known to be reciprocally responsive to a variety of manipulations, we suspected that the functioning of the mPFC is also responsive to the experience of peer play during development. Female Long-Evans rats were raised in conditions that varied with respect to the experience of peer play, and Golgi techniques were used to examine the neuronal morphology of the OFC and mPFC. The results indicated that the neurons of the OFC responded to the number of peers present, not whether those peers engaged in play or not, whereas the neurons of the mPFC responded specifically to the experience of play.
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“Even if not completely isolated, but instead deprived of peer contact by being reared solely with an adult animal, adolescent rodents show brain-level changes including reduced synaptic pruning in the prefrontal cortex.53”
From The effects of social deprivation on adolescent development and mental health (2020) · cites this paper as [53]
In the citing paper
“The same lesions, however, broadly impair social cognition and thus may not be specific to play (Bell et al., 2010).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Bell et al., 2010
In the citing paper
“The dendritic complexity of cortical pyramidal neurons is reduced in animals given multiple play partners over an extended period of time compared to those either socially deprived or given only limited access to the same partner (Bell et al., 2010).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Bell et al., 2010
In the citing paper
“The mPFC is also changed in response to play experience.”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Bell et al., 2010
In the citing paper
“Rats demonstrate enhanced cognitive abilities and a rich social repertoire paired with neural complexity, particularly in brain regions implicated in ASD pathology such as the frontal cortex [10–12].”
From Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders (2016) · cites this paper as [10]
In the citing paper
“the development of the medial prefrontal cortex (mPFC) and associated socio-cognitive skills is influenced by the experience of RTP with peers in the juvenile period (about 28–40 days post birth; Bell et al., 2010; Baarendse et al., 2013; Schneider et al., 2016)”
From The rough-and-tumble play of rats as a natural behavior suitable for studying the social brain (2022) · cites this paper as Bell et al., 2010
In the citing paper
“Lack of social play experience during postweaning development has been reported to cause long-lasting changes in PFC circuitry and function (Leussis et al., 2008;Bell et al., 2010;Baarendse et al., 2013;Vanderschuren and Trezza, 2014).”
From Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in Rats (2022) · cites this paper as Bell et al., 2010
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“ 66 Whether these effects are specific to play deprivation or merely reflect the generic effect of a lack of stimulation requires further study.”
BackgroundInfluentialExperience and the developing prefrontal cortex
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“In contrast, in the mPFC, no peer play groups had significantly greater dendritic length and more complex arbors than the single or multiple peer play groups (Bell et al., 2010).”
Background
Metadata
- Authors
- Bell, H. C., Pellis, S. M., & Kolb, B.
- Affiliations
- University of Lethbridge (CA)
- Corresponding author
- Bell, Heather C.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-02-11
- Volume
- 207
- Issue
- 1
- Pages
- 7-13
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2159471102
- Semantic Scholar
- 42bad78d1e7212e62089b41a5ef8861c76be5794
- Cited by
- 217
- References
- 72
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 14 · 2023: 19 · 2022: 12 · 2021: 10 · 2020: 11 · 2019: 14 · 2018: 15 · 2017: 17 · 2016: 14 · 2015: 15 · 2014: 14 · 2013: 18 · 2012: 11
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- peer play, orbitofrontal cortex, medial prefrontal cortex, neuronal morphology, social behavior development, rat development, Golgi staining
- MeSH terms
- Analysis of Variance, Animals, Dendrites, Female, Neuronal Plasticity, Peer Group, Play and Playthings, Social Behavior, Social Isolation, Silver Staining, Prefrontal Cortex, Rats, Long-Evans, Dendritic Spines, Rats
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