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Cited by 114Memory and Neural MechanismsNeuroendocrine regulation and behaviorNeural and Behavioral Psychology Studies

The role of the medial prefrontal cortex in the play fighting of rats.

Bell, Heather C., McCaffrey, David R., Forgie, Margaret L., Kolb, Bryan, Pellis, Sergio M.·2009·Behavioral Neuroscience
DOI 10.1037/a0017617
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Abstract

Although decorticated rats are able to engage in play, their play is abnormal in three ways. First, decorticates do not display the normal, age-related shifts in defensive strategies during development. Second, decorticates do not modify their defensive tactics in response to the social identity of their partners. Third, decorticates display a global shift in defensive tactics from more complex to less complex strategies. It has been shown that lesions of the motor cortex (MC) selectively produce the abnormal developmental effects on play, and that lesions of the orbitofrontal cortex (OFC) selectively produce the deficits in behavioral discrimination between social partners. In the current set of experiments, we demonstrate that lesions of the medial prefrontal cortex (mPFC) produce the shift from more complex to less complex defensive tactics, while leaving intact the age-related and partner-related modulation of defensive strategies. Thus, we have evidence for a triple dissociation of function between the MC, the OFC, and the mPFC with respect to social play behavior.

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Crossref · 10.1037/a0017617

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57 of 57 references verified0 citation errors · 0 not checkable

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  • Rats with lesions to the medial prefrontal cortex (mPFC) initiate play more frequently but have a decreased likelihood of responding to play initiation from a partner.

    “Rats with lesions to the medial prefrontal cortex (mPFC) initiate play more frequently but have a decreased likelihood of responding to play initiation from a partner (Bell et al., 2009).”

    From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Bell et al., 2009

  • The prefrontal cortex (PFC) does not regulate sex differences but instead contributes generally to play.

    “A third node, the prefrontal cortex (PFC), does not regulate sex differences but instead contributes generally to play (Bell, et al., 2009) (Figure 2).”

    From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Bell, et al., 2009

  • Neonatal lesions of the mPFC impair play in a variety of ways, largely resulting in a disruption of the animal's play structure and ability to respond to play initiations.

    “As noted previously, neonatal lesions of the mPFC impair play in a variety of ways, largely resulting in a disruption the animal’s play structure and ability to respond to play initiations (Panksepp et al., 1994; Bell et al., 2009).”

    From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Bell et al., 2009

  • The medial prefrontal cortex has a crucial role in coordinating actions with partners as juveniles and as adults in both playful and non-playful social interactions.

    “and the mPFC has a crucial role in coordinating actions with partners as juveniles and as adults in both playful and non-playful social interactions (Bell et al., 2009; Van Kerkhof et al., 2013; Himmler et al., 2014; Stark and Pellis, 2020).”

    From The rough-and-tumble play of rats as a natural behavior suitable for studying the social brain (2022) · cites this paper as Bell et al., 2009

  • Lesions or inactivation of the PFC impair social play.

    “Social play behavior involves PFC activity (van Kerkhof et al., 2013b), and lesions or inactivation of the PFC have been found to impair social play (Bell et al., 2009;van Kerkhof et al., 2013a).”

    From Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in Rats (2022) · cites this paper as Bell et al., 2009

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Authors
Bell, H. C., McCaffrey, D. R., Forgie, M. L., Kolb, B., & Pellis, S. M.
Affiliations
University of Lethbridge (CA)
ORCID
Venue
Behavioral Neuroscience
Publisher
American Psychological Association (APA)
Published
2009-12
Volume
123
Issue
6
Pages
1158-1168
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
DOI
10.1037/a0017617
OpenAlex
W2042920810
Cited by
114
References
57
Citations by year
2026: 3 · 2025: 3 · 2024: 7 · 2023: 10 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 13 · 2014: 3 · 2013: 10 · 2012: 1
FWCI
1.61
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Sciences and Engineering Research Council
  • Alberta Heritage Foundation for Medical Research
  • Norlien Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
medial prefrontal cortex, play fighting, social play, rats, decortication, motor cortex, orbitofrontal cortex, defense strategy, social identity, age-related development, behavioral discrimination
MeSH terms
Age Factors, Aggression, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Female, Image Processing, Computer-Assisted, Male, Play and Playthings, Sex Factors, Social Behavior, Sterilization, Tubal, Video Recording, Prefrontal Cortex, Rats, Long-Evans, Rats

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