Daily injections alter spine density in rat medial prefrontal cortex
Abstract
Apical dendrites of pyramidal neurons in medial prefrontal cortex are reorganized after chronic corticosterone treatment. In this study, we assessed the effects of chronic corticosterone administration on dendritic spines. Adult male rats received sc injections of either corticosterone or vehicle daily for 3 weeks or were left untreated. Layer II-III neurons in medial prefrontal cortex were stained using a Golgi-Cox procedure and spines were counted on the portions of apical dendrites where maximal corticosterone-induced dendritic changes occur. In vehicle- and corticosterone-treated rats, spine density proximal to the soma was increased relative to untreated rats, while spine density in the distal portion of the apical arbor was unchanged, suggesting that daily handling alone altered spine density. This stress-induced change in spine density likely reflects important functional changes in excitatory synaptic inputs in prefrontal cortex.
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Sustained stress exposure induces loss of dendrites and spines in layer II/III pyramidal cells of rodent PFC and loss of the dendritic tufts of layer V pyramidal cells.
“Sustained stress exposure induces loss of dendrites and spines in layer II/III pyramidal cells of rodent PFC70–73 and loss of the dendritic tufts of layer V pyramidal cells74.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [70]
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- Authors
- Seib, L. M., & Wellman, C. L.
- Affiliations
- Indiana University Bloomington (US)
- Corresponding author
- Wellman, Cara L.
- ORCID
- Wellman, Cara L.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 337
- Issue
- 1
- Pages
- 29-32
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2141167930
- Cited by
- 100
- References
- 1
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 7 · 2018: 6 · 2017: 1 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 8
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- corticosterone, dendritic spines, spine density, medial prefrontal cortex, apical dendrites, pyramidal neurons, dendritic reorganization, stress, excitatory synaptic input, Golgi-Cox staining
- MeSH terms
- Animals, Corticosterone, Dendrites, Humans, Male, Rats, Sprague-Dawley, Prefrontal Cortex, Pyramidal Cells, Rats
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