Dysfunctional long-term potentiation-like plasticity in schizophrenia revealed by transcranial direct current stimulation
Abstract
Neural and cortical plasticity represent the ability of the brain to reorganize its function in response to a challenge. Plasticity involves changing synaptic activity and connectivity. Long-term-potentiation is one important mechanism underlying these synaptic changes. Disturbed neuronal plasticity is considered to be part of the pathophysiology of schizophrenia and has been linked to the different clinical features of this severe illness. The aim of the present study was to investigate nonfocal cortical plasticity and cortical excitability in recent-onset and multi-episode schizophrenia compared with healthy subjects. Nonfocal cortical plasticity can be induced in the motor cortex of healthy subjects with anodal transcranial direct current stimulation. Animal and human research indicates that this long-term-potentiation-like plasticity is glutamate-dependent and that these plasticity shifts can last for several hours. Transcranial direct current stimulation-induced plasticity was monitored by transcranial magnetic stimulation-generated motor evoked potentials. Well-characterized transcranial magnetic stimulation protocols were applied to determine the physiological basis of plasticity changes. Multi-episode schizophrenia patients showed significantly reduced long-term-potentiation-like plasticity compared to recent-onset schizophrenia patients and healthy controls. All schizophrenia patients demonstrated reduced cortical inhibition. Our results indicate that the long-term-potentiation-like plasticity deficit in schizophrenia patients is related to the disease course. Disturbances of N-methyl-d-aspartate, gamma-aminobutyric acid and dopamine receptors may account for this plasticity deficit. LTP-like plasticity deficits might be related to disturbed information processing in schizophrenia patients.
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First onset patients do not differ significantly from healthy controls in plasticity, with a trend toward increased plasticity.
“First onset patients instead do not differ significantly from healthy controls with a trend toward increased plasticity (59).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [59]
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- Authors
- Hasan, A., Nitsche, M. A., Rein, B., Schneider-Axmann, T., Guse, B., Gruber, O., Falkai, P., & Wobrock, T.
- Affiliations
- University of Göttingen (DE)
- Corresponding author
- Hasan, Alkomiet
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 224
- Issue
- 1
- Pages
- 15-22
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2048532846
- Cited by
- 156
- References
- 60
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 11 · 2020: 4 · 2019: 7 · 2018: 13 · 2017: 10 · 2016: 13 · 2015: 24 · 2014: 21 · 2013: 18 · 2012: 11
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (HA 6091/1-1, NI 683/6-1, FA 241/10-1)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- schizophrenia, long-term potentiation, cortical plasticity, transcranial direct current stimulation, cortical excitability, cortical inhibition, motor evoked potentials, NMDA receptor, GABA receptors, dopamine receptors, clinical course, recent-onset schizophrenia
- MeSH terms
- Adult, Analysis of Variance, Electromyography, Female, Humans, Male, Middle Aged, Motor Cortex, Reaction Time, Schizophrenia, Paranoid, Antipsychotic Agents, Chi-Square Distribution, Case-Control Studies, Long-Term Potentiation, Evoked Potentials, Motor, Transcranial Magnetic Stimulation
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