BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?
Open accessAbstract
Brain-derived neurotrophic factor (BDNF) is of interest because of its putative role in stress and psychiatric disorders. Maternal separation is used as an animal model of early-life stress and of irritable bowel syndrome (IBS). Animals exposed to the paradigm show altered gut function together with heightened levels of arousal and corticosterone. Some probiotic organisms have been shown to be of benefit in IBS and influence the brain-gut axis. Our objective was to investigate the effects of maternal separation on BDNF under basal conditions and in response to the probiotic Bifidobacterium breve 6330. The study implemented the maternal separation model which we have previously described. Polymerase chain reaction and in situ hybridisation were performed to measure the effect of maternal separation on both BDNF total variants and BDNF splice variant (exon) IV in the hippocampus. Maternally separated and non-separated rats were treated with B. breve 6330, to investigate the effect of this probiotic on BDNF total variant and BDNF exon IV expression. Maternal separation increased BDNF total variants (P<0.01), whilst having no effect on BDNF exon IV. B. breve 6330 increased BDNF total variants (P<0.01), and decreased BDNF splice variant IV, in non-separated rats (P<0.01). B. breve 6330 did not alter BDNF levels in the maternally separated rats. Maternal separation caused a marked increase in BDNF in the hippocampus. While B. breve 6330 influenced BDNF in normal animals, it had no significant effect on BDNF in those which were maternally separated. We have demonstrated that an orally administered probiotic can influence hippocampal BDNF.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the maternal separation rat model of IBS, Bifidobacterium breve 6330 influenced hippocampal BDNF gene expression.
“In the maternal separation (MS) rat model of IBS, Bifidobacterium breve 6330 influenced hippocampal BDNF gene expression [250]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [250]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · see citing works
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927 · see citing works
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775 · see citing works
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670 · see citing works
Regulation of Cell Survival by Secreted Proneurotrophins
Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001) · Science · doi:10.1126/science.1065057 · Cited by 1,670 · see citing works
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06810.2002 · Cited by 1,662 · see citing works
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · see citing works
Maternal care, hippocampal synaptogenesis and cognitive development in rats
Liu, D., Diorio, J., Day, J. C., Francis, D. D., & Meaney, M. J. (2000) · Nature Neuroscience · doi:10.1038/77702 · Cited by 1,195 · see citing works
Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
Pang, P. T., Teng, H. K., Zaitsev, E., Woo, N. T., Sakata, K., Zhen, S., Teng, K. K., Yung, W.-H., Hempstead, B. L., & Lu, B. (2004) · Science · doi:10.1126/science.1100135 · Cited by 1,136 · see citing works
O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works
Self-citationTeng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013 · see citing works
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works
Self-citationRequirement for BDNF in activity-dependent survival of cortical neurons
Ghosh, A., Carnahan, J., & Greenberg, M. E. (1994) · Science · doi:10.1126/science.7907431 · Cited by 989 · see citing works
Mouse and rat <i>BDNF</i> gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works
Magariños, A. M., McEwen, B. S., Flügge, G., & Fuchs, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03534.1996 · Cited by 864 · see citing works
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815 · see citing works
The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review
Moayyedi, P., Ford, A. C., Talley, N. J., Cremonini, F., Foxx-Orenstein, A. E., Brandt, L. J., & Quigley, E. M. M. (2010) · Gut · doi:10.1136/gut.2008.167270 · Cited by 728 · see citing works
Self-citationLong-term behavioral and neuroendocrine adaptations to adverse early experience
Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., Meaney, M. J., & Plotsky, P. M. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62132-9 · Cited by 717 · see citing works
Mirescu, C., & Gould, E. (2006) · Hippocampus · doi:10.1002/hipo.20155 · Cited by 701 · see citing works
Tyler, W. J., Alonso, M., Bramham, C. R., & Pozzo‐Miller, L. D. (2002) · Learning & Memory · doi:10.1101/lm.51202 · Cited by 679 · see citing works
Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia
Weickert, C. S., Hyde, T. M., Lipska, B. K., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001308 · Cited by 533 · see citing works
A structural superfamily of growth factors containing a cystine knot motif
McDonald, N. Q., & Hendrickson, W. A. (1993) · Cell · doi:10.1016/0092-8674(93)90127-c · Cited by 532 · see citing works
Ladd, C. O., Owens, M. J., & Nemeroff, C. B. (1996) · Endocrinology · doi:10.1210/endo.137.4.8625891 · Cited by 511 · see citing works
Wigger, A., & Neumann, I. D. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00300-x · Cited by 443 · see citing works
Role for brain-derived neurotrophic factor in learning and memory
Yamada, K., Mizuno, M., & Nabeshima, T. (2002) · Life Sciences · doi:10.1016/s0024-3205(01)01461-8 · Cited by 420 · see citing works
Maternal separation as a model of brain-gut axis dysfunction
O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415 · see citing works
Smith, M. E. (2005) · Hippocampus · doi:10.1002/hipo.20102 · Cited by 395 · see citing works
Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats
Huot, R. L., Plotsky, P. M., Lenox, R. H., & McNamara, R. K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02985-2 · Cited by 383 · see citing works
Corticotropin-releasing factor receptors and stress-related alterations of gut motor function
Taché, Y., & Bonaz, B. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30085 · Cited by 373 · see citing works
Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.007 · Cited by 368 · see citing works
Pathophysiology of depression: the concept of synaptic plasticity
Duman, R. S. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00654-5 · Cited by 361 · see citing works
Long-term behavioural and molecular alterations associated with maternal separation in rats
Lippmann, M., Bress, A., Nemeroff, C. B., Plotsky, P. M., & Monteggia, L. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05522.x · Cited by 355 · see citing works
Russo-Neustadt, A., Ha, T., Ramirez, R., & Kesslak, J. P. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00364-8 · Cited by 346 · see citing works
Roceri, M., Cirulli, F., Pessina, C., Peretto, P., Racagni, G., & Riva, M. A. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.011 · Cited by 317 · see citing works
Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning
Buwalda, B., Kole, M. H. P., Veenema, A. H., Huininga, M., de Boer, S. F., Korte, S. M., & Koolhaas, J. M. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.05.005 · Cited by 304 · see citing works
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases
Seidah, N. G., Benjannet, S., Pareek, S., Savaria, D., Hamelin, J., Goulet, B., Laliberté, J., Lazure, C., Chrétien, M., & MURPHY, R. A. (1996) · Biochemical Journal · doi:10.1042/bj3140951 · Cited by 291 · see citing works
Major depressive disorder: probiotics may be an adjuvant therapy.
Logan, A., & Katzman, M. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2004.08.019 · Cited by 277 · see citing works
A role for BDNF in the late-phase of hippocampal long-term potentiation
Körte, M., Kang, H., Bonhoeffer, T., & Schuman, E. M. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00035-5 · Cited by 268 · see citing works
McIntosh, J. F., Anisman, H., & Merali, Z. (1999) · Developmental Brain Research · doi:10.1016/s0165-3806(99)00005-x · Cited by 255 · see citing works
Smith, M. A., Makino, S., Kim, S. Y., & Květňanský, R. (1995) · Endocrinology · doi:10.1210/endo.136.9.7649080 · Cited by 226 · see citing works
Neurotrophic Mechanisms in Drug Addiction
Bolaños, C. A., & Nestler, E. J. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:1:069 · Cited by 195 · see citing works
Review article: probiotics and prebiotics in irritable bowel syndrome
SPILLER, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03750.x · Cited by 190 · see citing works
Nair, A., Vadodaria, K. C., Banerjee, S. B., Benekareddy, M., Dias, B. G., Duman, R. S., & Vaidya, V. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301276 · Cited by 189 · see citing works
Cytokine and growth factor involvement in schizophrenia—support for the developmental model
Nawa, H., Takahashi, M., & Patterson, P. H. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000730 · Cited by 189 · see citing works
Oitzl, M. S., Workel, J. O., Fluttert, M., van Loenen-Frösch, F., & de Kloet, E. R. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00231.x · Cited by 185 · see citing works
Verdú, E. F., Bercík, P., Bergonzelli, G. E., Huang, X.-X., Blennerhasset, P., Rochat, F., Fiaux, M., Mansourian, R., Corthésy-Theulaz, I., & Collins, S. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.007 · Cited by 180 · see citing works
Aisa, B., Elizalde, N., Tordera, R. M., Lasheras, B., Rı́o, J. D., & Ramírez, M. J. (2009) · Hippocampus · doi:10.1002/hipo.20586 · Cited by 178 · see citing works
Biagini, G., Pich, E. M., Carani, C., Marrama, P., & Agnati, L. F. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00019-7 · Cited by 149 · see citing works
Mayer, E. A., Tillisch, K., & Bradesi, S. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03078.x · Cited by 139 · see citing works
Molteni, R., Calabrese, F., Cattaneo, A., Mancini, M., Gennarelli, M., Racagni, G., & Riva, M. A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.208 · Cited by 125 · see citing works
Greisen, M. H., Altar, C. A., Bolwig, T. G., Whitehead, R. E., & Wörtwein, G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20418 · Cited by 120 · see citing works
Robinson, R. C., Choe, S., Radziejewski, C. H., Spraggon, G., Greenwald, J., Kostura, M., Burtnick, L. D., Stuart, D. I., & Jones, E. Y. (1999) · Protein Science · doi:10.1110/ps.8.12.2589 · Cited by 104 · see citing works
Bravo, J. A., Dinan, T. G., & Cryan, J. F. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000994 · Cited by 103 · see citing works
Self-citationWorkel, J. O., Oitzl, M. S., Fluttert, M., Lesscher, H. M. B., Karssen, A. M., & de Kloet, E. R. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00668.x · Cited by 102 · see citing works
Neurotrophic factors and the maldevelopmental hypothesis of schizophrenic psychoses
Thome, J., Foley, P., & Riederer, P. F. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050040 · Cited by 101 · see citing works
Arborelius, L., Hawks, B. W., Owens, M. J., Plotsky, P. M., & Nemeroff, C. B. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1883-x · Cited by 89 · see citing works
Stress and the Developing Hippocampus: A Double-Edged Sword?
Brunson, K. L., Chen, Y., Avishai‐Eliner, S., & Baram, T. Z. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:2:121 · Cited by 86 · see citing works
Lu, J., Wu, Y., Sousa, N., & Almeida, O. F. X. (2005) · Development · doi:10.1242/dev.01893 · Cited by 80 · see citing works
Law, A. J., Pei, Q., Walker, M. A., Gordon-Andrews, H., Weickert, C. S., Feldon, J., Pryce, C. R., & Harrison, P. J. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.106 · Cited by 73 · see citing works
The Ontogeny of Glucocorticoid Negative Feedback: Influence of Maternal Deprivation1
van Oers, H. J. J., de Kloet, E. R., Li, C., & Levine, S. D. (1998) · Endocrinology · doi:10.1210/endo.139.6.6037 · Cited by 70 · see citing works
Quigley, E. M. M. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.009 · Cited by 67 · see citing works
Self-citationBerninger, B., Schinder, A. F., & Poo, M. (1999) · Learning & Memory · doi:10.1101/lm.6.3.232 · Cited by 59 · see citing works
Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology.
Shanahan, F. (1999) · PubMed · Cited by 57 · see citing works
Lee, T., Kato, H., Chen, S.-T., Kogure, K., & Itoyama, Y. (2002) · Neuroreport · doi:10.1097/00001756-200212030-00020 · Cited by 48 · see citing works
The Gut–Brain Axis in Childhood Developmental Disorders
Wakefield, A. J. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200205001-00004 · Cited by 35 · see citing works
Hyland, N. P., Julio‐Pieper, M., O’Mahony, S. M., Bulmer, D. C., Lee, K., Quigley, E. M. M., Dinan, T. G., & Cryan, J. F. (2009) · Gut · doi:10.1136/gut.2008.167882 · Cited by 34 · see citing works
Self-citationClarke, G. A., O’Mahony, S. M., Hennessy, A. A., Ross, R. P., Stanton, C., Cryan, J. F., & Dinan, T. G. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.008 · Cited by 33 · see citing works
Self-citationJaworska, N., Dwyer, S. M., & Rusak, B. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.10.012 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Self-citationThe gut microbiota in anxiety and depression—A systematic review
Simpson, C. A., Diaz-Arteche, C., Eliby, D., Schwartz, O. S., Simmons, J. G., & Cowan, C. S. M. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101943 · Cited by 912 · see citing works
Collective unconscious: How gut microbes shape human behavior
Dinan, T. G., Stilling, R. M., Stanton, C., & Cryan, J. F. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.02.021 · Cited by 571 · see citing works
Self-citationMicrobiota and host determinants of behavioural phenotype in maternally separated mice
De Palma, G., Blennerhassett, P., Lu, J., Deng, Y., Park, A. J., Green, W., Denou, E., Silva, M. A., Santacruz, A., Sanz, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms8735 · Cited by 517 · see citing works
Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.191 · Cited by 513 · see citing works
Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12427 · Cited by 418 · see citing works
Savignac, H. M., Corona, G., Mills, H., Chen, L., Spencer, J. P. E., Tzortzis, G., & Burnet, P. W. J. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.10.006 · Cited by 377 · see citing works
Bifidobacteria modulate cognitive processes in an anxious mouse strain
Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365 · see citing works
Self-citationEffect of probiotics on central nervous system functions in animals and humans: a systematic review
Wang, H., Lee, I.-S., Braun, C., & Enck, P. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16018 · Cited by 334 · see citing works
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies
Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2219 · Cited by 320 · see citing works
Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish
Borrelli, L., Aceto, S., Agnisola, C., De Paolo, S., Dipineto, L., Stilling, R. M., Dinan, T. G., Cryan, J. F., Menna, L. F., & Fioretti, A. (2016) · Scientific Reports · doi:10.1038/srep30046 · Cited by 225 · see citing works
Self-citationMaternal high-fat diet in mice programs emotional behavior in adulthood
Peleg-Raibstein, D., Luca, E., & Wolfrum, C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.027 · Cited by 167 · see citing works
Peterson, C. T. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20957225 · Cited by 160 · see citing works
Nikolova, V., Cleare, A., Young, A., & Stone, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040647 · Cited by 106 · see citing works
MahmoudianDehkordi, S., Bhattacharyya, S., Brydges, C. R., Jia, W., Fiehn, O., Rush, A. J., Dunlop, B. W., & Kaddurah-Daouk, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.937906 · Cited by 75 · see citing works
Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67 · see citing works
Peng, Y., Tao, H., Wang, S., Xiao, J., Wang, Y., & Su, H. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104463 · Cited by 31 · see citing works
- Authors
- O'Sullivan, E., Barrett, E., Grenham, S., Fitzgerald, P., Stanton, C., Ross, R., Quigley, E., Cryan, J., & Dinan, T.
- Affiliations
- University College Cork, Alimentary Pharmabiotic Centre, College Road, Cork, Ireland
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- Venue
- Beneficial Microbes
- Publisher
- Walter de Gruyter GmbH
- Published
- 2011-09-01
- Volume
- 2
- Issue
- 3
- Pages
- 199-207
- ISSN
- 1876-2883 (ISSN-L)
- 1876-2891
- OpenAlex
- W2146214392
- Cited by
- 92
- References
- 73
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 3 · 2023: 8 · 2022: 11 · 2021: 11 · 2020: 12 · 2019: 7 · 2018: 7 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Beneficial Microbes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- brain-derived neurotrophic factor, maternal separation, early life stress, probiotics, hippocampus, gut-brain axis, irritable bowel syndrome, stress-related psychiatric disorders
- MeSH terms
- Animals, Animals, Newborn, Bifidobacterium, Female, Hippocampus, Humans, Male, Maternal Deprivation, Up-Regulation, Gene Expression, Rats, Sprague-Dawley, Alternative Splicing, Brain-Derived Neurotrophic Factor, Probiotics, Models, Animal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
