Involvement of hippocampal NMDA receptors in encoding and consolidation, but not retrieval, processes of spontaneous object location memory in rats
Abstract
The hippocampus is thought to be involved in object location recognition memory, yet the contribution of hippocampal NMDA receptors to the memory processes, such as encoding, retention and retrieval, is unknown. First, we confirmed that hippocampal infusion of a competitive NMDA receptor antagonist, AP5 (2-amino-5-phosphonopentanoic acid, 20-40nmol), impaired performance of spontaneous object location recognition test but not that of novel object recognition test in Wistar rats. Next, the effects of hippocampal AP5 treatment on each process of object location recognition memory were examined with three different injection times using a 120min delay-interposed test: 15min before the sample phase (Time I), immediately after the sample phase (Time II), and 15min before the test phase (Time III). The blockade of hippocampal NMDA receptors before and immediately after the sample phase, but not before the test phase, markedly impaired performance of object location recognition test, suggesting that hippocampal NMDA receptors play an important role in encoding and consolidation/retention, but not retrieval, of spontaneous object location memory.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The treatment influenced consolidation of information but not retrieval processes.
“suggesting that the treatment influenced consolidation of information, but not retrieval processes”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Yamada et al., 2017
Post-sample AP5 infusion into the hippocampus impaired OPP, while pre-test AP5 infusion had no influence.
“Post-sample AP5 infusion into the hippocampus impaired OPP, while pre-test AP5 infusion had no influence”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Yamada et al., 2017
Pre-sample AP5 microinjections into the hippocampus did not impair NOP.
“but not NOP”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Yamada et al., 2017
Cites
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
Synaptic plasticity: LTP and LTD
Bear, M. F., & Malenka, R. C. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90101-5 · Cited by 1,355 · see citing works
When Is the Hippocampus Involved in Recognition Memory?
Barker, G. R. I., & Warburton, E. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6413-10.2011 · Cited by 818 · see citing works
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740 · see citing works
Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., & Lehmann, H. (2002) · Learning & Memory · doi:10.1101/lm.41302 · Cited by 714 · see citing works
Barker, G. R. I., Bird, F., Alexander, V., & Warburton, E. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5289-06.2007 · Cited by 691 · see citing works
Ennaceur, A., Neave, N., & Aggleton, J. P. (1997) · Experimental Brain Research · doi:10.1007/pl00005603 · Cited by 670 · see citing works
Winters, B. D., Forwood, S., Cowell, R. A., Saksida, L. M., & Bussey, T. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1346-04.2004 · Cited by 588 · see citing works
Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval
Winters, B. D., Saksida, L. M., & Bussey, T. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.04.004 · Cited by 568 · see citing works
NMDA Receptor-Dependent Synaptic Reinforcement as a Crucial Process for Memory Consolidation
Shimizu, E., Tang, Y., Rampon, C., & Tsien, J. Z. (2000) · Science · doi:10.1126/science.290.5494.1170 · Cited by 532 · see citing works
Memories of NMDA receptors and LTP
Collingridge, G. L., & Bliss, T. V. P. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80016-u · Cited by 493 · see citing works
Synaptic plasticity of NMDA receptors: mechanisms and functional implications
Hunt, D. L., & Castillo, P. E. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.01.007 · Cited by 380 · see citing works
Robust Conjunctive Item–Place Coding by Hippocampal Neurons Parallels Learning What Happens Where
Komorowski, R. W., Manns, J. R., & Eichenbaum, H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1378-09.2009 · Cited by 372 · see citing works
Effects of Stress and Hippocampal NMDA Receptor Antagonism on Recognition Memory in RatsPreprint
Baker, K. B., & Kim, J. J. (2002) · Learning & Memory · doi:10.1101/lm.46102 · Cited by 292 · see citing works
Winters, B. D., & Bussey, T. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3827-04.2005 · Cited by 283 · see citing works
Glutamate-receptor-mediated encoding and retrieval of paired-associate learning
Day, M., Langston, R. F., & Morris, R. (2003) · Nature · doi:10.1038/nature01769 · Cited by 259 · see citing works
Forwood, S., Winters, B. D., & Bussey, T. J. (2004) · Hippocampus · doi:10.1002/hipo.20059 · Cited by 259 · see citing works
Hannesson, D. K., Howland, J. G., & Phillips, A. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5517-03.2004 · Cited by 231 · see citing works
Norman, G., & Eacott, M. J. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.2.557 · Cited by 217 · see citing works
Barker, G. R. I., & Warburton, E. C. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht245 · Cited by 159 · see citing works
Bachevalier, J., & Nemanic, S. (2007) · Hippocampus · doi:10.1002/hipo.20369 · Cited by 147 · see citing works
Winters, B. D., & Bussey, T. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04055.x · Cited by 141 · see citing works
Mumby, D. G., Glenn, M. J., Nesbitt, C., & Kyriazis, D. A. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00444-2 · Cited by 120 · see citing works
Role of the dorsal hippocampus in object memory load
Sannino, S., Russo, F., Torromino, G., Pendolino, V., Calabresi, P., & De Leonibus, E. (2012) · Learning & Memory · doi:10.1101/lm.025213.111 · Cited by 57 · see citing works
Yoshihara, T., & Ichitani, Y. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.030 · Cited by 49 · see citing works
Self-citationPhosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity
Olivito, L., Saccone, P., Perri, V., Bachman, J. L., Fragapane, P., Mele, A., Huganir, R. L., & Leonibus, E. D. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0927-1 · Cited by 36 · see citing works
Visual callosal connections in the golden hamster
Rhoades, R. W., & Dellacroce, D. D. (1980) · Brain Research · doi:10.1016/0006-8993(80)91175-0 · Cited by 30 · see citing works
Suenaga, T., & Ichitani, Y. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.029 · Cited by 28 · see citing works
Self-citationIwamura, E., Yamada, K., & Ichitani, Y. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.048 · Cited by 20 · see citing works
Sugita, M., Yamada, K., Iguchi, N., & Ichitani, Y. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.001 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
- Authors
- Yamada, K., Arai, M., Suenaga, T., & Ichitani, Y.
- Affiliations
- University of Tsukuba (JP)
- Tokyo University of Social Welfare (JP)
- Corresponding author
- Ichitani, Yukio
- ORCID
- Yamada, Kazuo
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 331
- Pages
- 14-19
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2611357816
- Cited by
- 16
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (16K04419, 15K04180)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- memory encoding, memory consolidation, memory retrieval, AP5, NMDA receptor antagonists, novel object recognition, rats
- MeSH terms
- Animals, Hippocampus, Male, Memory, Space Perception, Visual Perception, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Rats, Wistar, Excitatory Amino Acid Antagonists, Maze Learning, Recognition, Psychology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
