Role of the dorsal hippocampus in object memory load
Open accessAbstract
The dorsal hippocampus is crucial for mammalian spatial memory, but its exact role in item memory is still hotly debated. Recent evidence in humans suggested that the hippocampus might be selectively involved in item short-term memory to deal with an increasing memory load. In this study, we sought to test this hypothesis. To this aim we developed a novel behavioral procedure to study object memory load in mice by progressively increasing the stimulus set size in the spontaneous object recognition task. Using this procedure, we demonstrated that naive mice have a memory span, which is the number of elements they can remember for a short-time interval, of about six objects. Then, we showed that excitotoxic selective lesions of the dorsal hippocampus did not impair novel object discrimination in the condition of low memory load. In contrast, the same lesion impaired novel object discrimination in the high memory load condition, and reduced the object memory span to four objects. These results have important heuristic and clinical implications because they open new perspective toward the understanding of the role of the hippocampus in item memory and in memory span deficits occurring in human pathologies, such as Alzheimer's disease and schizophrenia.
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Dorsal hippocampus-lesioned mice were impaired in remembering six distinct objects.
“Studies have shown that the dorsal hippocampus-lesioned mice were impaired in remembering six distinct objects (Sannino et al., 2012), although this finding seems hard to explain the mentioned discrepancies because two identical objects are usually used in the NOP test (Table 3).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Sannino et al., 2012
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- Authors
- Sannino, S., Russo, F., Torromino, G., Pendolino, V., Calabresi, P., & De Leonibus, E.
- Affiliations
- Institute of Genetics and Biophysics (IT)
- Sapienza University of Rome (IT)
- Fondazione Santa Lucia (IT)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-04-20
- Volume
- 19
- Issue
- 5
- Pages
- 211-218
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- OpenAlex
- W2060763281
- Cited by
- 57
- References
- 43
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Alzheimer's Association (NIRG-10-173992)
- Fondazione Telethon
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- dorsal hippocampus, object memory, memory load, memory span, novel object recognition, excitotoxic lesions, stimulus set size, Alzheimer's disease, schizophrenia
- MeSH terms
- Animals, Hippocampus, Male, Recognition, Psychology, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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