Hippocampal NMDA receptors are involved in rats’ spontaneous object recognition only under high memory load condition
Abstract
The possible involvement of hippocampal N-methyl-D-aspartate (NMDA) receptors in spontaneous object recognition was investigated in rats under different memory load conditions. We first estimated rats' object memory span using 3-5 objects in "Different Objects Task (DOT)" in order to confirm the highest memory load condition in object recognition memory. Rats were allowed to explore a field in which 3 (3-DOT), 4 (4-DOT), or 5 (5-DOT) different objects were presented. After a delay period, they were placed again in the same field in which one of the sample objects was replaced by another object, and their object exploration behavior was analyzed. Rats could differentiate the novel object from the familiar ones in 3-DOT and 4-DOT but not in 5-DOT, suggesting that rats' object memory span was about 4. Then, we examined the effects of hippocampal AP5 infusion on performance in both 2-DOT (2 different objects were used) and 4-DOT. The drug treatment before the sample phase impaired performance only in 4-DOT. These results suggest that hippocampal NMDA receptors play a critical role in spontaneous object recognition only when the memory load is high.
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Pre-sample AP5 infusions into the hippocampus impaired memory when there were four but not two sample objects.
“pre-sample AP5 infusions into the hippocampus impaired memory when there were four, but not two, sample objects”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Sugita et al., 2015
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- Authors
- Sugita, M., Yamada, K., Iguchi, N., & Ichitani, Y.
- Affiliations
- University of Tsukuba (JP)
- Corresponding author
- Yamada, Kazuo
- ORCID
- Yamada, Kazuo
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 1624
- Pages
- 370-379
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1122915946
- Cited by
- 14
- References
- 47
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (26590174, 24530909)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- object recognition memory, memory load, AP5, rats, novel object recognition
- MeSH terms
- Analysis of Variance, Animals, Discrimination, Psychological, Exploratory Behavior, Hippocampus, Male, Time Factors, Visual Perception, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Excitatory Amino Acid Antagonists, Recognition, Psychology, Rats
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