Physical activity dose-response effects on outcomes of depression and anxiety
Abstract
PURPOSE: The purpose of this study was to examine the scientific evidence for a dose-response relation of physical activity with depressive and anxiety disorders. METHODS: Computer database searches of MEDLINE, PsychLit, and Internet and personal retrieval systems to locate population studies, randomized controlled trials (RCTs), observational studies, and consensus panel judgments were conducted. RESULTS: Observational studies demonstrate that greater amounts of occupational and leisure time physical activity are generally associated with reduced symptoms of depression. Quasi-experimental studies show that light-, moderate-, and vigorous-intensity exercise can reduce symptoms of depression. However, no RCTs have varied frequency or duration of exercise and controlled for total energy expenditure in studies of depression or anxiety. Quasi-experimental and RCTs demonstrate that both resistance training and aerobic exercise can reduce symptoms of depression. Finally, the relation of exercise dose to changes in cardiorespiratory fitness is equivocal with some studies showing that fitness is associated with reduction of symptoms and others that have demonstrated reduction in symptoms without increases in fitness. CONCLUSION: All evidence for dose-response effects of physical activity and exercise come from B and C levels of evidence. There is little evidence for dose-response effects, though this is largely because of a lack of studies rather than a lack of evidence. A dose-response relation does, however, remain plausible.
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Exercise has been shown to be effective in improving mood, but the mechanisms that underlie these changes and the specifics regarding type and frequency of exercise remain unclear.
“Exercise has been shown to be effective in improving mood, but the mechanisms that underlie these changes and the specifics regarding type and frequency of exercise remain unclear. [31-33]”
From A pilot study on the effects of exercise on depression symptoms using levels of neurotransmitters and EEG as markers (2014) · cites this paper as [33]
There is growing evidence of the beneficial effects of exercise on mental health disorders, including depression and anxiety.
“There is growing evidence of the beneficial effects of exercise on mental health disorders, including depression and anxiety”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [33]
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- Authors
- DUNN, A. L., TRIVEDI, M. H., & O???NEAL, H. A.
- Affiliations
- Cooper Institute (US)
- Venue
- Medicine and Science in Sports and Exercise
- Published
- 2001-06
- Volume
- 33
- Issue
- Supplement
- Pages
- S587-S597
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W1999190561
- Cited by
- 816
- References
- 49
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 19 · 2023: 30 · 2022: 25 · 2021: 27 · 2020: 37 · 2019: 24 · 2018: 33 · 2017: 37 · 2016: 32 · 2015: 39 · 2014: 48 · 2013: 59 · 2012: 42
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- physical activity, exercise dose-response, depression, anxiety, depressive symptoms, anxiety symptoms, exercise intensity, resistance training, aerobic exercise, cardiorespiratory fitness, occupational physical activity, leisure-time physical activity, total energy expenditure
- MeSH terms
- Adult, Affect, Aged, Aged, 80 and over, Anxiety Disorders, Depression, Energy Metabolism, Exercise Therapy, Female, Humans, Male, Middle Aged, Physical Fitness, Stress, Psychological, Weight Lifting, Exercise, Outcome Assessment, Health Care
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