Cited by 180Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Prefrontal cortex and drug abuse vulnerability: Translation to prevention and treatment interventions

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Perry, Jennifer L., Joseph, Jane E., Jiang, Yang, Zimmerman, Rick S., Kelly, Thomas H., Darna, Mahesh, Huettl, Peter, Dwoskin, Linda P. +1 more·2011·Brain Research Reviews

Abstract

Vulnerability to drug abuse is related to both reward seeking and impulsivity, two constructs thought to have a biological basis in the prefrontal cortex (PFC). This review addresses similarities and differences in neuroanatomy, neurochemistry and behavior associated with PFC function in rodents and humans. Emphasis is placed on monoamine and amino acid neurotransmitter systems located in anatomically distinct subregions: medial prefrontal cortex (mPFC); lateral prefrontal cortex (lPFC); anterior cingulate cortex (ACC); and orbitofrontal cortex (OFC). While there are complex interconnections and overlapping functions among these regions, each is thought to be involved in various functions related to health-related risk behaviors and drug abuse vulnerability. Among the various functions implicated, evidence suggests that mPFC is involved in reward processing, attention and drug reinstatement; lPFC is involved in decision-making, behavioral inhibition and attentional gating; ACC is involved in attention, emotional processing and self-monitoring; and OFC is involved in behavioral inhibition, signaling of expected outcomes and reward/punishment sensitivity. Individual differences (e.g., age and sex) influence functioning of these regions, which, in turn, impacts drug abuse vulnerability. Implications for the development of drug abuse prevention and treatment strategies aimed at engaging PFC inhibitory processes that may reduce risk-related behaviors are discussed, including the design of effective public service announcements, cognitive exercises, physical activity, direct current stimulation, feedback control training and pharmacotherapies. A major challenge in drug abuse prevention and treatment rests with improving intervention strategies aimed at strengthening PFC inhibitory systems among at-risk individuals.

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Crossref · 10.1016/j.brainresrev.2010.09.001

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  • Pre-existing prefrontal cortex dysfunction due to genetic factors, head trauma, or neurodevelopmental insults is recognized as a vulnerability risk factor for SUDs.

    “Pre- existing prefrontal cortex dysfunction due to genetic fac tors, head trauma, or neurodevelopmental insults is recognized as a vulnerability risk factor for SUDs 60 .”

    From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [60]

    The Prevention section (5.1; page not provided) links pre-existing PFC dysfunction to increased drug-abuse risk through ADHD. The Developmental Differences section (4.1; page not provided) also discusses developmental influences on PFC function and vulnerability. The passages do not establish genetic factors, head trauma, or neurodevelopmental insults as the specific causes of the dysfunction described in the claim. (LLM, conf=0.86)

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Research works printed but not linked: 3

  1. Arnsten AF The Emerging Neurobiology of Attention Deficit Hyperactivity Disorder: The Key Role of the Prefrontal Association Cortex J Pediatr 2009 154 I-S43 PMC2894421 20596295
  2. Floyd NS Price JL Ferry AT Keay KA Bandler R Orbitomedial prefrontal cortical projections to distinct longitudinal columns of the periaqueductal gray in the rat J Comp Neurol 2000 422 556 578 10861526
  3. Lishman WA Cerebral beriberi (Wernicke's encephalopathy) J Psychosom Res 1998 44 631 632 9678741

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Authors
Perry, J. L., Joseph, J. E., Jiang, Y., Zimmerman, R. S., Kelly, T. H., Darna, M., Huettl, P., Dwoskin, L. P., & Bardo, M. T.
Affiliations
University of Kentucky (US)
Corresponding author
Bardo, Michael T.
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
2011-01-01
Volume
65
Issue
2
Pages
124-149
ISSN
0165-0173 (ISSN-L)
OpenAlex
W1969360450
Cited by
180
References
366
Citations by year
2026: 8 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 25 · 2014: 18 · 2013: 16 · 2012: 14
FWCI
7.95
Type
journal article
Language
en
Open access
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (R01DA012964, T32DA007304, P50DA005312, P50 DA05312, R21DA024401)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
prefrontal cortex, drug abuse vulnerability, reward processing, impulsivity, medial prefrontal cortex, lateral prefrontal cortex, anterior cingulate cortex, orbitofrontal cortex, monoamines, amino acid neurotransmitters, behavioral inhibition, decision-making, individual differences, age and sex differences, substance use prevention, addiction treatment, transcranial direct current stimulation, cognitive exercises, physical activity, pharmacotherapy, public service announcements
MeSH terms
Animals, Exploratory Behavior, Humans, Impulsive Behavior, Motivation, Reward, Risk Factors, Prefrontal Cortex, Substance-Related Disorders, Genetic Predisposition to Disease, Risk Reduction Behavior, Rats, Executive Function

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