The P2X7 receptor: A main player in inflammation

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466

Pyroptosis: host cell death and inflammation

Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,288

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J. G., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,613

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167

The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )

Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,490

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

He, Y., Zeng, M. Y., Yang, D., Motro, B., & Núñez, G. (2016) · Nature · doi:10.1038/nature16959 · Cited by 1,295

The P2X7 Receptor in Infection and Inflammation

Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267

P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway

Mounieb, F., Abdel-Sattar, S. A., Balah, A., & Akool, E. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09977-4 · Cited by 3

Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration

Simões, J. L. B., Braga, G. D. C., Eichler, S. W., da Silva, G. B., & Bagatini, M. D. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-09998-7 · Cited by 4

Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats

Lu, Y., Cui, Y. R., Hou, L., Jiang, Y., Shang, J., Wang, L., Xu, H., Ye, W., Qiu, Y., & Guo, B. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1517127 · Cited by 3

Effect of suramin on urinary excretion of diabetes-induced glomerular and tubular injury parameters in rats

Sałaga-Zaleska, K., Pikuł, P., Kreft, E., Herman, S., Chyła-Danił, G., Dąbkowski, K., Kuchta, A., Lenartowicz, M., & Jankowski, M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111683 · Cited by 3

Nicotinamide Coenzymes and Metabolic Diseases

Lu, T., Qin, Z., & Wu, J. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_27 · Cited by 2

ATP/P2X7 receptor/NLRP3 pathway facilitates renal tubular epithelial-myofibroblast transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction

Tan, H. Z., Li, F., Cui, Y. C., Li, Z., Yan, S., & Deng, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1598151 · Cited by 2

Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction

Guo, X. Y., Liu, C., Wang, Y., Li, H., Ma, S., Lei, N., Ren, H., Lin, Y., & Wang, X. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1012772 · Cited by 2

Micheliolide interferes PKM2-P65 interaction and inhibits inflammasome activation in macrophage after ischemic stroke

Wang, J., Cai, W., Yang, G., Liang, R., Wang, Z., Li, S., Huang, X., Qiu, W., Lu, Z., Fan, X., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115231 · Cited by 2

Purinergic P2X receptor 7 (P2X7R) inhibition induced cytotoxicity in glioblastoma

Drill, M., Kan, L. K., Sequeira, R. P., Jayakrishnan, P. C., Hunn, M., Jones, N. C., O'Brien, T. J., & Monif, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0332212 · Cited by 2

Mechanisms of acupuncture in the treatment of dry eye disease: narrative review of experimental studies

Fu, Y., Liu, C., & Xu, G. (2025) · International Ophthalmology · doi:10.1007/s10792-025-03833-7 · Cited by 2

Early P2X7 receptor activation mitigates neonatal group B Streptococcus infection severity and long-term neurodevelopmental impairment

Fialho, S., Amorim, I., Quintas, C., Trieu‐Cuot, P., Ferreira, P. R., & Oliveira, L. M. A. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116113 · Cited by 2

The neuronal P2X7R controversy: Revisiting evidence, methods, and unresolved questions

Kachappilly, N., Pizzo, P., & Basso, E. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110876 · Cited by 2

P2X7R Signaling and Differential Regulation of Neuroinflammatory and Behavior Responses in Male and Female Mice During Chronic Ethanol Exposure

Togre, N. S., Bhoj, P. S., Mekala, N. K., Trivedi, J., Winfield, M., Hancock, R. E., Sriram, U., Rom, S., & Persidsky, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052332 · Cited by 2

P2X7 receptor-mediated cGAS-STING pathway activation underlies chronic stress-induced depressive-like behaviors

He, X.-M., Zhang, Y., Chen, C.-Y., Tang, Y.-L. H., & Li, X. (2026) · Purinergic Signalling · doi:10.1007/s11302-026-10150-w · Cited by 2

P2X receptors in immune cells: key regulators of inflammation and immune function

Adinolfi, E., Falzoni, S., Fortuna, F., Ricci, L., Ruo, L., Grignolo, M., Giuliani, A. L., & Pegoraro, A. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110976 · Cited by 2

Purinergic signaling and cancer neuroscience

Hu, J.-Q., Zhou, X., Qing-ling, R., & Han, Y. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111048 · Cited by 2

Probiotic Supplementation Attenuates Polystyrene Nanoplastic-Induced Pancreatic Injury through Modulation of Oxidative Stress, Inflammation, and P2X7 Receptor/Caspase-1 Signaling Pathway in Rats

Erbaş, E., Üstündağ, H., Gedikli, S., Gelen, V., Parlak, S. N., Çelebi, D., & Kara, A. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11091-x · Cited by 2

P2X7 blockade inhibits the growth of breast cancer in 4T1 breast cancer-bearing mice by NLRP3/caspase 1 pathway

Yu, X., Chen, X., Tang, X., Cao, Y. B., Tang, L. P., & Liu, Y. (2020) · Archives of Medical Science · doi:10.5114/aoms.2020.99013 · Cited by 2

Chagas disease, COVID‐19 and P2X7 receptor

Pereira, C. D. S. F., & Faria, R. X. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13135 · Cited by 2

Alterations of the Sympathoadrenal Axis Related to the Development of Alzheimer’s Disease in the 3xTg Mouse Model

Muñoz-Montero, A., de Pascual, R., Sáez-Mas, A., Colmena, I., & Gandı́a, L. (2022) · Biology · doi:10.3390/biology11040511 · Cited by 2

7-desacetoxy-6,7-dehydrogedunin discovered by high-throughput screening system suppresses melanogenesis through ATP-P2X7 signaling inhibition

Park, S., Choi, E. J., Kim, J. Y., Lee, E. J., Bae, Y. J., Seong, S. H., Lee, J., & Oh, S. H. (2022) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2022.12.011 · Cited by 2

Quantitative proteomics unveils known and previously unrecognized alterations in neuropathic nerves

Defilippi, V., Petereit, J., Handlos, V. J. L., & Notterpek, L. M. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16189 · Cited by 2

Could P2X7 receptor be a potencial target in neonatal sepsis?

Fialho, S., Trieu‐Cuot, P., Ferreira, P., & Oliveira, L. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112969 · Cited by 2

Blockade of connexin43-containing hemichannel attenuates the LPS-induced inflammatory response in human dental pulp cells by inhibiting the extracellular flux of ATP and HMGB1

Hu, P., Long, P., Li, R., Lan, X., He, Y., Li, G., & Li, S. (2024) · Frontiers in Oral Health · doi:10.3389/froh.2024.1496819 · Cited by 2

An association study of polymorphisms in the P2RX7 gene in an Iranian population with the risk of type 2 diabetes mellitus

Noori, H., Rajabian, M., Majidpour, M., Akbar-Abad, M. S., & Saravani, R. (2025) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-025-00639-1 · Cited by 2

Role of Pannexin 1, P2X7, and CFTR in ATP Release and Autocrine Signaling by Principal Cells of the Epididymis

Brochu, K., Minas, A., Belardin, L. B., Légaré, C., & Breton, S. (2025) · Function · doi:10.1093/function/zqaf016 · Cited by 2

P2X receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Virgilio, F. D., Evans, R. J., Falzoni, S., Jarvis, M. F., Kennedy, C., Khakh, B. S., King, B. F., Pellegatti, P., & Peters, J. A. (2019) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f77/2019.4 · Cited by 2

Activated P2X receptors can up-regulate the expressions of inflammation-related genes via NF-κB pathway in spotted sea bass (Lateolabrax maculatus)

Sun, Z., Gao, Q., Wei, Y., Zhou, Z., Chen, Y., Xu, C., Gao, J., & Liu, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1181067 · Cited by 2

Editorial: Purinergic signaling in metabolic diseases and inflammation pharmacology

Sánchez-Melgar, A., Sanz, J. M., & Giuliani, A. L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1631388 · Cited by 2

Characterization of the Active Enantiomer and Mapping of the Stereospecific Intermolecular Pattern of a Reference P2X7 Allosteric Antagonist

McGown, A., Renault, N., Barczyk, A., Nafie, J., Barluzzi, L., Guest, D., Tizzard, G. J., Coles, S. J., Leach, D., von Emloh, D., et al. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00582 · Cited by 1

CRISP3-PSP94 complex regulates P2RX7 mediated signalling in prostate cancer cells and macrophages via CITED2

Miya, V., & Pathak, B. R. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2025.119997 · Cited by 1

The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential

Xue, Y., Peng, X., Yan, M., Du, Y., Cao, Y., & Zhao, R. (2025) · Purinergic Signalling · doi:10.1007/s11302-025-10108-4 · Cited by 1

Targeting the Purinergic Axis with Phenolic Compounds to Disrupt the Oxidative-Inflammatory Cycle in Thyroid Cancer

Simões, J. L. B., & Bagatini, M. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178474 · Cited by 1

The P2X7 Receptor Regulates IL-1β Secretion in the Human Retina

Niyadurupola, N., Sidaway, P., Broadway, D. C., & Sanderson, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110345 · Cited by 1

Qiming granules regulate Müller cell pyroptosis and the P2X7R/NLRP3 immune inflammatory pathway in diabetic retinopathy

Zhou, Q. X., Tang, M., Wang, Y., Lv, H., Yang, G., Wang, F., & Ye, H. (2026) · Chinese Medicine · doi:10.1186/s13020-026-01370-8 · Cited by 1

Innate immunity and biomarkers of multiple sclerosis relapse versus remission

Karadeniz, M., Wesselingh, R., Jayakrishnan, P. C., Sequeira, R. P., van der Walt, A., Butzkueven, H., & Monif, M. (2026) · Autoimmunity Reviews · doi:10.1016/j.autrev.2026.104058 · Cited by 1

Unveiling the molecular crosstalk between the purinergic P2X7 receptor and cannabinoid subtype 2 receptor in human microglial HMC3 cells: New insights for multitarget therapies in neuroinflammation

Idrissi, I. G. E., Moreira, D., Márquez, R. P., Adinolfi, E., Pegoraro, A., Volpini, R., Buccioni, M., Francucci, B., Pierri, C. L., Abate, C., et al. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119646 · Cited by 1

Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site‐directed mutagenesis

Caseley, E. A., Muench, S. P., & Jiang, L. (2021) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26259 · Cited by 1

代谢物衍生型损伤相关分子模式与自身免疫相关疾病

Liu, W., Kang, N., Liu, S., & Duan, Q. (2024) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2024-0335 · Cited by 1

Global trends of purinergic receptors and depression: A bibliometric analysis from 2003 to 2023

Chen, W., Peng, C., Shen, X., Li, H., Chen, W., Chen, W., Yan, C., & Huang, B. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i2.102344 · Cited by 1

P2X receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

Virgilio, F. D., Evans, R. J., Falzoni, S., Fountain, S. J., Jarvis, M. F., Kennedy, C., Khakh, B. S., King, B. F., Nicke, A., Pellegatti, P., et al. (2020) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f77/2020.4 · Cited by 1

Rapid Morphologic and Molecular Activation of Microglial Cells by Stimulation of the P2X7 Receptor Correlates with Neuron LossPreprint

Campagno, K. E., Lu, W., Jassim, A. H., Albalawi, F., Cenaj, A., Tso, H., Clark, S. P., Sripinun, P., Gómez, N. M., & Mitchell, C. H. (2021) · Research Square · doi:10.21203/rs.3.rs-424697/v1 · Cited by 1

Neuroinflammation Protective Efficacy of Montelukast in a Mouse Model of Parkinson’s Disease Revealed by [18F]GSK1482160 PET Quantification Targeting P2X7RPreprint

Ye, P., Bi, L., Qiu, Y., Yang, M., Huang, G., Zhao, X., Liu, Y., Hou, Y., Sun, R., Zheng, P., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3913696/v1 · Cited by 1

Establishing the therapeutic potential of the P2X7 receptor ion channel in amyotrophic lateral sclerosis

Dongol, A. (2018) · Research Online (University of Wollongong)

Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function

Ahlmanner, F. (2019) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Estudo da ativação de inflamassoma por toxinas isoladas de venenos botrópicos e modulação da resposta imune

Silva, P. A. R. E. (2019) · doi:10.11606/t.42.2019.tde-23042019-135832

Participação do receptor P2X7 no controle das populações de células TFH e B esplênicas e na proteção contra o Plasmodium yoelii 17XNL

Cunha, I. D. A. (2019) · doi:10.11606/d.42.2019.tde-23042019-141848

Matrix metalloproteinases, purinergic signaling, and epigenetics, hubs in the spinal neuroglial network following nerve injury.Preprint

Luca, C. D., Virtuoso, A., Maggio, N., Cerasuolo, M., Colangelo, A. M., Lavitrano, M., & Papa, M. (2021) · Research Square · doi:10.21203/rs.3.rs-430667/v1

Serum uric acid as biomarker for mania: An exploratory prospective study

Pandey, A., Kalita, K. N., & Baruah, A. (2022) · IP Indian Journal of Neurosciences · doi:10.18231/j.ijn.2021.057

Sennoside a From Rheum Palmatum L. Is a Novel Inhibitor Targeting Caspase-1Preprint

Wu, J., Lan, Y., Shi, X., Huang, W., Li, S., Zhang, J., Wang, H., Wang, F., & Meng, X. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4094617

Suppressive effect of Thymoquinone on NLRP3 pathway in breast cancer: a novel multi-strike CALR and sec-PD-L1 inhibitorPreprint

Elgohary, S., Eissa, R. A., & Tayebi, H. M. E. (2022) · Research Square · doi:10.21203/rs.3.rs-2172339/v1

The Pathogenetic Role of DAMPs in Severe Infectious Diseases

Land, W. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-21776-0_5

LncTCONS_00058568 is involved in the pathophysiologic processes mediated by P2X7R in the lower thoracic spinal cord after acute kidney injury

Wang, Y. J., Chen, Z. S., Liu, Q., & Lv, Y. (2024) · The FASEB Journal · doi:10.1096/fj.202301622rrr

Global Trends Of Purinergic Receptors And Depression: A Bibliometric Analysis From 2003 to 2023Preprint

Chen, W., Peng, C., Shen, X., Li, H., Chen, W., Chen, W., Yan, C., & Biao, H. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4822543

Investigating the Involvement of C−X−C Motif Chemokine 5 and P2X7 Purinoceptor in Ectopic Calcification in Mouse Models of Duchenne Muscular Dystrophy

Rumney, R. M. H., Pomeroy, J., & Górecki, D. C. (2024) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30617

Thalamic Purinergic Receptors: A Gateway to Modulating Fibromyalgia Pain via NLRP3 Inflammasome Signaling and PyroptosisPreprint

Kamel, A. S. E. D., Mohamed, M. M., & Zaki, H. F. (2024) · Research Square · doi:10.21203/rs.3.rs-4560073/v1

P2X7-Driven NLRP3 Inflammasome Activation Unveils Novel Serum Biomarkers Associated with the Severity of Mycoplasma pneumoniae Pneumonia in ChildrenPreprint

Wang, P., Ding, W., Wang, L., Deng, Y., Zhan, Z., & Ding, S. (2025) · medRxiv · doi:10.1101/2025.05.09.25327287

Physiological roles and therapeutic potential of the purinergic P2X7 receptor

Dunker, C., Gross, S., Vinnenberg, L., Prinz, A., Koch, O., & Junker, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00063-7

Additional file 1 of PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139

Beaino, W., Janssen, B., Kooijman, E. J. M., Vos, R., Schuit, R. C., O’Brien-Brown, J., Kassiou, M., van het Hof, B., Vugts, D. J., de Vries, H. E., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13093766

Additional file 2 of Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure

Campagno, K. E., Lu, W., Jassim, A. H., Albalawi, F., Cenaj, A., Tso, H.-Y., Clark, S. P., Sripinun, P., Gómez, N., & Mitchell, C. H. (2021) · Figshare · doi:10.6084/m9.figshare.16650524

Additional file 1 of Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure

Campagno, K. E., Lu, W., Jassim, A. H., Albalawi, F., Cenaj, A., Tso, H.-Y., Clark, S. P., Sripinun, P., Gómez, N., & Mitchell, C. H. (2021) · Figshare · doi:10.6084/m9.figshare.16650518

Anthonoic Acids A–C, Sulfated and N-(2-Hydroxyethyl)-Substituted Lipidic Amino Acids from the Marine Sponge Antho ridgwayi with In Vitro Cytoprotective Activities

Guzii, A. G., Kudryashova, E. K., Shubina, L. K., Makarieva, T. N., Menshov, A. S., Popov, R. S., Yurchenko, E. A., Pislyagin, Е. А., Chingizova, E. A., Grebnev, B. B., et al. (2025) · Molecules · doi:10.3390/molecules31010036

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Pereira, C. D. S. F., & Faria, R. X. (2026) · Journal of Tropical Medicine · doi:10.1155/jotm/7015795

Extracellular ATP in inflammatory disorders

Fhaily, L. E., Abad, C., Tan, Y., & Adriouch, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00031-x

Extracellular ATP and the pancreas

Novak, I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00027-8

Extracellular ATP in psychiatric disorders

von Mücke-Heim, I.-A., & Deussing, J. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00015-1

Extracellular ATP and the peripheral nervous system

Sun, M.-J., Ren, W.-J., Rubini, P., Tang, Y., & Illes, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00005-9

40-Hz transauricular vagal nerve stimulation rescues cognition of 9-month-old APP/PS1 mice via inhibiting hippocampal P2X7 receptor signaling

Yu, Y., Wang, Y., Guo, S., Zhang, J., Bai, Y., Liu, C., Liu, X., Li, X., Jiang, X., Liu, P., et al. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1766813

Mechanisms of Tongdu Tiaoshen acupuncture therapy in protecting against cerebral ischemia reperfusion injury☆

Chen, S., Wei, H. A. N., Chong, C. H. E. N., Xiao-li, S. U. N., Zhang, W., & Sun, S. (2026) · 世界针灸杂志：英文版 · doi:10.1016/j.wjam.2026.03.004

The therapeutic potential of compounds from natural products for alleviating depression by targeting P2X7 receptor-mediated proinflammatory signaling pathways

Bai, X., Wang, G.-L., Zhang, Y., Cheng, Q., Feng, H.-N., Wei, L., Sheng, H.-Y., Yin, Y., Roger, S., Jiang, L., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1814913

Implication de nouvelles cibles microgliales, Cst7 et Clec7a/Dectin-1, dans le développement et la progression de la maladie d'Alzheimer

Hemonnot-Girard, A.-L. (2021) · theses.fr (ABES) · doi:10.70675/9c8a4775zd774z494ez9bbazf7566faefa8f

Increased P2X7 level does not affect anxiety or stress-coping behavior in male mice

Urbina-Treviño, L., Tang, H., von Mücke-Heim, I.-A., Engel, T., Nicke, A., & Deussing, J. M. (2026) · Purinergic Signalling · doi:10.1007/s11302-026-10157-3

Identification of the promoter region of the human P2RX7 gene

Liu, L., Kagawa, Y., Masters, C. L., Stylli, S. S., Mantamadiotis, T., & Gu, B. J. (2026) · Purinergic Signalling · doi:10.1007/s11302-026-10155-5

MALAT1–miR-20b-5p–P2RX7 Axis Regulates Mycobacterium bovis-Induced THP-1 Pyroptosis

Tian, T., Wang, X., Zhu, Y., Wang, Q., Zheng, W., Shi, K., & Du, R. (2026) · Veterinary Sciences · doi:10.3390/vetsci13060545

New N-Arylpiperazine-Based Compounds as Potential Inhibitors of Purinergic P2X7-Associated Signaling

Greifová, G., Dubničková, M., Nádaská, D., Šándrik, R., Kapustíková, I., Švajdlenka, E., Pisárčik, M., Csöllei, J., & Malík, I. (2026) · Life · doi:10.3390/life16071046

Altered Circulating Biomarkers of Purinergic Signaling, Inflammasome-Related Pathways, Pyroptosis, and Oxidative Stress in Fibromyalgia

Hayta, E., Ağbektas, T., Kabak, G., Dogan, G., Taş, A., & Siliğ, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156579

The P2X7 receptor: insights from the murine monoclonal antibody clone L4

Sluyter, R., Elhage, A., Bartlett, R., Watson, D., Stokes, L., Skarratt, K. K., Fuller, S. J., & Gu, B. J. (2026) · Purinergic Signalling · doi:10.1007/s11302-026-10176-0

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