Cited by 317Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.

Executive Dysfunction and the Course of Geriatric Depression

Alexopoulos, George S., Kiosses, Dimitris N., Heo, Moonseong, Murphy, Christopher F., Shanmugham, Bindu, Gunning-Dixon, Faith·2005·Biological Psychiatry

DOI 10.1016/j.biopsych.2005.04.024

Open this paper in CoChat — free account

Abstract

Background Executive dysfunction is common in geriatric depression and persists after improvement of depressive symptoms. This study examined the relationship of executive impairment to the course of depressive symptoms among elderly patients with major depression.Methods A total of 112 nondemented elderly patients with major depression participated in an 8-week citalopram trial at a target daily dose of 40 mg. Executive functions were assessed with the initiation/perseveration subscale of the Dementia Rating Scale and the Stroop Color-Word test. Medical burden was rated with the Cumulative Illness Rating Scale.Results Both abnormal initiation/perseveration and abnormal Stroop Color-Word scores were associated with an unfavorable response of geriatric depression to citalopram. In particular, initiation/perseveration scores below the median (< or =35) and Stroop scores at the lowest quartile (< or =22) predicted limited change in depressive symptoms. Impairment in other Dementia Rating Scale cognitive domains did not significantly influence the outcome of depression.Conclusions Executive dysfunction increases the risk for poor response of geriatric depression to citalopram. Because executive functions require frontostriatal-limbic integrity, this observation provides the rationale for investigation of the role of specific frontostriatal-limbic pathways in perpetuating geriatric depression. Depressed elderly patients with executive dysfunction require vigilant clinical attention because they might be at risk to fail treatment with a selective serotonin reuptake inhibiting antidepressant.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2005.04.024

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Research Diagnostic Criteria
Spitzer, R. L. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770300115013 · Cited by 6,946
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Dissociating the Role of the Dorsolateral Prefrontal and Anterior Cingulate Cortex in Cognitive Control
MacDonald, A. W., Cohen, J. D., Stenger, V. A., & Carter, C. S. (2000) · Science · doi:10.1126/science.288.5472.1835 · Cited by 3,666
Book Reviews
Mendelson, G. (1995) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048679509064964 · Cited by 2,592
Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale
Miller, M. D., Paradis, C. F., Houck, P. R., Mazumdar, S., Stack, J. A., Rifai, A. H., Mulsant, B., & Reynolds, C. F. (1992) · Psychiatry Research · doi:10.1016/0165-1781(92)90005-n · Cited by 1,990
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585

Flagged first, then by citations

Show all 57 references

1 of the 57 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Bezchlibnyk-Butler, 2000, CitalopramA review of pharmacological and clinical effects, J Psychiatry Neurosci, 25, 241
Sakai, 1998, Transition of brain activation from frontal to parietal areas in visuomotor sequence learning, J Neurosci, 18, 1827, 10.1523/JNEUROSCI.18-05-01827.1998 · DOI

Sorted by citations

Items 101–200 of 317

Cognitive Outcomes After Psychotherapeutic Interventions for Major Depression in Older Adults with Executive Dysfunction
Mackin, R. S., Nelson, J. C., Delucchi, K., Raue, P. J., Byers, A. L., Barnes, D. E., Satre, D. D., Yaffe, K. S., Alexopoulos, G. S., & Areán, P. A. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.11.002 · Cited by 51
The impact of executive function on response to cognitive behavioral therapy in late-life depression: Executive function and CBT response in late-life depression
Goodkind, M. S., Gallagher-Thompson, D., Thompson, L. W., Kesler, S. R., Anker, L., Flournoy, J., Berman, M. P., Holland, J. M., & O'Hara, R. M. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4325 · Cited by 50
“Multiple studies have found that worse executive functioning at baseline predicts poor response to antidepressants and a greater risk of relapse and recurrence of depression (Kalayam and Alexopoulos 1999; Potter et al., 2004; Alexopoulos et al., 2005; Sneed et al., 2007; Story et al., 2008).”
Background
BDNF Val66Met genotype and 6-month remission rates in late-life depression
Taylor, W. D., McQuoid, D. R., Ashley‐Koch, A. E., MacFall, J. R., Bridgers, J., Krishnan, R. R., & Steffens, D. C. (2010) · The Pharmacogenomics Journal · doi:10.1038/tpj.2010.12 · Cited by 50
Vascular Cognitive Impairment through the Looking Glass of Transcranial Magnetic Stimulation
Lanza, G., Bramanti, P., Cantone, M., Pennisi, M., Pennisi, G., & Bella, R. (2017) · Behavioural Neurology · doi:10.1155/2017/1421326 · Cited by 50
“Finally, different reports emphasize that WMLs and executive dysfunction are linked to both poor response to treatment and progression to chronic depression compared to those with lacunar infarcts [21, 26, 29].”
BackgroundResult
A digital intervention targeting cognitive control network dysfunction in middle age and older adults with major depression
Gunning, F. M., Anguera, J. A., Victoria, L. W., & Areán, P. A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01386-8 · Cited by 49
Developing an intervention for depressed, chronically medically ill elders: A model from COPD
Alexopoulos, G. S., Raue, P. J., Sirey, J. A., & Arean, P. A. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1925 · Cited by 48
“Impairment in some executive functions predicts poor or slow response to antidepressant treatment (Kalayam and Alexopoulos, 1999; Alexopoulos et al., 2004; Potter et al., 2004), as well as early relapse and recurrence of geriatric depression (Alexopoulos et al., 2005).”
Background
The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
Bogner, H. R., Bruce, M. L., Reynolds, C. F., Mulsant, B. H., Cary, M. S., Morales, K., & Alexopoulos, G. S. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1767 · Cited by 48
“…consisted mainly of pharmacotherapy which is a treatment modality to which many depressed patients with executive dysfunction respond poorly (Kalayam and Alexopoulos, 1999; Alexopoulos et al., 2000; Dunkin et al., 2000; Alexopoulos et al., 2004; Potter et al., 2004; Alexopoulos et al., 2005b).”
BackgroundResult
Gait Speed and the Natural Course of Depressive Symptoms in Late Life; An Independent Association With Chronicity?
Sanders, J. B., Bremmer, M. A., Comijs, H. C., Deeg, D. J. H., & Beekman, A. T. F. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.11.016 · Cited by 47
Biological Basis of Late Life Depression
Disabato, B. M., & Sheline, Y. I. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0279-6 · Cited by 48
Brain-based mechanisms of late-life depression: Implications for novel interventions
Gunning, F. M., Oberlin, L. E., Schier, M. M., & Victoria, L. W. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.002 · Cited by 49
MRI‐defined vascular depression: a review of the construct
Culang‐Reinlieb, M. E., Johnert, L. C., Brickman, A. M., Steffens, D. C., Garcon, E., & Sneed, J. R. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2668 · Cited by 45
“…research indicates that ED also predicts poor antidepressant treatment response and increased risk of relapse in LLD (Kalayam and Alexopoulos 1999; Alexopoulos et al., 2000, 2005; Baldwin et al., 2004; Murphy and Alexopoulos 2006; Sneed et al., 2007b; Morimoto et al., in press); however, not all…”
Background
Prevention of Poststroke Apathy Using Escitalopram or Problem-Solving Therapy
Mikami, K., Jorge, R. E., Moser, D. J., Arndt, S. V., Jang, M., Solodkin, A., Small, S. L., Fonzetti, P., Hegel, M. T., & Robinson, R. G. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.07.003 · Cited by 44
The Role of Executive Functioning in Adolescent Rumination and Depression
Dickson, K. S., Ciesla, J. A., & Zelic, K. J. (2016) · Cognitive Therapy and Research · doi:10.1007/s10608-016-9802-0 · Cited by 54
“difficulty with perseveration (Austin et al., 1999; Alexopoulos et al., 2005) and setshifting (Austin et al.”
Event-related potentials in an emotional go/no-go task and remission of geriatric depression
Alexopoulos, G. S., Murphy, C. F., Gunning‐Dixon, F. M., Kalayam, B., Katz, R., Kanellopoulos, D., Etwaroo, G. R., Klimstra, S., & Foxe, J. J. (2007) · Neuroreport · doi:10.1097/wnr.0b013e328013ceda · Cited by 44
“Abnormal performance in the Stroop Color-Word test has been associated with anterior cingulate dysfunction and may predict limited response of geriatric depression to citalopram [14].”
Background
Cognitive control, reward-related decision making and outcomes of late-life depression treated with an antidepressant
Alexopoulos, G. S., Manning, K., Kanellopoulos, D., McGovern, A., Seirup, J. K., Banerjee, S., & Gunning, F. (2015) · Psychological Medicine · doi:10.1017/s0033291715001075 · Cited by 43
“…cognitive inhibition, and semantic clustering have been associated with poor or slow improvement of late-life depression to antidepressants (Alexopoulos et al. 2005; Sneed et al. * Address for correspondence: G. S. Alexopoulos, M.D., Department of Psychiatry, Weill Cornell Medical College,…”
BackgroundResultInfluential
Course and outcomes of depression in the elderly
Kohn, R., & Epstein-Lubow, G. P. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0079-y · Cited by 43
The Impact of Antidepressant Treatment on Cognitive Functioning in Depressed Patients with Parkinson’s Disease
Dobkin, R. D., Menza, M. A., Bienfait, K., Gara, M. A., Marín, H., Mark, M. H., Dicke, A., & Tröster, A. I. (2010) · Journal of Neuropsychiatry · doi:10.1176/jnp.2010.22.2.188 · Cited by 39
Age-Related Repetitive Transcranial Magnetic Stimulation Effects on Executive Function in Depression: A Systematic Review
Ilieva, I. P., Alexopoulos, G. S., Dubin, M. J., Morimoto, S. S., Victoria, L. W., & Gunning, F. M. (2018) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.09.002 · Cited by 38
The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder
Gudayol‐Ferré, E., Herrera‐Guzmán, I., Camarena, B., Cortés‐Penagos, C., Herrera‐Abarca, J. E., Martínez‐Medina, P., la Cruz, D. C.-D., Hernández, S., Genis, A. D., Carrillo-Guerrero, M. Y., et al. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.002 · Cited by 42
“, 2000), or the Stroop test (Alexopoulos et al., 2005).”
Background
Differential associations between types of verbal memory and prefrontal brain structure in healthy aging and late life depression
Lamar, M., Charlton, R. A., Zhang, A., & Kumar, A. A. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.04.007 · Cited by 43
“…some of these deficits resolve; however, deficits in executive functioning have been shown to persist following both treatment and remission of LLD (Alexopoulos et al., 2000, 2005; Kalayam & Alexopoulos, 1999) suggesting that there are residual executive deficits associated with LLD that may…”
BackgroundInfluential
Neuroplasticity‐based computerized cognitive remediation for geriatric depression
Morimoto, S. S., Wexler, B. E., & Alexopoulos, G. S. (2012) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.3776 · Cited by 36
The lack of meaningful association between depression severity measures and neurocognitive performance
Keilp, J. G., Madden, S. P., Gorlyn, M., Burke, A. K., Oquendo, M. A., & Mann, J. J. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.034 · Cited by 37
Crosstalk between Depression and Dementia with Resting-State fMRI Studies and Its Relationship with Cognitive Functioning
Kim, J., & Kim, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9010082 · Cited by 36
Depression and cognitive impairment among newly admitted nursing home residents in the USA
Ulbricht, C. M., Rothschild, A. J., Hunnicutt, J. N., & Lapane, K. L. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4723 · Cited by 35
“Older adults with cognitive impairment are at higher risk than those with depression alone of experiencing depression relapse, poor antidepressant treatment response, functional impairment, preventable hospitalization, and suicide (Lara et al., 2015; Davydow et al., 2014; Koenig et al., 2014; Alexopoulos et al., 2005).”
Background
Cognitive Control Network Homogeneity and Executive Functions in Late-Life Depression
Respino, M., Hoptman, M. J., Victoria, L. W., Alexopoulos, G. S., Solomonov, N., Stein, A. T., Coluccio, M., Morimoto, S. S., Blau, C., Abreu, L., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.10.013 · Cited by 38
The Sensitivity and Specificity of Cognitive Screening Instruments to Detect Cognitive Impairment in Older Adults With Severe Psychiatric Illness
Mackin, R. S., Ayalon, L., Feliciano, L., & Areán, P. A. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988709358589 · Cited by 35
The specificity of neuropsychological impairment in predicting antidepressant non‐response in the very old depressed
Sneed, J. R., Keilp, J. G., Brickman, A. M., & Roose, S. P. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1889 · Cited by 35
“These findings converge with an emerging literature documenting the impact of response inhibition on antidepressant treatment response in late-life depression (Kalayam and Alexopoulos, 1999; Alexopoulos et al., 2005; Murphy and Alexopoulos, 2006).”
Result
Depression and Suicidal Ideation During Two Psychosocial Treatments in Older Adults with Major Depression and Dementia
Kiosses, D. N., Rosenberg, P. B., McGovern, A. R., Fonzetti, P., Zaydens, H., & Alexopoulos, G. S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150200 · Cited by 34
The characteristic of cognitive dysfunction in remitted late life depression and amnestic mild cognitive impairment
Liao, W., Zhang, X., Shu, H., Wang, Z., Liu, D., & Zhang, Z. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.01.024 · Cited by 34
Toward Prevention of Mild Cognitive Impairment in Older Adults With Depression: An Observational Study of Potentially Modifiable Risk Factors
Gallagher, D., Kiss, A., Lanctot, K. L., & Herrmann, N. (2018) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.18m12331 · Cited by 34
Diversity of approaches in assessment of executive functions in stroke: Limited evidence?
Conti, J., Sterr, A., Brucki, S. M. D., & Conforto, A. B. (2015) · eNeurologicalSci · doi:10.1016/j.ensci.2015.08.002 · Cited by 32
Intact Cognition in Depressed Elderly Veterans Providing Adequate Effort
Benitez, A. M., Horner, M. D., & Bachman, D. (2011) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acr001 · Cited by 31
Identification and treatment of depressive disorders in older adults with cancer
Saracino, R. M., & Nelson, C. J. (2019) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2019.02.005 · Cited by 33
A Critical Examination of Bifrontal Electroconvulsive Therapy
Crowley, K. O., Pickle, J., Dale, R. M., & Fattal, O. (2008) · Journal of Ect · doi:10.1097/yct.0b013e318168e72c · Cited by 32
High‐definition transcranial direct current stimulation—An open‐label pilot intervention in alleviating depressive symptoms and cognitive deficits in late‐life depression
Wong, H.-L., Chan, W. C., Wong, Y., Wong, S. P. Y., Yung, H., Wong, S. C., & Cheng, C. P.-W. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13253 · Cited by 30
Executive Dysfunction in Elderly Bipolar Manic Patients
Gunning‐Dixon, F. M., Murphy, C. F., Alexopoulos, G. S., Majcher-Tascio, M., & Young, R. C. (2008) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318172b3ec · Cited by 31
Psychosocial predictors of treatment response to cognitive-behavior therapy for late-life depression: an exploratory study
Marquett, R. M., Thompson, L. W., Reiser, R. P., Holland, J. M., O'Hara, R. M., Kesler, S. R., Stepanenko, A., Bilbrey, A. C., Rengifo, J., Majoros, A., et al. (2013) · Aging & Mental Health · doi:10.1080/13607863.2013.791661 · Cited by 30
“Prior research by Alexopoulos and colleagues on the impact of reduced cognitive function on the response to treatment for depression is well known (Alexopoulos et al., 2005; Alexopoulos et al., 2011).”
Background
Untangling Therapeutic Ingredients of a Personalized Intervention for Patients with Depression and Severe COPD
Alexopoulos, G. S., Kiosses, D. N., Sirey, J. A., Kanellopoulos, D., Seirup, J. K., Novitch, R. S., Ghosh, S., Banerjee, S., & Raue, P. J. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.05.006 · Cited by 30
“Overall cognitive impairment or executive dysfunction did not influence the efficacy of PID-C in depression although executive dysfunction has been shown to compromise the efficacy of antidepressant drugs (32, 33).”
Background
Dimensions of Poststroke Depression and Neuropsychological Deficits in Older Adults
Kanellopoulos, D., Wilkins, V. M., Avari, J., Oberlin, L. E., Arader, L., Chaplin, M., Banerjee, S., & Alexopoulos, G. S. (2020) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.01.009 · Cited by 30
“(45, 49) Similarly, executive dysfunction is associated with disability (50) and predicts poor response of late-life depression to antidepressants.(51-53)”
Background
The Patterns of Cognitive and Functional Impairment in Amnestic and Non-amnestic Mild Cognitive Impairment in Geriatric Depression
Culang‐Reinlieb, M. E., Ercoli, L. M., Siddarth, P., Cyr, N. S., & Lavretsky, H. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.10.010 · Cited by 32
Patient predictors of response to cognitive behaviour therapy and schema therapy for depression
Carter, J. D., McIntosh, V. V. W., Jordan, J., Porter, R., Douglas, K. M., FRAMPTON, C. M. A., & Joyce, P. R. (2018) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867417750756 · Cited by 35
Exekutive Funktionen bei depressiven Patienten
Vasić, N., Wolf, R. C., & Walter, H. (2007) · Der Nervenarzt · doi:10.1007/s00115-006-2240-6 · Cited by 28
Executive dysfunction in late-life depression.
Rajtar-Zembaty, A., Sałakowski, A., Rajtar-Zembaty, J., & Starowicz–Filip, A. (2016) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/63765 · Cited by 39
A Lifespan Model of Interference Resolution and Inhibitory Control: Risk for Depression and Changes with Illness Progression
Bessette, K. L., Karstens, A. J., Crane, N. A., Peters, A. T., Stange, J. P., Elverman, K. H., Morimoto, S. S., Weisenbach, S. L., & Langenecker, S. A. (2020) · Neuropsychology Review · doi:10.1007/s11065-019-09424-5 · Cited by 33
Surrogate markers of treatment outcome in major depressive disorder
Papakostas, G. I. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001246 · Cited by 29
“2007), executive dysfunction (Alexopoulos et al. 2005), physical symptoms of depression (pain, fatigue, anxiety, gastrointestinal symptoms) (Burns et al.”
Background
Incidence and Documentation of Cognitive Impairment Among Older Adults With Severe Mental Illness in a Community Mental Health Setting
Mackin, R. S., & Areán, P. A. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31818cd3e5 · Cited by 27
Effect of a Motivational Group Intervention on Exercise Self-Efficacy and Outcome Expectations for Exercise in Schizophrenia Spectrum Disorders
Beebe, L. H., Smith, K., Burk, R., Dessieux, O. L., Velligan, D. I., Tavakoli, A. S., & Tennison, C. (2010) · Journal of the American Psychiatric Nurses Association · doi:10.1177/1078390310364428 · Cited by 27
Co-occurrence of depressive symptoms and executive dysfunction after stroke: associations with brain pathology and prognosis
Douven, E., Aalten, P., Staals, J., Schievink, S. H. J., van Oostenbrugge, R. J., Verhey, F. R. J., & Köhler, S. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-317548 · Cited by 27
Subtypes of Late-Life Depression: A Data-Driven Approach on Cognitive Domains and Physical Frailty
Lugtenburg, A., Zuidersma, M., Wardenaar, K. J., Aprahamian, I., Rhebergen, D., Schoevers, R. A., & Voshaar, R. C. O. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa110 · Cited by 27
Aging with elevated autistic traits: Cognitive functioning among older adults with the broad autism phenotype
Stewart, G. R., Charlton, R. A., & Wallace, G. L. (2018) · Research in Autism · doi:10.1016/j.rasd.2018.06.009 · Cited by 31
Associations of cardiovascular disease and depression with memory related disease: A Chinese national prospective cohort study
Xue, Y., Liu, G., & Geng, Q. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.081 · Cited by 26
Depression and Anxiety in Late Life: Diagnostic Insights and Therapeutic Options
Kastenschmidt, E. K., & Kennedy, G. J. (2011) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20266 · Cited by 29
Depression, cognitive, and functional outcomes of Problem Adaptation Therapy (PATH) in older adults with major depression and mild cognitive deficits
Kanellopoulos, D., Rosenberg, P. B., Ravdin, L., Maldonado‐McGrath, D., Jamil, N., Quinn, C. G., & Kiosses, D. N. (2020) · International Psychogeriatrics · doi:10.1017/s1041610219001716 · Cited by 28
Improved Alertness Is Associated with Early Increase in Serum Brain-Derived Neurotrophic Factor and Antidepressant Treatment Outcome in Major Depression
Mikoteit, T., Hemmeter, U., Eckert, A., Brand, S., Bischof, R., Delini-Stula, A., Holsboer-Trachsler, E., & Beck, J. (2015) · Neuropsychobiology · doi:10.1159/000437439 · Cited by 25
Cognitive Functioning and the Natural Course of Depressive Symptoms in Late Life
Sanders, J. B., Bremmer, M. A., Comijs, H. C., Deeg, D. J. H., Lampe, I. K., & Beekman, A. T. F. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181f7d8e9 · Cited by 25
Separating mood disturbance from mild cognitive impairment in geriatric depression
Steffens, D. C. (2008) · International Review of Psychiatry · doi:10.1080/09540260802094589 · Cited by 25
“For example, presence of executive impairment may decrease the rate of depression response in older adults (Alexopoulos et al., 2005; Alexopoulos, Kiosses, Murphy, & Heo, 2004).”
Background
The P300, loneliness, and depression in older adults
Brush, C. J., Kallen, A. M., Meynadasy, M. A., King, T., Hajcak, G., & Sheffler, J. (2022) · Biological Psychology · doi:10.1016/j.biopsycho.2022.108339 · Cited by 26
Neural Correlates of Successful Response Inhibition in Unmedicated Patients With Late-Life Depression
Bobb, D. S., Adinoff, B. H., Laken, S. J., McClintock, S. M., Rubia, K., Huang, H.-W., Husain, M. M., Mapes, K. S., Tamminga, C. A., Cullum, C. M., et al. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318235b728 · Cited by 25
Role of Executive Dysfunction and Dysexecutive Behavior in Late-Life Depression and Disability
Gansler, D. A., Suvak, M., Arean, P., & Alexopoulos, G. S. (2015) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2015.05.003 · Cited by 24
Thioredoxin is not a marker for treatment-resistance depression but associated with cognitive function: An rTMS study
Aydın, E. P., Genç, A., Dalkıran, M., Uyar, E. T., Deniz, İ., Özer, Ö. A., & Karamustafalıoğlu, O. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.025 · Cited by 23
“Clinical Assessment Patients were assessed according to Turkish versions of HDRS (Akdemir et al., 2001), Hamilton Anxiety Rating Scale (HARS, Yazici et al.”
Contextual memory and encoding strategies in young and older adults with and without depressive symptoms
Balardin, J. B., Vedana, G., Ludwig, A., de Lima, D. B., Argimon, I. I. D. L., Schneider, R. H., Luz, C., Schröder, N., & Bromberg, E. (2009) · Aging & Mental Health · doi:10.1080/13607860802534583 · Cited by 23
“These impairments have been reported as resulting from abnormally functioning neural systems like the frontostriatal pathways and hippocampus (Alexopoulos et al. 2005).”
Cholinesterase Inhibitor Adjunctive Therapy for Cognitive Impairment and Depressive Symptoms in Older Adults with Depression
McDermott, C. L., & Gray, S. L. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1q445 · Cited by 23
Prediction of the time-course pattern of remission in depression by using clinical, neuropsychological, and genetic variables
Gudayol‐Ferré, E., Guàrdia‐Olmos, J., Peró, M., Herrera‐Guzmán, I., Camarena, B., Cortés‐Penagos, C., Herrera‐Abarca, J. E., & Martínez‐Medina, P. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.04.024 · Cited by 23
Moderation of antidepressant and placebo outcomes by baseline severity in late-life depression: A systematic review and meta-analysis
Locher, C., Kossowsky, J., Gaab, J., Kirsch, I., Bain, P. A., & Krummenacher, P. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.062 · Cited by 23
“We excluded studies investigating these neurological disorders because executive dysfunction and associated learning impairments in older patients with depression have been associated with a lower probability of antidepressant and placebo response (Alexopoulos et al., 2005; Benedetti et al., 2006a, 2006b).”
Background
Antiglucocorticoid therapy for older adults with anxiety and co-occurring cognitive dysfunction: results from a pilot study with mifepristone
Lenze, E. J., Hershey, T. G., Newcomer, J. W., Karp, J. F., Blumberger, D. M., Anger, J. T., Doré, P., & Dixon, D. J. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4085 · Cited by 23
“…(Alexopoulos et al., 2002; Gallo et al., 2003; Middleton and Yaffe, 2009; Butters et al., 2011), increased health care utilization (Mackin et al., 2011), and diminished treatment response (Potter et al., 2004; Alexopoulos et al., 2005; Caudle et al., 2007; Story et al., 2008; Sneed et al., 2010).”
Background
Correlations between Stroop task performance and white matter lesion measures in late-onset major depression
Dalby, R. B., Frandsen, J. R., Chakravarty, M. M., Ahdidan, J., Sørensen, L., Rosenberg, R., Østergaard, L., & Videbech, P. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.12.009 · Cited by 23
“…function in late-onset and/or late-life depression is associated with poorer treatment response, suggesting that cognitive measures, including ST performance, may be a predictor of treatment resistance (Baldwin et al., 2004; Alexopoulos et al., 2005; Sheline et al., 2010; Sneed et al., 2010).”
Association of White Matter Integrity With Executive Function and Antidepressant Treatment Outcome in Patients With Late-Life Depression
He, X., Pueraro, E., Kim, Y., Garcia, C. M., Maas, B., Choi, J.-W., Egglefield, D. A., Schiff, S., Sneed, J. R., Brown, P. J., et al. (2021) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2021.01.004 · Cited by 21
The prognostic significance of subsyndromal symptoms emerging after remission of late-life depression
Kiosses, D. N., & Alexopoulos, G. S. (2012) · Psychological Medicine · doi:10.1017/s0033291712000967 · Cited by 21
“Cognitive dysfunction (Story et al. 2008), impairment in some executive functions (Alexopoulos et al. 2005 ; Sneed et al. 2007) and psychomotor slowing (Butters et al. 2004) have each been associated with slow and/or poor response to antidepressant treatment.”
Background
Functional Neuroimaging in Geriatric Depression
Gunning, F. M., & Smith, G. S. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.02.010 · Cited by 24
“These initial task-based activation studies of late-life depression converge with emerging evidence from other clinical and cognitive neuroscience techniques that cognitive control systems are disrupted in late-life depression (see the earlier sections on PET and MRS).(105,106) The cognitive control system of interest…”
Cognitive Control of Emotion in Older Adults: A Review
Lantrip, C., & Huang, J. H. (2017) · Clinical Psychiatry · doi:10.21767/2471-9854.100040 · Cited by 26
“For example, poor cognitive inhibition contributes to poor emotion regulation and may sustain mood disorders and depressive episodes [24-27].”
Background
Pre-treatment letter fluency performance predicts antidepressant response to transcranial direct current stimulation
Martin, D. M., Yeung, K., & Loo, C. K. A. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.072 · Cited by 20
Neurocognitive performance predicts treatment outcome with cognitive behavioral therapy for major depressive disorder
Metts, A. V., Keilp, J. G., Kishon, R., Oquendo, M. A., Mann, J. J., & Miller, J. M. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.08.011 · Cited by 18
Be Fit, Be Sharp, Be Well: The Case for Exercise as a Treatment for Cognitive Impairment in Late-life Depression
Dotson, V. M., Gradone, A. M., Bogoian, H. R., Minto, L. R., Taiwo, Z., & Salling, Z. (2021) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617721000710 · Cited by 19
“The impact of latelife depression (LLD) on daily functioning, quality of life, and other outcomes is attributable at least in part to cognitive impairment (Alexopoulos et al., 2005). Unfortunately, traditional depression treatments—pharmacotherapy and psychotherapy—are generally ineffective in resolving the cognitive…”
BackgroundInfluential
Cognition as a therapeutic target in late-life depression: Potential for nicotinic therapeutics
Zurkovsky, L., Taylor, W. D., & NEWHOUSE, P. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.032 · Cited by 20
Glutamate-Mediated Neuroplasticity Deficits in Mood Disorders
Reznikov, L. R., Fadel, J. R., & Reagan, L. P. (2011) · doi:10.1007/978-1-908517-18-0_2 · Cited by 20
A pilot randomized sham controlled trial of bilateral iTBS for depression and executive function in older adults
Cristancho, P., Arora, J., Nishino, T., Berger, J., Carter, A., Blumberger, D., Miller, P., Snyder, A., Barch, D., & Lenze, E. J. (2023) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5851 · Cited by 19
Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression
Zhou, H., Zhong, X., Chen, B., Wang, Q., Zhang, M., Mai, N., Wu, Z., Huang, X., Chen, X., Peng, Q., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.931560 · Cited by 19
“Executive deterioration is common in patients with LLD and predicts a worse response to antidepressant therapy as well as a greater recurrence risk (Alexopoulos et al., 2005).”
Background
A multiple indicators multiple causes model of late-life depression in Latin American countries
Brăilean, A., Guerra, M., Chua, K., Prince, M. J., & Prina, M. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.05.053 · Cited by 19
“It was suggested that ageing-related dysfunctions of fronto-striatal structures and cerebrovascular disease may precipitate late-life depressive symptoms (Alexopoulos et al., 2005; Alexopoulos et al., 2002).”
Background
Implicit and explicit procedural learning in patients recently remitted from severe major depression
Pedersen, A., Kueppers, K. A., Behnken, A., Kroker, K., Schöning, S., Baune, B. T., Rist, F., Arolt, V., & Suslow, T. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.001 · Cited by 21
“For instance, they might continue to exhibit deficits on tasks of executive functioning or tasks of visuo-motor speed, which have been reported to persist after treatment and to be of prognostic significance in geriatric patients (Alexopoulos et al., 2000, 2005).”
Improvement in Depression is Associated with Improvement in Cognition in Late-Life Psychotic Depression
Victoria, L. W., Whyte, E. M., Butters, M. A., Meyers, B. S., Alexopoulos, G. S., Mulsant, B. H., Rothschild, A. J., Banerjee, S., & Flint, A. J. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.02.006 · Cited by 19
Depression subtypes and 5‐years risk of mortality in aged 70 years: a population‐based cohort study
Franch, J. V., Pujol, X. P., Pousa, S. L., Reglà, J. L., Merino‐Aguado, J., & Garre‐Olmo, J. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2691 · Cited by 19
“, 2006) is characterised by less depressive family history, underperformance in cognitive tests, neurological pathology, important anhedonia, greater cardiovascular comorbidity, higher likelihood of developing dementia and more structural damages in neuroimaging studies (especially white matter hyperintensities and in…”
BackgroundInfluential
Theory-of-mind abilities in older patients with common mental disorders – a cross-sectional study
Peters, M., & Schulz, H. (2021) · Aging & Mental Health · doi:10.1080/13607863.2021.1935461 · Cited by 19
“This is supported by further considerations: In both disorders, limited executive functions are important to consider in old age (Alexopoulos et al., 2005; Mohlman, 2005).”
Method
Associations of cardiovascular disease and depression with memory related disease: A Chinese national prospective cohort study
Xue, Y., Liu, G., & Geng, Q. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.054 · Cited by 18
Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression
Liu, X., Jiang, W., & Yuan, Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00310 · Cited by 19
Are there predictors of outcome in depressed elderly nursing home residents during treatment with mirtazapine orally disintegrating tablets?
Nelson, J. C., Holden, K. F., Roose, S. P., Salzman, C., Hollander, S. B., & Betzel, J. V. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1779 · Cited by 17
“…Mitchell and Subramaniam, 2005), cognitive impairment or dementia (Trappler and Cohen, 1998; Kalayam and Alexopoulos, 1999; Streim et al., 2000; Alexopoulos et al., 2005), medical burden (Keitner et al., 1991; Evans et al., 1997; Katon et al., 2002; Iosifescu et al., 2003; Lowe et al., 2005),…”
Background
A patient‐centered research agenda for the care of the acutely Ill older patient
Wald, H. L., Leykum, L. K., Mattison, M. L. P., Vasilevskis, E. E., & Meltzer, D. (2015) · Journal of Hospital Medicine · doi:10.1002/jhm.2356 · Cited by 18
Late-Life Depressive Symptoms as Partial Mediators in the Associations between Subclinical Cardiovascular Disease with Onset of Mild Cognitive Impairment and Dementia
Armstrong, N. M., Carlson, M. C., Schrack, J. A., Xue, Q., Carnethon, M. R., Rosano, C., Chaves, P. H. M., & Gross, A. L. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.11.004 · Cited by 17
Predictors of remission after repetitive transcranial magnetic stimulation for the treatment of late-life depression
Göke, K., Trevizol, A. P., Ma, C., Mah, L., Rajji, T. K., Daskalakis, Z. J., Downar, J. H., McClintock, S. M., Nestor, S. M., Noda, Y., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115822 · Cited by 19
“The "depression executive dysfunction syndrome" is a proposed subtype of LLD that affects about 30 – 40 % of individuals with LLD (Alexopoulos et al., 2005).”
Background
Toward an online cognitive and emotional battery to predict treatment remission in depression
Rekshan, W. R., Gordon, E., Palmer, D., Braund, T. A., & Rush, A. J. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75975 · Cited by 16
The Relationship Between the Acute Cerebral Metabolic Response to Citalopram and Chronic Citalopram Treatment Outcome
Smith, G. S., Workman, C. I., Kramer, E., Hermann, C. R., Ginsberg, R., Ma, Y., DHAWAN, V. M., Chaly, T., & Eidelberg, D. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181eafde4 · Cited by 16
Motivating Persons with Schizophrenia Spectrum Disorders to Exercise: Rationale and Design
Beebe, L. H., Burk, R., McIntyre, K., Smith, K., Velligan, D. I., Resnick, B. M., Tavakoli, A. S., Tennison, C., & Dessieux, O. L. (2009) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.3.2.6 · Cited by 16
“Problems with goal setting may be partially related to cognitive deficits associated with aging (27,28).”
Personalizing behavioral interventions: the case of late-life depression
Areán, P. A. (2012) · Neuropsychiatry · doi:10.2217/npy.12.15 · Cited by 16
Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naïve patients with first-episode major depression
Chen, G., Bian, H., Jiang, D., Cui, M., Sheng-zhang, J., Liu, M., Lang, X., & Zhuo, C. (2016) · Biomedical Reports · doi:10.3892/br.2016.796 · Cited by 16
Changes in activities of daily living during treatment of late‐life depression*
Saito, H., ICHIKAWA, K., Nomiyama, T., Tatsumi, N., Washizuka, S., Hanihara, T., & Amano, N. (2008) · Psychogeriatrics · doi:10.1111/j.1479-8301.2007.00216.x · Cited by 16
Economic Impact of Nonpersistence with Antidepressant Treatment in the Adult Population of Quebec: A Comparative Cost-Effectiveness Approach
Béland, S., Tournier, M., du Fort, G. G., Crott, R., Ducruet, T., Pariente, A., & Moride, Y. (2011) · Value in Health · doi:10.1016/j.jval.2010.11.015 · Cited by 15
The Role of Vascular Risk Factors in the Development of DED Syndrome Among an Elderly Community Sample
Kim, B., Lee, D.-H., Lee, D.-W., Bae, J. N., Chang, S. M., Kim, S.-K., & Cho, M. J. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31820119b6 · Cited by 16
Therapeutic relationship in the treatment of geriatric depression with executive dysfunction
Mace, R. A., Gansler, D. A., Suvak, M. K., Gabris, C., Areán, P. A., Raue, P. J., & Alexopoulos, G. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.006 · Cited by 15
Prediction of remission of depression with clinical variables, neuropsychological performance, and serotonergic/dopaminergic gene polymorphisms
Gudayol‐Ferré, E., Herrera‐Guzmán, I., Camarena, B., Cortés‐Penagos, C., Herrera‐Abarca, J. E., Martínez‐Medina, P., Asbún‐Bojalil, J., Lira‐Islas, Y., Reyes‐Ponce, C., & Guàrdia‐Olmos, J. (2012) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2267 · Cited by 15
“The following neuropsychological deficits have been found as predictors for a poor outcome to antidepressants: executive dysfunction, (Dunkin et al., 2000; Kampf-sherf et al., 2004; Potter et al., 2004; Alexopoulos et al., 2005; Gudayol-Ferré et al., 2010), psychomotor slowing (Taylor et al.”
BackgroundInfluential
Vascular Burden and Cognitive Functioning in Depressed Older Adults
Schneider, B. C., Ercoli, L. M., Siddarth, P., & Lavretsky, H. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31822ccd64 · Cited by 15
Correlation of cognitive functions with emotional dysregulation in alcohol dependence: A preliminary study
Ram, D., George, M., & Gowdappa, B. (2018) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_183_18 · Cited by 14
“Findings suggest that the DERS-SF has comparable concurrent validity to the original DERS.”
Background

Authors: Alexopoulos, G. S., Kiosses, D. N., Heo, M., Murphy, C. F., Shanmugham, B., & Gunning-Dixon, F.
Affiliations: Cornell University (US)
Corresponding author: Alexopoulos, George S.
ORCID: Alexopoulos, George S.
Kiosses, Dimitris N.
Heo, Moonseong
Murphy, Christopher F.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2005-08
Volume: 58
Issue: 3
Pages: 204-210
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2005.04.024
OpenAlex: W2030120831
Cited by: 317
References: 57
Citations by year: 2026: 9 · 2025: 9 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 21 · 2017: 18 · 2016: 13 · 2015: 21 · 2014: 15 · 2013: 24 · 2012: 25
FWCI: 9.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (P30MH068638, R01-MH51842, R01MH042819, R01MH065653)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: executive dysfunction, geriatric depression, citalopram, treatment response prediction, Stroop task, Mattis Dementia Rating Scale, medical burden, selective serotonin reuptake inhibitors, cognitive impairment
MeSH terms: Aged, Aged, 80 and over, Antidepressive Agents, Demography, Depression, Female, Humans, Learning Disabilities, Male, Neuropsychological Tests, Predictive Value of Tests, Problem Solving, Psychiatric Status Rating Scales, Time Factors, Citalopram, Geriatric Assessment, Multivariate Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Executive Dysfunction and the Course of Geriatric Depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks